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Items: 1 to 20 of 87

1.
The eIF2α kinases: their structures and functions
Neysan Donnelly, Adrienne M. Gorman, Sanjeev Gupta, Afshin Samali
Cell Mol Life Sci. 2013 Oct; 70(19): 3493–3511. Published online 2013 Jan 26. doi: 10.1007/s00018-012-1252-6
PMCID:
PMC11113696
AbstractArticlePDF–964K
2.
Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions
Jagannath Misra, Kenneth R Carlson, Dan F Spandau, Ronald C Wek
Nucleic Acids Res. 2024 Feb 28; 52(4): 1830–1846. Published online 2024 Jan 28. doi: 10.1093/nar/gkae006
PMCID:
PMC10899773
AbstractArticlePDF–2.7M
3.
Hepatitis E Virus Protease Inhibits the Activity of Eukaryotic Initiation Factor 2-Alpha Kinase 4 and Promotes Virus Survival
Amit Kumar, Chandru Subramani, Shivani Raj, C. T. Ranjith-Kumar, Milan Surjit
J Virol. 2023 Jun; 97(6): e00347-23. Published online 2023 May 18. doi: 10.1128/jvi.00347-23
PMCID:
PMC10308950
AbstractArticlePDF–2.3M
4.
Multiple Roles of the Stress Sensor GCN2 in Immune Cells
Chenxu Zhao, Han Guo, Yangxiao Hou, Tong Lei, Dong Wei, Yong Zhao
Int J Mol Sci. 2023 Mar; 24(5): 4285. Published online 2023 Feb 21. doi: 10.3390/ijms24054285
PMCID:
PMC10002013
AbstractArticlePDF–2.3M
5.
Lipidomic Profile Analysis of Lung Tissues Revealed Lipointoxication in Pulmonary Veno-Occlusive Disease
Spiro Khoury, Antoine Beauvais, Jenny Colas, Anaïs Saint-Martin Willer, Frédéric Perros, Marc Humbert, Clarisse Vandebrouck, David Montani, Thierry Ferreira, Fabrice Antigny
Biomolecules. 2022 Dec; 12(12): 1878. Published online 2022 Dec 14. doi: 10.3390/biom12121878
PMCID:
PMC9775349
AbstractArticlePDF–1.9M
6.
A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling
Johanna B. Brüggenthies, Alessandra Fiore, Marion Russier, Christina Bitsina, Julian Brötzmann, Susanne Kordes, Sascha Menninger, Alexander Wolf, Elena Conti, Jan E. Eickhoff, Peter J. Murray
J Biol Chem. 2022 Dec; 298(12): 102629. Published online 2022 Oct 20. doi: 10.1016/j.jbc.2022.102629
PMCID:
PMC9668732
AbstractArticlePDF–2.3M
7.
GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
Ricardo A Cordova, Jagannath Misra, Parth H Amin, Anglea J Klunk, Nur P Damayanti, Kenneth R Carlson, Andrew J Elmendorf, Hyeong-Geug Kim, Emily T Mirek, Bennet D Elzey, Marcus J Miller, X Charlie Dong, Liang Cheng, Tracy G Anthony, Roberto Pili, Ronald C Wek, Kirk A Staschke
eLife. 2022; 11: e81083. Published online 2022 Sep 15. doi: 10.7554/eLife.81083
PMCID:
PMC9578714
AbstractArticlePDF–16M
8.
Dengue Virus Induced COX-2 Signaling Is Regulated Through Nutrient Sensor GCN2
Sumbul Afroz, Srikanth Battu, Jeevan Giddaluru, Nooruddin Khan
Front Immunol. 2020; 11: 1831. Published online 2020 Aug 13. doi: 10.3389/fimmu.2020.01831
PMCID:
PMC7438581
AbstractArticlePDF–2.3M
9.
GCN2 drives macrophage and MDSC function and immune suppression in the tumor microenvironment.
