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Select item 105397041.

Glycine Decarboxylase (GLDC) Plays a Crucial Role in Regulating Energy Metabolism, Invasion, Metastasis and Immune Escape for Prostate Cancer

Ming-kun Chen, Zhuo-Yu Xiao, Zhi-Peng Huang, Kang-Yi Xue, Hui Xia, Jia-Wei Zhou, De-Ying Liao, Zhi-Jian Liang, Xiao Xie, Qing-Zhu Wei, Lin Zhong, Jian-Kun Yang, Cun-Dong Liu, Yang Liu, Shan-Chao Zhao

Int J Biol Sci. 2023; 19(15): 4726–4743. Published online 2023 Sep 4. doi: 10.7150/ijbs.85893

PMCID:: PMC10539704

Abstract Article PDF–9.4M

Select item 63289142.

Identification and characterization of GLDC as host susceptibility gene to severe influenza

Jie Zhou, Dong Wang, Bosco Ho‐Yin Wong, Cun Li, Vincent Kwok‐Man Poon, Lei Wen, Xiaoyu Zhao, Man Chun Chiu, Xiaojuan Liu, Ziwei Ye, Shuofeng Yuan, Kong‐Hung Sze, Jasper Fuk‐Woo Chan, Hin Chu, Kelvin Kai‐Wang To, Kwok Yung Yuen

EMBO Mol Med. 2019 Jan; 11(1): e9528. Published online 2018 Nov 28. doi: 10.15252/emmm.201809528

PMCID:: PMC6328914

Abstract Article PDF–2.0M

Select item 57552863.

A novel compound heterozygous variant identified in GLDC gene in a Chinese family with non-ketotic hyperglycinemia

Yiming Lin, Zhenzhu Zheng, Wenjia Sun, Qingliu Fu

BMC Med Genet. 2018; 19: 5. Published online 2018 Jan 5. doi: 10.1186/s12881-017-0517-1

PMCID:: PMC5755286

Abstract Article PDF–1.3M

Select item 4430764.

Identification of a common mutation in Finnish patients with nonketotic hyperglycinemia.

S Kure, M Takayanagi, K Narisawa, K Tada, J Leisti

J Clin Invest. 1992 Jul; 90(1): 160–164. doi: 10.1172/JCI115831

PMCID:: PMC443076

Summary Page Browse PDF–1.2M

Select item 93489755.

Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children

Sergey A Krupenko, Shelley A Cole, Ruixue Hou, Karin Haack, Sandra Laston, Nitesh R Mehta, Anthony G Comuzzie, Nancy F Butte, V Saroja Voruganti

Am J Clin Nutr. 2022 Aug; 116(2): 500–510. Published online 2022 Apr 23. doi: 10.1093/ajcn/nqac091

PMCID:: PMC9348975

Abstract Article PDF–962K

Select item 69087666.

Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity

Ahmet Alptekin, Bingwei Ye, Yajie Yu, Candace J. Poole, Jan van Riggelen, Yunhong Zha, Han-Fei Ding

Oncogene. Author manuscript; available in PMC 2020 Feb 23.

Published in final edited form as: Oncogene. 2019 Dec; 38(50): 7504–7520. Published online 2019 Aug 23. doi: 10.1038/s41388-019-0967-3

PMCID:: PMC6908766

Abstract Article PDF–3.3M

Select item 63899157.

Glycine decarboxylase induces autophagy and is downregulated by miRNA-30d-5p in hepatocellular carcinoma

Hao Zhuang, Fei Wu, Wen Wei, Yamei Dang, Baicai Yang, Xuda Ma, Feng Han, Yongmei Li

Cell Death Dis. 2019 Mar; 10(3): 192. Published online 2019 Feb 25. doi: 10.1038/s41419-019-1446-z

PMCID:: PMC6389915

Abstract Article PDF–4.4M

Select item 25980248.

Genomic deletion within GLDC is a major cause of non‐ketotic hyperglycinaemia

Junko Kanno, Tim Hutchin, Fumiaki Kamada, Ayumi Narisawa, Yoko Aoki, Yoichi Matsubara, Shigeo Kure

J Med Genet. 2007 Mar; 44(3): e69. doi: 10.1136/jmg.2006.043448

PMCID:: PMC2598024

Abstract Article PDF–315K

Select item 32982769.

Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans

Ayumi Narisawa, Shoko Komatsuzaki, Atsuo Kikuchi, Tetsuya Niihori, Yoko Aoki, Kazuko Fujiwara, Mitsuyo Tanemura, Akira Hata, Yoichi Suzuki, Caroline L. Relton, James Grinham, Kit-Yi Leung, Darren Partridge, Alexis Robinson, Victoria Stone, Peter Gustavsson, Philip Stanier, Andrew J. Copp, Nicholas D.E. Greene, Teiji Tominaga, Yoichi Matsubara, Shigeo Kure

Hum Mol Genet. 2012 Apr 1; 21(7): 1496–1503. Published online 2011 Dec 13. doi: 10.1093/hmg/ddr585

PMCID:: PMC3298276

Abstract Article PDF–264K

Select item 37082710.

Defective glycine cleavage system in nonketotic hyperglycinemia. Occurrence of a less active glycine decarboxylase and an abnormal aminomethyl carrier protein.

