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Items: 1 to 20 of 130

1.
Inhibition of 3-phosphoinositide–dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts
Sugyun An, Si-Young Cho, Junsoo Kang, Soobeom Lee, Hyung-Su Kim, Dae-Jin Min, EuiDong Son, Kwang-Hyun Cho
Proc Natl Acad Sci U S A. 2020 Dec 8; 117(49): 31535–31546. Published online 2020 Nov 23. doi: 10.1073/pnas.1920338117
PMCID:
PMC7733858
AbstractArticlePDF–2.5M
2.
Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma
Oluwaseun Adebayo Bamodu, Hang-Lung Chang, Jiann-Ruey Ong, Wei-Hwa Lee, Chi-Tai Yeh, Jo-Ting Tsai
Cells. 2020 Mar; 9(3): 746. Published online 2020 Mar 18. doi: 10.3390/cells9030746
PMCID:
PMC7140693
AbstractArticlePDF–2.9M
3.
Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells
Dandan Li, John E. Mullinax, Taylor Aiken, Hongwu Xin, Gordon Wiegand, Andrew Anderson, Snorri Thorgeirsson, Itzhak Avital, Udo Rudloff
BMC Cancer. 2018; 18: 772. Published online 2018 Jul 31. doi: 10.1186/s12885-018-4690-1
PMCID:
PMC6069886
AbstractArticlePDF–2.1M
4.
Kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer
Valerie M. Jansen, Neil E. Bhola, Joshua A. Bauer, Luigi Formisano, Kyung-min Lee, Katherine E. Hutchinson, Agnieszka K. Witkiewicz, Preston D. Moore, Mónica Valéria Estrada, Violeta Sánchez, Paula G. Ericsson, Melinda E. Sanders, Paula R. Pohlmann, Michael J. Pishvaian, David A. Riddle, Teresa C. Dugger, Wenyi Wei, Erik S. Knudsen, Carlos L. Arteaga
Cancer Res. Author manuscript; available in PMC 2018 May 1.
Published in final edited form as: Cancer Res. 2017 May 1; 77(9): 2488–2499. Published online 2017 Mar 1. doi: 10.1158/0008-5472.CAN-16-2653
Correction in:
Cancer Res. 2019 Feb 15; 79(4): 874.
PMCID:
PMC5421398
AbstractArticlePDF–2.3M
5.
Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs
Jiancheng Zhou, Eun-Jin Yun, Wei Chen, Ye Ding, Kaijie Wu, Bin Wang, Chunyong Ding, Elizabeth Hernandez, John Santoyo, Rey-Chen Pong, Haiying Chen, Dalin He, Jia Zhou, Jer-Tsong Hsieh
Cell Death Dis. 2017 Mar; 8(3): e2701. Published online 2017 Mar 23. doi: 10.1038/cddis.2017.121
PMCID:
PMC5386527
AbstractArticlePDF–2.3M
6.
PKCθ-Mediated PDK1 Phosphorylation Enhances T Cell Activation by Increasing PDK1 Stability
Jung-Ah Kang, Hyunwoo Choi, Taewoo Yang, Steve K. Cho, Zee-Yong Park, Sung-Gyoo Park
Mol Cells. 2017 Jan 31; 40(1): 37–44. Published online 2017 Jan 26. doi: 10.14348/molcells.2017.2236
PMCID:
PMC5303887
AbstractArticlePDF–2.1M
7.
Prostaglandin E2 stimulates normal bronchial epithelial cell growth through induction of c-Jun and PDK1, a kinase implicated in oncogenesis
Yu Fan, Ye Wang, Ke Wang
Respir Res. 2015; 16: 149. Published online 2015 Dec 18. doi: 10.1186/s12931-015-0309-0
PMCID:
PMC4699375
AbstractArticlePDF–2.3M
8.
A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1
T. Justin Rettenmaier, Jack D. Sadowsky, Nathan D. Thomsen, Steven C. Chen, Allison K. Doak, Michelle R. Arkin, James A. Wells
Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52): 18590–18595. Published online 2014 Dec 17. doi: 10.1073/pnas.1415365112
PMCID:
PMC4284534
AbstractArticlePDF–1.3M
9.
The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts
Joanna Zabkiewicz, Lorna Pearn, Robert K. Hills, Rhys G. Morgan, Alex Tonks, Alan K. Burnett, Richard L. Darley
Haematologica. 2014 May; 99(5): 858–864. doi: 10.3324/haematol.2013.096487
PMCID:
PMC4008098
AbstractArticlePDF–1.5M
10.
Immunohistochemical analysis of PDK1 expression in breast cancer
Ruza Arsenic
Diagn Pathol. 2014; 9: 82. Published online 2014 Apr 16. doi: 10.1186/1746-1596-9-82
PMCID:
PMC4005628
AbstractArticlePDF–776K
11.
