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Select item 109679301.

The Binding of the SARS-CoV-2 Spike Protein to Platelet Factor 4: A Proposed Mechanism for the Generation of Pathogenic Antibodies

Thi-Huong Nguyen, Li-Yu Chen, Nida Zaman Khan, Annerose Lindenbauer, Van-Chien Bui, Peter F. Zipfel, Doris Heinrich

Biomolecules. 2024 Mar; 14(3): 245. Published online 2024 Feb 20. doi: 10.3390/biom14030245

PMCID:: PMC10967930

Abstract Article PDF–2.1M

Select item 99924502.

Platelet-instructed SPP1⁺ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner

Konrad Hoeft, Gideon J.L. Schaefer, Hyojin Kim, David Schumacher, Tore Bleckwehl, Qingqing Long, Barbara Mara Klinkhammer, Fabian Peisker, Lars Koch, James Nagai, Maurice Halder, Susanne Ziegler, Elisa Liehn, Christoph Kuppe, Jennifer Kranz, Sylvia Menzel, Ivan Costa, Adam Wahida, Peter Boor, Rebekka K. Schneider, Sikander Hayat, Rafael Kramann

Cell Rep. 2023 Feb 28; 42(2): 112131. Published online 2023 Feb 18. doi: 10.1016/j.celrep.2023.112131

PMCID:: PMC9992450

Abstract Article

Select item 98206493.

CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells

Immacolata Pietraforte, Alessia Butera, Lucia Gaddini, Anna Mennella, Raffaella Palazzo, Doriana Campanile, Katia Stefanantoni, Valeria Riccieri, Roberto Lande, Loredana Frasca

Int J Mol Sci. 2023 Jan; 24(1): 653. Published online 2022 Dec 30. doi: 10.3390/ijms24010653

PMCID:: PMC9820649

Abstract Article PDF–2.8M

Select item 82923984.

CD8⁺ T cells inhibit metastasis and CXCL4 regulates its function

Robiya Joseph, Rama Soundararajan, Suhas Vasaikar, Fei Yang, Kendra L. Allton, Lin Tian, Petra den Hollander, Sevinj Isgandarova, Monika Haemmerle, Barbara Mino, Tieling Zhou, Crystal Shin, Melisa Martinez-Paniagua, Aysegul A. Sahin, Jaime Rodriguez-Canales, Juri Gelovani, Jeffrey T. Chang, Ghanashyam Acharya, Anil K. Sood, Ignacio I. Wistuba, Don L. Gibbons, Luisa M. Solis, Michelle C. Barton, Navin Varadarajan, Jeffrey M. Rosen, Xiang H. Zhang, Sendurai A. Mani

Br J Cancer. 2021 Jul 20; 125(2): 176–189. Published online 2021 Apr 1. doi: 10.1038/s41416-021-01338-5

PMCID:: PMC8292398

Abstract Article PDF–4.1M

Select item 82395955.

The complicated relationships of heparin‐induced thrombocytopenia and platelet factor 4 antibodies with COVID‐19

Emmanuel J. Favaloro, Brandon Michael Henry, Giuseppe Lippi

Int J Lab Hematol. 2021 Aug; 43(4): 547–558. Published online 2021 May 17. doi: 10.1111/ijlh.13582

PMCID:: PMC8239595

Abstract Article PDF–1.0M

Select item 78788756.

Reduced CXCL4/PF4 expression as a driver of increased human hematopoietic stem and progenitor cell proliferation in polycythemia vera

Fabienne Meier-Abt, Witold E. Wolski, Ge Tan, Sandra Kummer, Sabine Amon, Markus G. Manz, Ruedi Aebersold, Alexandre P. A. Theocharides

Blood Cancer J. 2021 Feb; 11(2): 31. Published online 2021 Feb 11. doi: 10.1038/s41408-021-00423-5

PMCID:: PMC7878875

Article PDF–1.2M

Select item 77945277.

Platelet CXCL4 mediates neutrophil extracellular traps formation in ANCA-associated vasculitis

Kotaro Matsumoto, Hidekata Yasuoka, Keiko Yoshimoto, Katsuya Suzuki, Tsutomu Takeuchi

Sci Rep. 2021; 11: 222. Published online 2021 Jan 8. doi: 10.1038/s41598-020-80685-4

PMCID:: PMC7794527

Abstract Article PDF–4.5M

Select item 76780608.

