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Select item 97505171.

Overexpression of fatty acid desaturase 3 predicts poor prognosis in head and neck squamous cell carcinoma

Kuiwei Su, Ying Wang, Hefeng Gu, Lan Ma, Guihong Xuan

Medicine (Baltimore) 2022 Dec 9; 101(49): e32119. Published online 2022 Dec 9. doi: 10.1097/MD.0000000000032119

PMCID:: PMC9750517

Abstract Article PDF–2.2M

Select item 68606032.

Genetic variation in polyunsaturated fatty acid metabolism and its potential relevance for human development and health

Claudia Glaser, Eva Lattka, Peter Rzehak, Colin Steer, Berthold Koletzko

Matern Child Nutr. 2011 Apr; 7(Suppl 2): 27–40. Published online 2011 Mar 2. doi: 10.1111/j.1740-8709.2011.00319.x

PMCID:: PMC6860603

Abstract Article PDF–454K

Select item 33863573.

Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts

Holly T. Reardon, Andrea T. Hsieh, Woo Jung Park, Kumar S.D. Kothapalli, Joshua C. Anthony, Peter W. Nathanielsz, J. Thomas Brenna

Prostaglandins Leukot Essent Fatty Acids. Author manuscript; available in PMC 2014 Jan 1.

Published in final edited form as: Prostaglandins Leukot Essent Fatty Acids. 2013 Jan; 88(1): 15–19. Published online 2012 Mar 6. doi: 10.1016/j.plefa.2012.02.003

PMCID:: PMC3386357

Abstract Article PDF–1.9M

Select item 70291044.

FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome

Gergely Karsai, Museer Lone, Zoltán Kutalik, J. Thomas Brenna, Hongde Li, Duojia Pan, Arnold von Eckardstein, Thorsten Hornemann

J Biol Chem. 2020 Feb 14; 295(7): 1889–1897. Published online 2019 Dec 20. doi: 10.1074/jbc.AC119.011883

PMCID:: PMC7029104

Abstract Article PDF–1.8M

Select item 36003995.

Umbilical cord PUFA are determined by maternal and child fatty acid desaturase (FADS) genetic variants in the Avon Longitudinal Study of Parents and Children (ALSPAC)

Eva Lattka, Berthold Koletzko, Sonja Zeilinger, Joseph R. Hibbeln, Norman Klopp, Susan M. Ring, Colin D. Steer

Br J Nutr. Author manuscript; available in PMC 2013 Apr 10.

Published in final edited form as: Br J Nutr. 2013 Apr; 109(7): 1196–1210. Published online 2012 Aug 9. doi: 10.1017/S0007114512003108

PMCID:: PMC3600399

Abstract Article PDF–429K

Select item 28175776.

The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues

Frédérique Pédrono, Hélène Blanchard, Maela Kloareg, Sabine D'andréa, Stéphanie Daval, Vincent Rioux, Philippe Legrand

J Lipid Res. 2010 Mar; 51(3): 472–479. doi: 10.1194/jlr.M000588

PMCID:: PMC2817577

Abstract Article PDF–1.1M

Select item 27305657.

A Systems Genetics Approach Implicates USF1, FADS3, and Other Causal Candidate Genes for Familial Combined Hyperlipidemia

Christopher L. Plaisier, Steve Horvath, Adriana Huertas-Vazquez, Ivette Cruz-Bautista, Miguel F. Herrera, Teresa Tusie-Luna, Carlos Aguilar-Salinas, Päivi Pajukanta

PLoS Genet. 2009 Sep; 5(9): e1000642. Published online 2009 Sep 11. doi: 10.1371/journal.pgen.1000642

PMCID:: PMC2730565

Abstract Article PDF–588K

Select item 29184598.

FADS genetic variants and ω-6 polyunsaturated fatty acid metabolism in a homogeneous island population

Rasika A. Mathias, Candelaria Vergara, Li Gao, Nicholas Rafaels, Tracey Hand, Monica Campbell, Carol Bickel, Priscilla Ivester, Susan Sergeant, Kathleen C. Barnes, Floyd H. Chilton

J Lipid Res. 2010 Sep; 51(9): 2766–2774. doi: 10.1194/jlr.M008359

PMCID:: PMC2918459

Abstract Article PDF–1.1M

Select item 27455629.

