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Select item 111894451.

Structural basis for hyperpolarization-dependent opening of human HCN1 channel

Verena Burtscher, Jonathan Mount, Jian Huang, John Cowgill, Yongchang Chang, Kathleen Bickel, Jianhan Chen, Peng Yuan, Baron Chanda

Nat Commun. 2024; 15: 5216. Published online 2024 Jun 18. doi: 10.1038/s41467-024-49599-x

PMCID:: PMC11189445

Abstract Article PDF–2.8M

Select item 105563622.

The Impact of Altered HCN1 Expression on Brain Function and Its Relationship with Epileptogenesis

Ke Zhao, Yinchao Li, Xiaofeng Yang, Liemin Zhou

Curr Neuropharmacol. 2023 Aug 15; 21(10): 2070–2078. Published online 2023 Aug 15. doi: 10.2174/1570159X21666230214110333

PMCID:: PMC10556362

Abstract Article PDF–4.0M

Select item 70782723.

Gating mechanism of hyperpolarization-activated HCN pacemaker channels

Rosamary Ramentol, Marta E. Perez, H. Peter Larsson

Nat Commun. 2020; 11: 1419. Published online 2020 Mar 17. doi: 10.1038/s41467-020-15233-9

PMCID:: PMC7078272

Abstract Article PDF–2.6M

Select item 69042164.

Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating

Marina A Kasimova, Debanjan Tewari, John B Cowgill, Willy Carrasquel Ursuleaz, Jenna L Lin, Lucie Delemotte, Baron Chanda

eLife. 2019; 8: e53400. Published online 2019 Nov 27. doi: 10.7554/eLife.53400

PMCID:: PMC6904216

Abstract Article PDF–5.0M

Select item 67422425.

Neuronal Hyperpolarization-Activated Pacemaker Channels Drive Neuropathic Pain

Sandra R. Chaplan, Hong-Qing Guo, Doo Hyun Lee, Lin Luo, Changlu Liu, Chester Kuei, Alexander A. Velumian, Matthew P. Butler, Sean M. Brown, Adrienne E. Dubin

J Neurosci. 2003 Feb 15; 23(4): 1169–1178. doi: 10.1523/JNEUROSCI.23-04-01169.2003

PMCID:: PMC6742242

Abstract Article PDF–580K

Select item 61021426.

Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide–gated cation channel

Christine Gross, Andrea Saponaro, Bina Santoro, Anna Moroni, Gerhard Thiel, Kay Hamacher

J Biol Chem. 2018 Aug 17; 293(33): 12908–12918. Published online 2018 Jun 23. doi: 10.1074/jbc.RA118.002139

PMCID:: PMC6102142

Abstract Article PDF–1.8M

Select item 43099077.

A di-arginine ER retention signal regulates trafficking of HCN1 channels from the early secretory pathway to the plasma membrane

Yuan Pan, Joseph G. Laird, David M. Yamaguchi, Sheila A. Baker

Cell Mol Life Sci. 2015 Feb; 72(4): 833–843. Published online 2014 Aug 21. doi: 10.1007/s00018-014-1705-1

PMCID:: PMC4309907

Abstract Article PDF–3.7M

Select item 31548048.

The magnitudes of hyperpolarization-activated and low-voltage-activated potassium currents co-vary in neurons of the ventral cochlear nucleus

Xiao-Jie Cao, Donata Oertel

J Neurophysiol. 2011 Aug; 106(2): 630–640. Published online 2011 May 11. doi: 10.1152/jn.00015.2010

PMCID:: PMC3154804

Abstract Article

Select item 54967749.

Structures of the human HCN1 hyperpolarization-activated channel

Chia-Hsueh Lee, Roderick MacKinnon

Cell. Author manuscript; available in PMC 2018 Jan 12.

Published in final edited form as: Cell. 2017 Jan 12; 168(1-2): 111–120.e11. Published online 2017 Jan 12. doi: 10.1016/j.cell.2016.12.023

PMCID:: PMC5496774

Abstract Article PDF–2.2M

Select item 514524310.

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Ye Han, Kyle A. Lyman, Matt Clutter, Gary E. Schiltz, Quratul-Ain Ismail, Xiangying Cheng, Chi-Hao Luan, Dane M. Chetkovich

J Vis Exp. 2016; (117): 54540. Published online 2016 Nov 11. doi: 10.3791/54540

PMCID:: PMC5145243

Abstract Article PDF–311K

Select item 270921011.

Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy

Bin Tang, Thomas Sander, Kimberley B. Craven, Anne Hempelmann, Andrew Escayg

Neurobiol Dis. Author manuscript; available in PMC 2009 Jul 13.

Published in final edited form as: Neurobiol Dis. 2008 Jan; 29(1): 59–70. Published online 2007 Aug 24. doi: 10.1016/j.nbd.2007.08.006

PMCID:: PMC2709210

Abstract Article PDF–1.2M

Select item 540055612.

Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer

Sung-Hsin Kuo, Shi-Yi Yang, San-Lin You, Huang-Chun Lien, Ching-Hung Lin, Po-Han Lin, Chiun-Sheng Huang

Oncotarget. 2017 Mar 28; 8(13): 20925–20938. Published online 2017 Feb 2. doi: 10.18632/oncotarget.14995

PMCID:: PMC5400556

Abstract Article PDF–2.0M

Select item 410447213.

TRIP8b-Independent Trafficking and Plasticity of Adult Cortical Presynaptic HCN1 Channels

Zhuo Huang, Rafael Lujan, Jose Martinez-Hernandez, Alan S. Lewis, Dane M. Chetkovich, Mala M. Shah

J Neurosci. 2012 Oct 17; 32(42): 14835–14848. doi: 10.1523/JNEUROSCI.1544-12.2012

PMCID:: PMC4104472

Abstract Article PDF–4.1M

Select item 310080714.

Enhanced Expression of a Specific Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel (HCN) in Surviving Dentate Gyrus Granule Cells of Human and Experimental Epileptic Hippocampus

Roland A. Bender, Sheila V. Soleymani, Amy L. Brewster, Snow T. Nguyen, Heinz Beck, Gary W. Mathern, Tallie Z. Baram

J Neurosci. 2003 Jul 30; 23(17): 6826–6836. doi: 10.1523/JNEUROSCI.23-17-06826.2003

PMCID:: PMC3100807

Abstract Article PDF–637K

Select item 809405315.

Genetic Analysis of Hyperpolarization‐Activated Cyclic Nucleotide‐Gated Cation Channels in Sudden Unexpected Death in Epilepsy Cases

Emily Tu, Louise Waterhouse, Johan Duflou, Richard D. Bagnall, Christopher Semsarian

Brain Pathol. 2011 Nov; 21(6): 692–698. Published online 2011 Aug 16. doi: 10.1111/j.1750-3639.2011.00500.x

PMCID:: PMC8094053

Abstract Article PDF–332K

Select item 328708216.

Colocalization of HCN Channel Subunits in Rat Retinal Ganglion Cells

Tyler W. Stradleigh, Genki Ogata, Gloria J. Partida, Hanako Oi, Kenneth P. Greenberg, Kalen S. Krempely, Andrew T. Ishida

J Comp Neurol. Author manuscript; available in PMC 2012 Feb 27.

Published in final edited form as: J Comp Neurol. 2011 Sep 1; 519(13): 2546–2573. doi: 10.1002/cne.22638

PMCID:: PMC3287082

Abstract Article PDF–6.6M

Select item 490187517.

Autism-Associated SHANK3 Haploinsufficiency Causes I_h-Channelopathy in Human Neurons

Fei Yi, Tamas Danko, Salome Calado Botelho, Christopher Patzke, ChangHui Pak, Marius Wernig, Thomas C. Südhof

Science. Author manuscript; available in PMC 2016 Jun 10.

Published in final edited form as: Science. 2016 May 6; 352(6286): aaf2669. Published online 2016 Mar 10. doi: 10.1126/science.aaf2669

PMCID:: PMC4901875

Abstract Article PDF–1.9M

Select item 268771518.

Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort

Christy G Woolcott, Gertraud Maskarinec, Christopher A Haiman, Martijn Verheus, Ian S Pagano, Loïc Le Marchand, Brian E Henderson, Laurence N Kolonel

Breast Cancer Res. 2009; 11(1): R10. Published online 2009 Feb 21. doi: 10.1186/bcr2229

PMCID:: PMC2687715

Abstract Article PDF–268K

Select item 853635219.

Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice

Anna Katharina Schlusche, Sabine Ulrike Vay, Niklas Kleinenkuhnen, Steffi Sandke, Rafael Campos-Martín, Marta Florio, Wieland Huttner, Achim Tresch, Jochen Roeper, Maria Adele Rueger, Igor Jakovcevski, Malte Stockebrand, Dirk Isbrandt

Proc Natl Acad Sci U S A. 2021 Aug 31; 118(35): e2009393118. Published online 2021 Aug 24. doi: 10.1073/pnas.2009393118