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Select item 114251971.

Dual role of Valosin-Containing Protein (VCP/p97) in mouse sperm during capacitation

Martina Jabloñski, Florenza A. La Spina, Liza J. Schiavi-Ehrenhaus, Clara I. Marín-Briggiler, Matias D. Gomez-Elias, Dario Krapf, Pablo E. Visconti, Diego Krapf, Guillermina M. Luque, Mariano G. Buffone

Reproduction. Author manuscript; available in PMC 2024 Sep 26.

Published in final edited form as: Reproduction. 2024 Aug 1; 168(2): e240069. Published online 2024 Jul 13. doi: 10.1530/REP-24-0069

PMCID:: PMC11425197

Article PDF–1.2M

Select item 112039542.

Cardiac-Specific Suppression of Valosin-Containing Protein Induces Progressive Heart Failure and Premature Mortality Correlating with Temporal Dysregulations in mTOR Complex 2 and Protein Phosphatase 1

Xiaonan Sun, Xicong Tang, Hongyu Qiu

Int J Mol Sci. 2024 Jun; 25(12): 6445. Published online 2024 Jun 11. doi: 10.3390/ijms25126445

PMCID:: PMC11203954

Article PDF–2.9M

Select item 111025943.

Vcp overexpression and leucine supplementation extend lifespan and ameliorate neuromuscular junction phenotypes of a SOD1^G93A-ALS mouse model

Tzyy-Nan Huang, Yu-Tzu Shih, Tzu-Li Yen, Yi-Ping Hsueh

Hum Mol Genet. 2024 Jun 1; 33(11): 935–944. Published online 2024 Feb 21. doi: 10.1093/hmg/ddae022

PMCID:: PMC11102594

Article PDF–1.4M

Select item 104970054.

Inhibition of VCP modulates NF-κB signaling pathway to suppress multiple myeloma cell proliferation and osteoclast differentiation

Rongfang Wei, Yuhao Cao, Hongjie Wu, Xin Liu, Mingmei Jiang, Xian Luo, Zhendong Deng, Ze Wang, Mengying Ke, Yongqiang Zhu, Siqing Chen, Chunyan Gu, Ye Yang

Aging (Albany NY) 2023 Aug 30; 15(16): 8220–8236. Published online 2023 Aug 21. doi: 10.18632/aging.204965

PMCID:: PMC10497005

Article PDF–1.5M

Select item 97155495.

Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage

Marta del Rio Oliva, Michael Basler

Cell Death Dis. 2022 Dec; 13(12): 1015. Published online 2022 Dec 1. doi: 10.1038/s41419-022-05461-w

PMCID:: PMC9715549

Article PDF–2.3M

Select item 91273706.

AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4

Koji Shibuya, Ken Ebihara, Chihiro Ebihara, Nagisa Sawayama, Masayo Isoda, Daisuke Yamamuro, Manabu Takahashi, Shuichi Nagashima, Shun Ishibashi

J Biol Chem. 2022 Jun; 298(6): 101936. Published online 2022 Apr 14. doi: 10.1016/j.jbc.2022.101936

PMCID:: PMC9127370

Article PDF–2.0M

Select item 84565147.

A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6

Henri Leinonen, Cheng Cheng, Marja Pitkänen, Christopher L. Sander, Jianye Zhang, Sama Saeid, Teemu Turunen, Alyaa Shmara, Lan Weiss, Lac Ta, Timothy Ton, Ari Koskelainen, Jesse D. Vargas, Virginia Kimonis, Krzysztof Palczewski

J Pharmacol Exp Ther. 2021 Jul; 378(1): 31–41. Published online 2021 Jul. doi: 10.1124/jpet.120.000486

PMCID:: PMC8456514

Article PDF–1.5M

Select item 77861238.

Social behaviors and contextual memory of Vcp mutant mice are sensitive to nutrition and can be ameliorated by amino acid supplementation

Tzyy-Nan Huang, Yu-Tzu Shih, Si-Cih Lin, Yi-Ping Hsueh

iScience. 2021 Jan 22; 24(1): 101949. Published online 2020 Dec 15. doi: 10.1016/j.isci.2020.101949

PMCID:: PMC7786123

Article PDF–4.6M

Select item 53978709.

The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo

Paulo Lizano, Eman Rashed, Shaunrick Stoll, Ning Zhou, Hairuo Wen, Tristan T. Hays, Gangjian Qin, Lai-Hua Xie, Christophe Depre, Hongyu Qiu

Sci Rep. 2017; 7: 46324. Published online 2017 Apr 20. doi: 10.1038/srep46324

PMCID:: PMC5397870

Article PDF–1.2M

Select item 537141510.

Mouse Mammary Tumor Virus Signal Peptide Uses a Novel p97-Dependent and Derlin-Independent Retrotranslocation Mechanism To Escape Proteasomal Degradation

Hyewon Byun, Poulami Das, Houqing Yu, Alejandro Aleman, Mary M. Lozano, Andreas Matouschek, Jaquelin P. Dudley

mBio. 2017 Mar-Apr; 8(2): e00328-17. Published online 2017 Mar 28. doi: 10.1128/mBio.00328-17

PMCID:: PMC5371415

Article PDF–2.3M

Select item 507456311.

IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation

Oznur Bayraktar, Ozlem Oral, Nur Mehpare Kocaturk, Yunus Akkoc, Karin Eberhart, Ali Kosar, Devrim Gozuacik

PLoS One. 2016; 11(10): e0164864. Published online 2016 Oct 21. doi: 10.1371/journal.pone.0164864

Correction in:: PLoS One. 2016; 11(11): e0167192.

PMCID:: PMC5074563

Article PDF–2.7M

Select item 490114212.

The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress

Carlos J. Rodriguez-Ortiz, Julio C. Flores, Joanna A. Valenzuela, Gema J. Rodriguez, Joannee Zumkehr, Diana N. Tran, Virginia E. Kimonis, Masashi Kitazawa

Am J Pathol. 2016 Jun; 186(6): 1623–1634. doi: 10.1016/j.ajpath.2016.02.007

PMCID:: PMC4901142

Article PDF–1.5M

Select item 448971313.

A Fine Balance of Dietary Lipids Improves Pathology of a Murine Model of VCP-Associated Multisystem Proteinopathy

Katrina J. Llewellyn, Naomi Walker, Christopher Nguyen, Baichang Tan, Lbachir BenMohamed, Virginia E. Kimonis, Angèle Nalbandian

PLoS One. 2015; 10(7): e0131995. Published online 2015 Jul 2. doi: 10.1371/journal.pone.0131995

PMCID:: PMC4489713

Article PDF–3.4M

Select item 440157114.

Rapamycin and Chloroquine: The In Vitro and In Vivo Effects of Autophagy-Modifying Drugs Show Promising Results in Valosin Containing Protein Multisystem Proteinopathy

Angèle Nalbandian, Katrina J. Llewellyn, Christopher Nguyen, Puya G. Yazdi, Virginia E. Kimonis

PLoS One. 2015; 10(4): e0122888. Published online 2015 Apr 17. doi: 10.1371/journal.pone.0122888

PMCID:: PMC4401571

Article PDF–11M

Select item 432905815.

Global Gene Expression Profiling in R155H Knock‐In Murine Model of VCP Disease

Angèle Nalbandian, Svetlana Ghimbovschi, Zuyi Wang, Susan Knoblach, Katrina J. Llewellyn, Jouni Vesa, Eric P. Hoffman, Virginia E. Kimonis

Clin Transl Sci. 2015 Feb; 8(1): 8–16. Published online 2014 Nov 12. doi: 10.1111/cts.12241

PMCID:: PMC4329058

Article PDF–449K

Select item 412296616.

Novel VCP modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosa

Hanako Ohashi Ikeda, Norio Sasaoka, Masaaki Koike, Noriko Nakano, Yuki Muraoka, Yoshinobu Toda, Tomohiro Fuchigami, Toshiyuki Shudo, Ayana Iwata, Seiji Hori, Nagahisa Yoshimura, Akira Kakizuka

Sci Rep. 2014; 4: 5970. Published online 2014 Aug 6. doi: 10.1038/srep05970

PMCID:: PMC4122966

Article PDF–2.8M

Select item 391900417.

Lipid-enriched diet rescues lethality and slows down progression in a murine model of VCP-associated disease

Katrina J. Llewellyn, Angèle Nalbandian, Kwang-Mook Jung, Christopher Nguyen, Agnesa Avanesian, Tahseen Mozaffar, Daniele Piomelli, Virginia E. Kimonis

Hum Mol Genet. 2014 Mar 1; 23(5): 1333–1344. Published online 2013 Oct 24. doi: 10.1093/hmg/ddt523

PMCID:: PMC3919004

Article PDF–2.0M

Select item 379403218.

Exercise Training Reverses Skeletal Muscle Atrophy in an Experimental Model of VCP Disease

Angèle Nalbandian, Christopher Nguyen, Veeral Katheria, Katrina J. Llewellyn, Mallikarjun Badadani, Vincent Caiozzo, Virginia E. Kimonis

PLoS One. 2013; 8(10): e76187. Published online 2013 Oct 9. doi: 10.1371/journal.pone.0076187

PMCID:: PMC3794032

Article PDF–5.1M

Select item 358718619.

Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase

Dominik Barthelme, Robert T. Sauer

Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9): 3327–3332. Published online 2013 Feb 11. doi: 10.1073/pnas.1300408110

PMCID:: PMC3587186

Article PDF–737K

Select item 355622320.

A Progressive Translational Mouse Model of Human VCP Disease: The VCP ^R155H/+ Mouse

Angèle Nalbandian, Katrina J. Llewellyn, Mallikarjun Badadani, Hong Z. Yin, Christopher Nguyen, Veeral Katheria, Giles Watts, Jogeshwar Mukherjee, Jouni Vesa, Vincent Caiozzo, Tahseen Mozaffar, John H. Weiss, Virginia E. Kimonis

Muscle Nerve. Author manuscript; available in PMC 2014 Feb 1.

Published in final edited form as: Muscle Nerve. 2013 Feb; 47(2): 260–270. Published online 2012 Nov 21. doi: 10.1002/mus.23522