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Select item 110991681.

Downregulation of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase response

Charlotte Ehle, Aishwarya Iyer-Bierhoff, Yunchen Wu, Shaojun Xing, Michael Kiehntopf, Alexander S. Mosig, Maren Godmann, Thorsten Heinzel

Commun Biol. 2024; 7: 589. Published online 2024 May 16. doi: 10.1038/s42003-024-06288-1

PMCID:: PMC11099168

Abstract Article PDF–2.2M

Select item 110701322.

Functional characterization of HNF4A gene variants identify promoter and cell line specific transactivation effects

Alba Kaci, Marie Holm Solheim, Trine Silgjerd, Jorunn Hjaltadottir, Lorentze Hope Hornnes, Janne Molnes, Andre Madsen, Gry Sjøholt, Christine Bellanné-Chantelot, Richard Caswell, Jørn V Sagen, Pål R Njølstad, Ingvild Aukrust, Lise Bjørkhaug

Hum Mol Genet. 2024 May 15; 33(10): 894–904. Published online 2024 Mar 3. doi: 10.1093/hmg/ddae027

PMCID:: PMC11070132

Abstract Article PDF–1.2M

Select item 103266003.

Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis

Omer Goldman, Lital N. Adler, Emma Hajaj, Tommaso Croese, Naama Darzi, Sivan Galai, Hila Tishler, Yarden Ariav, Dor Lavie, Liat Fellus-Alyagor, Roni Oren, Yuri Kuznetsov, Eyal David, Rami Jaschek, Chani Stossel, Oded Singer, Sergey Malitsky, Renana Barak, Rony Seger, Neta Erez, Ido Amit, Amos Tanay, Ann Saada, Talia Golan, Tamar Rubinek, Joo Sang Lee, Shay Ben-Shachar, Ido Wolf, Ayelet Erez

Cancer Discov. 2023 Jul 7; 13(7): 1616–1635. Published online 2023 Mar 27. doi: 10.1158/2159-8290.CD-22-1062

PMCID:: PMC10326600

Abstract Article PDF–16M

Select item 101740644.

Hepatic nuclear factor 4 alpha promotes the ferroptosis of lung adenocarcinoma via transcriptional activation of cytochrome P450 oxidoreductase

Valeria Besskaya, Huan Zhang, Yunyi Bian, Jiaqi Liang, Guoshu Bi, Guangyao Shan, Cheng Zhan, Zongwu Lin

PeerJ. 2023; 11: e15377. Published online 2023 May 8. doi: 10.7717/peerj.15377

PMCID:: PMC10174064

Abstract Article PDF–5.9M

Select item 100101715.

HNF4G increases cisplatin resistance in lung adenocarcinoma via the MAPK6/Akt pathway

Jiaqi Liang, Guangyin Zhao, Yunyi Bian, Guoshu Bi, Qihai Sui, Huan Zhang, Haochun Shi, Guangyao Shan, Yiwei Huang, Zhencong Chen, Lin Wang, Cheng Zhan

PeerJ. 2023; 11: e14996. Published online 2023 Mar 10. doi: 10.7717/peerj.14996

PMCID:: PMC10010171

Abstract Article PDF–1.8M

Select item 97621586.

Progressive loss of HNF4α activity in chronic liver diseases in humans

Sumedha Gunewardena, Ian Huck, Chad Walesky, Dakota Robarts, Steven Weinman, Udayan Apte

Hepatology. Author manuscript; available in PMC 2022 Dec 19.

Published in final edited form as: Hepatology. 2022 Aug; 76(2): 372–386. Published online 2022 Mar 4. doi: 10.1002/hep.32326

PMCID:: PMC9762158

Abstract Article PDF–3.0M

Select item 93372587.

Hepatocyte nuclear factor 4α in the pathogenesis of non-alcoholic fatty liver disease

Xiaoli Pan, Yanqiao Zhang

Chin Med J (Engl) 2022 May 20; 135(10): 1172–1181. Published online 2022 Feb 21. doi: 10.1097/CM9.0000000000002092

PMCID:: PMC9337258

Abstract Article PDF–1.4M

Select item 89656678.

Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells

Manuel Carrasco, Chencheng Wang, Anne M. Søviknes, Yngvild Bjørlykke, Shadab Abadpour, Joao A. Paulo, Erling Tjora, Pål Njølstad, Jonas Ghabayen, Ingrid Nermoen, Valeriya Lyssenko, Simona Chera, Luiza M. Ghila, Marc Vaudel, Hanne Scholz, Helge Ræder

Diabetes. 2022 Apr; 71(4): 862–869. Published online 2022 Jan 18. doi: 10.2337/db20-1279

PMCID:: PMC8965667

Abstract Article PDF–19M

Select item 88171089.

HNF4A Regulates the Proliferation and Tumor Formation of Cervical Cancer Cells through the Wnt/β-Catenin Pathway

Hong-Mei Ma, Qian Zhang, Xue-Mei Yang, Yan Hu, Juan Zhang, Lin Chen, Bin Zhao, Wen-ting Yang, Rui Xu

Oxid Med Cell Longev. 2022; 2022: 8168988. Published online 2022 Jan 28. doi: 10.1155/2022/8168988

PMCID:: PMC8817108

Abstract Article PDF–5.0M

Select item 847991310.

