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Select item 49740941.

Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis

Yukinori Okada, Akari Suzuki, Katsunori Ikari, Chikashi Terao, Yuta Kochi, Koichiro Ohmura, Koichiro Higasa, Masato Akiyama, Kyota Ashikawa, Masahiro Kanai, Jun Hirata, Naomasa Suita, Yik-Ying Teo, Huji Xu, Sang-Cheol Bae, Atsushi Takahashi, Yukihide Momozawa, Koichi Matsuda, Shigeki Momohara, Atsuo Taniguchi, Ryo Yamada, Tsuneyo Mimori, Michiaki Kubo, Matthew A. Brown, Soumya Raychaudhuri, Fumihiko Matsuda, Hisashi Yamanaka, Yoichiro Kamatani, Kazuhiko Yamamoto

Am J Hum Genet. 2016 Aug 4; 99(2): 366–374. Published online 2016 Aug 2. doi: 10.1016/j.ajhg.2016.06.019

PMCID:: PMC4974094

Abstract Article PDF–1.7M

Select item 47952142.

Genome-wide association analysis on five isolated populations identifies variants of the HLA-DOA gene associated with white wine liking

Nicola Pirastu, Maarten Kooyman, Michela Traglia, Antonietta Robino, Sara M Willems, Giorgio Pistis, Najaf Amin, Cinzia Sala, Lennart C Karssen, Cornelia M van Duijn, Daniela Toniolo, Paolo Gasparini

Eur J Hum Genet. 2015 Dec; 23(12): 1717–1722. Published online 2015 Mar 11. doi: 10.1038/ejhg.2015.34

PMCID:: PMC4795214

Abstract Article PDF–2.9M

Select item 44471403.

Exploring the diabetogenicity of the HLA-B18-DR3 CEH: independent association with T1D genetic risk close to HLA-DOA

Izortze Santin, Ainara Castellanos-Rubio, Ana María Aransay, Galder Gutierrez, Sonia Gaztambide, Itxaso Rica, Jose Luis Vicario, Janelle A. Noble, Luis Castaño, Jose Ramon Bilbao

Genes Immun. Author manuscript; available in PMC 2015 May 28.

Published in final edited form as: Genes Immun. 2009 Sep; 10(6): 596–600. Published online 2009 May 21. doi: 10.1038/gene.2009.41

PMCID:: PMC4447140

Abstract Article PDF–316K

Select item 29564364.

Genetic variants in Major Histocompatibility Complex-linked genes Associate with Pediatric Liver Transplant Rejection

Rakesh Sindhi, Brandon W. Higgs, Daniel E. Weeks, Chethan AshokKumar, Ronald Jaffe, Cecilia Kim, Patrick Wilson, Nydia Chien, Joseph Glessner, Anjan Talukdar, George Mazariegos, M. Michael Barmada, Edward Frackleton, Nancy Petro, Andrew Eckert, Hakon Hakonarson, Robert Ferrell

Gastroenterology. Author manuscript; available in PMC 2010 Oct 18.

Published in final edited form as: Gastroenterology. 2008 Sep; 135(3): 830–84010. Published online 2008 Jun 3. doi: 10.1053/j.gastro.2008.05.080

PMCID:: PMC2956436

Abstract Article PDF–386K

Select item 5544905.

The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions.

J Trowsdale, A Kelly

EMBO J. 1985 Sep; 4(9): 2231–2237. doi: 10.1002/j.1460-2075.1985.tb03919.x

PMCID:: PMC554490

Summary Page Browse PDF–1.5M

Select item 46615246.

pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity

Wei Jiang, Michael J. Strohman, Sriram Somasundaram, Sashi Ayyangar, Tieying Hou, Nan Wang, Elizabeth D. Mellins

Sci Rep. 2015; 5: 17333. Published online 2015 Nov 27. doi: 10.1038/srep17333

PMCID:: PMC4661524

Abstract Article PDF–1.9M

Select item 28091377.

Genetic association of htSNPs across the major histocompatibility complex with rheumatoid arthritis in an African American population

Richard J. Reynolds, James M. Kelley, Laura B. Hughes, Nengjun Yi, S. Louis Bridges, Jr

Genes Immun. Author manuscript; available in PMC 2010 Jul 1.

Published in final edited form as: Genes Immun. 2010 Jan; 11(1): 94–97. Published online 2009 Sep 10. doi: 10.1038/gene.2009.69

PMCID:: PMC2809137

Abstract Article PDF–190K

Select item 43952488.

Association of Polymorphisms in HLA Antigen Presentation-Related Genes with the Outcomes of HCV Infection

Peng Huang, Yuanyuan Zhang, Xiaomei Lu, Yin Xu, Jie Wang, Yun Zhang, Rongbin Yu, Jing Su

PLoS One. 2015; 10(4): e0123513. Published online 2015 Apr 13. doi: 10.1371/journal.pone.0123513

PMCID:: PMC4395248

Abstract Article PDF–180K

Select item 35378869.

HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism

Abigail I Guce, Sarah E Mortimer, Taejin Yoon, Corrie A Painter, Wei Jiang, Elizabeth D Mellins, Lawrence J Stern

Nat Struct Mol Biol. Author manuscript; available in PMC 2013 Jul 1.

