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Select item 106051891.

Exosc9 Initiates SUMO-Dependent lncRNA TERRA Degradation to Impact Telomeric Integrity in Endocrine Therapy Insensitive Hormone Receptor-Positive Breast Cancer

Maram Quttina, Kacie D. Waiters, Ashfia Fatima Khan, Samaneh Karami, Anthony S. Peidl, Mariam Funmi Babajide, Justus Pennington, Fatima A. Merchant, Tasneem Bawa-Khalfe

Cells. 2023 Oct; 12(20): 2495. Published online 2023 Oct 20. doi: 10.3390/cells12202495

PMCID:: PMC10605189

Abstract Article PDF–2.6M

Select item 72833152.

EXOSC9 depletion attenuates P-body formation, stress resistance, and tumorigenicity of cancer cells

Seiko Yoshino, Yusuke Matsui, Yuya Fukui, Masahide Seki, Kiyoshi Yamaguchi, Akane Kanamori, Yurika Saitoh, Teppei Shimamura, Yutaka Suzuki, Yoichi Furukawa, Shuichi Kaneko, Motoharu Seiki, Yoshinori Murakami, Jun-ichiro Inoue, Takeharu Sakamoto

Sci Rep. 2020; 10: 9275. Published online 2020 Jun 9. doi: 10.1038/s41598-020-66455-2

PMCID:: PMC7283315

Abstract Article PDF–10M

Select item 21908173.

Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex

J Exp Med. 1991 Apr 1; 173(4): 941–952. doi: 10.1084/jem.173.4.941

PMCID:: PMC2190817

Summary PDF–2.0M

Select item 59867334.

Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy

David T. Burns, Sandra Donkervoort, Juliane S. Müller, Ellen Knierim, Diana Bharucha-Goebel, Eissa Ali Faqeih, Stephanie K. Bell, Abdullah Y. AlFaifi, Dorota Monies, Francisca Millan, Kyle Retterer, Sarah Dyack, Sara MacKay, Susanne Morales-Gonzalez, Michele Giunta, Benjamin Munro, Gavin Hudson, Mena Scavina, Laura Baker, Tara C. Massini, Monkol Lek, Ying Hu, Daniel Ezzo, Fowzan S. AlKuraya, Peter B. Kang, Helen Griffin, A. Reghan Foley, Markus Schuelke, Rita Horvath, Carsten G. Bönnemann

Am J Hum Genet. 2018 May 3; 102(5): 858–873. Published online 2018 May 3. doi: 10.1016/j.ajhg.2018.03.011

PMCID:: PMC5986733

Abstract Article PDF–2.5M

Select item 1258125.

The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements

Devi Mukherjee, Min Gao, J.Patrick O’Connor, Reinout Raijmakers, Ger Pruijn, Carol S. Lutz, Jeffrey Wilusz

EMBO J. 2002 Jan 15; 21(1-2): 165–174. doi: 10.1093/emboj/21.1.165

PMCID:: PMC125812

Abstract Article PDF–270K

Select item 838436.

Autoantibodies directed to novel components of the PM/Scl complex, the human exosome

Rick Brouwer, Wilma TM Vree Egberts, Gerald JD Hengstman, Reinout Raijmakers, Baziel GM van Engelen, Hans Peter Seelig, Manfred Renz, Rudolf Mierau, Ekkehard Genth, Ger JM Pruijn, Walther J van Venrooij

Arthritis Res. 2002; 4(2): 134–138. Published online 2001 Nov 12. doi: 10.1186/ar389

PMCID:: PMC83843

Abstract Article PDF–56K

Select item 38146437.

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage

Patricia Richard, Shuang Feng, James L. Manley

Genes Dev. 2013 Oct 15; 27(20): 2227–2232. doi: 10.1101/gad.224923.113

PMCID:: PMC3814643

Abstract Article PDF–2.3M

Select item 18856448.

C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing

Geurt Schilders, Erwin van Dijk, Ger J.M. Pruijn

Nucleic Acids Res. 2007 Apr; 35(8): 2564–2572. Published online 2007 Apr 4. doi: 10.1093/nar/gkm082

PMCID:: PMC1885644

Abstract Article PDF–2.4M

Select item 95859119.

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication

Tobias Moll, Valerie Odon, Calum Harvey, Mark O Collins, Andrew Peden, John Franklin, Emily Graves, Jack NG Marshall, Cleide dos Santos Souza, Sai Zhang, Lydia Castelli, Guillaume Hautbergue, Mimoun Azzouz, David Gordon, Nevan Krogan, Laura Ferraiuolo, Michael P Snyder, Pamela J Shaw, Jan Rehwinkel, Johnathan Cooper-Knock

Life Sci Alliance. 2023 Jan; 6(1): e202201449. Published online 2022 Oct 14. doi: 10.26508/lsa.202201449

PMCID:: PMC9585911

Abstract Article PDF–1.7M

Select item 927418610.

Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis

Hong-Guang Zhang, Bin Wang, Yong Yang, Xuan Liu, Junjie Wang, Ning Xin, Shifeng Li, Ying Miao, Qiuyu Wu, Tingting Guo, Yukang Yuan, Yibo Zuo, Xiangjie Chen, Tengfei Ren, Chunsheng Dong, Jun Wang, Hang Ruan, Miao Sun, Xingshun Xu, Hui Zheng

Cell Res. 2022 Oct; 32(10): 897–913. Published online 2022 Jul 12. doi: 10.1038/s41422-022-00689-9

PMCID:: PMC9274186

Abstract Article PDF–6.7M

Select item 382397711.