GATA binding protein 4 promotes the expression and transcription of hepatitis B virus by facilitating hepatocyte nuclear factor 4 alpha in vitro

Xiaoqin Lv, Xia Xiang, Yue Wu, Yang Liu, Ruqing Xu, Qin Xiang, Guoqi Lai

Virol J. 2021; 18: 196. Published online 2021 Sep 28. doi: 10.1186/s12985-021-01668-z

PMCID:: PMC8479913

Abstract Article PDF–3.2M

Select item 819321111.

Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist

Seung-Hee Lee, Vimal Veeriah, Fred Levine

Cell Death Dis. 2021 Jun; 12(6): 603. Published online 2021 Jun 11. doi: 10.1038/s41419-021-03862-x

PMCID:: PMC8193211

Abstract Article PDF–2.8M

Select item 813228912.

Heterozygous Recurrent HNF4A variant p.Arg85Trp Causes Fanconi Renotubular Syndrome 4 with Maturity Onset Diabetes of the Young, an Autosomal Dominant Phenocopy of Fanconi Bickel Syndrome with Colobomas

Sarah E. Sheppard, Brett Barrett, Colleen Muraresku, Heather McKnight, Diva D. De Leon, Katherine Lord, Rebecca Ganetzky

Am J Med Genet A. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Am J Med Genet A. 2021 Feb; 185(2): 566–570. Published online 2020 Nov 30. doi: 10.1002/ajmg.a.61978

PMCID:: PMC8132289

Abstract Article PDF–293K

Select item 789356813.

Research on the circadian clock gene HNF4a in different malignant tumors

Meng-jun Qiu, Li Zhang, Xie-fan Fang, Qiu-ting Li, Li-sheng Zhu, Bin Zhang, Sheng-li Yang, Zhi-fan Xiong

Int J Med Sci. 2021; 18(6): 1339–1347. Published online 2021 Jan 21. doi: 10.7150/ijms.49997

PMCID:: PMC7893568

Abstract Article PDF–908K

Select item 760021514.

Control of Cell Identity by the Nuclear Receptor HNF4 in Organ Pathophysiology

Vanessa Dubois, Bart Staels, Philippe Lefebvre, Michael P. Verzi, Jérôme Eeckhoute

Cells. 2020 Oct; 9(10): 2185. Published online 2020 Sep 28. doi: 10.3390/cells9102185

PMCID:: PMC7600215

Abstract Article PDF–926K

Select item 754333915.

Intestinal Receptor of SARS-CoV-2 in Inflamed IBD Tissue Seems Downregulated by HNF4A in Ileum and Upregulated by Interferon Regulating Factors in Colon

Bram Verstockt, Sare Verstockt, Saeed Abdu Rahiman, Bo-jun Ke, Kaline Arnauts, Isabelle Cleynen, João Sabino, Marc Ferrante, Gianluca Matteoli, Séverine Vermeire

J Crohns Colitis. 2021 Mar; 15(3): 485–498. Published online 2020 Sep 11. doi: 10.1093/ecco-jcc/jjaa185

PMCID:: PMC7543339

Abstract Article PDF–10M

Select item 741413316.

HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer

Qing Xu, Yuanyuan Li, Xia Gao, Kai Kang, Jason G. Williams, Lingfeng Tong, Juan Liu, Ming Ji, Leesa J. Deterding, Xuemei Tong, Jason W. Locasale, Leping Li, Igor Shats, Xiaoling Li

Nat Commun. 2020; 11: 3978. Published online 2020 Aug 7. doi: 10.1038/s41467-020-17818-w

PMCID:: PMC7414133

Abstract Article PDF–2.4M

Select item 719658617.

Human Hepatocyte Nuclear Factor 4-α Encodes Isoforms with Distinct Transcriptional Functions

Élie Lambert, Jean-Philippe Babeu, Joël Simoneau, Jennifer Raisch, Laurie Lavergne, Dominique Lévesque, Émilie Jolibois, Mariano Avino, Michelle S. Scott, François Boudreau, Francois-Michel Boisvert

Mol Cell Proteomics. 2020 May; 19(5): 808–827. Published online 2020 Mar 2. doi: 10.1074/mcp.RA119.001909

PMCID:: PMC7196586

Abstract Article PDF–3.1M

Select item 703856118.

ABAT and ALDH6A1, regulated by transcription factor HNF4A, suppress tumorigenic capability in clear cell renal cell carcinoma

Jun Lu, Zhan Chen, Hu Zhao, Huiyue Dong, Ling Zhu, Yi Zhang, Jie Wang, Hehuan Zhu, Qiang Cui, Chuang Qi, Shuiliang Wang, Shushang Chen, Jichun Shao

J Transl Med. 2020; 18: 101. Published online 2020 Feb 24. doi: 10.1186/s12967-020-02268-1

PMCID:: PMC7038561

Abstract Article PDF–12M

Select item 691230019.

Human iPSCs-Derived Endothelial Cells with Mutation in HNF1A as a Model of Maturity-Onset Diabetes of the Young

Neli Kachamakova-Trojanowska, Jacek Stepniewski, Jozef Dulak

Cells. 2019 Nov; 8(11): 1440. Published online 2019 Nov 14. doi: 10.3390/cells8111440

PMCID:: PMC6912300

Abstract Article PDF–4.9M

Select item 670070520.

Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases

Matthew M Yeh, Dustin E Bosch, Sayed S Daoud

World J Gastroenterol. 2019 Aug 14; 25(30): 4074–4091. Published online 2019 Aug 14. doi: 10.3748/wjg.v25.i30.4074

PMCID:: PMC6700705

Abstract Article PDF–10M

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