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Items: 1 to 20 of 95

1.
The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation
Yael Aylon, Anat Gershoni, Ron Rotkopf, Inbal E. Biton, Ziv Porat, Anna P. Koh, Xiaochen Sun, Youngmin Lee, Maria-Isabel Fiel, Yujin Hoshida, Scott L. Friedman, Randy L. Johnson, Moshe Oren
Genes Dev. 2016 Apr 1; 30(7): 786–797. doi: 10.1101/gad.274167.115
PMCID:
PMC4826395
AbstractArticlePDF–1.2M
2.
Lats2 is critical for the pluripotency and proper differentiation of stem cells
Y Aylon, A Sarver, A Tovy, E Ainbinder, M Oren
Cell Death Differ. 2014 Apr; 21(4): 624–633. Published online 2014 Jan 10. doi: 10.1038/cdd.2013.188
PMCID:
PMC3950325
AbstractArticlePDF–2.6M
3.
Lats2 Modulates Adipocyte Proliferation and Differentiation via Hippo Signaling
Yang An, Qianqian Kang, Yaofeng Zhao, Xiaoxiang Hu, Ning Li
PLoS One. 2013; 8(8): e72042. Published online 2013 Aug 16. doi: 10.1371/journal.pone.0072042
PMCID:
PMC3745423
AbstractArticlePDF–8.3M
4.
Dual Transforming Activities of the FUS (TLS)-ERG Leukemia Fusion Protein Conferred by Two N-Terminal Domains of FUS (TLS)
Hitoshi Ichikawa, Kimiko Shimizu, Rieko Katsu, Misao Ohki
Mol Cell Biol. 1999 Nov; 19(11): 7639–7650. doi: 10.1128/mcb.19.11.7639
PMCID:
PMC84797
AbstractArticlePDF–1.7M
5.
Proximal Tubular Lats2 Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53
Chi Zhang, Zhihuang Zheng, Kexin Xu, Guozhe Cheng, Huijuan Wu, Jun Liu
Int J Mol Sci. 2023 Oct; 24(20): 15258. Published online 2023 Oct 17. doi: 10.3390/ijms242015258
PMCID:
PMC10607662
AbstractArticlePDF–22M
6.
Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload
Dan Shao, Peiyong Zhai, Chengchen Hu, Risa Mukai, Sebastiano Sciarretta, Dominic Del Re, Junichi Sadoshima
Sci Rep. 2021; 11: 23469. Published online 2021 Dec 6. doi: 10.1038/s41598-021-02846-3
PMCID:
PMC8648781
AbstractArticlePDF–7.1M
7.
Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma
Phoebe Carter, Ulrike Schnell, Christopher Chaney, Betty Tong, Xinchao Pan, Jianhua Ye, Glenda Mernaugh, Jennifer L. Cotton, Vitaly Margulis, Junhao Mao, Roy Zent, Bret M. Evers, Payal Kapur, Thomas J. Carroll
J Clin Invest. 2021 Jun 1; 131(11): e144108. Published online 2021 Jun 1. doi: 10.1172/JCI144108
PMCID:
PMC8159698
AbstractArticlePDF–49M
8.
A single copy of large tumor suppressor 1 or large tumor suppressor 2 is sufficient for normal hematopoiesis
Zhi-Gang Li, Xue-Mei Fu, Cheng-Yan Chai, Fang-Fang Sun, Fei-Fei Xiao, Yong-Xiu Huang, Kai Yao, Jie-Ping Chen, Yu Hou
Chin Med J (Engl) 2020 Aug 20; 133(16): 1943–1951. Published online 2020 Aug 20. doi: 10.1097/CM9.0000000000000934
PMCID:
PMC7462215
AbstractArticlePDF–1.4M
9.
MicroRNA-93 promotes angiogenesis and attenuates remodeling via inactivation of the Hippo/Yap pathway by targeting Lats2 after myocardial infarction
Chengjie Ma, Peipei Peng, Yan Zhou, Tianya Liu, Lijuan Wang, Chen Lu
Mol Med Rep. 2020 Jul; 22(1): 483–493. Published online 2020 Apr 21. doi: 10.3892/mmr.2020.11085
PMCID:
PMC7248469
AbstractArticlePDF–1.5M
10.
LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
Wenjian Gan, Xiaoming Dai, Xiangpeng Dai, Jun Xie, Shasha Yin, Junjie Zhu, Chen Wang, Yuchen Liu, Jianping Guo, Min Wang, Jing Liu, Jia Hu, Ryan J. Quinton, Neil J. Ganem, Pengda Liu, John M. Asara, Pier Paolo Pandolfi, Yingzi Yang, Zhigang He, Guangping Gao, Wenyi Wei
Nat Cell Biol. Author manuscript; available in PMC 2020 Aug 3.
Published in final edited form as: Nat Cell Biol. 2020 Feb; 22(2): 246–256. Published online 2020 Feb 3. doi: 10.1038/s41556-020-0463-6
PMCID:
PMC7076906
AbstractArticlePDF–7.0M
11.
The Hippo Kinase LATS2 Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Intestinal Metaplasia in Gastric Mucosa
Silvia Elena Molina-Castro, Camille Tiffon, Julie Giraud, Hélène Boeuf, Elodie Sifre, Alban Giese, Geneviève Belleannée, Philippe Lehours, Emilie Bessède, Francis Mégraud, Pierre Dubus, Cathy Staedel, Christine Varon
Cell Mol Gastroenterol Hepatol. 2020; 9(2): 257–276. Published online 2019 Oct 24. doi: 10.1016/j.jcmgh.2019.10.007
PMCID:
PMC6957828
AbstractArticlePDF–5.3M
12.
