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Select item 110645101.

Identification of KRAS mutation-associated gut microbiota in colorectal cancer and construction of predictive machine learning model

Zigui Huang, Xiaoliang Huang, Yili Huang, Kunmei Liang, Lei Chen, Chuzhuo Zhong, Yingxin Chen, Chuanbin Chen, Zhen Wang, Fuhai He, Mingjian Qin, Chenyan Long, Binzhe Tang, Yongqi Huang, Yongzhi Wu, Xianwei Mo, Tang Weizhong, Jungang Liu

Microbiol Spectr. 2024 May; 12(5): e02720-23. Published online 2024 Apr 4. doi: 10.1128/spectrum.02720-23

PMCID:: PMC11064510

Abstract Article PDF–4.0M

Select item 110064492.

Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRAS^G12D-mutated non-small-cell lung cancer

B. Ricciuti, J. V. Alessi, A. Elkrief, X. Wang, A. Cortellini, Y. Y. Li, V. R. Vaz, H. Gupta, F. Pecci, A. Barrichello, G. Lamberti, T. Nguyen, J. Lindsay, B. Sharma, K. Felt, S. J. Rodig, M. Nishino, L. M. Sholl, D. A. Barbie, M. V. Negrao, J. Zhang, A. D. Cherniack, J. V. Heymach, M. Meyerson, C. Ambrogio, P. A. Jänne, K. C. Arbour, D. J. Pinato, F. Skoulidis, A. J. Schoenfeld, M. M. Awad, J. Luo

Ann Oncol. Author manuscript; available in PMC 2024 Apr 10.

Published in final edited form as: Ann Oncol. 2022 Oct; 33(10): 1029–1040. Published online 2022 Jul 22. doi: 10.1016/j.annonc.2022.07.005

PMCID:: PMC11006449

Abstract Article PDF–1.4M

Select item 109922163.

Expansion of KRAS hotspot mutations reactive T cells from human pancreatic tumors using autologous T cells as the antigen-presenting cells

Sizhen Wang, Xiaohui Zhang, Xuemei Zou, Maorong Wen, Chi Gan, Xiaochun Jiang, Min Li, Rongxi Shen, Daojun Zhu, Anlong Yao, Yu Fang, Bernard A. Fox, Hong-Ming Hu, Guangjie Yu, Xinbo Wang

Cancer Immunol Immunother. 2023 May; 72(5): 1301–1313. Published online 2022 Nov 27. doi: 10.1007/s00262-022-03335-w

PMCID:: PMC10992216

Abstract Article PDF–4.8M

Select item 109317144.

Membrane-Driven Dimerization of the Peripheral Membrane Protein KRAS: Implications for Downstream Signaling

Ki-Young Lee

Int J Mol Sci. 2024 Mar; 25(5): 2530. Published online 2024 Feb 21. doi: 10.3390/ijms25052530

PMCID:: PMC10931714

Abstract Article PDF–7.2M

Select item 108667065.

The energetic and allosteric landscape for KRAS inhibition

Chenchun Weng, Andre J. Faure, Albert Escobedo, Ben Lehner

Nature. 2024; 626(7999): 643–652. Published online 2023 Dec 18. doi: 10.1038/s41586-023-06954-0

PMCID:: PMC10866706

Abstract Article PDF–9.5M

Select item 108416056.

Effects of KRAS genetic interactions on outcomes in cancers of the lung, pancreas, and colorectum

Isabella N. Grabski, John V. Heymach, Kenneth L. Kehl, Scott Kopetz, Ken S. Lau, Gregory J. Riely, Deborah Schrag, Rona Yaeger, Rafael A. Irizarry, Kevin M. Haigis

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2024 Jul 9.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2024 Jan 9; 33(1): 158–169. doi: 10.1158/1055-9965.EPI-23-0262

PMCID:: PMC10841605

Abstract Article PDF–815K

Select item 107545807.

KRAS modulates immune infiltration levels and survival outcomes in patients with lung adenocarcinoma

Na Li, Yue Tian, Xin Liu, Ciming Pan, Jian Xue

Medicine (Baltimore) 2023 Dec 29; 102(52): e36597. Published online 2023 Dec 29. doi: 10.1097/MD.0000000000036597

PMCID:: PMC10754580

Abstract Article PDF–796K

Select item 107073318.

