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Select item 111566441.

ATF4 inhibits tumor development and mediates p-GCN2/ASNS upregulation in colon cancer

Jiawei Chen, Xiaopeng Huang, Shuai Zhang, Xiaodong Zhu

Sci Rep. 2024; 14: 13042. Published online 2024 Jun 6. doi: 10.1038/s41598-024-63895-y

PMCID:: PMC11156644

Abstract Article PDF–3.9M

Select item 110584732.

Stem-loop-induced ribosome queuing in the uORF2/ATF4 overlap fine-tunes stress-induced human ATF4 translational control

Anna M. Smirnova, Vladislava Hronová, Mahabub Pasha Mohammad, Anna Herrmannová, Stanislava Gunišová, Denisa Petráčková, Petr Halada, Štěpán Coufal, Michał Świrski, Justin Rendleman, Kristína Jendruchová, Maria Hatzoglou, Petra Beznosková, Christine Vogel, Leoš Shivaya Valášek

Cell Rep. Author manuscript; available in PMC 2024 Apr 30.

Published in final edited form as: Cell Rep. 2024 Apr 23; 43(4): 113976. Published online 2024 Mar 19. doi: 10.1016/j.celrep.2024.113976

PMCID:: PMC11058473

Abstract Article PDF–2.1M

Select item 106377233.

Genome-wide census of ATF4 binding sites and functional profiling of trait-associated genetic variants overlapping ATF4 binding motifs

Tiit Örd, Daima Örd, Priit Adler, Tõnis Örd

PLoS Genet. 2023 Oct; 19(10): e1011014. Published online 2023 Oct 31. doi: 10.1371/journal.pgen.1011014

PMCID:: PMC10637723

Abstract Article PDF–3.2M

Select item 97896864.

Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival

Meng Li, Matthew R. Teater, Jun Young Hong, Noel R. Park, Cihangir Duy, Hao Shen, Ling Wang, Zhengming Chen, Leandro Cerchietti, Shawn M. Davidson, Hening Lin, Ari M. Melnick

Blood Cancer Discov. 2022 Jan; 3(1): 50–65. Published online 2021 Nov 9. doi: 10.1158/2643-3230.BCD-20-0183

PMCID:: PMC9789686

Abstract Article PDF–7.6M

Select item 95738655.

ATF4-dependent fructolysis fuels growth of glioblastoma multiforme

Chao Chen, Zhenxing Zhang, Caiyun Liu, Bin Wang, Ping Liu, Shu Fang, Fan Yang, Yongping You, Xinjian Li

Nat Commun. 2022; 13: 6108. Published online 2022 Oct 16. doi: 10.1038/s41467-022-33859-9

PMCID:: PMC9573865

Abstract Article PDF–3.1M

Select item 93752006.

uORF-Mediated Translational Regulation of ATF4 Serves as an Evolutionarily Conserved Mechanism Contributing to Non-Small-Cell Lung Cancer (NSCLC) and Stress Response

Wenjing Xiao, Yang Sun, Jinpeng Xu, Na Zhang, Lina Dong

J Mol Evol. 2022; 90(5): 375–388. Published online 2022 Aug 13. doi: 10.1007/s00239-022-10068-y

PMCID:: PMC9375200

Abstract Article PDF–2.0M

Select item 84967137.

ATF4 links ER stress with reticulophagy in glioblastoma cells

Svenja Zielke, Simon Kardo, Laura Zein, Muriel Mari, Adriana Covarrubias-Pinto, Maximilian N. Kinzler, Nina Meyer, Alexandra Stolz, Simone Fulda, Fulvio Reggiori, Donat Kögel, Sjoerd van Wijk

Autophagy. 2021; 17(9): 2432–2448. Published online 2020 Oct 28. doi: 10.1080/15548627.2020.1827780

PMCID:: PMC8496713

Abstract Article PDF–10M

Select item 82668218.

Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide

Nadja I. Lorenz, Alina C. M. Sittig, Hans Urban, Anna-Luisa Luger, Anna L. Engel, Christian Münch, Joachim P. Steinbach, Michael W. Ronellenfitsch

Sci Rep. 2021; 11: 14161. Published online 2021 Jul 8. doi: 10.1038/s41598-021-93663-1

PMCID:: PMC8266821

Abstract Article PDF–2.8M

Select item 78935639.

ATF4 promotes lung cancer cell proliferation and invasion partially through regulating Wnt/β-catenin signaling

Jiang Du, Haifeng Liu, Xiaoyun Mao, Yanan Qin, Chuifeng Fan

Int J Med Sci. 2021; 18(6): 1442–1448. Published online 2021 Jan 29. doi: 10.7150/ijms.43167

PMCID:: PMC7893563

Abstract Article PDF–1.5M

Select item 760516310.

TGF-β Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation

Erin M. O’Leary, Yufeng Tian, Recep Nigdelioglu, Leah J. Witt, Rengul Cetin-Atalay, Angelo Y. Meliton, Parker S. Woods, Lucas M. Kimmig, Kaitlyn A. Sun, Gizem A. Gökalp, Gökhan M. Mutlu, Robert B. Hamanaka

Am J Respir Cell Mol Biol. 2020 Nov; 63(5): 601–612. doi: 10.1165/rcmb.2020-0143OC

PMCID:: PMC7605163

Abstract Article PDF–1.5M

Select item 752892611.

