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Select item 103084511.

Crystal structure of the RNA lariat debranching enzyme Dbr1 with hydrolyzed phosphorothioate RNA product

Nathaniel E. Clark, Adam Katolik, Anastasia Welch, Christoph Schorl, Stephen P. Holloway, Jonathan P. Schuermann, P. John Hart, Alexander B. Taylor, Masad J. Damha, William G. Fairbrother

Biochemistry. Author manuscript; available in PMC 2023 Jun 29.

Published in final edited form as: Biochemistry. 2022 Dec 20; 61(24): 2933–2939. Published online 2022 Dec 9. doi: 10.1021/acs.biochem.2c00590

PMCID:: PMC10308451

Abstract Article PDF–1.4M

Select item 89020232.

The Role of DBR1 as a Candidate Prognosis Biomarker in Esophageal Squamous Cell Carcinoma

Xiaoqin Xu, Xin Yang, Xue Liu, Yanghui Bi, Pengzhou Kong, Yanqiang Wang, Xiaolong Cheng, Yanfeng Xi

Technol Cancer Res Treat. 2022; 21: 15330338221083105. Published online 2022 Mar 4. doi: 10.1177/15330338221083105

PMCID:: PMC8902023

Abstract Article PDF–1.7M

Select item 58863753.

Inborn errors of RNA lariat metabolism in humans with brainstem viral infection

Shen-Ying Zhang, Nathaniel E. Clark, Catherine A. Freije, Elodie Pauwels, Allison Taggart, Satoshi Okada, Hanna Mandel, Paula Garcia, Michael J. Ciancanelli, Anat Biran, Fabien G. Lafaille, Miyuki Tsumura, Aurélie Cobat, Jingchuan Luo, Stefano Volpi, Bastian Zimmer, Sonoko Sakata, Alexandra Dinis, Osamu Ohara, Eduardo J. Garcia Reino, Kerry Dobbs, Mary Hasek, Stephen P. Holloway, Karen McCammon, Stacy A. Hussong, Nicholas DeRosa, Candice E. Van Skike, Adam Katolik, Lazaro Lorenzo, Maki Hyodo, Emilia Faria, Rabih Halwani, Rie Fukuhara, Gregory A. Smith, Veronica Galvan, Masad J. Damha, Saleh Al-Muhsen, Yuval Itan, Jef D. Boeke, Luigi D. Notarangelo, Lorenz Studer, Masao Kobayashi, Luisa Diogo, William Fairbrother, Laurent Abel, Brad Rosenberg, John Hart, Amos Etzioni, Jean-Laurent Casanova

Cell. Author manuscript; available in PMC 2019 Feb 22.

Published in final edited form as: Cell. 2018 Feb 22; 172(5): 952–965.e18. doi: 10.1016/j.cell.2018.02.019

PMCID:: PMC5886375

Abstract Article PDF–1.9M

Select item 56867284.

Conformational Changes in the 5′ End of the HIV-1 Genome Dependent on the Debranching Enzyme DBR1 during Early Stages of Infection

Alvaro E. Galvis, Hugh E. Fisher, Hung Fan, David Camerini

J Virol. 2017 Dec 1; 91(23): e01377-17. Prepublished online 2017 Sep 20. Published online 2017 Nov 14. doi: 10.1128/JVI.01377-17

PMCID:: PMC5686728

Abstract Article PDF–905K

Select item 56086385.

Human DBR1 modulates the recycling of snRNPs to affect alternative RNA splicing and contributes to the suppression of cancer development

B Han, H K Park, T Ching, J Panneerselvam, H Wang, Y Shen, J Zhang, L Li, R Che, L Garmire, P Fei

Oncogene. 2017 Sep 21; 36(38): 5382–5391. Published online 2017 May 15. doi: 10.1038/onc.2017.150

PMCID:: PMC5608638

Abstract Article PDF–2.4M

Select item 40543836.

Impairment of HIV-1 cDNA Synthesis by DBR1 Knockdown

Alvaro E. Galvis, Hugh E. Fisher, Takayuki Nitta, Hung Fan, David Camerini

J Virol. 2014 Jun; 88(12): 7054–7069. doi: 10.1128/JVI.00704-14

PMCID:: PMC4054383

Abstract Article PDF–3.2M

Select item 12663997.

DBR1 siRNA inhibition of HIV-1 replication

Ying Ye, Jessica De Leon, Noriko Yokoyama, Yathi Naidu, David Camerini

Retrovirology. 2005; 2: 63. Published online 2005 Oct 18. doi: 10.1186/1742-4690-2-63

PMCID:: PMC1266399

Abstract Article PDF–359K

Select item 106308758.

Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation

Arjan F Theil, Alex Pines, Tuğba Kalayci, José M Heredia‐Genestar, Anja Raams, Marion H Rietveld, Sriram Sridharan, Sabine EJ Tanis, Klaas W Mulder, Nesimi Büyükbabani, Birsen Karaman, Zehra O Uyguner, Hülya Kayserili, Jan HJ Hoeijmakers, Hannes Lans, Jeroen AA Demmers, Joris Pothof, Umut Altunoglu, Abdoelwaheb El Ghalbzouri, Wim Vermeulen

EMBO Mol Med. 2023 Nov; 15(11): e17973. Published online 2023 Oct 6. doi: 10.15252/emmm.202317973

PMCID:: PMC10630875

Abstract Article PDF–3.9M

Select item 47261759.

In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity

Douglas E. V. Pires, Jing Chen, Tom L. Blundell, David B. Ascher

Sci Rep. 2016; 6: 19848. Published online 2016 Jan 22. doi: 10.1038/srep19848

PMCID:: PMC4726175

Abstract Article PDF–1.5M

Select item 434692110.

