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Select item 112039201.

Mitochondrial DNA Instability Supersedes Parkin Mutations in Driving Mitochondrial Proteomic Alterations and Functional Deficits in Polg Mutator Mice

Andrew J. Trease, Steven Totusek, Eliezer Z. Lichter, Kelly L. Stauch, Howard S. Fox

Int J Mol Sci. 2024 Jun; 25(12): 6441. Published online 2024 Jun 11. doi: 10.3390/ijms25126441

PMCID:: PMC11203920

Abstract Article PDF–4.4M

Select item 103491112.

Longitudinal in vivo metabolic labeling reveals tissue-specific mitochondrial proteome turnover rates and proteins selectively altered by parkin deficiency

K. L. Stauch, S. Totusek, A. J. Trease, L. D. Estrella, K. Emanuel, A. Fangmeier, H. S. Fox

Sci Rep. 2023; 13: 11414. Published online 2023 Jul 14. doi: 10.1038/s41598-023-38484-0

PMCID:: PMC10349111

Abstract Article PDF–5.7M

Select item 99937033.

Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity

Eun-Young Kim, Ji-Eun Kim, Young-Eun Kim, Bongkun Choi, Dong Hyun Sohn, Si-On Park, Yeon-Ho Chung, Yongsub Kim, William H. Robinson, Yong-Gil Kim, Eun-Ju Chang

Cell Biosci. 2023; 13: 48. Published online 2023 Mar 7. doi: 10.1186/s13578-023-00973-0

PMCID:: PMC9993703

Abstract Article PDF–10M

Select item 96876994.

Parkin Inhibits RANKL-Induced Osteoclastogenesis and Ovariectomy-Induced Bone Loss

Weiduo Hou, Mo Chen, Chenyi Ye, Erman Chen, Weixu Li, Wei Zhang

Biomolecules. 2022 Nov; 12(11): 1602. Published online 2022 Oct 31. doi: 10.3390/biom12111602

PMCID:: PMC9687699

Abstract Article PDF–5.1M

Select item 94368245.

Parkin Insufficiency Accentuates High-Fat Diet–Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca²⁺ Overload

Ne N. Wu, Yaguang Bi, Amir Ajoolabady, Fei You, James Sowers, Qiurong Wang, Asli F. Ceylan, Yingmei Zhang, Jun Ren

JACC Basic Transl Sci. 2022 Aug; 7(8): 779–796. Published online 2022 Aug 22. doi: 10.1016/j.jacbts.2022.03.007

Correction in:: JACC Basic Transl Sci. 2022 Oct; 7(10): 1066–1067.

PMCID:: PMC9436824

Abstract Article PDF–6.8M

Select item 93073096.

Lysosomal ceramides regulate cathepsin B-mediated processing of saposin C and glucocerebrosidase activity

Myung Jong Kim, Hyunkyung Jeong, Dimitri Krainc

Hum Mol Genet. 2022 Jul 15; 31(14): 2424–2437. Published online 2022 Feb 19. doi: 10.1093/hmg/ddac047

PMCID:: PMC9307309

Abstract Article PDF–1.7M

Select item 92496117.

Prkn knockout mice show autistic-like behaviors and aberrant synapse formation

Yuda Huo, Wen Lu, Yuan Tian, Qingming Hou, Heng-Ye Man

iScience. 2022 Jul 15; 25(7): 104573. Published online 2022 Jun 10. doi: 10.1016/j.isci.2022.104573

PMCID:: PMC9249611

Abstract Article PDF–5.1M

Select item 91396218.

Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons

Aurore Tourville, David Akbar, Olga Corti, Jochen H. M. Prehn, Ronald Melki, Stéphane Hunot, Patrick P. Michel

Cells. 2022 May; 11(10): 1640. Published online 2022 May 13. doi: 10.3390/cells11101640

PMCID:: PMC9139621

Abstract Article PDF–3.2M

Select item 88989039.

Evaluation of Parkin in the Regulation of Myocardial Mitochondria-Associated Membranes and Cardiomyopathy During Endotoxemia

Matthew Kim, Azadeh Nikouee, Yuxiao Sun, Qing-Jun Zhang, Zhi-Ping Liu, Qun Sophia Zang

Front Cell Dev Biol. 2022; 10: 796061. Published online 2022 Feb 21. doi: 10.3389/fcell.2022.796061

PMCID:: PMC8898903

Abstract Article PDF–4.0M

Select item 858141410.

Therapeutic potential of parkin as a tumor suppressor via transcriptional control of cyclins in glioblastoma cell and animal models

Lila Rouland, Eric Duplan, Lígia Ramos dos Santos, Aurore Bernardin, Karen S. Katula, Guidalberto Manfioletti, Ahmed Idbaih, Frédéric Checler, Cristine Alves da Costa

Theranostics. 2021; 11(20): 10047–10063. Published online 2021 Nov 1. doi: 10.7150/thno.57549

PMCID:: PMC8581414

Abstract Article PDF–2.1M

Select item 852599611.

