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Select item 102788191.

Lrpap1 (RAP) Inhibits Proximal Tubule Clathrin Mediated and Clathrin Independent Endocytosis, Ameliorating Renal Aminoglycoside Nephrotoxicity

Mark C. Wagner, Ruben M. Sandoval, Shiv Pratap S. Yadav, Silvia B. Campos, George J. Rhodes, Carrie L. Phillips, Bruce A. Molitoris

Kidney360. 2023 May; 4(5): 591–605. Published online 2023 Feb 27. doi: 10.34067/KID.0000000000000094

PMCID:: PMC10278819

Abstract Article PDF–1.6M

Select item 37209072.

Receptor-Associated Protein Blocks Internalization and Cytotoxicity of Myeloma Light Chain in Cultured Human Proximal Tubular Cells

Sule Sengul, Sehsuvar Erturk, Altaf M. Khan, Vecihi Batuman

PLoS One. 2013; 8(7): e70276. Published online 2013 Jul 23. doi: 10.1371/journal.pone.0070276

PMCID:: PMC3720907

Abstract Article PDF–907K

Select item 238543.

The solution structure of the N-terminal domain of α₂-macroglobulin receptor-associated protein

Peter R. Nielsen, Lars Ellgaard, Michael Etzerodt, Hans C. Thøgersen, Flemming M. Poulsen

Proc Natl Acad Sci U S A. 1997 Jul 8; 94(14): 7521–7525. doi: 10.1073/pnas.94.14.7521

PMCID:: PMC23854

Abstract Article PDF–1.6M

Select item 106874674.

LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation

Kyle M. Reid, Guy C. Brown

Front Immunol. 2023; 14: 1286474. Published online 2023 Nov 16. doi: 10.3389/fimmu.2023.1286474

PMCID:: PMC10687467

Abstract Article PDF–3.0M

Select item 82394625.

Molecular chaperone RAP interacts with LRP1 in a dynamic bivalent mode and enhances folding of ligand-binding regions of other LDLR family receptors

Ekaterina Marakasova, Philip Olivares, Elena Karnaukhova, Haarin Chun, Nancy E. Hernandez, James H. Kurasawa, Gabriela U. Hassink, Svetlana A. Shestopal, Dudley K. Strickland, Andrey G. Sarafanov

J Biol Chem. 2021 Jul; 297(1): 100842. Published online 2021 May 29. doi: 10.1016/j.jbc.2021.100842

PMCID:: PMC8239462

Abstract Article PDF–2.8M

Select item 50000886.

High Affinity Binding of the Receptor-associated Protein D1D2 Domains with the Low Density Lipoprotein Receptor-related Protein (LRP1) Involves Bivalent Complex Formation: CRITICAL ROLES OF LYSINES 60 AND 191

Joni M. Prasad, Patricia A. Young, Dudley K. Strickland

J Biol Chem. 2016 Aug 26; 291(35): 18430–18439. Published online 2016 Jul 11. doi: 10.1074/jbc.M116.744904

PMCID:: PMC5000088

Abstract Article PDF–1.3M

Select item 37388317.

Mutations in LRPAP1 Are Associated with Severe Myopia in Humans

Mohammed A. Aldahmesh, Arif O. Khan, Hisham Alkuraya, Nouran Adly, Shamsa Anazi, Ahmed A. Al-Saleh, Jawahir Y. Mohamed, Hadia Hijazi, Sarita Prabakaran, Marlene Tacke, Abdullah Al-Khrashi, Mais Hashem, Thomas Reinheckel, Abdullah Assiri, Fowzan S. Alkuraya

Am J Hum Genet. 2013 Aug 8; 93(2): 313–320. doi: 10.1016/j.ajhg.2013.06.002

PMCID:: PMC3738831

Abstract Article PDF–1.6M

Select item 21111218.

Lipoprotein Receptor-Related Protein-1 Mediates Amyloid-β-Mediated Cell Death of Cerebrovascular Cells

Micha M.M. Wilhelmus, Irene Otte-Höller, Jos J.J. van Triel, Robert Veerhuis, Marion L.C. Maat-Schieman, Guojun Bu, Robert M.W. de Waal, Marcel M. Verbeek

Am J Pathol. 2007 Dec; 171(6): 1989–1999. doi: 10.2353/ajpath.2007.070050

PMCID:: PMC2111121

Abstract Article PDF–3.0M

Select item 3983349.