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations

Andrew A. Hicks, Peter P. Pramstaller, Åsa Johansson, Veronique Vitart, Igor Rudan, Peter Ugocsai, Yurii Aulchenko, Christopher S. Franklin, Gerhard Liebisch, Jeanette Erdmann, Inger Jonasson, Irina V. Zorkoltseva, Cristian Pattaro, Caroline Hayward, Aaron Isaacs, Christian Hengstenberg, Susan Campbell, Carsten Gnewuch, A. CecileJ.W. Janssens, Anatoly V. Kirichenko, Inke R. König, Fabio Marroni, Ozren Polasek, Ayse Demirkan, Ivana Kolcic, Christine Schwienbacher, Wilmar Igl, Zrinka Biloglav, Jacqueline C. M. Witteman, Irene Pichler, Ghazal Zaboli, Tatiana I. Axenovich, Annette Peters, Stefan Schreiber, H.-Erich Wichmann, Heribert Schunkert, Nick Hastie, Ben A. Oostra, Sarah H. Wild, Thomas Meitinger, Ulf Gyllensten, Cornelia M. van Duijn, James F. Wilson, Alan Wright, Gerd Schmitz, Harry Campbell

PLoS Genet. 2009 Oct; 5(10): e1000672. Published online 2009 Oct 2. doi: 10.1371/journal.pgen.1000672

PMCID:: PMC2745562

Abstract Article PDF–604K

Select item 261303310.

Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study

Toshiko Tanaka, Jian Shen, Gonçalo R. Abecasis, Aliaksei Kisialiou, Jose M. Ordovas, Jack M. Guralnik, Andrew Singleton, Stefania Bandinelli, Antonio Cherubini, Donna Arnett, Michael Y. Tsai, Luigi Ferrucci

PLoS Genet. 2009 Jan; 5(1): e1000338. Published online 2009 Jan 16. doi: 10.1371/journal.pgen.1000338

PMCID:: PMC2613033

Abstract Article PDF–404K

Select item 366165511.

Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes

Weijia Xie, Andrew R. Wood, Valeriya Lyssenko, Michael N. Weedon, Joshua W. Knowles, Sami Alkayyali, Themistocles L. Assimes, Thomas Quertermous, Fahim Abbasi, Jussi Paananen, Hans Häring, Torben Hansen, Oluf Pedersen, Ulf Smith, Markku Laakso, the MAGIC Investigators, the DIAGRAM Consortium, the GENESIS Consortium, the RISC Consortium, Jacqueline M. Dekker, John J. Nolan, Leif Groop, Ele Ferrannini, Klaus-Peter Adam, Walter E. Gall, Timothy M. Frayling, Mark Walker

Diabetes. 2013 Jun; 62(6): 2141–2150. Published online 2013 May 17. doi: 10.2337/db12-0876

PMCID:: PMC3661655

Abstract Article PDF–575K

Select item 314561412.

Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium

Rozenn N. Lemaitre, Toshiko Tanaka, Weihong Tang, Ani Manichaikul, Millennia Foy, Edmond K. Kabagambe, Jennifer A. Nettleton, Irena B. King, Lu-Chen Weng, Sayanti Bhattacharya, Stefania Bandinelli, Joshua C. Bis, Stephen S. Rich, David R. Jacobs, Jr., Antonio Cherubini, Barbara McKnight, Shuang Liang, Xiangjun Gu, Kenneth Rice, Cathy C. Laurie, Thomas Lumley, Brian L. Browning, Bruce M. Psaty, Yii-Der I. Chen, Yechiel Friedlander, Luc Djousse, Jason H. Y. Wu, David S. Siscovick, André G. Uitterlinden, Donna K. Arnett, Luigi Ferrucci, Myriam Fornage, Michael Y. Tsai, Dariush Mozaffarian, Lyn M. Steffen

PLoS Genet. 2011 Jul; 7(7): e1002193. Published online 2011 Jul 28. doi: 10.1371/journal.pgen.1002193

PMCID:: PMC3145614

Abstract Article PDF–998K

Select item 268707413.

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

Yurii S Aulchenko, Samuli Ripatti, Ida Lindqvist, Dorret Boomsma, Iris M Heid, Peter P Pramstaller, Brenda W J H Penninx, A Cecile J W Janssens, James F Wilson, Tim Spector, Nicholas G Martin, Nancy L Pedersen, Kirsten Ohm Kyvik, Jaakko Kaprio, Albert Hofman, Nelson B Freimer, Marjo-Riitta Jarvelin, Ulf Gyllensten, Harry Campbell, Igor Rudan, Åsa Johansson, Fabio Marroni, Caroline Hayward, Veronique Vitart, Inger Jonasson, Cristian Pattaro, Alan Wright, Nick Hastie, Irene Pichler, Andrew A Hicks, Mario Falchi, Gonneke Willemsen, Jouke-Jan Hottenga, Eco J C de Geus, Grant W Montgomery, John Whitfield, Patrik Magnusson, Juha Saharinen, Markus Perola, Kaisa Silander, Aaron Isaacs, Eric J G Sijbrands, Andre G Uitterlinden, Jacqueline C M Witteman, Ben A Oostra, Paul Elliott, Aimo Ruokonen, Chiara Sabatti, Christian Gieger, Thomas Meitinger, Florian Kronenberg, Angela Döring, H-Erich Wichmann, Johannes H Smit, Mark I McCarthy, Cornelia M van Duijn, Leena Peltonen, for the ENGAGE Consortium

Nat Genet. Author manuscript; available in PMC 2009 Jul 1.

