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Select item 87454121.

Specific Mutations in Aph1 Cause γ-Secretase Activation

Hikari Watanabe, Chika Yoshida, Masafumi Hidaka, Tomohisa Ogawa, Taisuke Tomita, Eugene Futai

Int J Mol Sci. 2022 Jan; 23(1): 507. Published online 2022 Jan 3. doi: 10.3390/ijms23010507

PMCID:: PMC8745412

Abstract Article PDF–3.4M

Select item 27135492.

APH1 Polar Transmembrane Residues Regulate the Assembly and Activity of Presenilin Complexes

Raphaëlle Pardossi-Piquard, Seung-Pil Yang, Soshi Kanemoto, Yongjun Gu, Fusheng Chen, Christopher Böhm, Jean Sevalle, Tong Li, Philip C. Wong, Frédéric Checler, Gerold Schmitt-Ulms, Peter St. George-Hyslop, Paul E. Fraser

J Biol Chem. 2009 Jun 12; 284(24): 16298–16307. Published online 2009 Apr 15. doi: 10.1074/jbc.M109.000067

PMCID:: PMC2713549

Abstract Article PDF–1.7M

Select item 32598633.

Chemical Cross-linking Provides a Model of the γ-Secretase Complex Subunit Architecture and Evidence for Close Proximity of the C-terminal Fragment of Presenilin with APH-1

Harald Steiner, Edith Winkler, Christian Haass

J Biol Chem. 2008 Dec 12; 283(50): 34677–34686. doi: 10.1074/jbc.M709067200

PMCID:: PMC3259863

Abstract Article PDF–777K

Select item 29990094.

Reduced Alzheimer's Disease β-Amyloid Deposition in Transgenic Mice Expressing S-Palmitoylation-Deficient APH1aL and Nicastrin

Xavier Meckler, Jelita Roseman, Pritam Das, Haipeng Cheng, Susan Pei, Marcia Keat, Breanne Kassarjian, Todd E. Golde, Angèle T. Parent, Gopal Thinakaran

J Neurosci. 2010 Dec 1; 30(48): 16160–16169. doi: 10.1523/JNEUROSCI.4436-10.2010

PMCID:: PMC2999009

Abstract Article PDF–3.8M

Select item 49334505.

Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments

Xavier Meckler, Frédéric Checler

J Biol Chem. 2016 Jun 10; 291(24): 12821–12837. Published online 2016 Apr 8. doi: 10.1074/jbc.M115.708297

PMCID:: PMC4933450

Abstract Article PDF–6.0M

Select item 44347076.

Structural basis of human γ-secretase assembly

Linfeng Sun, Lingyun Zhao, Guanghui Yang, Chuangye Yan, Rui Zhou, Xiaoyuan Zhou, Tian Xie, Yanyu Zhao, Shenjie Wu, Xueming Li, Yigong Shi

Proc Natl Acad Sci U S A. 2015 May 12; 112(19): 6003–6008. Published online 2015 Apr 27. doi: 10.1073/pnas.1506242112

PMCID:: PMC4434707

Abstract Article PDF–1.8M

Select item 63205387.

Bax inhibitor 1 is a γ-secretase–independent presenilin-binding protein

Shenjie Wu, Wenqi Song, Catherine C. L. Wong, Yigong Shi

Proc Natl Acad Sci U S A. 2019 Jan 2; 116(1): 141–147. Published online 2018 Dec 17. doi: 10.1073/pnas.1810870116

PMCID:: PMC6320538

Abstract Article PDF–1.8M

Select item 28652928.

Human CRB2 Inhibits γ-Secretase Cleavage of Amyloid Precursor Protein by Binding to the Presenilin Complex

Yachiyo Mitsuishi, Hiroshi Hasegawa, Akinori Matsuo, Wataru Araki, Toshiharu Suzuki, Shinji Tagami, Masayasu Okochi, Masatoshi Takeda, Ronald Roepman, Masaki Nishimura

J Biol Chem. 2010 May 14; 285(20): 14920–14931. Published online 2010 Mar 18. doi: 10.1074/jbc.M109.038760

PMCID:: PMC2865292

Abstract Article PDF–2.0M

Select item 26155049.

S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1

Haipeng Cheng, Kulandaivelu S. Vetrivel, Renaldo C. Drisdel, Xavier Meckler, Ping Gong, Jae Yoon Leem, Tong Li, Meghan Carter, Ying Chen, Phuong Nguyen, Takeshi Iwatsubo, Taisuke Tomita, Philip C. Wong, William N. Green, Maria Z. Kounnas, Gopal Thinakaran

J Biol Chem. 2009 Jan 16; 284(3): 1373–1384. doi: 10.1074/jbc.M806380200

PMCID:: PMC2615504

Abstract Article PDF–1.5M

Select item 16445510.

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

W. Taylor Kimberly, Matthew J. LaVoie, Beth L. Ostaszewski, Wenjuan Ye, Michael S. Wolfe, Dennis J. Selkoe

Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6382–6387. Published online 2003 May 9. doi: 10.1073/pnas.1037392100

PMCID:: PMC164455

Abstract Article PDF–316K

Select item 413432311.

