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Select item 91989221.

Genetic variants of PKLR are associated with acute pain in sickle cell disease

Xunde Wang, Kate Gardner, Mickias B. Tegegn, Clifton L. Dalgard, Camille Alba, Stephan Menzel, Hamel Patel, Mehdi Pirooznia, Yi-Ping Fu, Fayaz T. Seifuddin, Swee Lay Thein

Blood Adv. 2022 Jun 14; 6(11): 3535–3540. Published online 2022 Jun 13. doi: 10.1182/bloodadvances.2021006668

PMCID:: PMC9198922

Abstract Article PDF–859K

Select item 89905302.

Identification of biochemically neutral positions in liver pyruvate kinase

Tyler A. Martin, Tiffany Wu, Qingling Tang, Larissa L. Dougherty, Daniel J. Parente, Liskin Swint-Kruse, Aron W. Fenton

Proteins. Author manuscript; available in PMC 2022 Apr 8.

Published in final edited form as: Proteins. 2020 Oct; 88(10): 1340–1350. Published online 2020 Jun 27. doi: 10.1002/prot.25953

PMCID:: PMC8990530

Abstract Article PDF–1.0M

Select item 88489623.

A novel homozygous missense variant p.D339N in the PKLR gene correlates with pyruvate kinase deficiency in a Pakistani family: a case report

Atta Ur Rehman, Abdur Rashid, Zubair Hussain, Khadim Shah

J Med Case Rep. 2022; 16: 66. Published online 2022 Feb 16. doi: 10.1186/s13256-022-03292-z

PMCID:: PMC8848962

Abstract Article PDF–1.3M

Select item 83967694.

Putative pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations

Ohanna Cavalcanti de Lima Bezerra, Lucia Elena Alvarado-Arnez, Nédio Mabunda, Graça Salomé, Amina de Sousa, Fernanda de Souza Gomes Kehdy, Carolinne Sales-Marques, Fernanda Saloum de Neves Manta, Rafaela Mota Andrade, Laís Pereira Ferreira, Thyago Leal-Calvo, Cynthia Chester Cardoso, Kelly Nunes, Mateus H. Gouveia, Sam M. Mbulaiteve, Edward D. Yeboah, Ann Hsing, Ana Carla Pereira Latini, André Luiz Leturiondo, Fabíola da Costa Rodrigues, Ariani Batista Noronha, Cynthia de Oliveira Ferreira, Carolina Talhari, Jamile Leão Rêgo, Léa Cristina de Carvalho Castellucci, Eduardo Tarazona-Santos, Elizeu Fagundes de Carvalho, Diogo Meyer, Roberta Olmo Pinheiro, Ilesh V. Jani, Antonio Guilherme Pacheco, Milton Ozório Moraes

PLoS Negl Trop Dis. 2021 Aug; 15(8): e0009434. Published online 2021 Aug 27. doi: 10.1371/journal.pntd.0009434

PMCID:: PMC8396769

Abstract Article PDF–1.7M

Select item 55614505.

Whole-protein Alanine-scanning Mutagenesis of Allostery: a Large Percentage of a Protein Can Contribute to Mechanism

Qingling Tang, Aron W. Fenton

Hum Mutat. Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: Hum Mutat. 2017 Sep; 38(9): 1132–1143. Published online 2017 Jun 16. doi: 10.1002/humu.23231

PMCID:: PMC5561450

Abstract Article PDF–1.3M

Select item 52868436.

Distinguishing the interactions in the fructose-1,6-bisphosphate binding site of human liver pyruvate kinase that contribute to allostery

Arjun Ishwar, Qingling Tang, Aron W. Fenton

Biochemistry. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: Biochemistry. 2015 Feb 24; 54(7): 1516–1524. Published online 2015 Feb 12. doi: 10.1021/bi501426w

PMCID:: PMC5286843

Abstract Article PDF–3.2M

Select item 48798807.

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

Lei Lv, Dong Li, Di Zhao, Ruiting Lin, Yajing Chu, Heng Zhang, Zhengyu Zha, Ying Liu, Zi Li, Yanping Xu, Gang Wang, Yiran Huang, Yue Xiong, Kun-Liang Guan, Qun-Ying Lei

Mol Cell. Author manuscript; available in PMC 2016 May 25.

Published in final edited form as: Mol Cell. 2011 Jun 24; 42(6): 719–730. doi: 10.1016/j.molcel.2011.04.025

PMCID:: PMC4879880

Abstract Article PDF–670K

Select item 47311658.

PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis

Alexander Nguyen, Jia Min Loo, Rohit Mital, Ethan M. Weinberg, Fung Ying Man, Zhaoshi Zeng, Philip B. Paty, Leonard Saltz, Yelena Y. Janjigian, Elisa de Stanchina, Sohail F. Tavazoie

J Clin Invest. 2016 Feb 1; 126(2): 681–694. Published online 2016 Jan 19. doi: 10.1172/JCI83587

PMCID:: PMC4731165

Abstract Article PDF–4.2M

Select item 46778159.

Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population

Rebekah van Bruggen, Christian Gualtieri, Alexandra Iliescu, Chalisa Louicharoen Cheepsunthorn, Punchalee Mungkalasut, Jean-François Trape, David Modiano, Bienvenu Sodiomon Sirima, Pratap Singhasivanon, Mark Lathrop, Anavaj Sakuntabhai, Jean-François Bureau, Philippe Gros

PLoS One. 2015; 10(12): e0144555. Published online 2015 Dec 14. doi: 10.1371/journal.pone.0144555

PMCID:: PMC4677815

Abstract Article PDF–861K

Select item 347480710.