Published in final edited form as: Nat Genet. 2009 Jan; 41(1): 47–55. Published online 2008 Dec 7. doi: 10.1038/ng.269

PMCID:: PMC2687074

Abstract Article PDF–596K

Select item 360503314.

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

Johannes Kettunen, Taru Tukiainen, Antti-Pekka Sarin, Alfredo Ortega-Alonso, Emmi Tikkanen, Leo-Pekka Lyytikäinen, Antti J Kangas, Pasi Soininen, Peter Würtz, Kaisa Silander, Danielle M Dick, Richard J Rose, Markku J Savolainen, Jorma Viikari, Mika Kähönen, Terho Lehtimäki, Kirsi H Pietiläinen, Michael Inouye, Mark I McCarthy, Antti Jula, Johan Eriksson, Olli T Raitakari, Veikko Salomaa, Jaakko Kaprio, Marjo-Riitta Järvelin, Leena Peltonen, Markus Perola, Nelson B Freimer, Mika Ala-Korpela, Aarno Palotie, Samuli Ripatti

Nat Genet. Author manuscript; available in PMC 2013 Mar 21.

Published in final edited form as: Nat Genet. 2012 Jan 29; 44(3): 269–276. Published online 2012 Jan 29. doi: 10.1038/ng.1073

PMCID:: PMC3605033

Abstract Article PDF–1.8M

Select item 328096815.

Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations

Ayşe Demirkan, Cornelia M. van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P. Pramstaller, Gerhard Liebisch, James F. Wilson, Åsa Johansson, Igor Rudan, Yurii S. Aulchenko, Anatoly V. Kirichenko, A. Cecile J. W. Janssens, Ritsert C. Jansen, Carsten Gnewuch, Francisco S. Domingues, Cristian Pattaro, Sarah H. Wild, Inger Jonasson, Ozren Polasek, Irina V. Zorkoltseva, Albert Hofman, Lennart C. Karssen, Maksim Struchalin, James Floyd, Wilmar Igl, Zrinka Biloglav, Linda Broer, Arne Pfeufer, Irene Pichler, Susan Campbell, Ghazal Zaboli, Ivana Kolcic, Fernando Rivadeneira, Jennifer Huffman, Nicholas D. Hastie, Andre Uitterlinden, Lude Franke, Christopher S. Franklin, Veronique Vitart, DIAGRAM Consortium, Christopher P. Nelson, Michael Preuss, CARDIoGRAM Consortium, Joshua C. Bis, Christopher J. O'Donnell, Nora Franceschini, CHARGE Consortium, Jacqueline C. M. Witteman, Tatiana Axenovich, Ben A. Oostra, Thomas Meitinger, Andrew A. Hicks, Caroline Hayward, Alan F. Wright, Ulf Gyllensten, Harry Campbell, Gerd Schmitz, on behalf of the EUROSPAN consortium

PLoS Genet. 2012 Feb; 8(2): e1002490. Published online 2012 Feb 16. doi: 10.1371/journal.pgen.1002490

PMCID:: PMC3280968

Abstract Article PDF–592K

Select item 412386216.

Genome-Wide Association Study of Plasma N6 Polyunsaturated Fatty Acids within the CHARGE Consortium

Weihua Guan, Brian T. Steffen, Rozenn N. Lemaitre, Jason H.Y. Wu, Toshiko Tanaka, Ani Manichaikul, Millennia Foy, Stephen S. Rich, Lu Wang, Jennifer A. Nettleton, Weihong Tang, Xiangjun Gu, Stafania Bandinelli, Irena B. King, Barbara McKnight, Bruce M. Psaty, David Siscovick, Luc Djousse, Yii-Der Ida Chen, Luigi Ferrucci, Myriam Fornage, Dariush Mozafarrian, Michael Y. Tsai, Lyn M. Steffen

Circ Cardiovasc Genet. Author manuscript; available in PMC 2015 Jun 1.

Published in final edited form as: Circ Cardiovasc Genet. 2014 Jun; 7(3): 321–331. Published online 2014 May 13. doi: 10.1161/CIRCGENETICS.113.000208

PMCID:: PMC4123862

Abstract Article PDF–430K

Select item 288167617.

