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Select item 112688191.

A systematic review of the role of TREM2 in Alzheimer’s disease

Yunsi Yin, Hanchen Yang, Ruiyang Li, Guangshan Wu, Qi Qin, Yi Tang

Chin Med J (Engl) 2024 Jul 20; 137(14): 1684–1694. Published online 2024 Jun 24. doi: 10.1097/CM9.0000000000003000

PMCID:: PMC11268819

Abstract Article PDF–1.4M

Select item 110055012.

Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer’s Disease and Reflect Central Neuroinflammation

Yi-Kuan Chiang, Yung-Shuan Lin, Chun-Yu Chen, Jiing-Feng Lirng, Yu-Hsiu Yang, Wei-Ju Lee, Jong-Ling Fuh

Am J Alzheimers Dis Other Demen. 2024 Jan-Dec; 39: 15333175241243183. Published online 2024 Apr 9. doi: 10.1177/15333175241243183

PMCID:: PMC11005501

Abstract Article PDF–769K

Select item 108526903.

Lack of Genetic Association Between TREM2 and Alzheimer’s Disease in East Asian Population: A Systematic Review and Meta-Analysis

Man Huang, Dejun Wang, Zhijun Xu, Yongshan Xu, Xiaoping Xu, Yuefeng Ma, Zheng Xia

Am J Alzheimers Dis Other Demen. 2015 Sep; 30(6): 541–546. Published online 2015 Apr 7. doi: 10.1177/1533317515577128

PMCID:: PMC10852690

Abstract Article PDF–453K

Select item 108103164.

Microglial TREM2 at the intersection of brain aging and Alzheimer’s disease

Wenhui Qu, Ling Li

Neuroscientist. Author manuscript; available in PMC 2024 Jan 25.

Published in final edited form as: Neuroscientist. 2023 Jun; 29(3): 302–316. Published online 2021 Sep 2. doi: 10.1177/10738584211040786

PMCID:: PMC10810316

Abstract Article PDF–1.9M

Select item 104474055.

Frontotemporal dementia presentation in patients with heterozygous p.H157Y variant of TREM2

Natalia Ogonowski, Hernando Santamaria-Garcia, Sandra Baez, Andrea Lopez, Andrés Laserna, Elkin Garcia-Cifuentes, Paola Ayala-Ramirez, Ignacio Zarante, Fernando Suarez-Obando, Pablo Reyes, Marcelo Kauffman, Nick Cochran, Michael Schulte, Daniel W Sirkis, Salvatore Spina, Jennifer S Yokoyama, Bruce L Miller, Kenneth S Kosik, Diana Matallana, Agustín Ibáñez

J Med Genet. 2023 Sep; 60(9): 894–904. Published online 2023 Feb 22. doi: 10.1136/jmg-2022-108627

PMCID:: PMC10447405

Abstract Article PDF–2.8M

Select item 104384646.

TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain

Stefanie Fruhwürth, Line S. Reinert, Carl Öberg, Marcelina Sakr, Marcus Henricsson, Henrik Zetterberg, Søren R. Paludan

Sci Adv. 2023 Aug; 9(33): eadf5808. Published online 2023 Aug 18. doi: 10.1126/sciadv.adf5808

PMCID:: PMC10438464

Abstract Article PDF–1.7M

Select item 104335327.

Novel TREM2 splicing isoform that lacks the V-set immunoglobulin domain is abundant in the human brain

Kostantin Kiianitsa, Irina Kurtz, Neal Beeman, Mark Matsushita, Wei-Ming Chien, Wendy H. Raskind, Olena Korvatska

J Leukoc Biol. Author manuscript; available in PMC 2023 Aug 17.

Published in final edited form as: J Leukoc Biol. 2021 Nov; 110(5): 829–837. Published online 2021 Jun 1. doi: 10.1002/JLB.2HI0720-463RR

PMCID:: PMC10433532

Abstract Article PDF–1.2M

Select item 103333758.

Acute and Chronic Macrophage Differentiation Modulates TREM2 in a Personalized Alzheimer’s Patient-Derived Assay

Nicoleta-Carmen Cosma, Neriman Eren, Berk Üsekes, Susanna Gerike, Isabella Heuser, Oliver Peters, Julian Hellmann-Regen

Cell Mol Neurobiol. 2023; 43(6): 3047–3060. Published online 2023 May 17. doi: 10.1007/s10571-023-01351-7

PMCID:: PMC10333375

Abstract Article PDF–2.5M

Select item 102503439.

Translational regulation and protein-coding capacity of the 5′ untranslated region of human TREM2

Motoaki Yanaizu, Haruka Adachi, Makoto Araki, Kenji Kontani, Yoshihiro Kino

Commun Biol. 2023; 6: 616. Published online 2023 Jun 8. doi: 10.1038/s42003-023-04998-6

PMCID:: PMC10250343

Abstract Article PDF–2.0M

Select item 1021837810.

TREM2 Expression and Amyloid-Beta Phagocytosis in Alzheimer’s Disease

Francesca La Rosa, Simone Agostini, Federica Piancone, Ivana Marventano, Ambra Hernis, Chiara Fenoglio, Daniela Galimberti, Elio Scarpini, Marina Saresella, Mario Clerici

Int J Mol Sci. 2023 May; 24(10): 8626. Published online 2023 May 11. doi: 10.3390/ijms24108626

PMCID:: PMC10218378

Abstract Article PDF–1.1M

Select item 1017568111.

