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Items: 1 to 20 of 72

1.
Molecular Recognition of Methacryllysine and Crotonyllysine by the AF9 YEATS Domain
Nurgül Bilgin, Laust Moesgaard, Mohammad M. Rahman, Vildan A. Türkmen, Jacob Kongsted, Jasmin Mecinović
Int J Mol Sci. 2023 Apr; 24(8): 7002. Published online 2023 Apr 10. doi: 10.3390/ijms24087002
PMCID:
PMC10138300
AbstractArticlePDF–1.5M
2.
Characterization of Copy Number Variations in Oral Cavity Squamous Cell Carcinoma Reveals a Novel Role for MLLT3 in Cell Invasiveness
Chun‐I Wang, Huang‐Kai Kao, Ting‐Wen Chen, Yenlin Huang, Hsing‐Wen Cheng, Jui‐Shan Yi, Shao‐Yu Hung, Chi‐Sheng Wu, Yun‐Shien Lee, Kai‐Ping Chang
Oncologist. 2019 Dec; 24(12): e1388–e1400. Published online 2019 Jul 4. doi: 10.1634/theoncologist.2019-0063
PMCID:
PMC6975970
AbstractArticlePDF–1.9M
3.
The intrinsically disordered proteins MLLT3 (AF9) and MLLT1 (ENL) – multimodal transcriptional switches with roles in normal hematopoiesis, MLL fusion leukemia, and kidney cancer
Ashish Kabra, John Bushweller
J Mol Biol. Author manuscript; available in PMC 2023 Jan 15.
Published in final edited form as: J Mol Biol. 2022 Jan 15; 434(1): 167117. Published online 2021 Jun 23. doi: 10.1016/j.jmb.2021.167117
PMCID:
PMC8695629
AbstractArticlePDF–1.3M
4.
BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity
Charles R. Schmidt, Nicholas J. Achille, Aravinda Kuntimaddi, Adam M. Boulton, Benjamin I. Leach, Shubin Zhang, Nancy J. Zeleznik-Le, John H. Bushweller
Blood Cancer Discov. 2020 Sep; 1(2): 162–177. Published online 2020 Jul 7. doi: 10.1158/2643-3230.BCD-20-0036
PMCID:
PMC7497807
AbstractArticlePDF–22M
5.
MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment
Vincenzo Calvanese, Andrew T. Nguyen, Timothy J. Bolan, Anastasia Vavilina, Trent Su, Lydia K. Lee, Yanling Wang, Fides D. Lay, Mattias Magnusson, Gay M. Crooks, Siavash K. Kurdistani, Hanna K. A. Mikkola
Nature. Author manuscript; available in PMC 2020 Jun 8.
Published in final edited form as: Nature. 2019 Dec; 576(7786): 281–286. Published online 2019 Nov 27. doi: 10.1038/s41586-019-1790-2
PMCID:
PMC7278275
AbstractArticlePDF–7.0M
6.
Bioflavonoids promote stable translocations between MLL-AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks
Bhawana Bariar, C. Greer Vestal, Bradley Deem, Donna Goodenow, Mimi Ughetta, R. Warren Engledove, Mark Sahyouni, Christine Richardson
Environ Mol Mutagen. Author manuscript; available in PMC 2020 Mar 1.
Published in final edited form as: Environ Mol Mutagen. 2019 Mar; 60(2): 154–167. Published online 2018 Nov 2. doi: 10.1002/em.22245
PMCID:
PMC6363851
AbstractArticlePDF–1.7M
7.
MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia
K H M Prange, A Mandoli, T Kuznetsova, S-Y Wang, A M Sotoca, A E Marneth, B A van der Reijden, H G Stunnenberg, J H A Martens
Oncogene. 2017 Jun 8; 36(23): 3346–3356. Published online 2017 Jan 23. doi: 10.1038/onc.2016.488
PMCID:
PMC5474565
AbstractArticlePDF–2.2M
8.
An AF9/ENL-targted peptide with therapeutic potential in mixed lineage leukemias
Nisha N. Barretto, Dean S. Karahalios, Dewen You, Charles S. Hemenway
J Exp Ther Oncol. Author manuscript; available in PMC 2016 Dec 20.
Published in final edited form as: J Exp Ther Oncol. 2014; 10(4): 293–300.
PMCID:
PMC5172450
AbstractArticlePDF–730K
9.
Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain
Qiang Zhang, Lei Zeng, ChengCheng Zhao, Ying Ju, Tsuyoshi Konuma, Ming-Ming Zhou
Structure. Author manuscript; available in PMC 2017 Sep 6.
Published in final edited form as: Structure. 2016 Sep 6; 24(9): 1606–1612. Published online 2016 Aug 18. doi: 10.1016/j.str.2016.05.023
PMCID:
PMC5014688
AbstractArticlePDF–1.3M
10.
Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.
T Nakamura, H Alder, Y Gu, R Prasad, O Canaani, N Kamada, R P Gale, B Lange, W M Crist, P C Nowell, et al.
Proc Natl Acad Sci U S A. 1993 May 15; 90(10): 4631–4635. doi: 10.1073/pnas.90.10.4631
PMCID:
PMC46566
SummaryPage BrowsePDF–1.1M
11.
