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Select item 91618051.

Bárbara Márquez-Tirado, Josué Gutiérrez-Tenorio, Agustín Tortajada, Laura Lucientes Continente, Fernando Caravaca-Fontán, Talat H. Malik, Raquel Roldán Montero, Sandra Elías, Ana Saiz Gonzalez, Gema Fernández-Juarez, Pilar Sánchez-Corral, Matthew C. Pickering, Manuel Praga, Santiago Rodríguez de Córdoba, Elena Goicoechea de Jorge

J Am Soc Nephrol. 2022 Jun; 33(6): 1137–1153. Published online 2022 Jun. doi: 10.1681/ASN.2021101318

PMCID:: PMC9161805

Abstract Article

Select item 86023452.

Sarah Irmscher, Svante L. H. Zipfel, Luke D. Halder, Lia Ivanov, Andres Gonzalez-Delgado, Christoph Waldeyer, Moritz Seiffert, Fabian J. Brunner, Monika von der Heide, Ina Löschmann, Sonia Wulf, Darina Czamara, Nikolina Papac-Milicevic, Olaf Strauß, Stefan Lorkowski, Hermann Reichenspurner, Michael V. Holers, Nirmal K. Banda, Tania Zeller, Elisabeth B. Binder, Christoph J. Binder, Thorsten Wiech, Peter F. Zipfel, Christine Skerka

Sci Rep. 2021; 11: 22511. Published online 2021 Nov 18. doi: 10.1038/s41598-021-02011-w

PMCID:: PMC8602345

Abstract Article PDF–6.9M

Select item 73783603.

Interaction of the Factor H Family Proteins FHR-1 and FHR-5 With DNA and Dead Cells: Implications for the Regulation of Complement Activation and Opsonization

Éva Kárpáti, Alexandra Papp, Andrea E. Schneider, Dávid Hajnal, Marcell Cserhalmi, Ádám I. Csincsi, Barbara Uzonyi, Mihály Józsi

Front Immunol. 2020; 11: 1297. Published online 2020 Jul 16. doi: 10.3389/fimmu.2020.01297

PMCID:: PMC7378360

Abstract Article PDF–2.3M

Select item 67551974.

CFHR1 is a potentially downregulated gene in lung adenocarcinoma

Geting Wu, Yuanliang Yan, Xiang Wang, Xinxin Ren, Xi Chen, Shuangshuang Zeng, Jie Wei, Long Qian, Xue Yang, Chunlin Ou, Wei Lin, Zhicheng Gong, Jianhua Zhou, Zhijie Xu

Mol Med Rep. 2019 Oct; 20(4): 3642–3648. Published online 2019 Sep 3. doi: 10.3892/mmr.2019.10644

PMCID:: PMC6755197

Abstract Article PDF–898K

Select item 57489185.

Factor H Competitor Generated by Gene Conversion Events Associates with Atypical Hemolytic Uremic Syndrome

Elena Goicoechea de Jorge, Agustín Tortajada, Sheila Pinto García, Sara Gastoldi, Héctor Martín Merinero, Jesús García-Fernández, Emilia Arjona, Mercedes Cao, Giuseppe Remuzzi, Marina Noris, Santiago Rodríguez de Córdoba

J Am Soc Nephrol. 2018 Jan; 29(1): 240–249. Published online 2017 Oct 9. doi: 10.1681/ASN.2017050518

PMCID:: PMC5748918

Abstract Article

Select item 12738956.

Demonstration of Factor H-Like Protein 1 Binding to Treponema denticola, a Pathogen Associated with Periodontal Disease in Humans

John V. McDowell, Justin Lankford, Lola Stamm, Tania Sadlon, David L. Gordon, Richard T. Marconi

Infect Immun. 2005 Nov; 73(11): 7126–7132. doi: 10.1128/IAI.73.11.7126-7132.2005

PMCID:: PMC1273895

Abstract Article PDF–251K

Select item 103259987.