The Role of KRAS Mutation in Colorectal Cancer-Associated Thrombosis

Radu Andrei Emilescu, Mariana Jinga, Horia Teodor Cotan, Ana Maria Popa, Cristina Maria Orlov-Slavu, Mihaela Cristina Olaru, Cristian Ion Iaciu, Andreea Ioana Parosanu, Mihaela Moscalu, Cornelia Nitipir

Int J Mol Sci. 2023 Dec; 24(23): 16930. Published online 2023 Nov 29. doi: 10.3390/ijms242316930

PMCID:: PMC10707331

Abstract Article PDF–1.1M

Select item 106904789.

KRAS Sequence Variation as Prognostic Marker in Patients With Young- vs Late-Onset Colorectal Cancer

Mayada A. Aljehani, Jeffrey Bien, Jerry S. H. Lee, George A. Fisher, Jr, Albert Y. Lin

JAMA Netw Open. 2023 Nov; 6(11): e2345801. Published online 2023 Nov 30. doi: 10.1001/jamanetworkopen.2023.45801

PMCID:: PMC10690478

Abstract Article

Select item 1066863410.

Activation of Kras^G12D in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma

Priyanka Chaudhary, Xia Xu, Guangfang Wang, Jacob P. Hoj, Rishi R. Rampersad, Marie-Liesse Asselin-Labat, Stephanie Ting, William Kim, Pablo Tamayo, Ann Marie Pendergast, Mark W. Onaitis

Cancer Res Commun. 2023 Nov; 3(11): 2400–2411. Published online 2023 Nov 24. doi: 10.1158/2767-9764.CRC-22-0408

PMCID:: PMC10668634

Abstract Article PDF–34M

Select item 1057559211.

Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer

Atish Mohanty, Arin Nam, Saumya Srivastava, Jeff Jones, Brett Lomenick, Sharad S. Singhal, Linlin Guo, Hyejin Cho, Aimin Li, Amita Behal, Tamara Mirzapoiazova, Erminia Massarelli, Marianna Koczywas, Leonidas D. Arvanitis, Tonya Walser, Victoria Villaflor, Stanley Hamilton, Isa Mambetsariev, Martin Sattler, Mohd W. Nasser, Maneesh Jain, Surinder K. Batra, Raffaella Soldi, Sunil Sharma, Marwan Fakih, Saswat Kumar Mohanty, Avijit Mainan, Xiwei Wu, Yihong Chen, Yanan He, Tsui-Fen Chou, Susmita Roy, John Orban, Prakash Kulkarni, Ravi Salgia

Sci Adv. 2023 Oct 13; 9(41): eade3816. Published online 2023 Oct 13. doi: 10.1126/sciadv.ade3816

PMCID:: PMC10575592

Abstract Article PDF–2.8M

Select item 1056330312.

A real-world analysis of trametinib in combination with hydroxychloroquine or CDK4/6 inhibitor as third- or later-line therapy in metastatic pancreatic adenocarcinoma

Hui Tang, Yuping Ge, Tingting You, Xiaoyuan Li, Yingyi Wang, Yuejuan Cheng, Chunmei Bai

BMC Cancer. 2023; 23: 958. Published online 2023 Oct 10. doi: 10.1186/s12885-023-11464-3

PMCID:: PMC10563303

Abstract Article PDF–1.2M

Select item 1054681213.

The Frequency of Specific KRAS Mutations, and Their Impact on Treatment Choice and Survival, in Patients With Metastatic Colorectal Cancer

Ana Fernández Montes, Vicente Alonso Orduña, Elena Asensio Martínez, Nuria Rodríguez Salas, Esperanza Torres, Diego Cacho Lavín, Rosa María Rodríguez Alonso, Esther Falcó, Joan Carles Oliva, Lluis Cirera, Jesus García Gómez, Carles Pericay

Oncologist. 2023 Oct; 28(10): e902–e909. Published online 2023 May 4. doi: 10.1093/oncolo/oyad117

PMCID:: PMC10546812

Abstract Article PDF–1.7M

Select item 1050245414.

