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Select item 113772271.

From mitochondria to tumor suppression: ACAT1's crucial role in gastric cancer

Wei He, Yanfang Li, Song-Bai Liu, Ying Chang, Shiyuan Han, Xingyu Han, Zixin Ma, Hesham M. Amin, Yao-Hua Song, Jin Zhou

Front Immunol. 2024; 15: 1449525. Published online 2024 Aug 23. doi: 10.3389/fimmu.2024.1449525

PMCID:: PMC11377227

Abstract Article PDF–8.6M

Select item 97534222.

Autophagy inhibition and reactive oxygen species elimination by acetyl-CoA acetyltransferase 1 through fused in sarcoma protein to promote prostate cancer

Jingqian Guan, Xizi Jiang, Yaoxing Guo, Wenhui Zhao, Ji Li, Yizhuo Li, Ming Cheng, Lin Fu, Yue Zhao, Qingchang Li

BMC Cancer. 2022; 22: 1313. Published online 2022 Dec 14. doi: 10.1186/s12885-022-10426-5

PMCID:: PMC9753422

Abstract Article PDF–10M

Select item 97506433.

Association between ACAT1 rs1044925 and increased hypertension risk in Tongdao Dong

Taimei Zhou, Hua Yang, Haiying Wang, Na Luo, Ying Xia, Xinglin Jiang

Medicine (Baltimore) 2022 Dec 9; 101(49): e32196. Published online 2022 Dec 9. doi: 10.1097/MD.0000000000032196

PMCID:: PMC9750643

Abstract Article PDF–841K

Select item 36758164.

Quantitative Proteomics Reveals That Enzymes of the Ketogenic Pathway Are Associated with Prostate Cancer Progression

Punit Saraon, Daniela Cretu, Natasha Musrap, George S. Karagiannis, Ihor Batruch, Andrei P. Drabovich, Theodorus van der Kwast, Atsushi Mizokami, Colm Morrissey, Keith Jarvi, Eleftherios P. Diamandis

Mol Cell Proteomics. 2013 Jun; 12(6): 1589–1601. Published online 2013 Feb 26. doi: 10.1074/mcp.M112.023887

PMCID:: PMC3675816

Abstract Article PDF–1.8M

Select item 4428755.

Identification of three mutant alleles of the gene for mitochondrial acetoacetyl-coenzyme A thiolase. A complete analysis of two generations of a family with 3-ketothiolase deficiency.

T Fukao, S Yamaguchi, T Orii, R B Schutgens, T Osumi, T Hashimoto

J Clin Invest. 1992 Feb; 89(2): 474–479. doi: 10.1172/JCI115608

PMCID:: PMC442875

Summary Page Browse PDF–1.6M

Select item 2940306.

Identification of a novel exonic mutation at -13 from 5' splice site causing exon skipping in a girl with mitochondrial acetoacetyl-coenzyme A thiolase deficiency.

T Fukao, S Yamaguchi, A Wakazono, T Orii, G Hoganson, T Hashimoto

J Clin Invest. 1994 Mar; 93(3): 1035–1041. doi: 10.1172/JCI117052

PMCID:: PMC294030

Summary Page Browse PDF–1.7M

Select item 77539917.

Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl‐CoA acetyltransferase 1

Jingqian Guan, Xizi Jiang, Junda Gai, Xiaodan Sun, Jinming Zhao, Ji Li, Yizhuo Li, Ming Cheng, Tengjiao Du, Lin Fu, Qingchang Li

J Cell Mol Med. 2020 Dec; 24(23): 14039–14049. Published online 2020 Oct 26. doi: 10.1111/jcmm.16016

PMCID:: PMC7753991

Abstract Article PDF–1.9M

Select item 75370458.

Cholesterol 25‐Hydroxylase inhibits SARS‐CoV‐2 and other coronaviruses by depleting membrane cholesterol

Shaobo Wang, Wanyu Li, Hui Hui, Shashi Kant Tiwari, Qiong Zhang, Ben A Croker, Stephen Rawlings, Davey Smith, Aaron F Carlin, Tariq M Rana

EMBO J. 2020 Nov 2; 39(21): e106057. Published online 2020 Oct 5. doi: 10.15252/embj.2020106057

PMCID:: PMC7537045

Abstract Article PDF–3.1M

Select item 62997919.

Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces β-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK

Ying Chen, Lu Zhu, Lei Ji, Ying Yang, Lu Lu, Xiaodong Wang, Guomin Zhou

Med Sci Monit. 2018; 24: 9007–9018. Published online 2018 Dec 12. doi: 10.12659/MSM.912862

PMCID:: PMC6299791

Abstract Article PDF–1.7M

Select item 596861810.

Insulin promotes progression of colon cancer by upregulation of ACAT1

Xin Chen, Huiling Liang, Qibin Song, Ximing Xu, Dedong Cao

Lipids Health Dis. 2018; 17: 122. Published online 2018 May 24. doi: 10.1186/s12944-018-0773-x

PMCID:: PMC5968618

Abstract Article PDF–873K

Select item 439518911.

Mitochondrial proteomics with siRNA knockdown to reveal ACAT1 and MDH2 in the development of doxorubicin-resistant uterine cancer

Yi-Wen Lo, Szu-Ting Lin, Shing-Jyh Chang, Chia-Hao Chan, Kevin W Lyu, Jo-Fan Chang, Eugenie Wong Soon May, Dai-Ying Lin, Hsiu-Chuan Chou, Hong-Lin Chan

J Cell Mol Med. 2015 Apr; 19(4): 744–759. Published online 2015 Jan 30. doi: 10.1111/jcmm.12388

PMCID:: PMC4395189

Abstract Article PDF–1.3M

Select item 32984812.

