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Select item 110916531.

The 5HT2b Receptor in Alzheimer’s Disease: Increased Levels in Patient Brains and Antagonist Attenuation of Amyloid and Tau Induced Dysfunction

Erica Acquarone, Elentina K. Argyrousi, Ottavio Arancio, D. Martin Watterson, Saktimayee M. Roy

J Alzheimers Dis. 2024; 98(4): 1349–1360. Prepublished online 2024 Apr 3. Published online 2024 Apr 16. doi: 10.3233/JAD-240063

PMCID:: PMC11091653

Abstract Article PDF–264K

Select item 103626392.

Variant rs17619600 in the gene encoding serotonin receptor 2B (HTR2B) increases the risk of gestational diabetes mellitus: a case–control study

Juliana Regina Chamlian Zucare Penno, Daniele Pereira Santos-Bezerra, Ana Mercedes Cavaleiro, Ana Maria da Silva Sousa, Tatiana Assunção Zaccara, Rafaela Alkmin da Costa, Rossana Pulcineli Vieira Francisco, Maria Lucia Correa-Giannella

Eur J Med Res. 2023; 28: 243. Published online 2023 Jul 21. doi: 10.1186/s40001-023-01211-6

PMCID:: PMC10362639

Abstract Article PDF–937K

Select item 88362043.

Contribution of the STAT Family of Transcription Factors to the Expression of the Serotonin 2B (HTR2B) Receptor in Human Uveal Melanoma

Manel Benhassine, Gaëtan Le-Bel, Sylvain L. Guérin

Int J Mol Sci. 2022 Feb; 23(3): 1564. Published online 2022 Jan 29. doi: 10.3390/ijms23031564

PMCID:: PMC8836204

Abstract Article PDF–3.2M

Select item 77253984.

Free energy calculations of the functional selectivity of 5-HT_2B G protein-coupled receptor

Brandon L. Peters, Jinxia Deng, Andrew L. Ferguson

PLoS One. 2020; 15(12): e0243313. Published online 2020 Dec 9. doi: 10.1371/journal.pone.0243313

PMCID:: PMC7725398

Abstract Article PDF–2.2M

Select item 64517655.

Molecular interactions between general anesthetics and the 5HT_2B receptor

Felipe Matsunaga, Lu Gao, Xi-Ping Huang, Jeffery G. Saven, Bryan L. Roth, Renyu Liu

J Biomol Struct Dyn. Author manuscript; available in PMC 2019 Apr 7.

Published in final edited form as: J Biomol Struct Dyn. 2015; 33(1): 211–218. Published online 2013 Dec 23. doi: 10.1080/07391102.2013.869483

PMCID:: PMC6451765

Abstract Article PDF–531K

Select item 62817826.

Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response

Janitza L. Montalvo-Ortiz, Hang Zhou, Ivana D’Andrea, Luc Maroteaux, Adriana Lori, Alicia Smith, Kerry J. Ressler, Yaira Z. Nuñez, Lindsay A. Farrer, Hongyu Zhao, Henry R. Kranzler, Joel Gelernter

Mol Psychiatry. Author manuscript; available in PMC 2019 Jan 3.

Published in final edited form as: Mol Psychiatry. 2018 Dec; 23(12): 2277–2286. Published online 2018 Jun 6. doi: 10.1038/s41380-018-0077-6

PMCID:: PMC6281782

Abstract Article PDF–875K

Select item 62141427.

Transcription of the Human 5-Hydroxytryptamine Receptor 2B (HTR2B) Gene Is under the Regulatory Influence of the Transcription Factors NFI and RUNX1 in Human Uveal Melanoma

Manel Benhassine, Sylvain L. Guérin

Int J Mol Sci. 2018 Oct; 19(10): 3272. Published online 2018 Oct 21. doi: 10.3390/ijms19103272

PMCID:: PMC6214142

Abstract Article PDF–4.4M

Select item 58564578.

Serotonin Receptor 2B Signaling with Interstitial Cell Activation and Leaflet Remodeling in Degenerative Mitral Regurgitation

Kathryn H Driesbaugh, Emanuela Branchetti, Juan B Grau, Samuel J. Keeney, Kimberly Glass, Mark A Oyama, Nancy Rioux, Salma Ayoub, Michael S Sacks, John Quackenbush, Robert J Levy, Giovanni Ferrari

J Mol Cell Cardiol. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: J Mol Cell Cardiol. 2018 Feb; 115: 94–103. Published online 2017 Dec 30. doi: 10.1016/j.yjmcc.2017.12.014

PMCID:: PMC5856457

Abstract Article PDF–1.6M

Select item 57888539.

Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells

Attila Szabo, Peter Gogolak, Gabor Koncz, Zsofia Foldvari, Kitti Pazmandi, Noemi Miltner, Szilard Poliska, Attila Bacsi, Srdjan Djurovic, Eva Rajnavolgyi

Sci Rep. 2018; 8: 1765. Published online 2018 Jan 29. doi: 10.1038/s41598-018-20173-y

PMCID:: PMC5788853

Abstract Article PDF–2.4M

Select item 554759810.

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody

Andrii Ishchenko, Daniel Wacker, Mili Kapoor, Ai Zhang, Gye Won Han, Shibom Basu, Nilkanth Patel, Marc Messerschmidt, Uwe Weierstall, Wei Liu, Vsevolod Katritch, Bryan L. Roth, Raymond C. Stevens, Vadim Cherezov

Proc Natl Acad Sci U S A. 2017 Aug 1; 114(31): 8223–8228. Published online 2017 Jul 17. doi: 10.1073/pnas.1700891114

PMCID:: PMC5547598

Abstract Article PDF–1.5M

Select item 528931111.

