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Select item 77440831.

S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling

Carolina Magdalen Greco, Marlene Cervantes, Jean-Michel Fustin, Kakeru Ito, Nicholas Ceglia, Muntaha Samad, Jiejun Shi, Kevin Brian Koronowski, Ignasi Forne, Suman Ranjit, Jonathan Gaucher, Kenichiro Kinouchi, Rika Kojima, Enrico Gratton, Wei Li, Pierre Baldi, Axel Imhof, Hitoshi Okamura, Paolo Sassone-Corsi

Sci Adv. 2020 Dec; 6(51): eabc5629. Published online 2020 Dec 16. doi: 10.1126/sciadv.abc5629

PMCID:: PMC7744083

Abstract Article PDF–4.5M

Select item 61374512.

Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma

Igor P. Pogribny, Kostiantyn Dreval, Iryna Kindrat, Stepan Melnyk, Leandro Jimenez, Aline de Conti, Volodymyr Tryndyak, Marta Pogribna, Juliana Festa Ortega, S. Jill James, Ivan Rusyn, Frederick A. Beland

FASEB J. 2018 Mar; 32(3): 1591–1601. Published online 2017 Nov 10. doi: 10.1096/fj.201700866R

PMCID:: PMC6137451

Abstract Article

Select item 28330453.

Crystallization of mouse S-adenosyl-l-homocysteine hydrolase

Masaaki Ishihara, Yoshio Kusakabe, Tsuyoshi Ohsumichi, Nobutada Tanaka, Masayuki Nakanishi, Yukio Kitade, Kazuo T. Nakamura

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1; 66(Pt 3): 313–315. Published online 2010 Feb 24. doi: 10.1107/S1744309110000771

PMCID:: PMC2833045

Abstract Article PDF–142K

Select item 107326234.

Inhibition of AHCY impedes proliferation and differentiation of mouse and human adipocyte progenitor cells

Paula Boczki, Marco Colombo, Juliane Weiner, Inka Rapöhn, Martin Lacher, Wieland Kiess, Martha Hanschkow, Antje Körner, Kathrin Landgraf

Adipocyte. 2024; 13(1): 2290218. Published online 2023 Dec 8. doi: 10.1080/21623945.2023.2290218

PMCID:: PMC10732623

Abstract Article PDF–2.3M

Select item 104472515.

Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

Johan Vande Voorde, Rory T. Steven, Arafath K. Najumudeen, Catriona A. Ford, Alex Dexter, Ariadna Gonzalez-Fernandez, Chelsea J. Nikula, Yuchen Xiang, Lauren Ford, Stefania Maneta Stavrakaki, Kathryn Gilroy, Lucas B. Zeiger, Kathryn Pennel, Phimmada Hatthakarnkul, Efstathios A. Elia, Ammar Nasif, Teresa Murta, Eftychios Manoli, Sam Mason, Michael Gillespie, Tamsin R. M. Lannagan, Nikola Vlahov, Rachel A. Ridgway, Colin Nixon, Alexander Raven, Megan Mills, Dimitris Athineos, Georgios Kanellos, Craig Nourse, David M. Gay, Mark Hughes, Amy Burton, Bin Yan, Katherine Sellers, Vincen Wu, Kobe De Ridder, Engy Shokry, Alejandro Huerta Uribe, William Clark, Graeme Clark, Kristina Kirschner, Bernard Thienpont, Vivian S. W. Li, Oliver D. K. Maddocks, Simon T. Barry, Richard J. A. Goodwin, James Kinross, Joanne Edwards, Mariia O. Yuneva, David Sumpton, Zoltan Takats, Andrew D. Campbell, Josephine Bunch, Owen J. Sansom

Nat Metab. 2023; 5(8): 1303–1318. Published online 2023 Aug 14. doi: 10.1038/s42255-023-00857-0

PMCID:: PMC10447251

Abstract Article PDF–17M

Select item 27867006.

S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation

Maria Elena Fernandez-Sanchez, Thomas Gonatopoulos-Pournatzis, Gavin Preston, Margaret A. Lawlor, Victoria H. Cowling

Mol Cell Biol. 2009 Dec; 29(23): 6182–6191. Published online 2009 Oct 5. doi: 10.1128/MCB.00973-09

PMCID:: PMC2786700

Abstract Article PDF–1.9M

Select item 3950207.

The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene.

M W Miller, D M Duhl, B M Winkes, F Arredondo-Vega, P J Saxon, G L Wolff, C J Epstein, M S Hershfield, G S Barsh

EMBO J. 1994 Apr 15; 13(8): 1806–1816. doi: 10.1002/j.1460-2075.1994.tb06449.x

PMCID:: PMC395020

Summary Page Browse PDF–3.1M

Select item 70601998.

DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase

Ji Cao, Xiaobing Chen, Li Jiang, Bin Lu, Meng Yuan, Difeng Zhu, Hong Zhu, Qiaojun He, Bo Yang, Meidan Ying

Nat Commun. 2020; 11: 1251. Published online 2020 Mar 6. doi: 10.1038/s41467-020-15109-y

PMCID:: PMC7060199

Abstract Article PDF–2.6M

Select item 47039059.

