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Select item 35099781.

Crystallization and preliminary X-ray crystallographic analysis of human Apaf-1-interacting protein

Wonchull Kang, Jin Kuk Yang

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1; 68(Pt 12): 1518–1520. Published online 2012 Nov 14. doi: 10.1107/S1744309112042832

PMCID:: PMC3509978

Abstract Article PDF–252K

Select item 38908072.

Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme

Wonchull Kang, Se Hoon Hong, Hye Min Lee, Na Yeon Kim, Yun Chan Lim, Le Thi My Le, Bitna Lim, Hyun Chul Kim, Tae Yeon Kim, Hiroki Ashida, Akiho Yokota, Sang Soo Hah, Keun Ho Chun, Yong-Keun Jung, Jin Kuk Yang

Proc Natl Acad Sci U S A. 2014 Jan 7; 111(1): E54–E61. Published online 2013 Dec 23. doi: 10.1073/pnas.1308768111

PMCID:: PMC3890807

Abstract Article PDF–1.8M

Select item 35320613.

Functional Identification of APIP as Human mtnB, a Key Enzyme in the Methionine Salvage Pathway

Camille Mary, Paula Duek, Lisa Salleron, Petra Tienz, Dirk Bumann, Amos Bairoch, Lydie Lane

PLoS One. 2012; 7(12): e52877. Published online 2012 Dec 28. doi: 10.1371/journal.pone.0052877

PMCID:: PMC3532061

Abstract Article PDF–3.4M

Select item 66029294.

Cardioprotective role of APIP in myocardial infarction through ADORA2B

Bitna Lim, Kwangmin Jung, Youngdae Gwon, Jae Gyun Oh, Jae-il Roh, Se-Hoon Hong, Changwon Kho, Woo-Jin Park, Han-Woong Lee, Jang-Whan Bae, Yong-Keun Jung

Cell Death Dis. 2019 Jul; 10(7): 511. Published online 2019 Jul 1. doi: 10.1038/s41419-019-1746-3

PMCID:: PMC6602929

Abstract Article PDF–2.0M

Select item 34351715.

Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death

Dennis C. Ko, Eric R. Gamazon, Kajal P. Shukla, Richard A. Pfuetzner, Dale Whittington, Tarah D. Holden, Mitchell J. Brittnacher, Christine Fong, Matthew Radey, Cassandra Ogohara, Amy L. Stark, Joshua M. Akey, M. Eileen Dolan, Mark M. Wurfel, Samuel I. Miller

Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35): E2343–E2352. Published online 2012 Jul 25. doi: 10.1073/pnas.1206701109

PMCID:: PMC3435171

Abstract Article PDF–1.4M

Select item 50083096.

APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis

Se-Hoon Hong, Won Jae Lee, Young Doo Kim, Hyunjoo Kim, Young-Jun Jeon, Bitna Lim, Dong-Hyung Cho, Won Do Heo, Doo-Hyun Yang, Chan-Young Kim, Han-Kwang Yang, Jin Kuk Yang, Yong-Keun Jung

Oncotarget. 2016 Apr 19; 7(16): 21601–21617. Published online 2016 Mar 1. doi: 10.18632/oncotarget.7802

PMCID:: PMC5008309

Abstract Article PDF–11M

Select item 32964867.

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

Fred A. Wright, Lisa J. Strug, Vishal K. Doshi, Clayton W. Commander, Scott M. Blackman, Lei Sun, Yves Berthiaume, David Cutler, Andreea Cojocaru, J. Michael Collaco, Mary Corey, Ruslan Dorfman, Katrina Goddard, Deanna Green, Jack W. Kent, Jr, Ethan M. Lange, Seunggeun Lee, Weili Li, Jingchun Luo, Gregory M. Mayhew, Kathleen M. Naughton, Rhonda G. Pace, Peter Paré, Johanna M. Rommens, Andrew Sandford, Jaclyn R. Stonebraker, Wei Sun, Chelsea Taylor, Lori L. Vanscoy, Fei Zou, John Blangero, Julian Zielenski, Wanda K. O’Neal, Mitchell L. Drumm, Peter R. Durie, Michael R. Knowles, Garry R. Cutting

Nat Genet. Author manuscript; available in PMC 2012 Mar 7.

Published in final edited form as: Nat Genet. 2011 Jun; 43(6): 539–546. Published online 2011 May 22. doi: 10.1038/ng.838

PMCID:: PMC3296486

Abstract Article PDF–1.1M

Select item 36224418.

Genome-Wide Association Analysis of Blood Biomarkers in Chronic Obstructive Pulmonary Disease

Deog Kyeom Kim, Michael H. Cho, Craig P. Hersh, David A. Lomas, Bruce E. Miller, Xiangyang Kong, Per Bakke, Amund Gulsvik, Alvar Agustí, Emiel Wouters, Bartolome Celli, Harvey Coxson, Jørgen Vestbo, William MacNee, Julie C. Yates, Stephen Rennard, Augusto Litonjua, Weiliang Qiu, Terri H. Beaty, James D. Crapo, John H. Riley, Ruth Tal-Singer, Edwin K. Silverman

Am J Respir Crit Care Med. 2012 Dec 15; 186(12): 1238–1247. Published online 2012 Dec 15. doi: 10.1164/rccm.201206-1013OC

PMCID:: PMC3622441

Abstract Article PDF–632K

Select item 3108769.

Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics

Chun-Hung Lai, Chang-Yuan Chou, Lan-Yang Ch'ang, Chung-Shyan Liu, Wen-chang Lin

Genome Res. 2000 May; 10(5): 703–713. doi: 10.1101/gr.10.5.703

PMCID:: PMC310876

Abstract Article PDF–1.2M

Select item 287256110.

An empirical framework for binary interactome mapping

Kavitha Venkatesan, Jean-François Rual, Alexei Vazquez, Ulrich Stelzl, Irma Lemmens, Tomoko Hirozane-Kishikawa, Tong Hao, Martina Zenkner, Xiaofeng Xin, Kwang-II Goh, Muhammed A Yildirim, Nicolas Simonis, Kathrin Heinzmann, Fana Gebreab, Julie M Sahalie, Sebiha Cevik, Christophe Simon, Anne-Sophie de Smet, Elizabeth Dann, Alex Smolyar, Arunachalam Vinayagam, Haiyuan Yu, David Szeto, Heather Borick, Amélie Dricot, Niels Klitgord, Ryan R Murray, Chenwei Lin, Maciej Lalowski, Jan Timm, Kirstin Rau, Charles Boone, Pascal Braun, Michael E Cusick, Frederick P Roth, David E Hill, Jan Tavernier, Erich E Wanker, Albert-László Barabási, Marc Vidal

Nat Methods. Author manuscript; available in PMC 2010 May 18.

Published in final edited form as: Nat Methods. 2009 Jan; 6(1): 83–90. Published online 2008 Dec 7. doi: 10.1038/nmeth.1280

PMCID:: PMC2872561

Abstract Article PDF–1.0M

Select item 631495711.

An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders

Siwei Chen, Robert Fragoza, Lambertus Klei, Yuan Liu, Jiebiao Wang, Kathryn Roeder, Bernie Devlin, Haiyuan Yu

Nat Genet. Author manuscript; available in PMC 2019 Jul 1.

Published in final edited form as: Nat Genet. 2018 Jul; 50(7): 1032–1040. Published online 2018 Jun 11. doi: 10.1038/s41588-018-0130-z

PMCID:: PMC6314957

Abstract Article PDF–1.3M

Select item 484875812.

An inter‐species protein–protein interaction network across vast evolutionary distance

Quan Zhong, Samuel J Pevzner, Tong Hao, Yang Wang, Roberto Mosca, Jörg Menche, Mikko Taipale, Murat Taşan, Changyu Fan, Xinping Yang, Patrick Haley, Ryan R Murray, Flora Mer, Fana Gebreab, Stanley Tam, Andrew MacWilliams, Amélie Dricot, Patrick Reichert, Balaji Santhanam, Lila Ghamsari, Michael A Calderwood, Thomas Rolland, Benoit Charloteaux, Susan Lindquist, Albert‐László Barabási, David E Hill, Patrick Aloy, Michael E Cusick, Yu Xia, Frederick P Roth, Marc Vidal

Mol Syst Biol. 2016 Apr; 12(4): 865. Published online 2016 Apr 23. doi: 10.15252/msb.20156484

PMCID:: PMC4848758

Abstract Article PDF–2.1M

Select item 51531613.

Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions

Yutaka Suzuki, Riu Yamashita, Matsuyuki Shirota, Yuta Sakakibara, Joe Chiba, Junko Mizushima-Sugano, Kenta Nakai, Sumio Sugano

Genome Res. 2004 Sep; 14(9): 1711–1718. doi: 10.1101/gr.2435604

PMCID:: PMC515316

Abstract Article PDF–181K

Select item 674264614.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 268304715.

Ubiquitin-mediated proteolysis of HuR by heat shock

Kotb Abdelmohsen, Subramanya Srikantan, Xiaoling Yang, Ashish Lal, Hyeon Ho Kim, Yuki Kuwano, Stefanie Galban, Kevin G Becker, Davida Kamara, Rafael de Cabo, Myriam Gorospe

EMBO J. 2009 May 6; 28(9): 1271–1282. Published online 2009 Mar 26. doi: 10.1038/emboj.2009.67

PMCID:: PMC2683047

Abstract Article PDF–1.4M

Select item 464794116.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

Abstract Article

Select item 910523517.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 503652718.

Panorama of ancient metazoan macromolecular complexes

Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Berzginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, Brent Derry, Elisabeth Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili

Nature. Author manuscript; available in PMC 2016 Sep 26.

Published in final edited form as: Nature. 2015 Sep 17; 525(7569): 339–344. Published online 2015 Sep 7. doi: 10.1038/nature14877

PMCID:: PMC5036527

Abstract Article PDF–4.7M

Select item 426658819.

A proteome-scale map of the human interactome network

Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal

Cell. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050

PMCID:: PMC4266588

Abstract Article PDF–3.1M

Select item 135612920.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

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