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Select item 74735811.

Clinical and molecular spectrum of CHOPS syndrome

Sarah E. Raible, Devanshi Mehta, Chiara Bettale, Sarah Fiordaliso, Maninder Kaur, Livija Medne, Marlene Rio, Eric Haan, Susan M. White, Kristina Cusmano-Ozog, Eriko Nishi, Yiran Guo, Honglin Wu, Xiaoqing Shi, Qingjie Zhao, Xueqin Zhang, Qi Lei, Aimei Lu, Xiyu He, Nobuhiko Okamoto, Noriko Miyake, Joseph Piccione, Julian Allen, Naomichi Matsumoto, Mary Pipan, Ian D. Krantz, Kosuke Izumi

Am J Med Genet A. Author manuscript; available in PMC 2020 Sep 4.

Published in final edited form as: Am J Med Genet A. 2019 Jul; 179(7): 1126–1138. Published online 2019 May 6. doi: 10.1002/ajmg.a.61174

PMCID:: PMC7473581

Abstract Article PDF–2.2M

Select item 73270542.

AFF4 regulates osteogenic differentiation of human dental follicle cells

Qingyue Xiao, Yuning Zhang, Xingying Qi, Yaqian Chen, Rui Sheng, Ruoshi Xu, Quan Yuan, Chenchen Zhou

Int J Oral Sci. 2020; 12: 20. Published online 2020 Jun 30. doi: 10.1038/s41368-020-0083-9

PMCID:: PMC7327054

Abstract Article PDF–1.6M

Select item 66157023.

Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization

Ying Chen, Patrick Cramer

J Biol Chem. 2019 Jul 5; 294(27): 10663–10673. Published online 2019 May 30. doi: 10.1074/jbc.RA119.008577

PMCID:: PMC6615702

Abstract Article PDF–2.9M

Select item 43807984.

Germline Gain-of-Function Mutations in AFF4 Cause a Developmental Syndrome Functionally Linking the Super Elongation Complex and Cohesin

Kosuke Izumi, Ryuichiro Nakato, Zhe Zhang, Andrew C. Edmondson, Sarah Noon, Matthew C. Dulik, Ramkakrishnan Rajagopalan, Charles P. Venditti, Karen Gripp, Joy Samanich, Elaine H. Zackai, Matthew A. Deardorff, Dinah Clark, Julian L. Allen, Dale Dorsett, Ziva Misulovin, Makiko Komata, Masashige Bando, Maninder Kaur, Yuki Katou, Katsuhiko Shirahige, Ian D. Krantz

Nat Genet. Author manuscript; available in PMC 2015 Oct 1.

Published in final edited form as: Nat Genet. 2015 Apr; 47(4): 338–344. Published online 2015 Mar 2. doi: 10.1038/ng.3229

PMCID:: PMC4380798

Abstract Article PDF–1.0M

Select item 60310635.

AFF4 promotes tumorigenesis and tumor-initiation capacity of head and neck squamous cell carcinoma cells by regulating SOX2

Peng Deng, Jiongke Wang, Xuefeng Zhang, Xingyu Wu, Ning Ji, Jing Li, Min Zhou, Lu Jiang, Xin Zeng, Qianming Chen

Carcinogenesis. 2018 Jul; 39(7): 937–947. Published online 2018 May 8. doi: 10.1093/carcin/bgy046

PMCID:: PMC6031063

Abstract Article PDF–37M

Select item 52902736.

Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription

Shiqian Qi, Zichong Li, Ursula Schulze-Gahmen, Goran Stjepanovic, Qiang Zhou, James H. Hurley

Nat Commun. 2017; 8: 14076. Published online 2017 Jan 30. doi: 10.1038/ncomms14076

PMCID:: PMC5290273

Abstract Article PDF–1.5M

Select item 18208767.

MCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcription

Maksymilian F. Niedzielski, Robert Hopewell, Zohra Ismail, Mario C. Estable

Int J Biol Sci. 2007; 3(4): 225–236. Published online 2007 Mar 1. doi: 10.7150/ijbs.3.225

PMCID:: PMC1820876

Abstract Article PDF–631K

Select item 108497828.

AFF4 regulates osteogenic potential of human periodontal ligament stem cells via mTOR‐ULK1‐autophagy axis

Li Zhu, Jiahe Wang, Zuping Wu, Sirui Chen, Yuying He, Yukun Jiang, Guowen Luo, Zhuoxuan Wu, Yuyu Li, Jing Xie, Shujuan Zou, Chenchen Zhou

Cell Prolif. 2024 Feb; 57(2): e13546. Published online 2023 Sep 20. doi: 10.1111/cpr.13546

PMCID:: PMC10849782

Abstract Article PDF–12M

Select item 50728419.

Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex

Ursula Schulze-Gahmen, Ignacia Echeverria, Goran Stjepanovic, Yun Bai, Huasong Lu, Dina Schneidman-Duhovny, Jennifer A Doudna, Qiang Zhou, Andrej Sali, James H Hurley

eLife. 2016; 5: e15910. Published online 2016 Oct 12. doi: 10.7554/eLife.15910

PMCID:: PMC5072841

Abstract Article PDF–3.6M

Select item 449915310.

Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription

Huasong Lu, Zichong Li, Wei Zhang, Ursula Schulze-Gahmen, Yuhua Xue, Qiang Zhou

Nucleic Acids Res. 2015 Jul 13; 43(12): 5868–5879. Published online 2015 May 24. doi: 10.1093/nar/gkv541

PMCID:: PMC4499153

Abstract Article PDF–7.1M

Select item 401371711.

AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter

Ursula Schulze-Gahmen, Huasong Lu, Qiang Zhou, Tom Alber

eLife. 2014; 3: e02375. Published online 2014 Apr 24. doi: 10.7554/eLife.02375

PMCID:: PMC4013717

Abstract Article PDF–1.6M

Select item 358982512.

The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat

Ursula Schulze-Gahmen, Heather Upton, Andrew Birnberg, Katherine Bao, Seemay Chou, Nevan J Krogan, Qiang Zhou, Tom Alber

eLife. 2013; 2: e00327. Published online 2013 Mar 5. doi: 10.7554/eLife.00327

PMCID:: PMC3589825

Abstract Article PDF–2.9M

Select item 303205713.

The molecular biology of HIV latency: Breaking and restoring the Tat-dependent transcriptional circuit

Jonathan Karn

Curr Opin HIV AIDS. Author manuscript; available in PMC 2012 Jan 1.

Published in final edited form as: Curr Opin HIV AIDS. 2011 Jan; 6(1): 4–11. doi: 10.1097/COH.0b013e328340ffbb

PMCID:: PMC3032057

Abstract Article PDF–277K

Select item 2447114.

AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)

Tomohiko Taki, Hirotsugu Kano, Masafumi Taniwaki, Masahiro Sako, Masayoshi Yanagisawa, Yasuhide Hayashi

Proc Natl Acad Sci U S A. 1999 Dec 7; 96(25): 14535–14540. doi: 10.1073/pnas.96.25.14535

PMCID:: PMC24471

Abstract Article PDF–318K

Select item 480079115.

A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency

Zichong Li, Huasong Lu, Qiang Zhou

Mol Cell Biol. 2016 Apr 1; 36(7): 1194–1205. Prepublished online 2016 Feb 1. Published online 2016 Mar 18. doi: 10.1128/MCB.00994-15

PMCID:: PMC4800791

Abstract Article PDF–2.2M

Select item 411172516.

Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4

Jianyou Gu, Nigar D Babayeva, Yoshiaki Suwa, Andrey G Baranovskiy, David H Price, Tahir H Tahirov

Cell Cycle. 2014 Jun 1; 13(11): 1788–1797. Published online 2014 Apr 11. doi: 10.4161/cc.28756

PMCID:: PMC4111725

Abstract Article PDF–2.6M

Select item 287202917.

AFF4, a component of the ELL/p-TEFb elongation complex and a shared subunit of MLL chimeras can link transcription elongation to leukemia

Chengqi Lin, Edwin R. Smith, Hidehisa Takahashi, Ka-Chun Lai, Skylar Martin-Brown, Laurence Florens, Michael P. Washburn, Joan W. Conaway, Ronald C. Conaway, Ali Shilatifard

Mol Cell. Author manuscript; available in PMC 2011 Feb 12.

Published in final edited form as: Mol Cell. 2010 Feb 12; 37(3): 429–437. doi: 10.1016/j.molcel.2010.01.026

PMCID:: PMC2872029

Abstract Article PDF–1.6M

Select item 354580018.

HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold

Seemay Chou, Heather Upton, Katherine Bao, Ursula Schulze-Gahmen, Avi J. Samelson, Nanhai He, Anna Nowak, Huasong Lu, Nevan J. Krogan, Qiang Zhou, Tom Alber

Proc Natl Acad Sci U S A. 2013 Jan 8; 110(2): E123–E131. Published online 2012 Dec 18. doi: 10.1073/pnas.1216971110

PMCID:: PMC3545800

Abstract Article PDF–1.6M

Select item 736718419.

Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2

Jun Wu, Yuhua Xue, Xiang Gao, Qiang Zhou

Nucleic Acids Res. 2020 Jul 27; 48(13): 7321–7332. Published online 2020 Jun 1. doi: 10.1093/nar/gkaa461

PMCID:: PMC7367184

Abstract Article PDF–3.8M

Select item 515515720.

K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression

Han-Tsang Wu, Yi-Chih Kuo, Jung-Jyh Hung, Chi-Hung Huang, Wei-Yi Chen, Teh-Ying Chou, Yeh Chen, Yi-Ju Chen, Yu-Ju Chen, Wei-Chung Cheng, Shu-Chun Teng, Kou-Juey Wu

Nat Commun. 2016; 7: 13644. Published online 2016 Dec 9. doi: 10.1038/ncomms13644

PMCID:: PMC5155157

Abstract Article PDF–3.6M

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