Lats1 and Lats2 are required for ovarian granulosa cell fate maintenance
Mayra Tsoi, Martin Morin, Charlène Rico, Randy L. Johnson, Marilène Paquet, Nicolas Gévry, Derek Boerboom
FASEB J. 2019 Oct; 33(10): 10819–10832. Published online 2019 Jul 3. doi: 10.1096/fj.201900609R
PMCID:
PMC6766663
AbstractArticle
13.
A Functional Interaction between Hippo-YAP Signaling and FoxO1 Mediates the Oxidative Stress Response
Dan Shao, Peiyong Zhai, Dominic P. Del Re, Sebastiano Sciarretta, Norikazu Yabuta, Hiroshi Nojima, Dae-Sik Lim, Duojia Pan, Junichi Sadoshima
Nat Commun. Author manuscript; available in PMC 2014 Aug 15.
Published in final edited form as: Nat Commun. 2014; 5: 3315. doi: 10.1038/ncomms4315
PMCID:
PMC3962829
AbstractArticlePDF–1.7M
14.
Lats2 is a negative regulator of myocyte size in the heart
Yutaka Matsui, Noritsugu Nakano, Dan Shao, Shumin Gao, Wenting Luo, Chull Hong, Peiyong Zhai, Eric Holle, Xianzhong Yu, Norikazu Yabuta, Wufan Tao, Thomas Wagner, Hiroshi Nojima, Junichi Sadoshima
Circ Res. Author manuscript; available in PMC 2009 Nov 21.
Published in final edited form as: Circ Res. 2008 Nov 21; 103(11): 1309–1318. Published online 2008 Oct 16. doi: 10.1161/CIRCRESAHA.108.180042
Correction in:
volume 104 on page e27
PMCID:
PMC2775813
AbstractArticlePDF–1.3M
15.
Lats2 deficiency protects the heart against myocardial infarction by reducing inflammation and inhibiting mitochondrial fission and STING/p65 signaling
Libao Liu, Shuai Huang, Yingzhen Du, Hao Zhou, Kai Zhang, Jinyuan He
Int J Biol Sci. 2023; 19(11): 3428–3440. Published online 2023 Jul 3. doi: 10.7150/ijbs.84426
PMCID:
PMC10367568
AbstractArticlePDF–7.2M
16.
Inactivation of the Hippo tumor suppressor pathway promotes melanoma
Marc A. Vittoria, Nathan Kingston, Kristyna Kotynkova, Eric Xia, Rui Hong, Lee Huang, Shayna McDonald, Andrew Tilston-Lunel, Revati Darp, Joshua D. Campbell, Deborah Lang, Xiaowei Xu, Craig J. Ceol, Xaralabos Varelas, Neil J. Ganem
Nat Commun. 2022; 13: 3732. Published online 2022 Jun 29. doi: 10.1038/s41467-022-31399-w
PMCID:
PMC9243107
AbstractArticlePDF–7.2M
17.
The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis
Ting Yuan, Karthika Annamalai, Shruti Naik, Blaz Lupse, Shirin Geravandi, Anasua Pal, Aleksandra Dobrowolski, Jaee Ghawali, Marina Ruhlandt, Kanaka Durga Devi Gorrepati, Zahra Azizi, Dae-Sik Lim, Kathrin Maedler, Amin Ardestani
Nat Commun. 2021; 12: 4928. Published online 2021 Aug 13. doi: 10.1038/s41467-021-25145-x
PMCID:
PMC8363615
AbstractArticlePDF–7.0M
18.
MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2
Xia Chen, Ai-li Wang, Yuan-yuan Liu, Chen-xi Zhao, Xue Zhou, Hai-long Liu, Mo-bin Lin
Oxid Med Cell Longev. 2020; 2020: 5316276. Published online 2020 Dec 19. doi: 10.1155/2020/5316276
PMCID:
PMC7769676
AbstractArticlePDF–2.7M
19.
LATS2 Positively Regulates Polycomb Repressive Complex 2
Kosuke Torigata, Okuzaki Daisuke, Satomi Mukai, Akira Hatanaka, Fumiharu Ohka, Daisuke Motooka, Shota Nakamura, Yasuyuki Ohkawa, Norikazu Yabuta, Yutaka Kondo, Hiroshi Nojima
PLoS One. 2016; 11(7): e0158562. Published online 2016 Jul 19. doi: 10.1371/journal.pone.0158562
PMCID:
PMC4951031
AbstractArticlePDF–5.4M
20.
Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis
Xiaolin He, Monica F. Tolosa, Tianzhou Zhang, Santosh Kumar Goru, Luisa Ulloa Severino, Paraish S. Misra, Caitríona M. McEvoy, Lauren Caldwell, Stephen G. Szeto, Feng Gao, Xiaolan Chen, Cassandra Atin, Victoria Ki, Noah Vukosa, Catherine Hu, Johnny Zhang, Christopher Yip, Adriana Krizova, Jeffrey L. Wrana, Darren A. Yuen
JCI Insight. 2022 Feb 22; 7(4): e146243. Published online 2022 Feb 22. doi: 10.1172/jci.insight.146243
PMCID:
PMC8876427
AbstractArticlePDF–28M

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