Molecular cloning and sequence of the complementary DNA encoding human mitochondrial acetoacetyl-coenzyme A thiolase and study of the variant enzymes in cultured fibroblasts from patients with 3-ketothiolase deficiency.

T Fukao, S Yamaguchi, M Kano, T Orii, Y Fujiki, T Osumi, T Hashimoto

J Clin Invest. 1990 Dec; 86(6): 2086–2092. doi: 10.1172/JCI114946

PMCID:: PMC329848

Summary Page Browse PDF–1.6M

Select item 324798513.

Structural Requirements for Interaction of Peroxisomal Targeting Signal 2 and Its Receptor PEX7

Markus Kunze, Georg Neuberger, Sebastian Maurer-Stroh, Jianmin Ma, Thomas Eck, Nancy Braverman, Johannes A. Schmid, Frank Eisenhaber, Johannes Berger

J Biol Chem. 2011 Dec 30; 286(52): 45048–45062. Published online 2011 Nov 5. doi: 10.1074/jbc.M111.301853

PMCID:: PMC3247985

Abstract Article PDF–4.4M

Select item 319986514.

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

Gabriele D Maurer, Daniel P Brucker, Oliver Bähr, Patrick N Harter, Elke Hattingen, Stefan Walenta, Wolfgang Mueller-Klieser, Joachim P Steinbach, Johannes Rieger

BMC Cancer. 2011; 11: 315. Published online 2011 Jul 26. doi: 10.1186/1471-2407-11-315

PMCID:: PMC3199865

Abstract Article PDF–1.4M

Select item 251700215.

The Catalytic and Lectin Domains of UDP-GalNAc:Polypeptide α-N-Acetylgalactosaminyltransferase Function in Concert to Direct Glycosylation Site Selection

Jayalakshmi Raman, Timothy A. Fritz, Thomas A. Gerken, Oliver Jamison, David Live, Mian Liu, Lawrence A. Tabak

J Biol Chem. 2008 Aug 22; 283(34): 22942–22951. doi: 10.1074/jbc.M803387200

PMCID:: PMC2517002

Abstract Article PDF–495K

Select item 736982316.

A Dipeptidyl Peptidase-4 Inhibitor Inhibits Foam Cell Formation of Macrophages in Type 1 Diabetes via Suppression of CD36 and ACAT-1 Expression

Michishige Terasaki, Hironori Yashima, Yusaku Mori, Tomomi Saito, Takanori Matsui, Munenori Hiromura, Hideki Kushima, Naoya Osaka, Makoto Ohara, Tomoyasu Fukui, Tsutomu Hirano, Sho-ichi Yamagishi

Int J Mol Sci. 2020 Jul; 21(13): 4811. Published online 2020 Jul 7. doi: 10.3390/ijms21134811

PMCID:: PMC7369823

Abstract Article PDF–991K

Select item 394393217.

Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex

Jun Fan, Changliang Shan, Hee-Bum Kang, Shannon Elf, Jianxin Xie, Meghan Tucker, Ting-Lei Gu, Mike Aguiar, Scott Lonning, Huaibin Chen, Moosa Mohammadi, Laura-Mae P. Britton, Benjamin A. Garcia, Masa Aleckovic, Yibin Kang, Stefan Kaluz, Narra Devi, Erwin Van Meir, Taro Hitosugi, Jae Ho Seo, Sagar Lonial, Manila Gaddh, Martha Arellano, Hanna J. Khoury, Fadlo R. Khuri, Titus J. Boggon, Sumin Kang, Jing Chen

Mol Cell. Author manuscript; available in PMC 2015 Feb 20.

Published in final edited form as: Mol Cell. 2014 Feb 20; 53(4): 534–548. Published online 2014 Jan 30. doi: 10.1016/j.molcel.2013.12.026

PMCID:: PMC3943932

Abstract Article PDF–5.8M

Select item 618004118.

Post-translational modification of OCT4 in breast cancer tumorigenesis

Yunhee Cho, Hyeok Gu Kang, Seok-Jun Kim, Seul Lee, Sujin Jee, Sung Gwe Ahn, Min Jueng Kang, Joon Seon Song, Joon-Yong Chung, Eugene C. Yi, Kyung-Hee Chun

Cell Death Differ. 2018 Oct; 25(10): 1781–1795. Published online 2018 Mar 6. doi: 10.1038/s41418-018-0079-6

Correction in:: Cell Death Differ. 2020 May; 27(5): 1743.

PMCID:: PMC6180041

Abstract Article PDF–4.1M

Select item 998490119.

P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma

Cheng Cheng, Tian He, Kai Chen, Yuanxia Cai, Yaoyao Gu, Lijia Pan, Peiwen Duan, Yeming Wu, Zhixiang Wu

Mol Cell Proteomics. 2023 Mar; 22(3): 100504. Published online 2023 Jan 26. doi: 10.1016/j.mcpro.2023.100504

PMCID:: PMC9984901

Abstract Article PDF–4.3M

Select item 113406420.

Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes

Nabila Aboulaich, Julia P. Vainonen, Peter Strålfors, Alexander V. Vener

Biochem J. 2004 Oct 15; 383(Pt 2): 237–248. Prepublished online 2004 Jul 9. Published online 2004 Oct 8. doi: 10.1042/BJ20040647

PMCID:: PMC1134064

Abstract Article PDF–712K

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