Identification of the Specific Interactors of the Human Lariat RNA Debranching Enzyme 1 Protein

So Masaki, Rei Yoshimoto, Daisuke Kaida, Asuka Hata, Takayuki Satoh, Mutsuhito Ohno, Naoyuki Kataoka

Int J Mol Sci. 2015 Feb; 16(2): 3705–3721. Published online 2015 Feb 9. doi: 10.3390/ijms16023705

PMCID:: PMC4346921

Abstract Article PDF–4.5M

Select item 11072011.

Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants

Jong-Wook Kim, Hyung-Cheol Kim, Gyoung-Mi Kim, Jun-Mo Yang, Jef D. Boeke, Kiebang Nam

Nucleic Acids Res. 2000 Sep 15; 28(18): 3666–3673. doi: 10.1093/nar/28.18.3666

PMCID:: PMC110720

Abstract Article PDF–679K

Select item 669962312.

The human regulatory protein Ki-1/57 is a target of SUMOylation and affects PML nuclear bodies formation

Ângela Saito, Edmarcia E. Souza, Fernanda C. Costa, Gabriela V. Meirelles, Kaliandra A. Gonçalves, Marcos T. Santos, Gustavo C. Bressan, Mark E. McComb, Catherine E. Costello, Stephen A. Whelan, Jörg Kobarg

J Proteome Res. Author manuscript; available in PMC 2019 Aug 19.

Published in final edited form as: J Proteome Res. 2017 Sep 1; 16(9): 3147–3157. Published online 2017 Jul 31. doi: 10.1021/acs.jproteome.7b00001

PMCID:: PMC6699623

Abstract Article PDF–1.0M

Select item 439027213.

Nicole St-Denis, Gagan D. Gupta, Zhen Yuan Lin, Beatriz Gonzalez-Badillo, Laurence Pelletier, Anne-Claude Gingras

Mol Cell Proteomics. 2015 Apr; 14(4): 946–960. Published online 2015 Feb 6. doi: 10.1074/mcp.M114.046086

PMCID:: PMC4390272

Abstract Article PDF–814K

Select item 794845214.

A conserved acetylation switch enables pharmacological control of tubby-like protein stability

Evan M. Kerek, Kevin H. Yoon, Shu Y. Luo, Jerry Chen, Robert Valencia, Olivier Julien, Andrew J. Waskiewicz, Basil P. Hubbard

J Biol Chem. 2021 Jan-Jun; 296: 100073. Published online 2020 Nov 23. doi: 10.1074/jbc.RA120.015839

PMCID:: PMC7948452

Abstract Article PDF–3.6M

Select item 921522715.

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication

Hainan Liu, Yu Bai, Xun Zhang, Ting Gao, Yue Liu, Entao Li, Xuefeng Wang, Zheng Cao, Lin Zhu, Qincai Dong, Yong Hu, Guangfei Wang, Caiwei Song, Xiayang Niu, Tong Zheng, Di Wang, Zijing Liu, Yanwen Jin, Ping Li, Xiuwu Bian, Cheng Cao, Xuan Liu

J Virol. 2022 Jun; 96(12): e00412-22. Published online 2022 Jun 2. doi: 10.1128/jvi.00412-22

PMCID:: PMC9215227

Abstract Article PDF–4.2M

Select item 403931016.

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms

Jiannong Li, Keiryn Bennett, Alexey Stukalov, Bin Fang, Guolin Zhang, Takeshi Yoshida, Isamu Okamoto, Jae-Young Kim, Lanxi Song, Yun Bai, Xiaoning Qian, Bhupendra Rawal, Michael Schell, Florian Grebien, Georg Winter, Uwe Rix, Steven Eschrich, Jacques Colinge, John Koomen, Giulio Superti-Furga, Eric B Haura

Mol Syst Biol. 2013; 9: 705. Published online 2013 Nov 5. doi: 10.1038/msb.2013.61

PMCID:: PMC4039310

Abstract Article PDF–3.2M

Select item 764586317.

N‐Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS‐CoV‐2 Main Protease

Tomas Koudelka, Juliane Boger, Alessandra Henkel, Robert Schönherr, Stefanie Krantz, Sabine Fuchs, Estefanía Rodríguez, Lars Redecke, Andreas Tholey

Proteomics. 2021 Jan; 21(2): 2000246. Published online 2020 Nov 17. doi: 10.1002/pmic.202000246

PMCID:: PMC7645863

Abstract Article PDF–497K

Select item 379029218.

Bcl2-associated Athanogene 3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity

Ying Chen, Li-Na Yang, Li Cheng, Shun Tu, Shu-Juan Guo, Huang-Ying Le, Qian Xiong, Ran Mo, Chong-Yang Li, Jun-Seop Jeong, Lizhi Jiang, Seth Blackshaw, Li-Jun Bi, Heng Zhu, Sheng-Ce Tao, Feng Ge

Mol Cell Proteomics. 2013 Oct; 12(10): 2804–2819. Published online 2013 Jul 3. doi: 10.1074/mcp.M112.025882

PMCID:: PMC3790292

Abstract Article PDF–2.6M

Select item 810809319.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary

Cell. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050

PMCID:: PMC8108093

Abstract Article PDF–3.5M

Select item 856452020.

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair

Maria Pilar Sanchez-Bailon, Soo-Youn Choi, Elizabeth R. Dufficy, Karan Sharma, Gavin S. McNee, Emma Gunnell, Kelly Chiang, Debashish Sahay, Sarah Maslen, Grant S. Stewart, J. Mark Skehel, Ingrid Dreveny, Clare C. Davies

Nat Commun. 2021; 12: 6313. Published online 2021 Nov 2. doi: 10.1038/s41467-021-26413-6

PMCID:: PMC8564520

Abstract Article PDF–2.3M

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