39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein.

G Bu, H J Geuze, G J Strous, A L Schwartz

EMBO J. 1995 May 15; 14(10): 2269–2280. doi: 10.1002/j.1460-2075.1995.tb07221.x

PMCID:: PMC398334

Summary Page Browse PDF–3.3M

Select item 4353510.

Functional domains of the receptor-associated protein (RAP).

R A Orlando, M G Farquhar

Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8): 3161–3165. doi: 10.1073/pnas.91.8.3161

PMCID:: PMC43535

Summary Page Browse PDF–1.3M

Select item 415661711.

Epac, Rap and Rab3 act in concert to mobilize calcium from sperm’s acrosome during exocytosis

María C Ruete, Ornella Lucchesi, Matías A Bustos, Claudia N Tomes

Cell Commun Signal. 2014; 12: 43. Published online 2014 Aug 27. doi: 10.1186/s12964-014-0043-0

PMCID:: PMC4156617

Abstract Article PDF–1020K

Select item 372465612.

Mapping the Binding Region on the Low Density Lipoprotein Receptor for Blood Coagulation Factor VIII

James H. Kurasawa, Svetlana A. Shestopal, Elena Karnaukhova, Evi B. Struble, Timothy K. Lee, Andrey G. Sarafanov

J Biol Chem. 2013 Jul 26; 288(30): 22033–22041. Published online 2013 Jun 10. doi: 10.1074/jbc.M113.468108

PMCID:: PMC3724656

Abstract Article PDF–1.5M

Select item 117115213.

Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding.

C Munck Petersen, M S Nielsen, C Jacobsen, J Tauris, L Jacobsen, J Gliemann, S K Moestrup, P Madsen

EMBO J. 1999 Feb 1; 18(3): 595–604. doi: 10.1093/emboj/18.3.595

PMCID:: PMC1171152

Summary PDF–434K

Select item 45019814.

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors.

T E Willnow, A Rohlmann, J Horton, H Otani, J R Braun, R E Hammer, J Herz

EMBO J. 1996 Jun 3; 15(11): 2632–2639.

PMCID:: PMC450198

Summary Page Browse PDF–2.1M

Select item 282187115.

Decoding of lipoprotein – receptor interactions; Properties of ligand binding modules governing interactions with ApoE

Miklos Guttman, J. Helena Prieto, Johnny E. Croy, Elizabeth A. Komives

Biochemistry. Author manuscript; available in PMC 2011 Feb 16.

Published in final edited form as: Biochemistry. 2010 Feb 16; 49(6): 1207. doi: 10.1021/bi9017208

PMCID:: PMC2821871

Abstract Article PDF–3.3M

Select item 278517816.

Receptor-associated Protein Interacts with Amyloid-β Peptide and Promotes Its Cellular Uptake

Takahisa Kanekiyo, Guojun Bu

J Biol Chem. 2009 Nov 27; 284(48): 33352–33359. Published online 2009 Oct 13. doi: 10.1074/jbc.M109.015032

PMCID:: PMC2785178

Abstract Article PDF–1.3M

Select item 45512117.

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.

J Herz, U Hamann, S Rogne, O Myklebost, H Gausepohl, K K Stanley

EMBO J. 1988 Dec 20; 7(13): 4119–4127. doi: 10.1002/j.1460-2075.1988.tb03306.x

PMCID:: PMC455121

Summary Page Browse PDF–1.9M

Select item 4197918.

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.

T E Willnow, S A Armstrong, R E Hammer, J Herz

Proc Natl Acad Sci U S A. 1995 May 9; 92(10): 4537–4541. doi: 10.1073/pnas.92.10.4537

PMCID:: PMC41979

Summary Page Browse PDF–1.1M

Select item 483627419.

Cytokine-Like Factor 1, an Essential Facilitator of Cardiotrophin-Like Cytokine:Ciliary Neurotrophic Factor Receptor α Signaling and sorLA-Mediated Turnover

Jakob Vejby Larsen, Anders Mejer Kristensen, Lone Tjener Pallesen, Johannes Bauer, Christian Bjerggaard Vægter, Morten Schallburg Nielsen, Peder Madsen, Claus Munck Petersen

Mol Cell Biol. 2016 Apr 15; 36(8): 1272–1286. Prepublished online 2016 Feb 8. Published online 2016 Apr 1. doi: 10.1128/MCB.00917-15