The absence of CFHR3 and CFHR1 genes from the T2T-CHM13 assembly can limit the molecular diagnosis of complement-related diseases

Abderaouf Hamza, Carine El-Sissy, Nadhir Yousfi, Paula Vieira Martins, Cédric Rafat, Julien Masliah-Planchon, Véronique Frémeaux-Bacchi, Laurent Mesnard

Eur J Hum Genet. 2023 Jul; 31(7): 730–732. Published online 2023 Apr 10. doi: 10.1038/s41431-023-01350-8

PMCID:: PMC10325998

Article PDF–614K

Select item 102089528.

CFH-CFHR1 hybrid genes in two cases of atypical hemolytic uremic syndrome

Yuka Sugawara, Hideki Kato, Masao Nagasaki, Yoko Yoshida, Madoka Fujisawa, Naoko Minegishi, Masayuki Yamamoto, Masaomi Nangaku

J Hum Genet. 2023; 68(6): 427–430. Published online 2023 Feb 9. doi: 10.1038/s10038-023-01129-1

PMCID:: PMC10208952

Abstract Article PDF–1.6M

Select item 94487179.

Anti-factor H antibody and its role in atypical hemolytic uremic syndrome

Rupesh Raina, Guneive Mangat, Gordon Hong, Raghav Shah, Nikhil Nair, Brian Abboud, Sumedha Bagga, Sidharth Kumar Sethi

Front Immunol. 2022; 13: 931210. Published online 2022 Aug 23. doi: 10.3389/fimmu.2022.931210

PMCID:: PMC9448717

Abstract Article PDF–753K

Select item 898052910.

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation

Alexandra Papp, Krisztián Papp, Barbara Uzonyi, Marcell Cserhalmi, Ádám I. Csincsi, Zsóka Szabó, Zsófia Bánlaki, David Ermert, Zoltán Prohászka, Anna Erdei, Viviana P. Ferreira, Anna M. Blom, Mihály Józsi

Front Immunol. 2022; 13: 845953. Published online 2022 Mar 22. doi: 10.3389/fimmu.2022.845953

PMCID:: PMC8980529

Abstract Article PDF–3.9M

Select item 886389511.

A synthetic protein as efficient multitarget regulator against complement over-activation

Natalia Ruiz-Molina, Juliana Parsons, Madeleine Müller, Sebastian N. W. Hoernstein, Lennard L. Bohlender, Steffen Pumple, Peter F. Zipfel, Karsten Häffner, Ralf Reski, Eva L. Decker

Commun Biol. 2022; 5: 152. Published online 2022 Feb 22. doi: 10.1038/s42003-022-03094-5

PMCID:: PMC8863895

Abstract Article PDF–2.4M

Select item 828866512.

Molecular bases for the association of FHR-1 with atypical hemolytic uremic syndrome and other diseases

Héctor Martin Merinero, Marta Subías, Amaia Pereda, Elena Gómez-Rubio, Lucia Juana Lopez, Constantino Fernandez, Elena Goicoechea de Jorge, Sonsoles Martin-Santamaria, Francisco Javier Cañada, Santiago Rodríguez de Córdoba

Blood. 2021 Jun 24; 137(25): 3484–3494. Prepublished online 2021 Mar 2. doi: 10.1182/blood.2020010069

PMCID:: PMC8288665

Abstract Article

Select item 795984213.

Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces

Arthur Dopler, Selina Stibitzky, Rachel Hevey, Marco Mannes, Mara Guariento, Britta Höchsmann, Hubert Schrezenmeier, Daniel Ricklin, Christoph Q. Schmidt

Front Immunol. 2021; 12: 615748. Published online 2021 Feb 25. doi: 10.3389/fimmu.2021.615748

PMCID:: PMC7959842

Abstract Article PDF–9.0M

Select item 579106114.

Deletion Variants of CFHR1 and CFHR3 Associate with Mesangial Immune Deposits but Not with Progression of IgA Nephropathy

Perrine Jullien, Blandine Laurent, Guillaume Claisse, Ingrid Masson, Miriana Dinic, Damien Thibaudin, Francois Berthoux, Eric Alamartine, Christophe Mariat, Nicolas Maillard

J Am Soc Nephrol. 2018 Feb; 29(2): 661–669. Published online 2017 Dec 7. doi: 10.1681/ASN.2017010019

PMCID:: PMC5791061

Abstract Article

Select item 561198715.

