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Select item 84561251.

Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the Human Pancreas

Hyo Jeong Yong, Gengqiang Xie, Chengyang Liu, Wei Wang, Ali Naji, Jerome Irianto, Yue J. Wang

Front Endocrinol (Lausanne) 2021; 12: 736286. Published online 2021 Sep 8. doi: 10.3389/fendo.2021.736286

PMCID:: PMC8456125

Abstract Article PDF–4.6M

Select item 83879192.

Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network

Valérie Schreiber, Reuben Mercier, Sara Jiménez, Tao Ye, Emmanuel García-Sánchez, Annabelle Klein, Aline Meunier, Sabitri Ghimire, Catherine Birck, Bernard Jost, Kristian Honnens de Lichtenberg, Christian Honoré, Palle Serup, Gérard Gradwohl

Mol Metab. 2021 Nov; 53: 101313. Published online 2021 Aug 3. doi: 10.1016/j.molmet.2021.101313

PMCID:: PMC8387919

Abstract Article PDF–4.4M

Select item 70828403.

A comprehensive structure-function study of Neurogenin3 disease causing alleles during human pancreas and intestinal organoid development.

Xinghao Zhang, Patrick S. McGrath, Joseph Salomone, Mohamed Rahal, Heather A. McCauley, Jamie Schweitzer, Rhett Kovall, Brian Gebelein, James Wells

Dev Cell. Author manuscript; available in PMC 2020 Aug 5.

Published in final edited form as: Dev Cell. 2019 Aug 5; 50(3): 367–380.e7. Published online 2019 Jun 6. doi: 10.1016/j.devcel.2019.05.017

PMCID:: PMC7082840

Abstract Article PDF–2.6M

Select item 45459474.

Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate

Danielle L. Gomez, Marci O’Driscoll, Timothy P. Sheets, Ralph H. Hruban, Jose Oberholzer, James J. McGarrigle, Michael J. Shamblott

PLoS One. 2015; 10(8): e0133862. Published online 2015 Aug 19. doi: 10.1371/journal.pone.0133862

PMCID:: PMC4545947

Abstract Article PDF–9.8M

Select item 44773515.

The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas

Patrick S. McGrath, Carey L. Watson, Cameron Ingram, Michael A. Helmrath, James M. Wells

Diabetes. 2015 Jul; 64(7): 2497–2505. Published online 2015 Jan 29. doi: 10.2337/db14-1412

PMCID:: PMC4477351

Abstract Article PDF–2.6M

Select item 41810416.

Neurogenin 3 is important but not essential for pancreatic islet development in humans

Oscar Rubio-Cabezas, Ethel Codner, Sarah E. Flanagan, José L. Gómez, Sian Ellard, Andrew T. Hattersley

Diabetologia. 2014; 57(11): 2421–2424. Published online 2014 Aug 14. doi: 10.1007/s00125-014-3349-y

PMCID:: PMC4181041

Article PDF–100K

Select item 39737097.

Prospectively Isolated NGN3-Expressing Progenitors From Human Embryonic Stem Cells Give Rise to Pancreatic Endocrine Cells

Qing Cai, Paola Bonfanti, Rangarajan Sambathkumar, Kim Vanuytsel, Jolien Vanhove, Conny Gysemans, Maria Debiec-Rychter, Susanna Raitano, Harry Heimberg, Laura Ordovas, Catherine M. Verfaillie

Stem Cells Transl Med. 2014 Apr; 3(4): 489–499. Published online 2014 Feb 3. doi: 10.5966/sctm.2013-0078

PMCID:: PMC3973709

Abstract Article PDF–2.5M

Select item 33513938.

Plasticity of Adult Human Pancreatic Duct Cells by Neurogenin3-Mediated Reprogramming

Nathalie Swales, Geert A. Martens, Stefan Bonné, Yves Heremans, Rehannah Borup, Mark Van de Casteele, Zhidong Ling, Daniel Pipeleers, Philippe Ravassard, Finn Nielsen, Jorge Ferrer, Harry Heimberg

PLoS One. 2012; 7(5): e37055. Published online 2012 May 14. doi: 10.1371/journal.pone.0037055

PMCID:: PMC3351393

Abstract Article PDF–652K

Select item 30641099.

Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3

Oscar Rubio-Cabezas, Jan N. Jensen, Maria I. Hodgson, Ethel Codner, Sian Ellard, Palle Serup, Andrew T. Hattersley

Diabetes. 2011 Apr; 60(4): 1349–1353. Published online 2011 Mar 22. doi: 10.2337/db10-1008

PMCID:: PMC3064109

Abstract Article PDF–681K

Select item 703087310.

Null mutations of NEUROG3 are associated with delayed-onset diabetes mellitus

R. Sergio Solorzano-Vargas, Matthew Bjerknes, Jiafang Wang, S. Vincent Wu, Manuel G. Garcia-Careaga, Pisit Pitukcheewanont, Hazel Cheng, Michael S. German, Senta Georgia, Martín G. Martín

JCI Insight. 2020 Jan 16; 5(1): e127657. Published online 2020 Jan 16. doi: 10.1172/jci.insight.127657

PMCID:: PMC7030873

Abstract Article PDF–9.4M

Select item 510531211.

