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Items: 1 to 20 of 80

1.
Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions
Clara Bueno, Fernando J Calero-Nieto, Xiaonan Wang, Rafael Valdés-Mas, Francisco Gutiérrez-Agüera, Heleia Roca-Ho, Veronica Ayllon, Pedro J Real, David Arambilet, Lluis Espinosa, Raul Torres-Ruiz, Antonio Agraz-Doblas, Ignacio Varela, Jasper de Boer, Anna Bigas, Bertie Gottgens, Rolf Marschalek, Pablo Menendez
Haematologica. 2019 Jun; 104(6): 1189–1201. Prepublished online 2019 Jan 24. doi: 10.3324/haematol.2018.202044
PMCID:
PMC6545840
AbstractArticlePDF–3.9M
2.
Association study of AFF1 rs340630 polymorphism with genetic susceptibility to rheumatoid arthritis in Chinese population
Qing-Qing Sun, Dong-Jin Hua, Si-Chao Huang, Han Cen, Li Zhou, Song Shao
Braz J Med Biol Res. 2018; 51(7): e7126. Published online 2018 May 17. doi: 10.1590/1414-431X20187126
PMCID:
PMC5972020
AbstractArticlePDF–96K
3.
Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion
Caterina Tretti Parenzan, Anna Dal Molin, Giorgia Longo, Enrico Gaffo, Alessia Buratin, Alice Cani, Elena Boldrin, Valentina Serafin, Paola Guglielmelli, Alessandro M. Vannucchi, Giovanni Cazzaniga, Andrea Biondi, Franco Locatelli, Lueder H. Meyer, Barbara Buldini, Geertruij te Kronnie, Silvia Bresolin, Stefania Bortoluzzi
Blood Adv. 2024 Mar 12; 8(5): 1305–1319. Published online 2023 Dec 1. doi: 10.1182/bloodadvances.2023011291
PMCID:
PMC10918493
AbstractArticlePDF–2.3M
4.
The role of reciprocal fusions in MLL-r acute leukemia: studying the chromosomal translocation t(4;11)
Alexander Wilhelm, Rolf Marschalek
Oncogene. 2021; 40(42): 6093–6102. Published online 2021 Sep 6. doi: 10.1038/s41388-021-02001-2
PMCID:
PMC8530991
AbstractArticlePDF–4.8M
5.
Genetic and Epigenetic Characterization of a Discordant KMT2A/AFF1-Rearranged Infant Monozygotic Twin Pair
Alessia Russo, Clara Viberti, Katia Mareschi, Elisabetta Casalone, Simonetta Guarrera, Giovanni Birolo, Giovanni Cazzaniga, Lilia Corral, Luca Trentin, Giuseppe Basso, Franca Fagioli, Giuseppe Matullo
Int J Mol Sci. 2021 Sep; 22(18): 9740. Published online 2021 Sep 9. doi: 10.3390/ijms22189740
PMCID:
PMC8466096
AbstractArticlePDF–1.6M
6.
AFF1 inhibits adipogenic differentiation via targeting TGM2 transcription
Yaqian Chen, Yuan Wang, Weimin Lin, Rui Sheng, Yunshu Wu, Ruoshi Xu, Chenchen Zhou, Quan Yuan
Cell Prolif. 2020 Jun; 53(6): e12831. Published online 2020 May 22. doi: 10.1111/cpr.12831
PMCID:
PMC7309944
AbstractArticlePDF–1.6M
7.
MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia
K H M Prange, A Mandoli, T Kuznetsova, S-Y Wang, A M Sotoca, A E Marneth, B A van der Reijden, H G Stunnenberg, J H A Martens
Oncogene. 2017 Jun 8; 36(23): 3346–3356. Published online 2017 Jan 23. doi: 10.1038/onc.2016.488
PMCID:
PMC5474565
AbstractArticlePDF–2.2M
8.
MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation
Laura Godfrey, Jon Kerry, Ross Thorne, Emmanouela Repapi, James O.J. Davies, Marta Tapia, Erica Ballabio, Jim R. Hughes, Huimin Geng, Marina Konopleva, Thomas A. Milne
Exp Hematol. 2017 Mar; 47: 64–75. doi: 10.1016/j.exphem.2016.11.003
PMCID:
PMC5333536
AbstractArticle
9.
A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese
Yukinori Okada, Kenichi Shimane, Yuta Kochi, Tomoko Tahira, Akari Suzuki, Koichiro Higasa, Atsushi Takahashi, Tetsuya Horita, Tatsuya Atsumi, Tomonori Ishii, Akiko Okamoto, Keishi Fujio, Michito Hirakata, Hirofumi Amano, Yuya Kondo, Satoshi Ito, Kazuki Takada, Akio Mimori, Kazuyoshi Saito, Makoto Kamachi, Yasushi Kawaguchi, Katsunori Ikari, Osman Wael Mohammed, Koichi Matsuda, Chikashi Terao, Koichiro Ohmura, Keiko Myouzen, Naoya Hosono, Tatsuhiko Tsunoda, Norihiro Nishimoto, Tsuneyo Mimori, Fumihiko Matsuda, Yoshiya Tanaka, Takayuki Sumida, Hisashi Yamanaka, Yoshinari Takasaki, Takao Koike, Takahiko Horiuchi, Kenshi Hayashi, Michiaki Kubo, Naoyuki Kamatani, Ryo Yamada, Yusuke Nakamura, Kazuhiko Yamamoto
PLoS Genet. 2012 Jan; 8(1): e1002455. Published online 2012 Jan 26. doi: 10.1371/journal.pgen.1002455
PMCID:
PMC3266877
AbstractArticlePDF–427K
10.