Marie Jo Halaby, Kebria Hezaveh, Sara Lamorte, M. Teresa Ciudad, Andreas Kloetgen, Bethany L. MacLeod, Mengdi Guo, Ankur Chakravarthy, Tiago Da Silva Medina, Stefano Ugel, Aristotelis Tsirigos, Vincenzo Bronte, David H. Munn, Trevor J. Pugh, Daniel D. DeCarvalho, Marcus O. Butler, Pamela S. Ohashi, David G. Brooks, Tracy L. McGaha
Sci Immunol. Author manuscript; available in PMC 2020 Jun 13.
Published in final edited form as: Sci Immunol. 2019 Dec 13; 4(42): eaax8189. doi: 10.1126/sciimmunol.aax8189
PMCID:
PMC7201901
AbstractArticlePDF–1.3M
10.
Activation of General Control Nonderepressible-2 Kinase Ameliorates Glucotoxicity in Human Peritoneal Mesothelial Cells, Preserves Their Integrity, and Prevents Mesothelial to Mesenchymal Transition
Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Evdokia Nikolaou, Spyridon Golfinopoulos, Vassilios Liakopoulos, Ioannis Stefanidis
Biomolecules. 2019 Dec; 9(12): 832. Published online 2019 Dec 5. doi: 10.3390/biom9120832
PMCID:
PMC6995539
AbstractArticlePDF–3.0M
11.
Activation of GCN2 by the ribosomal P-stalk
Alison J. Inglis, Glenn R. Masson, Sichen Shao, Olga Perisic, Stephen H. McLaughlin, Ramanujan S. Hegde, Roger L. Williams
Proc Natl Acad Sci U S A. 2019 Mar 12; 116(11): 4946–4954. Published online 2019 Feb 25. doi: 10.1073/pnas.1813352116
PMCID:
PMC6421407
AbstractArticlePDF–1.3M
12.
Phenotypic characterisation of EIF2AK4 mutation carriers in a large cohort of patients diagnosed clinically with pulmonary arterial hypertension
Charaka Hadinnapola, Marta Bleda, Matthias Haimel, Nicholas Screaton, Andrew Swift, Peter Dorfmüller, Stephen D Preston, Mark Southwood, Jules Hernandez-Sanchez, Jennifer Martin, Carmen Treacy, Katherine Yates, Harm Bogaard, Colin Church, Gerry Coghlan, Robin Condliffe, Paul A Corris, Simon Gibbs, Barbara Girerd, Simon Holden, Marc Humbert, David G Kiely, Allan Lawrie, Rajiv Machado, Robert MacKenzie Ross, Shahin Moledina, David Montani, Michael Newnham, Andrew Peacock, Joanna Pepke-Zaba, Paula Rayner-Matthews, Olga Shamardina, Florent Soubrier, Laura Southgate, Jay Suntharalingam, Mark Toshner, Richard Trembath, Anton Vonk Noordegraaf, Martin R Wilkins, Stephen J Wort, John Wharton, The NIHR BioResource – Rare Diseases Consortium, UK National Cohort Study of Idiopathic and Heritable PAH, Stefan Gräf, Nicholas W. Morrell
Circulation. Author manuscript; available in PMC 2018 Nov 21.
Published in final edited form as: Circulation. 2017 Nov 21; 136(21): 2022–2033. Published online 2017 Sep 28. doi: 10.1161/CIRCULATIONAHA.117.028351
PMCID:
PMC5700414
AbstractArticlePDF–1.1M
13.
D-serine, a novel uremic toxin, induces senescence in human renal tubular cells via GCN2 activation
Akira Okada, Masaomi Nangaku, Tzu-Ming Jao, Hiroshi Maekawa, Yu Ishimono, Takahisa Kawakami, Reiko Inagi
Sci Rep. 2017; 7: 11168. Published online 2017 Sep 11. doi: 10.1038/s41598-017-11049-8
PMCID:
PMC5593843
AbstractArticlePDF–6.2M
14.