AF9 sustains glycolysis in colorectal cancer via H3K9ac‐mediated PCK2 and FBP1 transcription
Xuefeng He, Xinyang Zhong, Yi Fang, Zijuan Hu, Zhiyu Chen, Yaxian Wang, Huixia Huang, Senlin Zhao, Dawei Li, Ping Wei
Clin Transl Med. 2023 Aug; 13(8): e1352. Published online 2023 Aug 10. doi: 10.1002/ctm2.1352
PMCID:
PMC10413954
AbstractArticlePDF–15M
12.
The miR-5694/AF9/Snail Axis Provides Metastatic Advantages and a Therapeutic Target in Basal-like Breast Cancer
Xin Tian, Hua Yu, Dong Li, Guojiang Jin, Shundong Dai, Pengchao Gong, Cuicui Kong, Xiongjun Wang
Mol Ther. 2021 Mar 3; 29(3): 1239–1257. Published online 2020 Nov 20. doi: 10.1016/j.ymthe.2020.11.022
PMCID:
PMC7934584
AbstractArticlePDF–4.3M
13.
FLT3N676K drives acute myeloid leukemia in a xenograft model of KMT2A-MLLT3 leukemogenesis
Axel Hyrenius-Wittsten, Mattias Pilheden, Antoni Falqués-Costa, Mia Eriksson, Helena Sturesson, Pauline Schneider, Priscilla Wander, Cristian Garcia-Ruiz, Jian Liu, Helena Ågerstam, Anne Hultquist, Henrik Lilljebjörn, Ronald W. Stam, Marcus Järås, Anna K. Hagström-Andersson
Leukemia. 2019; 33(9): 2310–2314. Published online 2019 Apr 5. doi: 10.1038/s41375-019-0465-1
PMCID:
PMC6756218
ArticlePDF–957K
14.
CBX8, a component of the repressive Polycomb PRC1 complex, modulates DOT1L-mediated gene expression through AF9/MLLT3
Bhavna Malik, Charles S. Hemenway
FEBS Lett. Author manuscript; available in PMC 2014 Sep 17.
Published in final edited form as: FEBS Lett. 2013 Sep 17; 587(18): 3038–3044. Published online 2013 Jul 25. doi: 10.1016/j.febslet.2013.07.034
PMCID:
PMC3800029
AbstractArticlePDF–1.7M
15.
An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model
Rachel J. Bergerson, Lara S. Collier, Aaron L. Sarver, Raha A. Been, Sanne Lugthart, Miechaleen D. Diers, Johannes Zuber, Amy R. Rappaport, Molly J. Nixon, Kevin A. T. Silverstein, Danhua Fan, Anne-Francoise J. Lamblin, Linda Wolff, John H. Kersey, Ruud Delwel, Scott W. Lowe, M. Gerard O'Sullivan, Scott C. Kogan, David J. Adams, David A. Largaespada
Blood. 2012 May 10; 119(19): 4512–4523. Prepublished online 2012 Mar 16. doi: 10.1182/blood-2010-04-281428
PMCID:
PMC3362364
AbstractArticle
16.
Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia
Junping Wei, Mark Wunderlich, Catherine Fox, Sara Alvarez, Juan C. Cigudosa, Jamie S. Wilhelm, Yi Zheng, Jose A. Cancelas, Yi Gu, Michael Jansen, Jorge F. DiMartino, James C. Mulloy
Cancer Cell. Author manuscript; available in PMC 2009 Jun 1.
Published in final edited form as: Cancer Cell. 2008 Jun; 13(6): 483–495. doi: 10.1016/j.ccr.2008.04.020
PMCID:
PMC2486365
AbstractArticlePDF–3.6M
17.
MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
Xinyue Chen, Daniel B. Burkhardt, Amaleah A. Hartman, Xiao Hu, Anna E. Eastman, Chao Sun, Xujun Wang, Mei Zhong, Smita Krishnaswamy, Shangqin Guo
Nat Commun. 2019; 10: 5767. Published online 2019 Dec 18. doi: 10.1038/s41467-019-13666-5
Correction in:
Nat Commun. 2020; 11: 681.
PMCID:
PMC6920141
AbstractArticlePDF–2.6M
18.
MLL fusion partner AF9 is an intrinsically disordered transcriptional regulator which recruits multiple partners via coupled folding and binding
Benjamin I Leach, Aravinda Kuntimaddi, Charles R Schmidt, Tomasz Cierpicki, Stephanie A Johnson, John H. Bushweller
Structure. Author manuscript; available in PMC 2014 Jan 8.
Published in final edited form as: Structure. 2013 Jan 8; 21(1): 176–183. Published online 2012 Dec 20. doi: 10.1016/j.str.2012.11.011
PMCID:
PMC3545106
AbstractArticlePDF–1.0M
19.
Oncogenic All1 fusion proteins target Drosha-mediated microRNA processing
Tatsuya Nakamura, Eli Canaani, Carlo M. Croce
Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26): 10980–10985. Published online 2007 Jun 20. doi: 10.1073/pnas.0704559104
PMCID:
PMC1904159
AbstractArticlePDF–445K
20.
Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain
Brianna J. Klein, Kendra R. Vann, Forest H. Andrews, Wesley W. Wang, Jibo Zhang, Yi Zhang, Anastasia A. Beloglazkina, Wenyi Mi, Yuanyuan Li, Haitao Li, Xiaobing Shi, Andrei G. Kutateladze, Brian D. Strahl, Wenshe R. Liu, Tatiana G. Kutateladze
Nat Commun. 2018; 9: 4574. Published online 2018 Nov 1. doi: 10.1038/s41467-018-07072-6
PMCID:
PMC6212594
AbstractArticlePDF–2.5M

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