H3K79 methylation profiles define murine and human MLL-AF4 leukemias
Andrei V. Krivtsov, Zhaohui Feng, Madeleine E. Lemieux, Joerg Faber, Sridhar Vempati, Amit U. Sinha, Xiaobo Xia, Jonathan Jesneck, Adrian P. Bracken, Lewis B. Silverman, Jeffery L. Kutok, Andrew L. Kung, Scott A. Armstrong
Cancer Cell. Author manuscript; available in PMC 2009 Nov 4.
Published in final edited form as: Cancer Cell. 2008 Nov 4; 14(5): 355–368. doi: 10.1016/j.ccr.2008.10.001
PMCID:
PMC2591932
AbstractArticlePDF–6.4M
11.
A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy
Weili Chen, Quanzhi Li, Wendy A. Hudson, Ashish Kumar, Nicole Kirchhof, John H. Kersey
Blood. 2006 Jul 15; 108(2): 669–677. Prepublished online 2006 Mar 21. doi: 10.1182/blood-2005-08-3498
PMCID:
PMC1895483
AbstractArticle
12.
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression
Zhen-Biao Xia, Relja Popovic, Jing Chen, Catherine Theisler, Tara Stuart, Donna A. Santillan, Frank Erfurth, Manuel O. Diaz, Nancy J. Zeleznik-Le
Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39): 14028–14033. Published online 2005 Sep 16. doi: 10.1073/pnas.0506464102
PMCID:
PMC1236570
AbstractArticlePDF–444K
13.
Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6
Leslie J. Raffini, Diana J. Slater, Eric F. Rappaport, Luca Lo Nigro, Nai-Kong V. Cheung, Jaclyn A. Biegel, Peter C. Nowell, Beverly J. Lange, Carolyn A. Felix
Proc Natl Acad Sci U S A. 2002 Apr 2; 99(7): 4568–4573. doi: 10.1073/pnas.062066799
PMCID:
PMC123688
AbstractArticlePDF–351K
14.
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.
P H Domer, S S Fakharzadeh, C S Chen, J Jockel, L Johansen, G A Silverman, J H Kersey, S J Korsmeyer
Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16): 7884–7888. doi: 10.1073/pnas.90.16.7884
PMCID:
PMC47247
SummaryPage BrowsePDF–1.0M
15.
Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.
T Nakamura, H Alder, Y Gu, R Prasad, O Canaani, N Kamada, R P Gale, B Lange, W M Crist, P C Nowell, et al.
Proc Natl Acad Sci U S A. 1993 May 15; 90(10): 4631–4635. doi: 10.1073/pnas.90.10.4631
PMCID:
PMC46566
SummaryPage BrowsePDF–1.1M
16.
Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias
Maureen D. Megonigal, Eric F. Rappaport, Douglas H. Jones, Caroline S. Kim, Peter C. Nowell, Beverly J. Lange, Carolyn A. Felix
Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21): 11583–11588. doi: 10.1073/pnas.94.21.11583
PMCID:
PMC23546
AbstractArticlePDF–377K
17.
AF4/FMR2、IL-10基因多态性与强直性脊柱炎的遗传易感性和免疫浸润相关
穆 杰, 徐 永申, 朱 辉
Nan Fang Yi Ke Da Xue Xue Bao. 2023 May 20; 43(5): 741–748. Chinese. doi: 10.12122/j.issn.1673-4254.2023.05.09
PMCID:
PMC10267226
AbstractArticlePDF–1.8M
18.
Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription
Huasong Lu, Zichong Li, Wei Zhang, Ursula Schulze-Gahmen, Yuhua Xue, Qiang Zhou
Nucleic Acids Res. 2015 Jul 13; 43(12): 5868–5879. Published online 2015 May 24. doi: 10.1093/nar/gkv541
PMCID:
PMC4499153
AbstractArticlePDF–7.1M
19.
Proteasome Inhibitors Evoke Latent Tumor Suppression Programs in Pro-B MLL Leukemias Through MLL-AF4
Han Liu, Todd D. Westergard, Amanda Cashen, David R. Piwnica-Worms, Lori Kunkle, Ravi Vij, Can G. Pham, John DiPersio, Emily H. Cheng, James J. Hsieh
Cancer Cell. Author manuscript; available in PMC 2015 Apr 14.
Published in final edited form as: Cancer Cell. 2014 Apr 14; 25(4): 530–542. doi: 10.1016/j.ccr.2014.03.008
PMCID:
PMC4097146
AbstractArticlePDF–3.9M
20.
AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter
Ursula Schulze-Gahmen, Huasong Lu, Qiang Zhou, Tom Alber
eLife. 2014; 3: e02375. Published online 2014 Apr 24. doi: 10.7554/eLife.02375
PMCID:
PMC4013717
AbstractArticlePDF–1.6M

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