PMC Links for Gene (Select 29928) - PMC

Select item 81014451.

The TIM22 complex mediates the import of sideroflexins and is required for efficient mitochondrial one-carbon metabolism

Thomas D. Jackson, Daniella H. Hock, Kenji M. Fujihara, Catherine S. Palmer, Ann E. Frazier, Yau C. Low, Yilin Kang, Ching-Seng Ang, Nicholas J. Clemons, David R. Thorburn, David A. Stroud, Diana Stojanovski

Mol Biol Cell. 2021 Mar 15; 32(6): 475–491. doi: 10.1091/mbc.E20-06-0390

PMCID:: PMC8101445

Abstract Article PDF–757K

Select item 74084252.

Biogenesis of Mitochondrial Metabolite Carriers

Patrick Horten, Lilia Colina-Tenorio, Heike Rampelt

Biomolecules. 2020 Jul; 10(7): 1008. Published online 2020 Jul 7. doi: 10.3390/biom10071008

PMCID:: PMC7408425

Abstract Article PDF–1.5M

Select item 70903833.

Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos

Ridhima Gomkale, Luis Daniel Cruz-Zaragoza, Ida Suppanz, Bernard Guiard, Julio Montoya, Sylvie Callegari, David Pacheu-Grau, Bettina Warscheid, Peter Rehling

Curr Biol. 2020 Mar 23; 30(6): 1119–1127.e5. doi: 10.1016/j.cub.2020.01.024

PMCID:: PMC7090383

Abstract Article

Select item 52153924.

TIM29 is a subunit of the human carrier translocase required for protein transport

Sylvie Callegari, Frank Richter, Katarzyna Chojnacka, Daniel C. Jans, Isotta Lorenzi, David Pacheu‐Grau, Stefan Jakobs, Christof Lenz, Henning Urlaub, Jan Dudek, Agnieszka Chacinska, Peter Rehling

FEBS Lett. 2016 Dec; 590(23): 4147–4158. Published online 2016 Oct 26. doi: 10.1002/1873-3468.12450

PMCID:: PMC5215392

Abstract Article PDF–710K

Select item 50160925.

Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability

Yilin Kang, Michael James Baker, Michael Liem, Jade Louber, Matthew McKenzie, Ishara Atukorala, Ching-Seng Ang, Shivakumar Keerthikumar, Suresh Mathivanan, Diana Stojanovski

eLife. 2016; 5: e17463. Published online 2016 Aug 24. doi: 10.7554/eLife.17463

PMCID:: PMC5016092

Abstract Article PDF–5.0M

Select item 80270376.

Cryo-EM structure of the human mitochondrial translocase TIM22 complex

Liangbo Qi, Qiang Wang, Zeyuan Guan, Yan Wu, Cuicui Shen, Sixing Hong, Jianbo Cao, Xing Zhang, Chuangye Yan, Ping Yin

Cell Res. 2021 Mar; 31(3): 369–372. Published online 2020 Sep 8. doi: 10.1038/s41422-020-00400-w

PMCID:: PMC8027037

Article PDF–1.3M

Select item 48937337.

The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly

Lidia Wrobel, Anna M. Sokol, Magdalena Chojnacka, Agnieszka Chacinska

Sci Rep. 2016; 6: 27484. Published online 2016 Jun 6. doi: 10.1038/srep27484

PMCID:: PMC4893733

Abstract Article PDF–3.3M

Select item 3111638.

Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs

Harukazu Suzuki, Yoshifumi Fukunishi, Ikuko Kagawa, Rintaro Saito, Hiroshi Oda, Toshinori Endo, Shinji Kondo, Hidemasa Bono, Yasushi Okazaki, Yoshihide Hayashizaki

Genome Res. 2001 Oct; 11(10): 1758–1765. doi: 10.1101/gr.180101

PMCID:: PMC311163

Abstract Article PDF–205K

Select item 27686679.

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

Ji Luo, Michael J. Emanuele, Danan Li, Chad J. Creighton, Michael R. Schlabach, Thomas F. Westbrook, Kwok-kin Wong, Stephen J. Elledge

Cell. Author manuscript; available in PMC 2009 Nov 29.

Published in final edited form as: Cell. 2009 May 29; 137(5): 835–848. doi: 10.1016/j.cell.2009.05.006

PMCID:: PMC2768667

Abstract Article PDF–4.0M

Select item 642645510.

Mapping the genetic landscape of human cells

Max A. Horlbeck, Albert Xu, Min Wang, Neal K. Bennett, Chong Y. Park, Derek Bogdanoff, Britt Adamson, Eric D. Chow, Martin Kampmann, Tim R. Peterson, Ken Nakamura, Michael A. Fischbach, Jonathan S. Weissman, Luke A. Gilbert

Cell. Author manuscript; available in PMC 2019 Aug 9.

Published in final edited form as: Cell. 2018 Aug 9; 174(4): 953–967.e22. Published online 2018 Jul 19. doi: 10.1016/j.cell.2018.06.010

PMCID:: PMC6426455

Abstract Article PDF–3.6M

Select item 294347611.

Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression

Sher L. Hendrickson, James A. Lautenberger, Leslie Wei Chinn, Michael Malasky, Efe Sezgin, Lawrence A. Kingsley, James J. Goedert, Gregory D. Kirk, Edward D. Gomperts, Susan P. Buchbinder, Jennifer L. Troyer, Stephen J. O'Brien

PLoS One. 2010; 5(9): e12862. Published online 2010 Sep 21. doi: 10.1371/journal.pone.0012862

PMCID:: PMC2943476

Abstract Article PDF–461K

Select item 926261412.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 756688113.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 268304714.

Ubiquitin-mediated proteolysis of HuR by heat shock

Kotb Abdelmohsen, Subramanya Srikantan, Xiaoling Yang, Ashish Lal, Hyeon Ho Kim, Yuki Kuwano, Stefanie Galban, Kevin G Becker, Davida Kamara, Rafael de Cabo, Myriam Gorospe

EMBO J. 2009 May 6; 28(9): 1271–1282. Published online 2009 Mar 26. doi: 10.1038/emboj.2009.67

PMCID:: PMC2683047

Abstract Article PDF–1.4M

Select item 835296415.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 716998316.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x