Identification of TREM2-positive tumor-associated macrophages in esophageal squamous cell carcinoma: implication for poor prognosis and immunotherapy modulation

Hongmu Li, Yu Miao, Leqi Zhong, Songjie Feng, Yue Xu, Lu Tang, Chun Wu, Xianzhou Zhang, Ling Gu, Hengyi Diao, Huiyun Wang, Zhesheng Wen, Minglei Yang

Front Immunol. 2023; 14: 1162032. Published online 2023 Apr 28. doi: 10.3389/fimmu.2023.1162032

PMCID:: PMC10175681

Abstract Article PDF–15M

Select item 1017546312.

TREM2 gene expression associations with Alzheimer’s disease neuropathology are region-specific: implications for cortical versus subcortical microglia

Rebecca L. Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A. Bennett, Angela L. Jefferson, Timothy J. Hohman

Acta Neuropathol. 2023; 145(6): 733–747. Published online 2023 Mar 25. doi: 10.1007/s00401-023-02564-2

PMCID:: PMC10175463

Abstract Article PDF–2.2M

Select item 1017534613.

Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation

Fabia Filipello, Shih-Feng You, Farzaneh S. Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A. Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A. Minaya, Arun Renganathan, Anil G. Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K. Iyer, Marina Cella, Wendy H. Raskind, Laura Piccio, Celeste M. Karch

Acta Neuropathol. 2023; 145(6): 749–772. Published online 2023 Apr 28. doi: 10.1007/s00401-023-02568-y

PMCID:: PMC10175346

Abstract Article PDF–4.9M

Select item 1010883514.

Soluble TREM2: Innocent bystander or active player in neurological diseases?

Fabia Filipello, Claire Goldsbury, Shih Feng You, Alberto Locca, Celeste M. Karch, Laura Piccio

Neurobiol Dis. Author manuscript; available in PMC 2023 Apr 17.

Published in final edited form as: Neurobiol Dis. 2022 Apr; 165: 105630. Published online 2022 Jan 15. doi: 10.1016/j.nbd.2022.105630

PMCID:: PMC10108835

Abstract Article PDF–871K

Select item 989792115.

TREM2 as a Potential Immune-Related Biomarker of Prognosis in Patients with Skin Cutaneous Melanoma Microenvironment

Xinlin Zhu, Zhaoxiang Zeng, Min Chen, Xianzhen Chen, Dongying Hu, Weiwei Jiang, Mingwei Du, Tianyang Chen, Tiancheng Chen, Wanqing Liao, Chao Zhang, Ying Qu, Weihua Pan

Dis Markers. 2023; 2023: 8101837. Published online 2023 Jan 27. doi: 10.1155/2023/8101837

PMCID:: PMC9897921

Abstract Article PDF–2.9M

Select item 987468616.

TREM2 is associated with tumor immunity and implies poor prognosis in glioma

Mingchen Yu, Yuanhao Chang, You Zhai, Bo Pang, Peng Wang, Guanzhang Li, Tao Jiang, Fan Zeng

Front Immunol. 2022; 13: 1089266. Published online 2023 Jan 11. doi: 10.3389/fimmu.2022.1089266

PMCID:: PMC9874686

Abstract Article PDF–20M

Select item 983637317.

TREM2‐induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology

Anna Fracassi, Michela Marcatti, Batbayar Tumurbaatar, Randall Woltjer, Sandra Moreno, Giulio Taglialatela

Brain Pathol. 2023 Jan; 33(1): e13108. Published online 2022 Jul 11. doi: 10.1111/bpa.13108

PMCID:: PMC9836373

Abstract Article PDF–12M

Select item 983212418.

TREM2 has a significant, gender-specific, effect on human obesity

Tzila Reich, Orit Adato, Naomi Schneid Kofman, Ariel Feiglin, Ron Unger

Sci Rep. 2023; 13: 482. Published online 2023 Jan 10. doi: 10.1038/s41598-022-27272-x

Correction in:: Sci Rep. 2023; 13: 5125.

PMCID:: PMC9832124

Abstract Article PDF–837K

Select item 978348119.

TREM2 dependent and independent functions of microglia in Alzheimer’s disease

Jinchao Hou, Yun Chen, Gary Grajales-Reyes, Marco Colonna

Mol Neurodegener. 2022; 17: 84. Published online 2022 Dec 23. doi: 10.1186/s13024-022-00588-y

PMCID:: PMC9783481

Abstract Article PDF–3.1M

Select item 964363620.

TREM2 risk variants are associated with atypical Alzheimer’s disease

Boram Kim, EunRan Suh, Aivi T. Nguyen, Stefan Prokop, Bailey Mikytuck, Olamide A. Olatunji, John L. Robinson, Murray Grossman, Jeffrey S. Phillips, David J. Irwin, Dawn Mechanic-Hamilton, David A. Wolk, John Q. Trojanowski, Corey T. McMillan, Vivianna M. Van Deerlin, Edward B. Lee

Acta Neuropathol. Author manuscript; available in PMC 2023 Dec 1.

Published in final edited form as: Acta Neuropathol. 2022 Dec; 144(6): 1085–1102. Published online 2022 Sep 16. doi: 10.1007/s00401-022-02495-4

PMCID:: PMC9643636

Abstract Article PDF–1.8M

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