Circulating complement factor H–related proteins 1 and 5 correlate with disease activity in IgA nephropathy

Nicholas R. Medjeral-Thomas, Hannah J. Lomax-Browne, Hannah Beckwith, Michelle Willicombe, Adam G. McLean, Paul Brookes, Charles D. Pusey, Mario Falchi, H. Terence Cook, Matthew C. Pickering

Kidney Int. 2017 Oct; 92(4): 942–952. doi: 10.1016/j.kint.2017.03.043

PMCID:: PMC5611987

Abstract Article PDF–389K

Select item 509671516.

Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions

Jonathan P. Hannan, Jennifer Laskowski, Joshua M. Thurman, Gregory S. Hageman, V. Michael Holers

PLoS One. 2016; 11(11): e0166200. Published online 2016 Nov 4. doi: 10.1371/journal.pone.0166200

PMCID:: PMC5096715

Abstract Article PDF–3.0M

Select item 504267317.

Fine Mapping Implicates a Deletion of CFHR1 and CFHR3 in Protection from IgA Nephropathy in Han Chinese

Jingyuan Xie, Krzysztof Kiryluk, Yifu Li, Nikol Mladkova, Li Zhu, Ping Hou, Hong Ren, Weiming Wang, Hong Zhang, Nan Chen, Ali G. Gharavi

J Am Soc Nephrol. 2016 Oct; 27(10): 3187–3194. Published online 2016 Mar 3. doi: 10.1681/ASN.2015111210

PMCID:: PMC5042673

Abstract Article

Select item 443349618.

A Novel Hybrid CFHR1/CFH Gene Causes Atypical Hemolytic Uremic Syndrome

Stephen J. Eyler, Nicole C. Meyer, Yuzhou Zhang, Xue Xiao, Carla M. Nester, Richard J.H. Smith

Pediatr Nephrol. Author manuscript; available in PMC 2015 May 16.

Published in final edited form as: Pediatr Nephrol. 2013 Nov; 28(11): 2221–2225. Published online 2013 Jul 24. doi: 10.1007/s00467-013-2560-2

PMCID:: PMC4433496

Abstract Article PDF–304K

Select item 439225519.

The Major Autoantibody Epitope on Factor H in Atypical Hemolytic Uremic Syndrome Is Structurally Different from Its Homologous Site in Factor H-related Protein 1, Supporting a Novel Model for Induction of Autoimmunity in This Disease

Arnab Bhattacharjee, Stefanie Reuter, Eszter Trojnár, Robert Kolodziejczyk, Harald Seeberger, Satu Hyvärinen, Barbara Uzonyi, Ágnes Szilágyi, Zoltán Prohászka, Adrian Goldman, Mihály Józsi, T. Sakari Jokiranta

J Biol Chem. 2015 Apr 10; 290(15): 9500–9510. Published online 2015 Feb 6. doi: 10.1074/jbc.M114.630871

PMCID:: PMC4392255

Abstract Article PDF–2.2M

Select item 382013920.

Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration

Morad Ansari, Paul M. Mckeigue, Christine Skerka, Caroline Hayward, Igor Rudan, Veronique Vitart, Ozren Polasek, Ana-Maria Armbrecht, John R.W. Yates, Zoran Vatavuk, Goran Bencic, Ivana Kolcic, Ben A. Oostra, Cornelia M. Van Duijn, Susan Campbell, Chloe M. Stanton, Jennifer Huffman, Xinhua Shu, Jane C. Khan, Humma Shahid, Simon P. Harding, Paul N. Bishop, Ian J. Deary, Anthony T. Moore, Baljean Dhillon, Pavao Rudan, Peter F. Zipfel, Robert B. Sim, Nicholas D. Hastie, Harry Campbell, Alan F. Wright

Hum Mol Genet. 2013 Dec 1; 22(23): 4857–4869. Published online 2013 Jul 19. doi: 10.1093/hmg/ddt336

PMCID:: PMC3820139

Abstract Article PDF–828K

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