K Hiraga, H Kochi, K Hayasaka, G Kikuchi, W L Nyhan

J Clin Invest. 1981 Aug; 68(2): 525–534. doi: 10.1172/JCI110284

PMCID:: PMC370827

Summary Page Browse PDF–1.6M

Select item 276273611.

Binding specificity of Toll-like receptor cytoplasmic domains

Victoria Brown, Rachel A. Brown, Adrian Ozinsky, Jay R. Hesselberth, Stanley Fields

Eur J Immunol. Author manuscript; available in PMC 2009 Oct 16.

Published in final edited form as: Eur J Immunol. 2006 Mar; 36(3): 742–753. doi: 10.1002/eji.200535158

PMCID:: PMC2762736

Abstract Article PDF–6.1M

Select item 338310312.

Genome-wide Association Study of Periodontal Pathogen Colonization

K. Divaris, K.L. Monda, K.E. North, A.F. Olshan, E.M. Lange, K. Moss, S.P. Barros, J.D. Beck, S. Offenbacher

J Dent Res. 2012 Jul; 91(7 Suppl): S21–S28. doi: 10.1177/0022034512447951

PMCID:: PMC3383103

Abstract Article PDF–2.0M

Select item 827099913.

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis

Rui Liu, Lin-Wen Zeng, Rong Gong, Fanen Yuan, Hong-Bing Shu, Shu Li

Nat Commun. 2021; 12: 4227. Published online 2021 Jul 9. doi: 10.1038/s41467-021-24321-3

PMCID:: PMC8270999

Abstract Article PDF–3.8M

Select item 722681214.

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex

Marissa M. Minor, F. Blaine Hollinger, Adrienne L. McNees, Sung Yun Jung, Antrix Jain, Joseph M. Hyser, Karl-Dimiter Bissig, Betty L. Slagle

Cells. 2020 Apr; 9(4): 834. Published online 2020 Mar 30. doi: 10.3390/cells9040834

PMCID:: PMC7226812

Abstract Article PDF–2.3M

Select item 947546215.

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold

Wenjing Yang, Beili Wang, Qian Yu, Te Liu, Tong Li, Tongtong Tian, Anli Jin, Lin Ding, Wei Chen, Hao Wang, Jingrong Xian, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo

Theranostics. 2022; 12(14): 6189–6206. Published online 2022 Aug 21. doi: 10.7150/thno.72134

PMCID:: PMC9475462

Abstract Article PDF–4.6M

Select item 875541916.

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation

Yuzheng Zhou, Rong Zheng, Sixu Liu, Cyrollah Disoma, Ashuai Du, Shiqin Li, Zongpeng Chen, Zijun Dong, Yongxing Zhang, Sijia Li, Pinjia Liu, Aroona Razzaq, Xuan Chen, Yujie Liao, Siyi Tao, Yuxin Liu, Lunan Xu, Qianjun Zhang, Jian Peng, Xu Deng, Shanni Li, Taijiao Jiang, Zanxian Xia

J Biol Chem. 2022 Feb; 298(2): 101584. Published online 2022 Jan 13. doi: 10.1016/j.jbc.2022.101584

PMCID:: PMC8755419

Abstract Article PDF–3.5M

Select item 944065317.

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy

Shouheng Jin, Xing He, Ling Ma, Zhen Zhuang, Yiliang Wang, Meng Lin, Sihui Cai, Lu Wei, Zheyu Wang, Zhiyao Zhao, Yaoxing Wu, Lin Sun, Chunwei Li, Weihong Xie, Yong Zhao, Zhou Songyang, Ke Peng, Jincun Zhao, Jun Cui

Nat Commun. 2022; 13: 5204. Published online 2022 Sep 3. doi: 10.1038/s41467-022-32957-y

PMCID:: PMC9440653

Abstract Article PDF–2.9M

Select item 294347618.

Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression

Sher L. Hendrickson, James A. Lautenberger, Leslie Wei Chinn, Michael Malasky, Efe Sezgin, Lawrence A. Kingsley, James J. Goedert, Gregory D. Kirk, Edward D. Gomperts, Susan P. Buchbinder, Jennifer L. Troyer, Stephen J. O'Brien

PLoS One. 2010; 5(9): e12862. Published online 2010 Sep 21. doi: 10.1371/journal.pone.0012862

PMCID:: PMC2943476

Abstract Article PDF–461K

Select item 271642219.

Defining the Human Deubiquitinating Enzyme Interaction Landscape

Mathew E. Sowa, Eric J. Bennett, Steven P. Gygi, J. Wade Harper

Cell. Author manuscript; available in PMC 2010 Jul 23.

Published in final edited form as: Cell. 2009 Jul 23; 138(2): 389–403. Published online 2009 Jul 16. doi: 10.1016/j.cell.2009.04.042

PMCID:: PMC2716422

Abstract Article PDF–6.1M

Select item 572549420.

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

Huiming Lu, Raghavendra A. Shamanna, Jessica K. de Freitas, Mustafa Okur, Prabhat Khadka, Tomasz Kulikowicz, Priscella P. Holland, Jane Tian, Deborah L. Croteau, Anthony J. Davis, Vilhelm A. Bohr

Nat Commun. 2017; 8: 2039. Published online 2017 Dec 11. doi: 10.1038/s41467-017-02146-3

PMCID:: PMC5725494

Abstract Article PDF–4.0M

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