Improved Cough and Cough-Specific Quality of Life in Patients Treated for Scleroderma-Related Interstitial Lung Disease: Results of Scleroderma Lung Study II
Donald P. Tashkin, Elizabeth R. Volkmann, Chi-Hong Tseng, Michael D. Roth, Dinesh Khanna, Daniel E. Furst, Philip J. Clements, Arthur Theodore, Suzanne Kafaja, Grace Hyun Kim, Jonathan Goldin, Edgar Ariolla, Robert M. Elashoff
Chest. 2017 Apr; 151(4): 813–820. Published online 2016 Dec 22. doi: 10.1016/j.chest.2016.11.052
PMCID:
PMC5472514
AbstractArticlePDF–257K
15.
EIF2AK4 mutation in pulmonary veno-occlusive disease: A case report and review of the literature
Li Liang, Guofeng Ma, Kai Chen, Yangxiang Liu, Xiaohong Wu, Kejing Ying, Ruifeng Zhang
Medicine (Baltimore) 2016 Sep; 95(39): e5030. Published online 2016 Sep 30. doi: 10.1097/MD.0000000000005030
PMCID:
PMC5265969
AbstractArticlePDF–483K
16.
EIF2AK4 mutation as “second hit” in hereditary pulmonary arterial hypertension
Christina A. Eichstaedt, Jie Song, Nicola Benjamin, Satenik Harutyunova, Christine Fischer, Ekkehard Grünig, Katrin Hinderhofer
Respir Res. 2016; 17: 141. Published online 2016 Nov 4. doi: 10.1186/s12931-016-0457-x
PMCID:
PMC5095976
AbstractArticlePDF–754K
17.
GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2
Jiangbin Ye, Wilhelm Palm, Min Peng, Bryan King, Tullia Lindsten, Ming O. Li, Constantinos Koumenis, Craig B. Thompson
Genes Dev. 2015 Nov 15; 29(22): 2331–2336. doi: 10.1101/gad.269324.115
PMCID:
PMC4691887
AbstractArticlePDF–653K
18.
Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells
Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Vassilios Liakopoulos, Ioannis Stefanidis
Immunology. 2015 Oct; 146(2): 292–300. Published online 2015 Jul 27. doi: 10.1111/imm.12502
PMCID:
PMC4582970
AbstractArticlePDF–598K
19.
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
Troy D Querec, Rama S Akondy, Eva K Lee, Weiping Cao, Helder I Nakaya, Dirk Teuwen, Ali Pirani, Kim Gernert, Jiusheng Deng, Bruz Marzolf, Kathleen Kennedy, Haiyan Wu, Soumaya Bennouna, Herold Oluoch, Joseph Miller, Ricardo Z Vencio, Mark Mulligan, Alan Aderem, Rafi Ahmed, Bali Pulendran
Nat Immunol. Author manuscript; available in PMC 2014 Jun 9.
Published in final edited form as: Nat Immunol. 2009 Jan; 10(1): 116–125. Published online 2008 Nov 23. doi: 10.1038/ni.1688
PMCID:
PMC4049462
AbstractArticlePDF–1.4M
20.
EIF2AK4 Mutations in Pulmonary Capillary Hemangiomatosis
D. Hunter Best, Kelli L. Sumner, Eric D. Austin, Wendy K. Chung, Lynette M. Brown, Alain C. Borczuk, Erika B. Rosenzweig, Pinar Bayrak-Toydemir, Rong Mao, Barbara C. Cahill, Henry D. Tazelaar, Kevin O. Leslie, Anna R. Hemnes, Ivan M. Robbins, C. Gregory Elliott
Chest. 2014 Feb; 145(2): 231–236. Published online 2013 Oct 17. doi: 10.1378/chest.13-2366
PMCID:
PMC3921094
AbstractArticlePDF–1.1M

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