Pyruvate Kinase Deficiency in Sub-Saharan Africa: Identification of a Highly Frequent Missense Mutation (G829A;Glu277Lys) and Association with Malaria

Patrícia Machado, Licínio Manco, Cláudia Gomes, Cristina Mendes, Natércia Fernandes, Graça Salomé, Luis Sitoe, Sérgio Chibute, José Langa, Letícia Ribeiro, Juliana Miranda, Jorge Cano, João Pinto, António Amorim, Virgílio E. do Rosário, Ana Paula Arez

PLoS One. 2012; 7(10): e47071. Published online 2012 Oct 17. doi: 10.1371/journal.pone.0047071

PMCID:: PMC3474807

Abstract Article PDF–355K

Select item 271416611.

An activating interaction between the unphosphorylated N-terminus of human liver pyruvate kinase and the main body of the protein is interrupted by phosphorylation

Aron W Fenton, Qingling Tang

Biochemistry. Author manuscript; available in PMC 2010 May 12.

Published in final edited form as: Biochemistry. 2009 May 12; 48(18): 3816–3818. doi: 10.1021/bi900421f

PMCID:: PMC2714166

Abstract Article PDF–459K

Select item 29568312.

Molecular study of pyruvate kinase deficient patients with hereditary nonspherocytic hemolytic anemia.

L Baronciani, E Beutler

J Clin Invest. 1995 Apr; 95(4): 1702–1709. doi: 10.1172/JCI117846

PMCID:: PMC295683

Summary Page Browse PDF–1.3M

Select item 27986513.

Human liver type pyruvate kinase: complete amino acid sequence and the expression in mammalian cells.

K Tani, H Fujii, S Nagata, S Miwa

Proc Natl Acad Sci U S A. 1988 Mar; 85(6): 1792–1795. doi: 10.1073/pnas.85.6.1792

PMCID:: PMC279865

Summary Page Browse PDF–842K

Select item 5247814.

cDNA cloning of human R-type pyruvate kinase and identification of a single amino acid substitution (Thr384----Met) affecting enzymatic stability in a pyruvate kinase variant (PK Tokyo) associated with hereditary hemolytic anemia.

H Kanno, H Fujii, A Hirono, S Miwa

Proc Natl Acad Sci U S A. 1991 Sep 15; 88(18): 8218–8221. doi: 10.1073/pnas.88.18.8218

PMCID:: PMC52478

Summary Page Browse PDF–1.0M

Select item 4649915.

Analysis of pyruvate kinase-deficiency mutations that produce nonspherocytic hemolytic anemia.

L Baronciani, E Beutler

Proc Natl Acad Sci U S A. 1993 May 1; 90(9): 4324–4327. doi: 10.1073/pnas.90.9.4324

PMCID:: PMC46499

Summary Page Browse PDF–674K

Select item 942600216.

Haematological profile of malaria patients with G6PD and PKLR variants (erythrocytic enzymopathies): a cross-sectional study in Thailand

Punchalee Mungkalasut, Patcharakorn Kiatamornrak, Watcharapong Jugnam-Ang, Srivicha Krudsood, Poonlarp Cheepsunthorn, Chalisa Louicharoen Cheepsunthorn

Malar J. 2022; 21: 250. Published online 2022 Aug 30. doi: 10.1186/s12936-022-04267-7

PMCID:: PMC9426002

Abstract Article PDF–1.5M

Select item 893435217.

Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine differentiation of prostate cancer by ZBTB10 deficiency

Yu-Ching Wen, Wei-Yu Chen, Van Thi Ngoc Tram, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Wassim Abou-Kheir, Jiaoti Huang, Michael Hsiao, Yen-Nien Liu

Cell Death Dis. 2022 Mar; 13(3): 252. Published online 2022 Mar 19. doi: 10.1038/s41419-022-04694-z

PMCID:: PMC8934352

Abstract Article PDF–6.4M

Select item 837641918.

Rheostat functional outcomes occur when substitutions are introduced at nonconserved positions that diverge with speciation

Liskin Swint‐Kruse, Tyler A. Martin, Braelyn M. Page, Tiffany Wu, Paige M. Gerhart, Larissa L. Dougherty, Qingling Tang, Daniel J. Parente, Brian R. Mosier, Leonidas E. Bantis, Aron W. Fenton

Protein Sci. 2021 Sep; 30(9): 1833–1853. Published online 2021 Jun 11. doi: 10.1002/pro.4136

PMCID:: PMC8376419

Abstract Article PDF–4.8M

Select item 778824519.

Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner

Karthickeyan Chella Krishnan, Raquel R. Floyd, Simon Sabir, Dulshan W. Jayasekera, Paola V. Leon-Mimila, Anthony E. Jones, Angel A. Cortez, Varun Shravah, Miklós Péterfy, Linsey Stiles, Samuel Canizales-Quinteros, Ajit S. Divakaruni, Adriana Huertas-Vazquez, Aldons J. Lusis

Cell Mol Gastroenterol Hepatol. 2021; 11(2): 389–406. Published online 2020 Sep 14. doi: 10.1016/j.jcmgh.2020.09.004

PMCID:: PMC7788245

Abstract Article PDF–4.6M

Select item 708730820.

SARS-CoV nucleocapsid protein interacts with cellular pyruvate kinase protein and inhibits its activity

Wei-Yen Wei, Hui-Chun Li, Chiung-Yao Chen, Chee-Hing Yang, Shen-Kao Lee, Chia-Wen Wang, Hsin-Chieh Ma, Yue-Li Juang, Shih-Yen Lo

Arch Virol. 2012; 157(4): 635–645. Published online 2012 Jan 6. doi: 10.1007/s00705-011-1221-7

PMCID:: PMC7087308

Abstract Article PDF–549K

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