Protein Interaction Analysis of Senataxin and the ALS4 L389S Mutant Yields Insights into Senataxin Post-Translational Modification and Uncovers Mutant-Specific Binding with a Brain Cytoplasmic RNA-Encoded Peptide

Craig L. Bennett, Yingzhang Chen, Marissa Vignali, Russell S. Lo, Amanda G. Mason, Asli Unal, Nabiha P. Huq Saifee, Stanley Fields, Albert R. La Spada

PLoS One. 2013; 8(11): e78837. Published online 2013 Nov 11. doi: 10.1371/journal.pone.0078837

PMCID:: PMC3823977

Abstract Article PDF–1.1M

Select item 189493412.

Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways

Erwin L. van Dijk, Geurt Schilders, Ger J.M. Pruijn

RNA. 2007 Jul; 13(7): 1027–1035. doi: 10.1261/rna.575107

PMCID:: PMC1894934

Abstract Article PDF–719K

Select item 31694713.

The yeast exosome and human PM–Scl are related complexes of 3′ → 5′ exonucleases

Christine Allmang, Elisabeth Petfalski, Alexandre Podtelejnikov, Matthias Mann, David Tollervey, Philip Mitchell

Genes Dev. 1999 Aug 15; 13(16): 2148–2158. doi: 10.1101/gad.13.16.2148

PMCID:: PMC316947

Abstract Article PDF–1.1M

Select item 344254714.

Phosphatase of Regenerating Liver 2 (PRL2) Is Essential for Placental Development by Down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and Activating Akt Protein

Yuanshu Dong, Lujuan Zhang, Sheng Zhang, Yunpeng Bai, Hanying Chen, Xiaoxin Sun, Weidong Yong, Wei Li, Stephanie C. Colvin, Simon J. Rhodes, Weinian Shou, Zhong-Yin Zhang

J Biol Chem. 2012 Sep 14; 287(38): 32172–32179. Published online 2012 Jul 12. doi: 10.1074/jbc.M112.393462

PMCID:: PMC3442547

Abstract Article PDF–2.6M

Select item 306511415.

The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates

Uttiya Basu, Fei-Long Meng, Celia Keim, Veronika Grinstein, Evangelos Pefanis, Jennifer Eccleston, Tingting Zhang, Darienne Myers, Duane R. Wesemann, Kurt Januszyk, Richard I. Gregory, Haiteng Deng, Christopher D. Lima, Frederick W. Alt

Cell. Author manuscript; available in PMC 2011 Aug 4.

Published in final edited form as: Cell. 2011 Feb 4; 144(3): 353–363. Published online 2011 Jan 20. doi: 10.1016/j.cell.2011.01.001

PMCID:: PMC3065114

Abstract Article PDF–2.9M

Select item 494267516.

Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex

Eva Kowalinski, Alexander Kögel, Judith Ebert, Peter Reichelt, Elisabeth Stegmann, Bianca Habermann, Elena Conti

Mol Cell. 2016 Jul 7; 63(1): 125–134. doi: 10.1016/j.molcel.2016.05.028

PMCID:: PMC4942675

Abstract Article

Select item 560372917.

Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase

Sebastian Falk, Fabien Bonneau, Judith Ebert, Alexander Kögel, Elena Conti

Cell Rep. 2017 Sep 5; 20(10): 2279–2286. Published online 2017 Sep 5. doi: 10.1016/j.celrep.2017.08.033

PMCID:: PMC5603729

Abstract Article

Select item 291027218.

Dis3-like 1: a novel exoribonuclease associated with the human exosome

Raymond H J Staals, Alfred W Bronkhorst, Geurt Schilders, Shimyn Slomovic, Gadi Schuster, Albert J R Heck, Reinout Raijmakers, Ger J M Pruijn

EMBO J. 2010 Jul 21; 29(14): 2358–2367. Published online 2010 Jun 8. doi: 10.1038/emboj.2010.122

PMCID:: PMC2910272

Abstract Article PDF–914K

Select item 291027119.

The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L

Rafal Tomecki, Maiken S Kristiansen, Søren Lykke-Andersen, Aleksander Chlebowski, Katja M Larsen, Roman J Szczesny, Karolina Drazkowska, Agnieszka Pastula, Jens S Andersen, Piotr P Stepien, Andrzej Dziembowski, Torben Heick Jensen

EMBO J. 2010 Jul 21; 29(14): 2342–2357. Published online 2010 Jun 8. doi: 10.1038/emboj.2010.121

PMCID:: PMC2910271

Abstract Article PDF–2.7M

Select item 272791720.

Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex

Jian Ouyang, Yujiang Shi, Alvaro Valin, Yan Xuan, Grace Gill

Mol Cell. Author manuscript; available in PMC 2010 Apr 24.

Published in final edited form as: Mol Cell. 2009 Apr 24; 34(2): 145–154. doi: 10.1016/j.molcel.2009.03.013

PMCID:: PMC2727917

Abstract Article PDF–1.0M

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