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Select item 94267601.

Influence of Glutathione-S-Transferase A1*B Allele on the Metabolism of the Aromatase Inhibitor, Exemestane, in Human Liver Cytosols and in Patients Treated With Exemestane

Irina Teslenko, Julia Trudeau, Shaman Luo, Christy J.W. Watson, Gang Chen, Cristina I. Truica, Philip Lazarus

J Pharmacol Exp Ther. 2022 Sep; 382(3): 327–334. Published online 2022 Sep. doi: 10.1124/jpet.122.001232

PMCID:: PMC9426760

Abstract Article PDF–996K

Select item 80748922.

The Interaction of Human Glutathione Transferase GSTA1-1 with Reactive Dyes

Mohammed Hamed Alqarni, Ahmed Ibrahim Foudah, Magdy Mohamed Muharram, Nikolaos E. Labrou

Molecules. 2021 Apr; 26(8): 2399. Published online 2021 Apr 20. doi: 10.3390/molecules26082399

PMCID:: PMC8074892

Abstract Article PDF–5.0M

Select item 79300393.

The analysis of GSTA1 promoter genetic and functional diversity of human populations

Vid Mlakar, Patricia Huezo-Diaz Curtis, Marc Armengol, Victor Ythier, Isabelle Dupanloup, Khalil Ben Hassine, Laurence Lesne, Rabih Murr, Simona Jurkovic Mlakar, Tiago Nava, Marc Ansari

Sci Rep. 2021; 11: 5038. Published online 2021 Mar 3. doi: 10.1038/s41598-021-83996-2

PMCID:: PMC7930039

Abstract Article PDF–1.3M

Select item 51479144.

The rs3957357C>T SNP in GSTA1 Is Associated with a Higher Risk of Occurrence of Hepatocellular Carcinoma in European Individuals

Hanane Akhdar, Said El Shamieh, Orlando Musso, Romain Désert, Wissam Joumaa, Dominique Guyader, Caroline Aninat, Anne Corlu, Fabrice Morel

PLoS One. 2016; 11(12): e0167543. Published online 2016 Dec 9. doi: 10.1371/journal.pone.0167543

PMCID:: PMC5147914

Abstract Article PDF–1.6M

Select item 41475865.

Is Increased Susceptibility to Balkan Endemic Nephropathy in Carriers of Common GSTA1 (*A/*B) Polymorphism Linked with the Catalytic Role of GSTA1 in Ochratoxin A Biotransformation? Serbian Case Control Study and In Silico Analysis

Zorica Reljic, Mario Zlatovic, Ana Savic-Radojevic, Tatjana Pekmezovic, Ljubica Djukanovic, Marija Matic, Marija Pljesa-Ercegovac, Jasmina Mimic-Oka, Dejan Opsenica, Tatjana Simic

Toxins (Basel) 2014 Aug; 6(8): 2348–2362. Published online 2014 Aug 8. doi: 10.3390/toxins6082348

PMCID:: PMC4147586

Abstract Article PDF–874K

Select item 39470696.

Glutathione S-transferase A1 polymorphism and the risk of recurrent spontaneous abortion in Chinese Han population

Chen Zong, Yanwei Sha, Huifen Xiang, Jing Wang, Dawei Chen, Juan Liu, Binbin Wang, Yunxia Cao

J Assist Reprod Genet. 2014 Mar; 31(3): 379–382. Published online 2014 Jan 5. doi: 10.1007/s10815-013-0163-2

PMCID:: PMC3947069

Abstract Article PDF–128K

Select item 36899997.

Enzymatic Detoxication, Conformational Selection, and the Role of Molten Globule Active Sites

Matthew T. Honaker, Mauro Acchione, Wei Zhang, Bengt Mannervik, William M. Atkins

J Biol Chem. 2013 Jun 21; 288(25): 18599–18611. Published online 2013 May 6. doi: 10.1074/jbc.M112.445767

PMCID:: PMC3689999

Abstract Article PDF–2.7M

Select item 35840698.

The Interaction of the Chemotherapeutic Drug Chlorambucil with Human Glutathione Transferase A1-1: Kinetic and Structural Analysis

Michael Karpusas, Irine Axarli, Lykourgos Chiniadis, Athanasios Papakyriakou, Kostas Bethanis, Katholiki Scopelitou, Yannis D. Clonis, Nikolaos E. Labrou

PLoS One. 2013; 8(2): e56337. Published online 2013 Feb 27. doi: 10.1371/journal.pone.0056337

PMCID:: PMC3584069

Abstract Article PDF–733K

Select item 35196939.

Low Levels of GSTA1 Expression Are Required for Caco-2 Cell Proliferation

Humaira Adnan, Holly Quach, Kimberley MacIntosh, Monica Antenos, Gordon M. Kirby

PLoS One. 2012; 7(12): e51739. Published online 2012 Dec 10. doi: 10.1371/journal.pone.0051739

PMCID:: PMC3519693

Abstract Article PDF–882K

Select item 323498210.

Ensemble Perspective for Catalytic Promiscuity: CALORIMETRIC ANALYSIS OF THE ACTIVE SITE CONFORMATIONAL LANDSCAPE OF A DETOXIFICATION ENZYME

Matthew T. Honaker, Mauro Acchione, John P. Sumida, William M. Atkins

J Biol Chem. 2011 Dec 9; 286(49): 42770–42776. Published online 2011 Oct 14. doi: 10.1074/jbc.M111.304386

PMCID:: PMC3234982

Abstract Article PDF–1.6M

Select item 275328511.

