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Select item 101577271.

Hypoxia Induces M2 Macrophages to Express VSIG4 and Mediate Cardiac Fibrosis After Myocardial Infarction

Yan Wang, Yu Zhang, Jiao Li, Chaofu Li, Ranzun Zhao, Changyin Shen, Weiwei Liu, Jidong Rong, Zhenglong Wang, Junbo Ge, Bei Shi

Theranostics. 2023; 13(7): 2192–2209. Published online 2023 Apr 2. doi: 10.7150/thno.78736

PMCID:: PMC10157727

Abstract Article PDF–12M

Select item 81398692.

VSIG4(+) peritoneal macrophages induce apoptosis of double-positive thymocyte via the secretion of TNF-α in a CLP-induced sepsis model resulting in thymic atrophy

Hae-Yun Cho, Yun Gyeong Yang, Youkyoung Jeon, Chae-Kwan Lee, InHak Choi, Soo-Woong Lee

Cell Death Dis. 2021 Jun; 12(6): 526. Published online 2021 May 22. doi: 10.1038/s41419-021-03806-5

PMCID:: PMC8139869

Abstract Article PDF–4.0M

Select item 75762413.

Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue

Brandon M. Hall, Anatoli S. Gleiberman, Evguenia Strom, Peter A. Krasnov, David Frescas, Slavoljub Vujcic, Olga V. Leontieva, Marina P. Antoch, Valeria Kogan, Igor E. Koman, Yi Zhu, Tamara Tchkonia, James L. Kirkland, Olga B. Chernova, Andrei V. Gudkov

Aging Cell. 2020 Oct; 19(10): e13219. Published online 2020 Aug 28. doi: 10.1111/acel.13219

PMCID:: PMC7576241

Abstract Article PDF–3.3M

Select item 21185954.

A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis

Kenneth J. Katschke, Jr., Karim Y. Helmy, Micah Steffek, Hongkang Xi, JianPing Yin, Wyne P. Lee, Peter Gribling, Kai H. Barck, Richard A.D. Carano, Robin E. Taylor, Linda Rangell, Lauri Diehl, Philip E. Hass, Christian Wiesmann, Menno van Lookeren Campagne

J Exp Med. 2007 Jun 11; 204(6): 1319–1325. doi: 10.1084/jem.20070432

PMCID:: PMC2118595

Abstract Article PDF–2.6M

Select item 96916545.

Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes

Matthew A. Liu, Shandy Shahabi, Suborno Jati, Kechun Tang, Hong Gao, Zhongmou Jin, Wyatt Miller, Frédéric A. Meunier, Wei Ying, Geert van den Bogaart, Gourisankar Ghosh, Sushil K. Mahata

Front Endocrinol (Lausanne) 2022; 13: 1037465. Published online 2022 Nov 11. doi: 10.3389/fendo.2022.1037465

PMCID:: PMC9691654

Abstract Article PDF–19M

Select item 57287206.

CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells

Xiaomei Yuan, Bi-Huei Yang, Yi Dong, Asami Yamamura, Wenxian Fu

eLife. 2017; 6: e29540. Published online 2017 Nov 24. doi: 10.7554/eLife.29540

PMCID:: PMC5728720

Abstract Article PDF–2.5M

Select item 56738897.

VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism

Jialin Li, Bo Diao, Sheng Guo, Xiaoyong Huang, Chengying Yang, Zeqing Feng, Weiming Yan, Qin Ning, Lixin Zheng, Yongwen Chen, Yuzhang Wu

Nat Commun. 2017; 8: 1322. Published online 2017 Nov 6. doi: 10.1038/s41467-017-01327-4

PMCID:: PMC5673889

Abstract Article PDF–3.5M

Select item 50827718.

Extracellular stimulation of VSIG4/complement receptor Ig suppresses intracellular bacterial infection by inducing autophagy

Kwang H. Kim, Beom K. Choi, Young H. Kim, Chungyong Han, Ho S. Oh, Don G. Lee, Byoung S. Kwon

Autophagy. 2016; 12(9): 1647–1659. Published online 2016 Jul 20. doi: 10.1080/15548627.2016.1196314

PMCID:: PMC5082771

Abstract Article PDF–1.3M

Select item 86608159.

CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease

Yi Duan, Huikuan Chu, Katharina Brandl, Lu Jiang, Suling Zeng, Nairika Meshgin, Eleni Papachristoforou, Josepmaria Argemi, Beatriz G. Mendes, Yanhan Wang, Hua Su, Weizhong Sun, Cristina Llorente, Tim Hendrikx, Xiao Liu, Mojgan Hosseini, Tatiana Kisseleva, David A. Brenner, Ramon Bataller, Prakash Ramachandran, Michael Karin, Wenxian Fu, Bernd Schnabl

Nat Commun. 2021; 12: 7172. Published online 2021 Dec 9. doi: 10.1038/s41467-021-27385-3

PMCID:: PMC8660815

Abstract Article PDF–2.5M

Select item 688383910.

CRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complement

Gongguan Liu, Yong Fu, Mohammed Yosri, Yanli Chen, Peng Sun, Jinjun Xu, Mingshun Zhang, Donglei Sun, Ashley B. Strickland, Zachary B. Mackey, Meiqing Shi

Proc Natl Acad Sci U S A. 2019 Nov 26; 116(48): 24214–24220. Published online 2019 Nov 13. doi: 10.1073/pnas.1913443116

PMCID:: PMC6883839

Abstract Article PDF–1.2M

Select item 890879111.

Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria

Haoran An, Chenyun Qian, Yijia Huang, Jing Li, Xianbin Tian, Jiaying Feng, Jiao Hu, Yujie Fang, Fangfang Jiao, Yuna Zeng, Xueting Huang, Xianbin Meng, Xue Liu, Xin Lin, Zhutian Zeng, Martin Guilliams, Alain Beschin, Yongwen Chen, Yuzhang Wu, Jing Wang, Marco Rinaldo Oggioni, John Leong, Jan-Willem Veening, Haiteng Deng, Rong Zhang, Hui Wang, Jiang Wu, Yan Cui, Jing-Ren Zhang

J Exp Med. 2022 Apr 4; 219(4): e20212032. Published online 2022 Mar 8. doi: 10.1084/jem.20212032

PMCID:: PMC8908791

Abstract Article PDF–8.0M

Select item 632675212.

VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages

Xiaoyong Huang, Zeqing Feng, Yuanzhong Jiang, Jialin Li, Qun Xiang, Sheng Guo, Chengying Yang, Lei Fei, Guoning Guo, Lixin Zheng, Yuzhang Wu, Yongwen Chen

Sci Adv. 2019 Jan; 5(1): eaau7426. Published online 2019 Jan 9. doi: 10.1126/sciadv.aau7426

PMCID:: PMC6326752

Abstract Article PDF–8.8M

Select item 600265713.

Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung

Nagaraja Nagre, Xiaofei Cong, César Terrazas, Ian Pepper, John M. Schreiber, Hongyun Fu, Joshua M. Sill, John W. Christman, Abhay R. Satoskar, Xiaoli Zhao

Am J Respir Cell Mol Biol. 2018 Jun; 58(6): 756–766. doi: 10.1165/rcmb.2017-0236OC

PMCID:: PMC6002657

Abstract Article PDF–1.7M

Select item 1037350314.

Gut lumen-leaked microbial DNA causes myocardial inflammation and impairs cardiac contractility in ageing mouse heart

Hong Gao, Ke Wang, Jorge A. Suarez, Zhongmou Jin, Karina Cunha e Rocha, Dinghong Zhang, Andrea Farrell, Tyler Truong, Yasemin Tekin, Breanna Tan, Hyun Suh Jung, Julia Kempf, Sushil K. Mahata, Wolfgang H. Dillmann, Jorge Suarez, Wei Ying

Front Immunol. 2023; 14: 1216344. Published online 2023 Jul 13. doi: 10.3389/fimmu.2023.1216344

PMCID:: PMC10373503

Abstract Article PDF–5.9M

Select item 1010490615.

In situ expansion and reprogramming of Kupffer cells elicit potent tumoricidal immunity against liver metastasis

Wei Liu, Xia Zhou, Qi Yao, Chen Chen, Qing Zhang, Keshuo Ding, Lu Li, Zhutian Zeng

J Clin Invest. 2023 Apr 17; 133(8): e157937. Published online 2023 Apr 17. doi: 10.1172/JCI157937

PMCID:: PMC10104906

Abstract Article PDF–21M

Select item 266185616.

Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry

Takashi Miwa, Lin Zhou, Yuko Kimura, David Kim, Avinash Bhandoola, Wen-Chao Song

Blood. 2009 Mar 19; 113(12): 2684–2694. Prepublished online 2009 Jan 9. doi: 10.1182/blood-2008-05-157966

PMCID:: PMC2661856

Abstract Article

Select item 678344017.

Fungal dissemination is limited by liver macrophage filtration of the blood

Donglei Sun, Peng Sun, Hongmei Li, Mingshun Zhang, Gongguan Liu, Ashley B. Strickland, Yanli Chen, Yong Fu, Juan Xu, Mohammed Yosri, Yuchen Nan, Hong Zhou, Xiquan Zhang, Meiqing Shi

Nat Commun. 2019; 10: 4566. Published online 2019 Oct 8. doi: 10.1038/s41467-019-12381-5

PMCID:: PMC6783440

Abstract Article PDF–3.1M

Select item 157863118.

VSIG4, a B7 family–related protein, is a negative regulator of T cell activation

Lorenz Vogt, Nicole Schmitz, Michael O. Kurrer, Monika Bauer, Heather I. Hinton, Silvia Behnke, Dominique Gatto, Peter Sebbel, Roger R. Beerli, Ivo Sonderegger, Manfred Kopf, Philippe Saudan, Martin F. Bachmann

J Clin Invest. 2006 Oct 2; 116(10): 2817–2826. Published online 2006 Oct 2. doi: 10.1172/JCI25673

PMCID:: PMC1578631

Abstract Article PDF–1.0M

Select item 1022668019.

Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus

Jessica Spring, Aly A. Khan, Sophie Lara, Kelly O’Grady, Jessica Wilks, Sandeep Gurbuxani, Steven Erickson, Michael Fischbach, Amy Jacobson, Alexander Chervonsky, Tatyana Golovkina

Cell Rep. Author manuscript; available in PMC 2023 May 29.

Published in final edited form as: Cell Rep. 2022 Sep 13; 40(11): 111341. doi: 10.1016/j.celrep.2022.111341

PMCID:: PMC10226680

Abstract Article PDF–1.1M

Select item 251513620.

Deficiency of decay-accelerating factor and complement receptor 1–related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg

David D. Kim, Takashi Miwa, Yuko Kimura, Reto A. Schwendener, Menno van Lookeren Campagne, Wen-Chao Song

Blood. 2008 Aug 15; 112(4): 1109–1119. Prepublished online 2008 Jun 4. doi: 10.1182/blood-2008-01-134304

PMCID:: PMC2515136

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