Adult human pancreas-derived cells expressing stage-specific embryonic antigen 4 differentiate into Sox9-expressing and Ngn3-expressing pancreatic ducts in vivo

Song Lee, Chan Mi Lee, Song Cheol Kim

Stem Cell Res Ther. 2016; 7: 162. Published online 2016 Nov 11. doi: 10.1186/s13287-016-0422-0

PMCID:: PMC5105312

Abstract Article PDF–3.0M

Select item 217304712.

Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3

Yves Heremans, Mark Van De Casteele, Peter in't Veld, Gerard Gradwohl, Palle Serup, Ole Madsen, Daniel Pipeleers, Harry Heimberg

J Cell Biol. 2002 Oct 28; 159(2): 303–312. doi: 10.1083/jcb.200203074

PMCID:: PMC2173047

Abstract Article PDF–521K

Select item 801582413.

Recognition of maturity‐onset diabetes of the young in China

Hua Liang, Yanan Zhang, Maixinyue Li, Jinhua Yan, Daizhi Yang, Sihui Luo, Xueying Zheng, Guoqing Yang, Zhuo Li, Wen Xu, Leif Groop, Jianping Weng

J Diabetes Investig. 2021 Apr; 12(4): 501–509. Published online 2020 Sep 9. doi: 10.1111/jdi.13378

PMCID:: PMC8015824

Abstract Article PDF–281K

Select item 679130714.

The cellular regulators PTEN and BMI1 help mediate NEUROGENIN-3–induced cell cycle arrest

R. Sergio Solorzano-Vargas, Matthew Bjerknes, S. Vincent Wu, Jiafang Wang, Matthias Stelzner, James C. Y. Dunn, Sangeeta Dhawan, Hazel Cheng, Senta Georgia, Martín G. Martín

J Biol Chem. 2019 Oct 11; 294(41): 15182–15192. Published online 2019 Jul 24. doi: 10.1074/jbc.RA119.008926

PMCID:: PMC6791307

Abstract Article PDF–3.2M

Select item 566746715.

PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration

Yaxi Zhu, Qian Liu, Zhiguang Zhou, Yasuhiro Ikeda

Stem Cell Res Ther. 2017; 8: 240. Published online 2017 Nov 2. doi: 10.1186/s13287-017-0694-z

PMCID:: PMC5667467

Abstract Article PDF–565K

Select item 483849116.

Proinflammatory cytokines induce endocrine differentiation in pancreatic ductal cells via STAT3-dependent NGN3 activation

Ivan Achel Valdez, Ercument Dirice, Manoj K. Gupta, Jun Shirakawa, Adrian Kee Keong Teo, Rohit N. Kulkarni

Cell Rep. Author manuscript; available in PMC 2016 Apr 20.

Published in final edited form as: Cell Rep. 2016 Apr 19; 15(3): 460–470. Published online 2016 Apr 7. doi: 10.1016/j.celrep.2016.03.036

PMCID:: PMC4838491

Abstract Article PDF–1.2M

Select item 295117917.

In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets

Karen Piper Hanley, Tom Hearn, Andrew Berry, Melanie J Carvell, Ann-Marie Patch, Louise J Williams, Sarah A Sugden, David I Wilson, Sian Ellard, Neil A Hanley

J Endocrinol. 2010 Nov; 207(2): 151–161. Prepublished online 2010 Aug 31. doi: 10.1677/JOE-10-0120

PMCID:: PMC2951179

Abstract Article PDF–482K

Select item 551731518.

Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors

Nicole A.J. Krentz, Dennis van Hoof, Zhongmei Li, Akie Watanabe, Mei Tang, Cuilan Nian, Michael S. German, Francis C. Lynn

Dev Cell. Author manuscript; available in PMC 2018 Apr 24.

Published in final edited form as: Dev Cell. 2017 Apr 24; 41(2): 129–142.e6. doi: 10.1016/j.devcel.2017.02.006

PMCID:: PMC5517315

Abstract Article PDF–990K

Select item 354796019.

Association Study of 25 Type 2 Diabetes Related Loci with Measures of Obesity in Indian Sib Pairs

Vipin Gupta, Donipadi Guru Vinay, Ulla Sovio, Sajjad Rafiq, Madamchetty Venkata Kranthi Kumar, Charles Spurgeon Janipalli, David Evans, Kulathu Radha Mani, Madana Narasimha Sandeep, Amy Taylor, Sanjay Kinra, Ruth Sullivan, Liza Bowen, Nicholas Timpson, George Davey Smith, Frank Dudbridge, Dorairaj Prabhakaran, Yoav Ben-Shlomo, Kolli Srinath Reddy, Shah Ebrahim, Giriraj Ratan Chandak, the Indian Migration Study Group

PLoS One. 2013; 8(1): e53944. Published online 2013 Jan 17. doi: 10.1371/journal.pone.0053944

PMCID:: PMC3547960

Abstract Article PDF–188K

Select item 542525120.

Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation

Roberta Azzarelli, Christopher Hurley, Magdalena K. Sznurkowska, Steffen Rulands, Laura Hardwick, Ivonne Gamper, Fahad Ali, Laura McCracken, Christopher Hindley, Fiona McDuff, Sonia Nestorowa, Richard Kemp, Kenneth Jones, Berthold Göttgens, Meritxell Huch, Gerard Evan, Benjamin D. Simons, Douglas Winton, Anna Philpott

Dev Cell. 2017 May 8; 41(3): 274–286.e5. doi: 10.1016/j.devcel.2017.04.004

PMCID:: PMC5425251

Abstract Article PDF–3.5M

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