Structural Analysis of a Glutathione Transferase A1-1 Mutant Tailored for High Catalytic Efficiency with Toxic Alkenals

Larissa M. Balogh, Isolde Le Trong, Kimberly A. Kripps, Kaspars Tars, Ronald E. Stenkamp, Bengt Mannervik, William M. Atkins

Biochemistry. Author manuscript; available in PMC 2010 Aug 18.

Published in final edited form as: Biochemistry. 2009 Aug 18; 48(32): 7698–7704. doi: 10.1021/bi900895b

PMCID:: PMC2753285

Abstract Article PDF–953K

Select item 267889112.

Dehydroalanine analog of glutathione: An electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1

Islam R. Younis, Meenal Elliott, Cody J. Peer, Arthur J.L. Cooper, John T. Pinto, Gregory W. Konat, Michal Kraszpulski, William P. Petros, Patrick S. Callery

J Pharmacol Exp Ther. Author manuscript; available in PMC 2009 May 7.

Published in final edited form as: J Pharmacol Exp Ther. 2008 Dec; 327(3): 770–776. Published online 2008 Sep 12. doi: 10.1124/jpet.108.142208

PMCID:: PMC2678891

Abstract Article PDF–213K

Select item 136070213.

The intersubunit lock-and-key motif in human glutathione transferase A1-1: role of the key residues Met⁵¹ and Phe⁵² in function and dimer stability

Carla S. Alves, Diane C. Kuhnert, Yasien Sayed, Heini W. Dirr

Biochem J. 2006 Jan 15; 393(Pt 2): 523–528. Prepublished online 2005 Sep 29. Published online 2005 Dec 23. doi: 10.1042/BJ20051066

PMCID:: PMC1360702

Abstract Article PDF–366K

Select item 122248414.

Thermodynamics of the ligandin function of human class Alpha glutathione transferase A1-1: energetics of organic anion ligand binding.

Yasien Sayed, Judith A T Hornby, Marimar Lopez, Heini Dirr

Biochem J. 2002 Apr 15; 363(Pt 2): 341–346. doi: 10.1042/0264-6021:3630341

PMCID:: PMC1222484

Summary PDF–148K

Select item 115002815.

The contribution of the C-terminal sequence to the catalytic activity of GST2, a human alpha-class glutathione transferase.

P G Board, B Mannervik

Biochem J. 1991 Apr 1; 275(Pt 1): 171–174. doi: 10.1042/bj2750171

PMCID:: PMC1150028

Summary Page Browse PDF–801K

Select item 51654216.

Incorporation of a single His residue by rational design enables thiol-ester hydrolysis by human glutathione transferase A1-1

Sofia Hederos, Kerstin S. Broo, Emma Jakobsson, Gerard J. Kleywegt, Bengt Mannervik, Lars Baltzer

Proc Natl Acad Sci U S A. 2004 Sep 7; 101(36): 13163–13167. Published online 2004 Aug 27. doi: 10.1073/pnas.0403045101

PMCID:: PMC516542

Abstract Article PDF–386K

Select item 683732217.

GSTM1-null and GSTA1-low activity genotypes are associated with enhanced oxidative damage in bladder cancer

Ana Savic-Radojevic, Tatjana Djukic, Tatjana Simic, Marija Pljesa-Ercegovac, Dejan Dragicevic, Tatjana Pekmezovic, Milica Cekerevac, Veljko Santric, Marija Matic

Redox Rep. 2013; 18(1): 1–7. Published online 2013 Jul 19. doi: 10.1179/1351000212Y.0000000031

PMCID:: PMC6837322

Abstract Article PDF–225K

Select item 486802518.

Impact of CYP2E1, GSTA1 and GSTP1 gene variants on serum alpha glutathione S-transferase level in patients undergoing anaesthesia

Adam Mikstacki, Marzena Skrzypczak-Zielinska, Oliwia Zakerska-Banaszak, Barbara Tamowicz, Maria Skibinska, Marta Molinska-Glura, Marlena Szalata, Ryszard Slomski

BMC Med Genet. 2016; 17: 40. Published online 2016 May 14. doi: 10.1186/s12881-016-0302-6

PMCID:: PMC4868025

Abstract Article PDF–871K

Select item 450591419.

Glutathione Transferase Gene Variants Influence Busulfan Pharmacokinetics and Outcome After Myeloablative Conditioning

Sara Bremer, Yngvar Fløisand, Lorentz Brinch, Tobias Gedde-Dahl, Stein Bergan

Ther Drug Monit. 2015 Aug; 37(4): 493–500. Published online 2015 Jul 24. doi: 10.1097/FTD.0000000000000180

PMCID:: PMC4505914

Abstract Article PDF–321K

Select item 405113620.

Glutathione S-transferase iso-enzymes in perfusate from pumped kidneys are associated with delayed graft function

Isaac E. Hall, Ronik S. Bhangoo, Peter P. Reese, Mona D. Doshi, Francis L. Weng, Kwangik Hong, Haiqun Lin, Gang Han, Rick D. Hasz, Michael J. Goldstein, Bernd Schröppel, Chirag R. Parikh

Am J Transplant. Author manuscript; available in PMC 2014 Jun 10.

Published in final edited form as: Am J Transplant. 2014 Apr; 14(4): 886–896. Published online 2014 Feb 24. doi: 10.1111/ajt.12635