Alternative mitochondrial quality control mediated by extracellular release

Chi-Jing Choong, Tatsusada Okuno, Kensuke Ikenaka, Kousuke Baba, Hideki Hayakawa, Masato Koike, Mutsumi Yokota, Junko Doi, Keita Kakuda, Toshihide Takeuchi, Akiko Kuma, Shuhei Nakamura, Yoshitaka Nagai, Seiichi Nagano, Tamotsu Yoshimori, Hideki Mochizuki

Autophagy. 2021; 17(10): 2962–2974. Published online 2020 Dec 10. doi: 10.1080/15548627.2020.1848130

PMCID:: PMC8525996

Abstract Article PDF–3.0M

Select item 819603812.

AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections

Nathaniel B. Bone, Eugene J. Becker, Jr., Maroof Husain, Shaoning Jiang, Anna A. Zmijewska, Dae-Won Park, Balu Chacko, Victor Darley-Usmar, Murielle Grégoire, Jean-Marc Tadie, Victor J. Thannickal, Jaroslaw W. Zmijewski

Sci Rep. 2021; 11: 12387. Published online 2021 Jun 11. doi: 10.1038/s41598-021-90573-0

PMCID:: PMC8196038

Abstract Article PDF–3.5M

Select item 766254813.

Loss of Parkin Results in Altered Muscle Stem Cell Differentiation during Regeneration

Marcos V. Esteca, Matheus B. Severino, João G. Silvestre, Gustavo Palmeira dos Santos, Letícia Tamborlin, Augusto D. Luchessi, Anselmo S. Moriscot, Åsa B. Gustafsson, Igor L. Baptista

Int J Mol Sci. 2020 Nov; 21(21): 8007. Published online 2020 Oct 28. doi: 10.3390/ijms21218007

PMCID:: PMC7662548

Abstract Article PDF–30M

Select item 746156114.

Parkin Coordinates Platelet Stress Response in Diabetes Mellitus: A Big Role in a Small Cell

Seung Hee Lee, Jing Du, John Hwa, Won-Ho Kim

Int J Mol Sci. 2020 Aug; 21(16): 5869. Published online 2020 Aug 15. doi: 10.3390/ijms21165869

PMCID:: PMC7461561

Abstract Article PDF–3.5M

Select item 734980715.

Parkin Overexpression Attenuates Sepsis-Induced Muscle Wasting

Jean-Philippe Leduc-Gaudet, Dominique Mayaki, Olivier Reynaud, Felipe E. Broering, Tomer J. Chaffer, Sabah N. A. Hussain, Gilles Gouspillou

Cells. 2020 Jun; 9(6): 1454. Published online 2020 Jun 11. doi: 10.3390/cells9061454

PMCID:: PMC7349807

Abstract Article PDF–3.0M

Select item 728428516.

Sustained mitochondrial biogenesis is essential to maintain caloric restriction-induced beige adipocytes

Raja Gopal Reddy Mooli, Dhanunjay Mukhi, Mikayla Watt, Lia Edmunds, Bingxian Xie, Joseph Capooci, Matthew Reslink, Chetachukwu Eze, Amanda Mills, Donna B. Stolz, Michael Jurczak, Sadeesh K. Ramakrishnan

Metabolism. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: Metabolism. 2020 Jun; 107: 154225. Published online 2020 Apr 7. doi: 10.1016/j.metabol.2020.154225

PMCID:: PMC7284285

Abstract Article PDF–1.7M

Select item 724457817.

Nuclear Parkin Activates the ERRα Transcriptional Program and Drives Widespread Changes in Gene Expression Following Hypoxia

Sarah E. Shires, Justin M. Quiles, Rita H. Najor, Leonardo J. Leon, Melissa Q. Cortez, Mark A. Lampert, Adam Mark, Åsa B. Gustafsson

Sci Rep. 2020; 10: 8499. Published online 2020 May 22. doi: 10.1038/s41598-020-65438-7

PMCID:: PMC7244578

Abstract Article PDF–7.5M

Select item 723741718.

Intermittent Use of a Short-Course Glucagon-like Peptide-1 Receptor Agonist Therapy Limits Adverse Cardiac Remodeling via Parkin-dependent Mitochondrial Turnover

Juliana de F. Germano, Chengqun Huang, Jon Sin, Yang Song, Kyle C. Tucker, David J. R. Taylor, Hannaneh Saadaeijahromi, Aleksandr Stotland, Honit Piplani, Roberta A. Gottlieb, Robert M. Mentzer, Jr., Allen M. Andres

Sci Rep. 2020; 10: 8284. Published online 2020 May 19. doi: 10.1038/s41598-020-64924-2

PMCID:: PMC7237417

Abstract Article PDF–6.6M

Select item 690273519.

Mitophagy protects against statin-mediated skeletal muscle toxicity

Mridula Ramesh, Juliane C. Campos, Pamela Lee, Yang Song, Genaro Hernandez, Jon Sin, Kyle C. Tucker, Hannaneh Saadaeijahromi, Michael Gurney, Julio C. B. Ferreira, Allen M. Andres

FASEB J. 2019 Nov; 33(11): 11857–11869. Published online 2019 Aug 23. doi: 10.1096/fj.201900807RR