Mutant KRAS Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma

Yao Kong, Yuming Luo, Shangyou Zheng, Jiabin Yang, Dingwen Zhang, Yue Zhao, Hanhao Zheng, Mingjie An, Yan Lin, Le Ai, Xiayao Diao, Qing Lin, Changhao Chen, Rufu Chen

Cancer Res. 2023 Sep 15; 83(18): 3077–3094. Published online 2023 Jun 26. doi: 10.1158/0008-5472.CAN-22-3997

PMCID:: PMC10502454

Abstract Article PDF–52M

Select item 1049476715.

Different oncological features of colorectal cancer codon-specific KRAS mutations: Not codon 13 but codon 12 have prognostic value

Hong-Min Ahn, Duck-Woo Kim, Hyeon Jeong Oh, Hyung Kyung Kim, Hye Seung Lee, Tae Gyun Lee, Hye-Rim Shin, In Jun Yang, Jeehye Lee, Jung Wook Suh, Heung-Kwon Oh, Sung-Bum Kang

World J Gastroenterol. 2023 Aug 28; 29(32): 4883–4899. Published online 2023 Aug 28. doi: 10.3748/wjg.v29.i32.4883

PMCID:: PMC10494767

Abstract Article PDF–1.6M

Select item 1044126816.

Molecular Tumor Board Case Series: Targeting KRAS G12C in Lung Cancer

Beth Gustafson, Lindsey Douglass, Timothy Pluard, Janakiraman Subramanian

Mo Med. 2023 Jul-Aug; 120(4): 314–317.

PMCID:: PMC10441268

Abstract Article PDF–289K

Select item 1042303617.

Oncogenic Kras reverts differentiated cells back into alveolar stem cells that generate lepidic adenocarcinoma

Nicholas H. Juul, Jung-Ki Yoon, Marina C. Martinez, Neha Rishi, Yana I. Kazadaeva, Maurizio Morri, Norma F. Neff, Winston L. Trope, Joseph B. Shrager, Rahul Sinha, Tushar J. Desai

Nature. Author manuscript; available in PMC 2023 Aug 12.

Published in final edited form as: Nature. 2023 Jul; 619(7971): 860–867. Published online 2023 Jul 19. doi: 10.1038/s41586-023-06324-w

PMCID:: PMC10423036

Abstract Article PDF–3.4M

Select item 1041711518.

Association of the rs8720 and rs12587 KRAS Gene Variants with Colorectal Cancer in a Mexican Population and Their Analysis In Silico

Martha Patricia Gallegos-Arreola, Asbiel Felipe Garibaldi-Ríos, José Israel Cruz-Sánchez, Luis Eduardo Figuera, Carlos Alberto Ronquillo-Carreón, Mónica Alejandra Rosales-Reynoso, Belinda Claudia Gómez-Meda, Irving Alejandro Carrillo-Dávila, Ana María Puebla-Pérez, Héctor Montoya-Fuentes, Valeria Peralta-Leal, Guillermo M. Zúñiga-González

Cells. 2023 Aug; 12(15): 1941. Published online 2023 Jul 26. doi: 10.3390/cells12151941

PMCID:: PMC10417115

Abstract Article PDF–2.5M

Select item 1031582819.

Correlation between KRAS mutation subtypes and prognosis in Chinese advanced non‐squamous non‐small cell lung cancer patients

Feiwen Liu, Fang Wang, Jianbo He, Shaozhang Zhou, Min Luo

Cancer Med. 2023 Jun; 12(12): 13123–13134. Published online 2023 May 4. doi: 10.1002/cam4.5995

PMCID:: PMC10315828

Abstract Article PDF–1.7M

Select item 1031476220.

K-Ras4A Plays a More Significant Role than K-Ras4B in Ductal Carcinoma of Breast

Mohamad Mahdi Mortazavipour, Zeinab Mohamadalizadeh-Hanjani, Loabat Geranpayeh, Reza Mahdian, Shirin Shahbazi

Iran Biomed J. 2023 Mar-May; 27(2-3): 126–135. Published online 2023 Jan 1. doi: 10.52547/ibj.3857

PMCID:: PMC10314762

Abstract Article PDF–1.2M

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