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Select item 110558681.

Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer

Irineos Papakyriacou, Ginte Kutkaite, Marta Rúbies Bedós, Divya Nagarajan, Liam P. Alford, Michael P. Menden, Yumeng Mao

Nat Commun. 2024; 15: 3581. Published online 2024 Apr 27. doi: 10.1038/s41467-024-47987-x

PMCID:: PMC11055868

Abstract Article PDF–4.0M

Select item 109856672.

NEDD8在不同病理类型慢性鼻窦炎伴鼻息肉中的表达差异

孟琛, 闫冰, 黄雨晴, 王成硕, 张罗

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023 Nov 3; 37(11): 897–901. Chinese. doi: 10.13201/j.issn.2096-7993.2023.11.008

PMCID:: PMC10985667

Abstract Article PDF–2.3M

Select item 109197583.

Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review)

Tianyu Wang, Xiaobing Li, Ruijie Ma, Jian Sun, Shuhong Huang, Zhigang Sun, Meng Wang

Int J Oncol. 2024 Apr; 64(4): 39. Published online 2024 Feb 21. doi: 10.3892/ijo.2024.5627

PMCID:: PMC10919758

Abstract Article PDF–2.4M

Select item 63179574.

Neural precursor cell expressed, developmentally downregulated 8 promotes tumor progression and predicts poor prognosis of patients with bladder cancer

Da‐Wei Tian, Zhou‐Liang Wu, Li‐Ming Jiang, Jie Gao, Chang‐Li Wu, Hai‐Long Hu

Cancer Sci. 2019 Jan; 110(1): 458–467. Published online 2018 Dec 10. doi: 10.1111/cas.13865

PMCID:: PMC6317957

Abstract Article PDF–1.2M

Select item 52610225.

Distinct outcomes of CRL–Nedd8 pathway inhibition reveal cancer cell plasticity

Anastasia V Rulina, Frédérique Mittler, Patricia Obeid, Sophie Gerbaud, Laurent Guyon, Eric Sulpice, Frédérique Kermarrec, Nicole Assard, Monika E Dolega, Xavier Gidrol, Maxim Y Balakirev

Cell Death Dis. 2016 Dec; 7(12): e2505. Published online 2016 Dec 1. doi: 10.1038/cddis.2016.395

PMCID:: PMC5261022

Abstract Article PDF–2.7M

Select item 51290216.

The use of the NEDD8 inhibitor MLN4924 (Pevonedistat) in a cyclotherapy approach to protect wild-type p53 cells from MLN4924 induced toxicity

Lara J. Bou Malhab, Simon Descamps, Benedicte Delaval, Dimitris P. Xirodimas

Sci Rep. 2016; 6: 37775. Published online 2016 Nov 30. doi: 10.1038/srep37775

PMCID:: PMC5129021

Abstract Article PDF–1.2M

Select item 46232397.

Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells

Yanchun Wang, Zhongguang Luo, Yongfu Pan, Weige Wang, Xiaoyan Zhou, Lak Shin Jeong, Yiwei Chu, Jie Liu, Lijun Jia

Cancer Biol Ther. 2015 Mar; 16(3): 420–429. Published online 2015 Mar 17. doi: 10.1080/15384047.2014.1003003

PMCID:: PMC4623239

Abstract Article PDF–861K

Select item 35285148.

Structural mechanism of ubiquitin and NEDD8 deamidation catalyzed by bacterial effectors that induce macrophage-specific apoptosis

Qing Yao, Jixin Cui, Jiayi Wang, Ting Li, Xiaobo Wan, Tianming Luo, Yi-Nan Gong, Ying Xu, Niu Huang, Feng Shao

Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50): 20395–20400. Published online 2012 Nov 21. doi: 10.1073/pnas.1210831109

PMCID:: PMC3528514

Abstract Article PDF–1.5M

Select item 33908739.

The molecular basis of ubiquitin-like protein NEDD8 deamidation by the bacterial effector protein Cif

Allister Crow, Richard K. Hughes, Frédéric Taieb, Eric Oswald, Mark J. Banfield

Proc Natl Acad Sci U S A. 2012 Jul 3; 109(27): E1830–E1838. Published online 2012 Jun 12. doi: 10.1073/pnas.1112107109

PMCID:: PMC3390873

Abstract Article PDF–1.5M

Select item 863266510.

Map of ubiquitin-like post-translational modifications in chronic lymphocytic leukemia. Role of p53 lysine 120 NEDDylation

Sara Bravo-Navas, Lucrecia Yáñez, Íñigo Romón, Montserrat Briz, Juan José Domínguez-García, Carlos Pipaón

Leukemia. 2021; 35(12): 3568–3572. Published online 2021 May 8. doi: 10.1038/s41375-021-01184-7

PMCID:: PMC8632665

Article PDF–650K

Select item 851824311.

A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1)

Zhanxia Zhang, Junqian Zhang, Jianhui Tian, Hegen Li

J Nanobiotechnology. 2021; 19: 323. Published online 2021 Oct 15. doi: 10.1186/s12951-021-01063-4

PMCID:: PMC8518243

Abstract Article PDF–4.9M

Select item 664207212.

Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer

Lihui Li, Jihui Kang, Wenjuan Zhang, Lili Cai, Shiwen Wang, Yupei Liang, Yanyu Jiang, Xiaojun Liu, Yunjing Zhang, Hongfeng Ruan, Guoan Chen, Mingsong Wang, Lijun Jia

EBioMedicine. 2019 Jul; 45: 81–91. Published online 2019 Jun 14. doi: 10.1016/j.ebiom.2019.06.005

PMCID:: PMC6642072

Abstract Article PDF–3.8M

Select item 648908713.

Inhibition of neddylation modification by MLN4924 sensitizes hepatocellular carcinoma cells to sorafenib

Zelong Yang, Jie Zhang, Xiaotong Lin, Di Wu, Guixi Li, Chunlian Zhong, Lei Fang, Peng Jiang, Liangyu Yin, Leida Zhang, Ping Bie, Chuan-Ming Xie

Oncol Rep. 2019 Jun; 41(6): 3257–3269. Published online 2019 Apr 4. doi: 10.3892/or.2019.7098

PMCID:: PMC6489087

Abstract Article PDF–1.9M

Select item 575526614.

Inhibition of neddylation facilitates cell migration through enhanced phosphorylation of caveolin-1 in PC3 and U373MG cells

Sung Yeon Park, Jong-Wan Park, Gun-Woo Lee, Lan Li, Yang-Sook Chun

BMC Cancer. 2018; 18: 30. Published online 2018 Jan 5. doi: 10.1186/s12885-017-3942-9

PMCID:: PMC5755266

Abstract Article PDF–1.7M

Select item 552088115.

Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target

Ping Xie, Jun-Ping Yang, Yun Cao, Li-Xia Peng, Li-Sheng Zheng, Rui Sun, Dong-Fang Meng, Meng-Yao Wang, Yan Mei, Yuan-Yuan Qiang, Li Cao, Yan-Qun Xiang, Dong-Hua Luo, Jing-Ping Yun, Bi-Jun Huang, Li-Jun Jia, Chao-Nan Qian

Cell Death Dis. 2017 Jun; 8(6): e2834. Published online 2017 Jun 1. doi: 10.1038/cddis.2017.195