Common variants at 30 loci contribute to polygenic dyslipidemia

Sekar Kathiresan, Cristen J Willer, Gina Peloso, Serkalem Demissie, Kiran Musunuru, Eric Schadt, Kaplan Lee, Derrick Bennett, Yun Li, Toshiko Tanaka, Benjamin F Voight, Lori L Bonnycastle, Anne U Jackson, Gabriel Crawford, Aarti Surti, Candace Guiducci, Noel Burtt, Sarah Parish, Robert Clarke, Diana Zelenika, Kari A Kubalanza, Mario A Morken, Laura J Scott, Heather M Stringham, Pilar Galan, Amy J Swift, Johanna Kuusisto, Richard N Bergman, Jouko Sundvall, Markku Laakso, Luigi Ferrucci, Paul Scheet, Serena Sanna, Manuela Uda, Qiong Yang, Kathryn Lunetta, Josee Dupuis, Paul I deBakker, Christopher J O’Donnell, John C Chambers, Jaspal S Kooner, Serge Hercberg, Pierre Meneton, Edward G Lakatta, Angelo Scuteri, David Schlessinger, Jaakko Tuomilehto, Francis S Collins, Leif Groop, David Altshuler, Rory Collins, G Mark Lathrop, Olle Melander, Veikko Salomaa, Leena Peltonen, Marju Orho-Melander, Jose M Ordovas, Michael Boehnke, Gonçalo R Abecasis, Karen L Mohlke, L Adrienne Cupples

Nat Genet. Author manuscript; available in PMC 2010 Jun 7.

Published in final edited form as: Nat Genet. 2009 Jan; 41(1): 56–65. Published online 2008 Dec 7. doi: 10.1038/ng.291

PMCID:: PMC2881676

Abstract Article PDF–1.4M

Select item 389105418.

Genome-Wide Association Study Identifies Novel Loci Associated With Concentrations of Four Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway: Results from the CHARGE Consortium

Jason H.Y. Wu, Rozenn N. Lemaitre, Ani Manichaikul, Weihua Guan, Toshiko Tanaka, Millennia Foy, Edmond K. Kabagambe, Luc Djousse, David Siscovick, Amanda M. Fretts, Catherine Johnson, Irena B. King, Bruce M. Psaty, Barbara McKnight, Stephen S. Rich, Yii-Der I. Chen, Jennifer A. Nettleton, Weihong Tang, Stefania Bandinelli, David R. Jacobs, Jr, Brian L. Browning, Cathy C. Laurie, Xiangjun Gu, Michael Y. Tsai, Lyn M. Steffen, Luigi Ferrucci, Myriam Fornage, Dariush Mozaffarian

Circ Cardiovasc Genet. Author manuscript; available in PMC 2014 Apr 1.

Published in final edited form as: Circ Cardiovasc Genet. 2013 Apr; 6(2): 171–183. Published online 2013 Jan 29. doi: 10.1161/CIRCGENETICS.112.964619

PMCID:: PMC3891054

Abstract Article PDF–1.9M

Select item 342092119.

Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis

Michael Inouye, Samuli Ripatti, Johannes Kettunen, Leo-Pekka Lyytikäinen, Niku Oksala, Pirkka-Pekka Laurila, Antti J. Kangas, Pasi Soininen, Markku J. Savolainen, Jorma Viikari, Mika Kähönen, Markus Perola, Veikko Salomaa, Olli Raitakari, Terho Lehtimäki, Marja-Riitta Taskinen, Marjo-Riitta Järvelin, Mika Ala-Korpela, Aarno Palotie, Paul I. W. de Bakker

PLoS Genet. 2012 Aug; 8(8): e1002907. Published online 2012 Aug 16. doi: 10.1371/journal.pgen.1002907

PMCID:: PMC3420921

Abstract Article PDF–919K

Select item 284229820.

Genome-Wide Association of Lipid-Lowering Response to Statins in Combined Study Populations

Mathew J. Barber, Lara M. Mangravite, Craig L. Hyde, Daniel I. Chasman, Joshua D. Smith, Catherine A. McCarty, Xiaohui Li, Russell A. Wilke, Mark J. Rieder, Paul T. Williams, Paul M. Ridker, Aurobindo Chatterjee, Jerome I. Rotter, Deborah A. Nickerson, Matthew Stephens, Ronald M. Krauss

PLoS One. 2010; 5(3): e9763. Published online 2010 Mar 22. doi: 10.1371/journal.pone.0009763

PMCID:: PMC2842298

Abstract Article PDF–162K

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