ATF4 Mediates Mitochondrial Unfolded Protein Response in Alveolar Epithelial Cells

Dingyuan Jiang, Huachun Cui, Na Xie, Sami Banerjee, Rui-Ming Liu, Huaping Dai, Victor J. Thannickal, Gang Liu

Am J Respir Cell Mol Biol. 2020 Oct; 63(4): 478–489. doi: 10.1165/rcmb.2020-0107OC

PMCID:: PMC7528926

Abstract Article PDF–1.7M

Select item 682400612.

Elevated ATF4 Expression in Odontogenic Keratocysts Epithelia: Potential Involvement in Tissue Hypoxia and Stromal M2 Macrophage Infiltration

Wen-Qun Zhong, Zhi-Zheng Li, Hao Jiang, Yan-Ping Zou, Hai-Tao Wang, Yu Cai, Yi Zhao, Ji-Hong Zhao

J Histochem Cytochem. 2019 Nov; 67(11): 801–812. Published online 2019 Aug 19. doi: 10.1369/0022155419871550

PMCID:: PMC6824006

Abstract Article PDF–1.2M

Select item 604889713.

ER stress regulates alkaline phosphatase gene expression in vascular smooth muscle cells via an ATF4-dependent mechanism

Malgorzata Furmanik, Catherine M. Shanahan

BMC Res Notes. 2018; 11: 483. Published online 2018 Jul 16. doi: 10.1186/s13104-018-3582-4

PMCID:: PMC6048897

Abstract Article PDF–1.2M

Select item 599640914.

The Transcription Factor ATF4 Promotes Expression of Cell Stress Genes and Cardiomyocyte Death in a Cellular Model of Atrial Fibrillation

Johanna K. Freundt, Gerrit Frommeyer, Fabian Wötzel, Andreas Huge, Andreas Hoffmeier, Sven Martens, Lars Eckardt, Philipp S. Lange

Biomed Res Int. 2018; 2018: 3694362. Published online 2018 May 29. doi: 10.1155/2018/3694362

PMCID:: PMC5996409

Abstract Article PDF–1.7M

Select item 543234715.

Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells

Florent Mesclon, Sarah Lambert-Langlais, Valérie Carraro, Laurent Parry, Isabelle Hainault, Céline Jousse, Anne-Catherine Maurin, Alain Bruhat, Pierre Fafournoux, Julien Averous

Oncotarget. 2017 Apr 18; 8(16): 27440–27453. Published online 2017 Mar 2. doi: 10.18632/oncotarget.15828

PMCID:: PMC5432347

Abstract Article PDF–2.9M

Select item 540753516.

Association of ATF4 Expression With Tissue Hypoxia and M2 Macrophage Infiltration in Infantile Hemangioma

Hou-fu Xia, Jun-yi Zhu, Jing-nan Wang, Jian-gang Ren, Yu Cai, Feng-qin Wang, Wei Zhang, Gang Chen, Yi-fang Zhao, Ji-hong Zhao

J Histochem Cytochem. 2017 May; 65(5): 285–294. Published online 2017 Feb 1. doi: 10.1369/0022155417694872

PMCID:: PMC5407535

Abstract Article PDF–3.8M

Select item 509668917.

Nutritional stress induced by tryptophan-degrading enzymes results in ATF4-dependent reprogramming of the amino acid transporter profile in tumor cells

Elina Timosenko, Hemza Ghadbane, Jonathan D. Silk, Dawn Shepherd, Uzi Gileadi, Lauren J. Howson, Robert Laynes, Qi Zhao, Robert L. Strausberg, Lars R. Olsen, Stephen Taylor, Francesca M. Buffa, Richard Boyd, Vincenzo Cerundolo

Cancer Res. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: Cancer Res. 2016 Nov 1; 76(21): 6193–6204. Published online 2016 Sep 20. doi: 10.1158/0008-5472.CAN-15-3502

PMCID:: PMC5096689

Abstract Article PDF–1.6M

Select item 496840618.

ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases

C. Leah B. Kline, A. Pieter J. Van den Heuvel, Joshua E. Allen, Varun V. Prabhu, David T. Dicker, Wafik S. El-Deiry

Sci Signal. Author manuscript; available in PMC 2016 Aug 16.

Published in final edited form as: Sci Signal. 2016 Feb 16; 9(415): ra18. Published online 2016 Feb 16. doi: 10.1126/scisignal.aac4374

PMCID:: PMC4968406

Abstract Article PDF–1.7M

Select item 414975519.

Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions

Jimena Baleriola, Chandler A. Walker, Ying Y. Jean, John F. Crary, Carol M. Troy, Peter L. Nagy, Ulrich Hengst

Cell. Author manuscript; available in PMC 2015 Aug 28.

Published in final edited form as: Cell. 2014 Aug 28; 158(5): 1159–1172. doi: 10.1016/j.cell.2014.07.001

PMCID:: PMC4149755

Abstract Article PDF–3.5M

Select item 411756920.

Activating Transcription Factor 4 Promotes Esophageal Squamous Cell Carcinoma Invasion and Metastasis in Mice and Is Associated with Poor Prognosis in Human Patients

Hongwu Zhu, Xiong Chen, Bin Chen, Bei Chen, Weibing Song, Dayong Sun, Yagang Zhao

PLoS One. 2014; 9(7): e103882. Published online 2014 Jul 31. doi: 10.1371/journal.pone.0103882

PMCID:: PMC4117569

Abstract Article PDF–4.8M

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