Crystal structure of an LSD-bound human serotonin receptor

Daniel Wacker, Sheng Wang, John D. McCorvy, Robin M. Betz, A. J. Venkatakrishnan, Anat Levit, Katherine Lansu, Zachary L. Schools, Tao Che, David E. Nichols, Brian K. Shoichet, Ron O. Dror, Bryan L. Roth

Cell. Author manuscript; available in PMC 2018 Jan 26.

Published in final edited form as: Cell. 2017 Jan 26; 168(3): 377–389.e12. doi: 10.1016/j.cell.2016.12.033

PMCID:: PMC5289311

Abstract Article PDF–2.5M

Select item 506876312.

Impulsive alcohol-related risk-behavior and emotional dysregulation among individuals with a serotonin 2B receptor stop codon

R Tikkanen, J Tiihonen, M R Rautiainen, T Paunio, L Bevilacqua, R Panarsky, D Goldman, M Virkkunen

Transl Psychiatry. 2015 Nov; 5(11): e681. Published online 2015 Nov 17. doi: 10.1038/tp.2015.170

PMCID:: PMC5068763

Abstract Article PDF–398K

Select item 495122213.

Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients

Ana-Maria Buga, Ovidiu Ciobanu, George Mihai Bădescu, Catalin Bogdan, Ria Weston, Mark Slevin, Mario Di Napoli, Aurel Popa-Wagner

Oncotarget. 2016 Apr 5; 7(14): 17415–17430. Published online 2016 Mar 22. doi: 10.18632/oncotarget.8277

PMCID:: PMC4951222

Abstract Article PDF–5.2M

Select item 364439014.

Structural Features for Functional Selectivity at Serotonin Receptors

Daniel Wacker, Chong Wang, Vsevolod Katritch, Gye Won Han, Xi-Ping Huang, Eyal Vardy, John D. McCorvy, Yi Jiang, Meihua Chu, Fai Yiu Siu, Wei Liu, H. Eric Xu, Vadim Cherezov, Bryan L. Roth, Raymond C. Stevens

Science. Author manuscript; available in PMC 2014 May 3.

Published in final edited form as: Science. 2013 May 3; 340(6132): 615–619. Published online 2013 Mar 21. doi: 10.1126/science.1232808

PMCID:: PMC3644390

Abstract Article PDF–3.0M

Select item 157323515.

5-HT_2B receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro

R A Borman, N S Tilford, D W Harmer, N Day, E S Ellis, R L G Sheldrick, J Carey, R A Coleman, G S Baxter

Br J Pharmacol. 2002 Mar; 135(5): 1144–1151. doi: 10.1038/sj.bjp.0704571

PMCID:: PMC1573235

Abstract Article PDF–536K

Select item 1053066716.

Synergistic Interaction of 5-HT_1B and 5-HT_2B Receptors in Cytoplasmic Ca²⁺ Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in Pathologies

Elena Yu. Rybakova, Piotr P. Avdonin, Sergei K. Trufanov, Nikolay V. Goncharov, Pavel V. Avdonin

Int J Mol Sci. 2023 Sep; 24(18): 13833. Published online 2023 Sep 8. doi: 10.3390/ijms241813833

PMCID:: PMC10530667

Abstract Article PDF–3.6M

Select item 382070717.

Structure-Activity Relationships of Constrained Phenylethylamine Ligands for the Serotonin 5-HT₂ Receptors

Vignir Isberg, James Paine, Sebastian Leth-Petersen, Jesper L. Kristensen, David E. Gloriam

PLoS One. 2013; 8(11): e78515. Published online 2013 Nov 7. doi: 10.1371/journal.pone.0078515

Correction in:: PLoS One. 2014; 9(1): 10.1371/annotation/c0047d59-f3e8-4923-8883-dcc991c0e61e.

PMCID:: PMC3820707

Abstract Article PDF–1.6M

Select item 151040618.

Functional evidence for a 5-HT2B receptor mediating contraction of longitudinal muscle in human small intestine.

R A Borman, D E Burleigh

Br J Pharmacol. 1995 Apr; 114(8): 1525–1527. doi: 10.1111/j.1476-5381.1995.tb14935.x

PMCID:: PMC1510406

Summary Page Browse PDF–442K

Select item 569065019.

Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT_2A and 5-HT_2B receptors in chondrocytes

Ayaka Hori, Takashi Nishida, Shogo Takashiba, Satoshi Kubota, Masaharu Takigawa

PLoS One. 2017; 12(11): e0188014. Published online 2017 Nov 16. doi: 10.1371/journal.pone.0188014

PMCID:: PMC5690650

Abstract Article PDF–8.5M

Select item 383826420.

5-HT₂ Receptors Facilitate JC Polyomavirus Entry

Benedetta Assetta, Melissa S. Maginnis, Irene Gracia Ahufinger, Sheila A. Haley, Gretchen V. Gee, Christian D. S. Nelson, Bethany A. O'Hara, Stacy-ann A. Allen Ramdial, Walter J. Atwood

J Virol. 2013 Dec; 87(24): 13490–13498. doi: 10.1128/JVI.02252-13