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Select item 110592361.

Enhanced Sampling for Conformational Changes and Molecular Mechanisms of Human NTHL1

Ryan E. Odstrcil, Prashanta Dutta, Jin Liu

J Phys Chem Lett. Author manuscript; available in PMC 2024 Apr 30.

Published in final edited form as: J Phys Chem Lett. 2024 Mar 21; 15(11): 3206–3213. Published online 2024 Mar 14. doi: 10.1021/acs.jpclett.4c00161

PMCID:: PMC11059236

Abstract Article PDF–1.5M

Select item 106894552.

NTHL1 is a recessive cancer susceptibility gene

Anna K. Nurmi, Liisa M. Pelttari, Johanna I. Kiiski, Sofia Khan, Mika Nurmikolu, Maija Suvanto, Niina Aho, Tiina Tasmuth, Eija Kalso, Johanna Schleutker, Anne Kallioniemi, Päivi Heikkilä, FinnGen, Kristiina Aittomäki, Carl Blomqvist, Heli Nevanlinna

Sci Rep. 2023; 13: 21127. Published online 2023 Nov 30. doi: 10.1038/s41598-023-47441-w

PMCID:: PMC10689455

Abstract Article PDF–1.1M

Select item 86827923.

Caught in motion: human NTHL1 undergoes interdomain rearrangement necessary for catalysis

Brittany L Carroll, Karl E Zahn, John P Hanley, Susan S Wallace, Julie A Dragon, Sylvie Doublié

Nucleic Acids Res. 2021 Dec 16; 49(22): 13165–13178. Published online 2021 Dec 6. doi: 10.1093/nar/gkab1162

PMCID:: PMC8682792

Abstract Article PDF–3.5M

Select item 78996964.

Monoallelic NTHL1 Loss-of-Function Variants and Risk of Polyposis and Colorectal Cancer

Fadwa A. Elsayed, Judith E. Grolleman, Abiramy Ragunathan, NTHL1 study group, Daniel D. Buchanan, Tom van Wezel, Richarda M. de Voer

Gastroenterology. Author manuscript; available in PMC 2021 Feb 22.

Published in final edited form as: Gastroenterology. 2020 Dec; 159(6): 2241–2243.e6. Published online 2020 Aug 26. doi: 10.1053/j.gastro.2020.08.042

PMCID:: PMC7899696

Article PDF–466K

Select item 77480675.

NTHL1 in Genomic Integrity, Aging and Cancer

Lipsa Das, Victoria G. Quintana, Joann B. Sweasy

DNA Repair (Amst) Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: DNA Repair (Amst). 2020 Sep; 93: 102920. doi: 10.1016/j.dnarep.2020.102920

PMCID:: PMC7748067

Abstract Article PDF–1.3M

Select item 76673756.

Evaluating the role of NTHL1 p.Q90* allele in inherited breast cancer predisposition

Timo Kumpula, Anna Tervasmäki, Tuomo Mantere, Susanna Koivuluoma, Laura Huilaja, Kaisa Tasanen, Robert Winqvist, Richarda M. de Voer, Katri Pylkäs

Mol Genet Genomic Med. 2020 Nov; 8(11): e1493. Published online 2020 Sep 19. doi: 10.1002/mgg3.1493

PMCID:: PMC7667375

Abstract Article PDF–274K

Select item 71801347.

An Excimer Clamp for Measuring Damaged Base Excision by the DNA Repair Enzyme NTH1

Yong Woong Jun, David L. Wilson, Anna M. Kietrys, Elizabeth R. Lotsof, Savannah G. Conlon, Sheila S. David, Eric T. Kool

Angew Chem Int Ed Engl. Author manuscript; available in PMC 2021 May 4.

Published in final edited form as: Angew Chem Int Ed Engl. 2020 May 4; 59(19): 7450–7455. Published online 2020 Mar 17. doi: 10.1002/anie.202001516

PMCID:: PMC7180134

Abstract Article PDF–980K

Select item 65886108.

NTHL1 biallelic mutations seldom cause colorectal cancer, serrated polyposis or a multi-tumor phenotype, in absence of colorectal adenomas

Sami Belhadj, Isabel Quintana, Pilar Mur, Pau M. Munoz-Torres, M. Henar Alonso, Matilde Navarro, Mariona Terradas, Virginia Piñol, Joan Brunet, Victor Moreno, Conxi Lázaro, Gabriel Capellá, Laura Valle

Sci Rep. 2019; 9: 9020. Published online 2019 Jun 21. doi: 10.1038/s41598-019-45281-1

PMCID:: PMC6588610

Abstract Article PDF–1.1M

Select item 55695759.

Human cells contain a factor that facilitates the DNA glycosylase-mediated excision of oxidized bases from occluded sites in nucleosomes

R.L. Maher, C.G. Marsden, A.M. Averill, S.S. Wallace, D.S. Pederson, J.B. Sweasy

DNA Repair (Amst) Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: DNA Repair (Amst). 2017 Sep; 57: 91–97. Published online 2017 Jul 5. doi: 10.1016/j.dnarep.2017.06.029

PMCID:: PMC5569575

Abstract Article PDF–552K

Select item 216940710.

Initiation of Base Excision Repair of Oxidative Lesions in Nucleosomes by the Human, Bifunctional DNA Glycosylase NTH1

Amalthiya Prasad, Susan S. Wallace, David S. Pederson

Mol Cell Biol. 2007 Dec; 27(24): 8442–8453. Published online 2007 Oct 8. doi: 10.1128/MCB.00791-07

PMCID:: PMC2169407

Abstract Article PDF–520K

Select item 13708411.

Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein

Izumi Miyabe, Qiu-Mei Zhang, Katsuhito Kino, Hiroshi Sugiyama, Masashi Takao, Akira Yasui, Shuji Yonei

Nucleic Acids Res. 2002 Aug 1; 30(15): 3443–3448. doi: 10.1093/nar/gkf460

PMCID:: PMC137084

Abstract Article PDF–151K

Select item 3725812.

Escherichia coli Nth and human hNTH1 DNA glycosylases are involved in removal of 8-oxoguanine from 8-oxoguanine/guanine mispairs in DNA

Yukiko Matsumoto, Qiu-Mei Zhang, Masashi Takao, Akira Yasui, Shuji Yonei

Nucleic Acids Res. 2001 May 1; 29(9): 1975–1981. doi: 10.1093/nar/29.9.1975

PMCID:: PMC37258

Abstract Article PDF–247K

Select item 1115951213.

The human endonuclease III enzyme is a relevant target to potentiate cisplatin cytotoxicity in Y‐box‐binding protein‐1 overexpressing tumor cells

David Guay, Chantal Garand, Shanti Reddy, Chris Schmutte, Michel Lebel

Cancer Sci. 2008 Apr; 99(4): 762–769. Published online 2008 Feb 27. doi: 10.1111/j.1349-7006.2008.00739.x

PMCID:: PMC11159512

Abstract Article PDF–347K

Select item 823207214.

Prevalence and Characterization of Biallelic and Monoallelic NTHL1 and MSH3 Variant Carriers From a Pan-Cancer Patient Population

Erin E. Salo-Mullen, Anna Maio, Semanti Mukherjee, Chaitanya Bandlamudi, Jinru Shia, Yelena Kemel, Karen A. Cadoo, Ying Liu, Maria Carlo, Megha Ranganathan, Sarah Kane, Preethi Srinivasan, Shweta S. Chavan, Mark T. A. Donoghue, Caitlin Bourque, Margaret Sheehan, Prince Rainier Tejada, Zalak Patel, Angela G. Arnold, Jennifer A. Kennedy, Kimberly Amoroso, Kelsey Breen, Amanda Catchings, Rosalba Sacca, Vanessa Marcell, Arnold J. Markowitz, Alicia Latham, Michael Walsh, Maksym Misyura, Ozge Ceyhan-Birsoy, David B. Solit, Michael F. Berger, Mark E. Robson, Barry S. Taylor, Kenneth Offit, Diana Mandelker, Zsofia K. Stadler

JCO Precis Oncol. 2021; 5: PO.20.00443. Published online 2021 Feb 26. doi: 10.1200/PO.20.00443

PMCID:: PMC8232072

Abstract Article PDF–541K

Select item 645110515.

The lyase activity of bifunctional DNA glycosylases and the 3′-diesterase activity of APE1 contribute to the repair of oxidized bases in nucleosomes

Robyn L Maher, Susan S Wallace, David S Pederson

Nucleic Acids Res. 2019 Apr 8; 47(6): 2922–2931. Published online 2019 Jan 16. doi: 10.1093/nar/gky1315

PMCID:: PMC6451105

Abstract Article PDF–2.8M

Select item 597443216.

NTH1 Is a New Target for Ubiquitylation-Dependent Regulation by TRIM26 Required for the Cellular Response to Oxidative Stress

Sarah C. Williams, Jason L. Parsons

Mol Cell Biol. 2018 Jun 15; 38(12): e00616-17. Prepublished online 2018 Apr 2. Published online 2018 May 29. doi: 10.1128/MCB.00616-17

PMCID:: PMC5974432

Abstract Article PDF–1.9M

Select item 596118517.

Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer

Kristin L Limpose, Kelly S Trego, Zhentian Li, Sara W Leung, Altaf H Sarker, Jason A Shah, Suresh S Ramalingam, Erica M Werner, William S Dynan, Priscilla K Cooper, Anita H Corbett, Paul W Doetsch

Nucleic Acids Res. 2018 May 18; 46(9): 4515–4532. Published online 2018 Mar 7. doi: 10.1093/nar/gky162

PMCID:: PMC5961185

Abstract Article PDF–6.4M

Select item 586072418.

Validation of Recently Proposed Colorectal Cancer Susceptibility Gene Variants in an Analysis of Families and Patients—a Systematic Review

Peter Broderick, Sara E Dobbins, Daniel Chubb, Ben Kinnersley, Malcolm G Dunlop, Ian Tomlinson, Richard S Houlston

Gastroenterology. Author manuscript; available in PMC 2018 Mar 20.

Published in final edited form as: Gastroenterology. 2017 Jan; 152(1): 75–77.e4. Published online 2016 Oct 3. doi: 10.1053/j.gastro.2016.09.041

PMCID:: PMC5860724

Abstract Article PDF–274K

Select item 542131719.

Probing the Activity of NTHL1 Orthologs by Targeting Conserved Amino Acid Residues

Susan M. Robey-Bond, Meredith A. Benson, Ramiro Barrantes-Reynolds, Jeffrey P. Bond, Susan S. Wallace

DNA Repair (Amst) Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: DNA Repair (Amst). 2017 May; 53: 43–51. Published online 2017 Mar 6. doi: 10.1016/j.dnarep.2017.02.014

PMCID:: PMC5421317

Abstract Article PDF–919K

Select item 14827620.

Nucleotide excision repair 3' endonuclease XPG stimulates the activity of base excision repairenzyme thymine glycol DNA glycosylase.

T Bessho

Nucleic Acids Res. 1999 Feb 15; 27(4): 979–983. doi: 10.1093/nar/27.4.979

PMCID:: PMC148276

Summary PDF–106K

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