Published in final edited form as: Nat Struct Mol Biol. 2013 Jan; 20(1): 90–98. Published online 2012 Dec 9. doi: 10.1038/nsmb.2460

PMCID:: PMC3537886

Abstract Article PDF–2.2M

Select item 45221810.

HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport.

M Liljedahl, T Kuwana, W P Fung-Leung, M R Jackson, P A Peterson, L Karlsson

EMBO J. 1996 Sep 16; 15(18): 4817–4824.

PMCID:: PMC452218

Summary Page Browse PDF–2.1M

Select item 447199411.

Association of Granulomatosis With Polyangiitis (Wegener’s) With HLA–DPB1*04 and SEMA6A Gene Variants Evidence From Genome-Wide Analysis

Gang Xie, Delnaz Roshandel, Richard Sherva, Paul A. Monach, Emily Yue Lu, Tabitha Kung, Keisha Carrington, Steven S. Zhang, Sara L. Pulit, Stephan Ripke, Simon Carette, Paul F. Dellaripa, Jeffrey C. Edberg, Gary S. Hoffman, Nader Khalidi, Carol A. Langford, Alfred D. Mahr, E. William St.Clair, Philip Seo, Ulrich Specks, Robert F. Spiera, John H. Stone, Steven R. Ytterberg, Soumya Raychaudhuri, Paul I. W. de Bakker, Lindsay A. Farrer, Christopher I. Amos, Peter A. Merkel, Katherine A. Siminovitch

Arthritis Rheum. Author manuscript; available in PMC 2015 Jun 18.

Published in final edited form as: Arthritis Rheum. 2013 Sep; 65(9): 2457–2468. doi: 10.1002/art.38036

PMCID:: PMC4471994

Abstract Article PDF–1.0M

Select item 339651712.

Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis

Taejin Yoon, Henriette Macmillan, Sarah E. Mortimer, Wei Jiang, Cornelia H. Rinderknecht, Lawrence J. Stern, Elizabeth D. Mellins

Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28): 11276–11281. Published online 2012 Jun 25. doi: 10.1073/pnas.1113966109

PMCID:: PMC3396517

Abstract Article PDF–1.2M

Select item 22841913.

Down-Modulation of Mature Major Histocompatibility Complex Class II and Up-Regulation of Invariant Chain Cell Surface Expression Are Well-Conserved Functions of Human and Simian Immunodeficiency Virus nef Alleles

Michael Schindler, Stephanie Würfl, Philippe Benaroch, Thomas C. Greenough, Rod Daniels, Philippa Easterbrook, Matthias Brenner, Jan Münch, Frank Kirchhoff

J Virol. 2003 Oct; 77(19): 10548–10556. doi: 10.1128/JVI.77.19.10548-10556.2003

PMCID:: PMC228419

Abstract Article PDF–348K

Select item 5978214.

HIV-1 Nef impairs MHC class II antigen presentation and surface expression

Pamela Stumptner-Cuvelette, Stephanie Morchoisne, Marc Dugast, Sylvie Le Gall, Graça Raposo, Olivier Schwartz, Philippe Benaroch

Proc Natl Acad Sci U S A. 2001 Oct 9; 98(21): 12144–12149. Published online 2001 Oct 2. doi: 10.1073/pnas.221256498

PMCID:: PMC59782

Abstract Article PDF–249K

Select item 431072615.

Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

Tomomitsu Hirota, Atsushi Takahashi, Michiaki Kubo, Tatsuhiko Tsunoda, Kaori Tomita, Satoru Doi, Kimie Fujita, Akihiko Miyatake, Tadao Enomoto, Takehiko Miyagawa, Mitsuru Adachi, Hiroshi Tanaka, Akio Niimi, Hisako Matsumoto, Isao Ito, Hironori Masuko, Tohru Sakamoto, Nobuyuki Hizawa, Masami Taniguchi, John J. Lima, Charles G. Irvin, Stephen P. Peters, Blanca E. Himes, Augusto A. Litonjua, Kelan G. Tantisira, Scott T. Weiss, Naoyuki Kamatani, Yusuke Nakamura, Mayumi Tamari

Nat Genet. Author manuscript; available in PMC 2015 Jan 29.

Published in final edited form as: Nat Genet. 2011 Sep; 43(9): 893–896. Published online 2011 Jul 31. doi: 10.1038/ng.887

PMCID:: PMC4310726

Article PDF–376K

Select item 340844316.

Strategy for Identifying Dendritic Cell-Processed CD4⁺ T Cell Epitopes from the HIV Gag p24 Protein

Leonia Bozzacco, Haiqiang Yu, Jörn Dengjel, Christine Trumpfheller, Henry A. Zebroski, III, Nawei Zhang, Victoria Küttner, Beatrix M. Ueberheide, Haiteng Deng, Brian T. Chait, Ralph M. Steinman, Svetlana Mojsov, David Fenyö

PLoS One. 2012; 7(7): e41897. Published online 2012 Jul 30. doi: 10.1371/journal.pone.0041897