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN

Hélène F. E. Gleitz, Aurélien J. F. Dugourd, Nils B. Leimkühler, Inge A. M. Snoeren, Stijn N. R. Fuchs, Sylvia Menzel, Susanne Ziegler, Nicolaus Kröger, Ioanna Triviai, Guntram Büsche, Hans Kreipe, Bella Banjanin, Jessica E. Pritchard, Remco Hoogenboezem, Eric M. Bindels, Neele Schumacher, Stefan Rose-John, Shannon Elf, Julio Saez-Rodriguez, Rafael Kramann, Rebekka K. Schneider

Blood. 2020 Oct 29; 136(18): 2051–2064. Prepublished online 2020 Jul 29. doi: 10.1182/blood.2019004095

PMCID:: PMC7678060

Abstract Article

Select item 75274159.

CXCL4 Links Inflammation and Fibrosis by Reprogramming Monocyte-Derived Dendritic Cells in vitro

Sandra C. Silva-Cardoso, Weiyang Tao, Chiara Angiolilli, Ana P. Lopes, Cornelis P. J. Bekker, Abhinandan Devaprasad, Barbara Giovannone, Jaap van Laar, Marta Cossu, Wioleta Marut, Erik Hack, Rob J. de Boer, Marianne Boes, Timothy R. D. J. Radstake, Aridaman Pandit

Front Immunol. 2020; 11: 2149. Published online 2020 Sep 17. doi: 10.3389/fimmu.2020.02149

PMCID:: PMC7527415

Abstract Article PDF–3.5M

Select item 740420810.

Anti-CXCL4 Antibody Reactivity Is Present in Systemic Sclerosis (SSc) and Correlates with the SSc Type I Interferon Signature

Roberto Lande, Anna Mennella, Raffaella Palazzo, Immacolata Pietraforte, Katia Stefanantoni, Nicoletta Iannace, Alessia Butera, Monica Boirivant, Roberta Pica, Curdin Conrad, Carlo Chizzolini, Valeria Riccieri, Loredana Frasca

Int J Mol Sci. 2020 Jul; 21(14): 5102. Published online 2020 Jul 19. doi: 10.3390/ijms21145102

PMCID:: PMC7404208

Abstract Article PDF–1.9M

Select item 649482311.

CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis

Roberto Lande, Ernest Y. Lee, Raffaella Palazzo, Barbara Marinari, Immacolata Pietraforte, Giancarlo Santiago Santos, Yves Mattenberger, Francesca Spadaro, Katia Stefanantoni, Nicoletta Iannace, Aleksandra Maria Dufour, Mario Falchi, Manuela Bianco, Elisabetta Botti, Luca Bianchi, Montserrat Alvarez, Valeria Riccieri, Marie-Elise Truchetet, Gerard C.L. Wong, Carlo Chizzolini, Loredana Frasca

Nat Commun. 2019; 10: 1731. Published online 2019 May 1. doi: 10.1038/s41467-019-09683-z

PMCID:: PMC6494823

Abstract Article PDF–3.6M

Select item 635462212.

Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses

Amrita Ojha, Angika Bhasym, Sriparna Mukherjee, Gowtham K. Annarapu, Teena Bhakuni, Irshad Akbar, Tulika Seth, Naval K. Vikram, Sudhanshu Vrati, Anirban Basu, Sankar Bhattacharyya, Prasenjit Guchhait

EBioMedicine. 2019 Jan; 39: 332–347. Published online 2018 Dec 5. doi: 10.1016/j.ebiom.2018.11.049

PMCID:: PMC6354622

Abstract Article PDF–4.5M

Select item 588817813.

CXCL4 is a novel inducer of human Th17 cells and correlates with IL‐17 and IL‐22 in psoriatic arthritis

Alsya J. Affandi, Sandra C. Silva‐Cardoso, Samuel Garcia, Emmerik F. A. Leijten, Tessa S. van Kempen, Wioleta Marut, Joel A. G. van Roon, Timothy R. D. J. Radstake

Eur J Immunol. 2018 Mar; 48(3): 522–531. Published online 2018 Jan 15. doi: 10.1002/eji.201747195

PMCID:: PMC5888178

Abstract Article PDF–2.2M

Select item 547076314.