H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase

Jichun Zhou, Lihua Yang, Tianyu Zhong, Martin Mueller, Yi Men, Na Zhang, Juanke Xie, Karolyn Giang, Hunter Chung, Xueguang Sun, Lingeng Lu, Gordon G Carmichael, Hugh S Taylor, Yingqun Huang

Nat Commun. 2015; 6: 10221. Published online 2015 Dec 21. doi: 10.1038/ncomms10221

PMCID:: PMC4703905

Abstract Article PDF–2.0M

Select item 266014410.

Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1α

Siming Li, Erland Arning, Chang Liu, Victor Vitvitsky, Carlos Hernandez, Ruma Banerjee, Teodoro Bottiglieri, Jiandie D. Lin

Am J Physiol Endocrinol Metab. 2009 Mar; 296(3): E543–E548. Published online 2009 Jan 21. doi: 10.1152/ajpendo.90719.2008

PMCID:: PMC2660144

Abstract Article

Select item 316457411.

Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2⁻^/y mice

Traci L. Pawlowski, Silvia Heringer-Walther, Chun-Huai Cheng, John G. Archie, Chin-Fu Chen, Thomas Walther, Anand K. Srivastava

Genomics. Author manuscript; available in PMC 2011 Aug 31.

Published in final edited form as: Genomics. 2009 Sep; 94(3): 188–195. Published online 2009 Jun 6. doi: 10.1016/j.ygeno.2009.05.011

PMCID:: PMC3164574

Abstract Article PDF–2.0M

Select item 646392312.

Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia

Teresa Partearroyo, Silvia Murillo-Cuesta, Néstor Vallecillo, Jose M. Bermúdez-Muñoz, Lourdes Rodríguez-de la Rosa, Giacomo Mandruzzato, Adelaida M. Celaya, Steven H. Zeisel, María A. Pajares, Gregorio Varela-Moreiras, Isabel Varela-Nieto

FASEB J. 2019 May; 33(5): 5942–5956. Published online 2019 Feb 12. doi: 10.1096/fj.201801533R

PMCID:: PMC6463923

Abstract Article

Select item 830418513.

IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing Loss

Adelaida M. Celaya, Lourdes Rodríguez-de la Rosa, Jose M. Bermúdez-Muñoz, José M. Zubeldia, Carlos Romá-Mateo, Carlos Avendaño, Federico V. Pallardó, Isabel Varela-Nieto

Cells. 2021 Jul; 10(7): 1686. Published online 2021 Jul 3. doi: 10.3390/cells10071686

PMCID:: PMC8304185

Abstract Article PDF–7.1M

Select item 816379014.

Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma

Yassene Mohammed, Sarah A. Michaud, Helena Pětrošová, Juncong Yang, Milan Ganguly, David Schibli, Ann M. Flenniken, Lauryl M. J. Nutter, Hibret A. Adissu, K. C. Kent Lloyd, Colin McKerlie, Christoph H. Borchers

NPJ Syst Biol Appl. 2021; 7: 25. Published online 2021 May 28. doi: 10.1038/s41540-021-00184-8

PMCID:: PMC8163790

Abstract Article PDF–6.9M

Select item 50883815.

Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.

M Mehrabian, P Z Wen, J Fisler, R C Davis, A J Lusis

J Clin Invest. 1998 Jun 1; 101(11): 2485–2496. doi: 10.1172/JCI1748

PMCID:: PMC508838

Summary PDF–1.0M

Select item 854859616.

Liver and brain differential expression of one-carbon metabolism genes during ontogenesis

Apolline Imbard, Leslie Schwendimann, Sophie Lebon, Pierre Gressens, Henk J. Blom, Jean-François Benoist

Sci Rep. 2021; 11: 21132. Published online 2021 Oct 26. doi: 10.1038/s41598-021-00311-9

PMCID:: PMC8548596

Abstract Article PDF–1.3M

Select item 723606017.

Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism

Arielle N. Valdez-Sinon, Austin Lai, Liang Shi, Carly L. Lancaster, Avanti Gokhale, Victor Faundez, Gary J. Bassell

iScience. 2020 May 22; 23(5): 101132. Published online 2020 May 1. doi: 10.1016/j.isci.2020.101132

PMCID:: PMC7236060

Abstract Article PDF–6.1M

Select item 960386018.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 343226419.

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

Dyna I. Shirasaki, Erin R. Greiner, Ismael Al-Ramahi, Michelle Gray, Pinmanee Boontheung, Daniel H. Geschwind, Juan Botas, Giovanni Coppola, Steve Horvath, Joseph A. Loo, X. William Yang

Neuron. Author manuscript; available in PMC 2013 Jul 12.

Published in final edited form as: Neuron. 2012 Jul 12; 75(1): 41–57. doi: 10.1016/j.neuron.2012.05.024

PMCID:: PMC3432264

Abstract Article PDF–4.9M

Select item 624418320.

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells

Sunyuan Zhang, Nicholas A. Williamson, Marie A. Bogoyevitch

Sci Data. 2018; 5: 180262. Published online 2018 Nov 20. doi: 10.1038/sdata.2018.262

PMCID:: PMC6244183

Abstract Article PDF–753K

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