3-Phosphoinositide-Dependent Kinase 1 Controls Breast Tumor Growth in a Kinase-Dependent but Akt-Independent Manner
Paolo Armando Gagliardi, Laura di Blasio, Francesca Orso, Giorgio Seano, Roberto Sessa, Daniela Taverna, Federico Bussolino, Luca Primo
Neoplasia. 2012 Aug; 14(8): 719–731. doi: 10.1593/neo.12856
PMCID:
PMC3431179
AbstractArticlePDF–5.1M
12.
PDK1 in apical signaling endosomes participates in the rescue of the polarity complex atypical PKC by intermediate filaments in intestinal epithelia
Anastasia Mashukova, Radia Forteza, Flavia A. Wald, Pedro J. Salas
Mol Biol Cell. 2012 May 1; 23(9): 1664–1674. doi: 10.1091/mbc.E11-12-0988
PMCID:
PMC3338434
AbstractArticlePDF–2.0M
13.
Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITOR
Kumiko Nagashima, Stuart D. Shumway, Sriram Sathyanarayanan, Albert H. Chen, Brian Dolinski, Youyuan Xu, Heike Keilhack, Thi Nguyen, Maciej Wiznerowicz, Lixia Li, Bart A. Lutterbach, An Chi, Cloud Paweletz, Timothy Allison, Youwei Yan, Sanjeev K. Munshi, Anke Klippel, Manfred Kraus, Ekaterina V. Bobkova, Sujal Deshmukh, Zangwei Xu, Uwe Mueller, Alexander A. Szewczak, Bo-Sheng Pan, Victoria Richon, Roy Pollock, Peter Blume-Jensen, Alan Northrup, Jannik N. Andersen
J Biol Chem. 2011 Feb 25; 286(8): 6433–6448. Published online 2010 Nov 30. doi: 10.1074/jbc.M110.156463
PMCID:
PMC3057779
AbstractArticlePDF–6.7M
14.
Discovery of PDK1 Kinase Inhibitors with a Novel Mechanism of Action by Ultrahigh Throughput Screening
Ekaterina V. Bobkova, Michael J. Weber, Zangwei Xu, Yan-Ling Zhang, Joon Jung, Peter Blume-Jensen, Alan Northrup, Priya Kunapuli, Jannik N. Andersen, Ilona Kariv
J Biol Chem. 2010 Jun 11; 285(24): 18838–18846. Published online 2010 Apr 12. doi: 10.1074/jbc.M109.089946
PMCID:
PMC2881806
AbstractArticlePDF–2.2M
15.
PDK1 potentiates upstream lesions on the PI3K pathway in breast carcinoma
Matthew Maurer, Tao Su, Lao H. Saal, Susan Koujak, Benjamin D. Hopkins, Christina R. Barkley, Jiaping Wu, Subhadra Nandula, Bhaskar Dutta, Yuli Xie, Y. Rebecca Chin, Da-In Kim, Jennifer S. Ferris, Sofia K. Gruvberger-Saal, Mervi Laakso, Xiaomei Wang, Lorenzo Memeo, Albert Rojtman, Tulio Matos, Jennifer S. Yu, Carlos Cordon-Cardo, Jorma Isola, Mary Beth Terry, Alex Toker, Gordon B. Mills, Jean J. Zhao, Vundavalli V. V. S. Murty, Hanina Hibshoosh, Ramon Parsons
Cancer Res. Author manuscript; available in PMC 2010 Aug 1.
Published in final edited form as: Cancer Res. 2009 Aug 1; 69(15): 6299–6306. Published online 2009 Jul 14. doi: 10.1158/0008-5472.CAN-09-0820
PMCID:
PMC2727605
AbstractArticlePDF–1.9M
16.
Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer
H-J Lin, F-C Hsieh, H Song, J Lin
Br J Cancer. 2005 Dec 12; 93(12): 1372–1381. Published online 2005 Nov 15. doi: 10.1038/sj.bjc.6602862
PMCID:
PMC2361529
AbstractArticlePDF–242K
17.
PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound
L Cen, F-C Hsieh, H-J Lin, C-S Chen, S J Qualman, J Lin
Br J Cancer. 2007 Sep 11; 97(6): 785–791. Published online 2007 Sep 11. doi: 10.1038/sj.bjc.6603952
PMCID:
PMC2360380
AbstractArticlePDF–218K
18.
STEADY-STATE KINETIC MECHANISM OF PDK1
Xinxin Gao, Thomas K. Harris
J Biol Chem. Author manuscript; available in PMC 2006 Oct 3.
Published in final edited form as: J Biol Chem. 2006 Aug 4; 281(31): 21670–21681. Published online 2006 May 31. doi: 10.1074/jbc.M602448200
PMCID:
PMC1587617
AbstractArticlePDF–825K
19.
Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo.
A Casamayor, N A Morrice, D R Alessi
Biochem J. 1999 Sep 1; 342(Pt 2): 287–292.
PMCID:
PMC1220463
SummaryPDF–212K
20.
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.
R A Currie, K S Walker, A Gray, M Deak, A Casamayor, C P Downes, P Cohen, D R Alessi, J Lucocq
Biochem J. 1999 Feb 1; 337(Pt 3): 575–583.
PMCID:
PMC1220012
SummaryPDF–317K

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