Three-dimensional structure of human γ-secretase

Peilong Lu, Xiao-chen Bai, Dan Ma, Tian Xie, Chuangye Yan, Linfeng Sun, Guanghui Yang, Yanyu Zhao, Rui Zhou, Sjors H.W. Scheres, Yigong Shi

Nature. Author manuscript; available in PMC 2015 Feb 14.

Published in final edited form as: Nature. 2014 Aug 14; 512(7513): 166–170. Published online 2014 Jun 29. doi: 10.1038/nature13567

PMCID:: PMC4134323

Abstract Article PDF–2.6M

Select item 324797712.

Comparison of Presenilin 1 and Presenilin 2 γ-Secretase Activities Using a Yeast Reconstitution System

Yoji Yonemura, Eugene Futai, Sosuke Yagishita, Satoshi Suo, Taisuke Tomita, Takeshi Iwatsubo, Shoichi Ishiura

J Biol Chem. 2011 Dec 30; 286(52): 44569–44575. Published online 2011 Nov 10. doi: 10.1074/jbc.M111.270108

PMCID:: PMC3247977

Abstract Article PDF–1.0M

Select item 285701613.

Aph-1 Associates Directly with Full-length and C-terminal Fragments of γ-Secretase Substrates

Allen C. Chen, Lucie Y. Guo, Beth L. Ostaszewski, Dennis J. Selkoe, Matthew J. LaVoie

J Biol Chem. 2010 Apr 9; 285(15): 11378–11391. Published online 2010 Feb 9. doi: 10.1074/jbc.M109.088815

PMCID:: PMC2857016

Abstract Article PDF–4.3M

Select item 255596114.

Tumor Necrosis Factor-α–elicited Stimulation of γ-Secretase Is Mediated by c-Jun N-terminal Kinase-dependent Phosphorylation of Presenilin and Nicastrin

Lan-Hsin Kuo, Ming-Kuan Hu, Wen-Ming Hsu, Ying-Tsen Tung, Bo-Jeng Wang, Wang-Wei Tsai, Chen-Tung Yen, Yung-Feng Liao

Mol Biol Cell. 2008 Oct; 19(10): 4201–4212. doi: 10.1091/mbc.E07-09-0987

PMCID:: PMC2555961

Abstract Article PDF–1.1M

Select item 456830615.

An atomic structure of human γ-secretase

Xiao-chen Bai, Chuangye Yan, Guanghui Yang, Peilong Lu, Dan Ma, Linfeng Sun, Rui Zhou, Sjors H.W. Scheres, Yigong Shi

Nature. Author manuscript; available in PMC 2016 Mar 10.

Published in final edited form as: Nature. 2015 Sep 10; 525(7568): 212–217. Published online 2015 Aug 17. doi: 10.1038/nature14892

PMCID:: PMC4568306

Abstract Article PDF–6.7M

Select item 120150616.

Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes

Kulandaivelu S. Vetrivel, Haipeng Cheng, William Lin, Takashi Sakurai, Tong Li, Nobuyuki Nukina, Philip C. Wong, Huaxi Xu, Gopal Thinakaran

J Biol Chem. Author manuscript; available in PMC 2005 Sep 13.

Published in final edited form as: J Biol Chem. 2004 Oct 22; 279(43): 44945–44954. Published online 2004 Aug 17. doi: 10.1074/jbc.M407986200

PMCID:: PMC1201506

Abstract Article PDF–784K

Select item 674121817.

Proteolytic Processing of the p75 Neurotrophin Receptor and Two Homologs Generates C-Terminal Fragments with Signaling Capability

Kevin C. Kanning, Mark Hudson, Paul S. Amieux, Jesse C. Wiley, Mark Bothwell, Leslayann C. Schecterson

J Neurosci. 2003 Jul 2; 23(13): 5425–5436. doi: 10.1523/JNEUROSCI.23-13-05425.2003

PMCID:: PMC6741218

Abstract Article PDF–745K

Select item 51492418.

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists

Christof Haffner, Mélanie Frauli, Stephanie Topp, Martin Irmler, Kay Hofmann, Jörg T Regula, Laure Bally-Cuif, Christian Haass

EMBO J. 2004 Aug 4; 23(15): 3041–3050. Published online 2004 Jul 15. doi: 10.1038/sj.emboj.7600307

PMCID:: PMC514924

Abstract Article PDF–445K

Select item 541523519.

The Identification of Novel Proteins That Interact With the GLP-1 Receptor and Restrain its Activity

X. Huang, F. F. Dai, G. Gaisano, K. Giglou, J. Han, M. Zhang, S. Kittanakom, V. Wong, L. Wei, A. D. Showalter, K. W. Sloop, I. Stagljar, M. B. Wheeler

Mol Endocrinol. September 1, 2013; 27(9): 1550–1563. Published online 2013 Jul 17. doi: 10.1210/me.2013-1047

PMCID:: PMC5415235

Abstract Article

Select item 621963320.

ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas

Christopher G. Abraham, Michael P. Ludwig, Zdenek Andrysik, Ahwan Pandey, Molishree Joshi, Matthew D. Galbraith, Kelly D. Sullivan, Joaquin M. Espinosa

Cell Rep. Author manuscript; available in PMC 2018 Nov 6.

Published in final edited form as: Cell Rep. 2018 Sep 18; 24(12): 3224–3236. doi: 10.1016/j.celrep.2018.08.058