Steroids Regulate CXCL4 in the Human Endometrium During Menstruation to Enable Efficient Endometrial Repair

Jacqueline A. Maybin, Uma Thiruchelvam, Mayank Madhra, Philippa T.K. Saunders, Hilary O.D. Critchley

J Clin Endocrinol Metab. 2017 Jun 1; 102(6): 1851–1860. Published online 2017 Feb 27. doi: 10.1210/jc.2016-3604

PMCID:: PMC5470763

Abstract Article

Select item 535449515.

Platelet Factor 4 Binds to Vascular Proteoglycans and Controls Both Growth Factor Activities and Platelet Activation

Megan S. Lord, Bill Cheng, Brooke L. Farrugia, Simon McCarthy, John M. Whitelock

J Biol Chem. 2017 Mar 10; 292(10): 4054–4063. Published online 2017 Jan 23. doi: 10.1074/jbc.M116.760660

PMCID:: PMC5354495

Abstract Article PDF–1.3M

Select item 462991116.

CXCL4 Plasma Levels Are Not Associated with the Extent of Coronary Artery Disease or with Coronary Plaque Morphology

Christian Erbel, Grigorios Korosoglou, Pearlyn Ler, Mohammadreza Akhavanpoor, Gabriele Domschke, Fabian Linden, Andreas O. Doesch, Sebastian J. Buss, Evangelos Giannitsis, Hugo A. Katus, Christian A. Gleissner

PLoS One. 2015; 10(11): e0141693. Published online 2015 Nov 2. doi: 10.1371/journal.pone.0141693

PMCID:: PMC4629911

Abstract Article PDF–319K

Select item 444162417.

Disruption of PF4/H multimolecular complex formation with a minimally anticoagulant heparin (ODSH)

Manali V. Joglekar, Pedro M. Quintana Diez, Stephen Marcus, Rui Qi, Benjamin Espinasse, Mark R. Wiesner, Elizabeth Pempe, Jian Liu, Dougald M. Monroe, Gowthami M. Arepally

Thromb Haemost. Author manuscript; available in PMC 2015 May 22.

Published in final edited form as: Thromb Haemost. 2012 Apr; 107(4): 717–725. Published online 2012 Feb 8. doi: 10.1160/TH11-11-0795

PMCID:: PMC4441624

Abstract Article PDF–1.0M

Select item 428182418.

Heparin-independent, PF4-dependent binding of HIT antibodies to platelets: implications for HIT pathogenesis

Anand Padmanabhan, Curtis G. Jones, Daniel W. Bougie, Brian R. Curtis, Janice G. McFarland, Demin Wang, Richard H. Aster

Blood. 2015 Jan 1; 125(1): 155–161. Prepublished online 2014 Oct 23. doi: 10.1182/blood-2014-06-580894

PMCID:: PMC4281824

Abstract Article

Select item 386400819.

Genetic Variants in Platelet Factor 4 Modulate Inflammatory and Platelet Activation Biomarkers

Pallav Bhatnagar, Xiaochun Lu, Michele K. Evans, Thomas A. LaVeist, Alan B. Zonderman, Darryl L. Carter, Dan E. Arking, Craig A. Fletcher

Circ Cardiovasc Genet. Author manuscript; available in PMC 2013 Dec 16.

Published in final edited form as: Circ Cardiovasc Genet. 2012 Aug 1; 5(4): 10.1161/CIRCGENETICS.111.961813. Published online 2012 Jul 4. doi: 10.1161/CIRCGENETICS.111.961813

PMCID:: PMC3864008

Abstract Article PDF–2.0M

Select item 382915520.

Distinct Specificity and Single-molecule Kinetics Characterize the Interaction of Pathogenic and Non-pathogenic Antibodies against Platelet Factor 4-Heparin Complexes with Platelet Factor 4

Rustem I. Litvinov, Serge V. Yarovoi, Lubica Rauova, Valeri Barsegov, Bruce S. Sachais, Ann H. Rux, Jillian L. Hinds, Gowthami M. Arepally, Douglas B. Cines, John W. Weisel

J Biol Chem. 2013 Nov 15; 288(46): 33060–33070. Published online 2013 Oct 4. doi: 10.1074/jbc.M113.481598

PMCID:: PMC3829155

Abstract Article PDF–478K

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