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Select item 106636121.

Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis

Ryutaro Tamura, Yusuke Sabu, Tadahaya Mizuno, Seiya Mizuno, Satoshi Nakano, Mitsuyoshi Suzuki, Daiki Abukawa, Shunsaku Kaji, Yoshihiro Azuma, Ayano Inui, Tatsuya Okamoto, Seiichi Shimizu, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara, Satoru Takahashi, Hiroyuki Kusuhara, Yoh Zen, Tomohiro Ando, Hisamitsu Hayashi

Nat Commun. 2023; 14: 6763. Published online 2023 Nov 21. doi: 10.1038/s41467-023-42424-x

PMCID:: PMC10663612

Abstract Article PDF–2.4M

Select item 79699452.

Reduced spontaneous itch in mouse models of cholestasis

Jacqueline Langedijk, Ruth Bolier, Dagmar Tolenaars, Lysbeth ten Bloemendaal, Suzanne Duijst, Dirk de Waart, Ulrich Beuers, Piter Bosma, Ronald Oude Elferink

Sci Rep. 2021; 11: 6127. Published online 2021 Mar 17. doi: 10.1038/s41598-021-85660-1

PMCID:: PMC7969945

Abstract Article PDF–1.2M

Select item 70725013.

Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis

Simon Hohenester, Veronika Kanitz, Andreas E. Kremer, Coen C. Paulusma, Ralf Wimmer, Helen Kuehn, Gerald Denk, David Horst, Ronald Oude Elferink, Ulrich Beuers

Cells. 2020 Feb; 9(2): 281. Published online 2020 Jan 23. doi: 10.3390/cells9020281

PMCID:: PMC7072501

Abstract Article PDF–3.3M

Select item 63397974.

Oxidative stress induces club cell proliferation and pulmonary fibrosis in Atp8b1 mutant mice

Jutaro Fukumoto, Joseph Leung, Ruan Cox, Jr, Alexander Czachor, Prasanna Tamarapu Parthasarathy, Venu Lagishetty, Maria Mandry, Nima Hosseinian, Priyanshi Patel, Brittany Perry, Mason T. Breitzig, Matthew Alleyn, Athena Failla, Young Cho, Andrew J. Cooke, Lakshmi Galam, Ramani Soundararajan, Nirmal Sharma, Richard F. Lockey, Narasaiah Kolliputi

Aging (Albany NY) 2019 Jan 15; 11(1): 209–229. Published online 2019 Jan 13. doi: 10.18632/aging.101742

PMCID:: PMC6339797

Abstract Article PDF–6.7M

Select item 28138825.

Strain Background Modifies Phenotypes in the ATP8B1-Deficient Mouse

Sohela Shah, Ukina R. Sanford, Julie C. Vargas, Hongmei Xu, Annamiek Groen, Coen C. Paulusma, James P. Grenert, Ludmila Pawlikowska, Saunak Sen, Ronald P. J. Oude Elferink, Laura N. Bull

PLoS One. 2010; 5(2): e8984. Published online 2010 Feb 1. doi: 10.1371/journal.pone.0008984

PMCID:: PMC2813882

Abstract Article PDF–607K

Select item 95880326.

Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Wan-jun Yang, Rong-chang Cao, Wang Xiao, Xiao-lou Zhang, Hao Xu, Meng Wang, Zhi-tao Zhou, Huo-ji Chen, Jia Xu, Xue-mei Chen, Jun-ling Zeng, Shu-ji Li, Min Luo, Yan-jiang Han, Xiao-bing Yang, Guo-dong Feng, Yu-heng Lu, Yuan-yuan Ni, Chan-gui Wu, Jun-jie Bai, Zi-qi Yuan, Jin Jin, Guo-wei Zhang

Cell Death Dis. 2022 Oct; 13(10): 893. Published online 2022 Oct 22. doi: 10.1038/s41419-022-05322-6

Correction in:: Cell Death Dis. 2022 Nov; 13(11): 930.

PMCID:: PMC9588032

Abstract Article PDF–6.1M

Select item 89615147.

Matrix Metalloproteinase 7 Expression and Apical Epithelial Defects in Atp8b1 Mutant Mouse Model of Pulmonary Fibrosis

Emma Westermann-Clark, Ramani Soundararajan, Jutaro Fukumoto, Sahebgowda Sidramagowda Patil, Timothy M. Stearns, Smita Saji, Alexander Czachor, Helena Hernandez-Cuervo, Mason Breitzig, Sudarshan Krishnamurthy, Richard F. Lockey, Narasaiah Kolliputi

Biomolecules. 2022 Feb; 12(2): 283. Published online 2022 Feb 9. doi: 10.3390/biom12020283

PMCID:: PMC8961514

Abstract Article PDF–2.5M

Select item 61753748.

Na⁺‐taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice

Davor Slijepcevic, Reinout L.P. Roscam Abbing, Claudia D. Fuchs, Lizette C.M. Haazen, Ulrich Beuers, Michael Trauner, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf

Hepatology. 2018 Sep; 68(3): 1057–1069. Published online 2018 Apr 27. doi: 10.1002/hep.29888

PMCID:: PMC6175374

Abstract Article PDF–1.1M

Select item 45867379.

ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization

Lucas J.M. Bruurs, Lisa Donker, Susan Zwakenberg, Fried J. Zwartkruis, Harry Begthel, A.S. Knisely, George Posthuma, Stan F.J. van de Graaf, Coen C. Paulusma, Johannes L. Bos

J Cell Biol. 2015 Sep 28; 210(7): 1055–1063. doi: 10.1083/jcb.201505118

PMCID:: PMC4586737

Abstract Article PDF–4.6M

Select item 450019210.

Dynamic regulation of cardiolipin by the lipid pump, ATP8b1, determines the severity of lung injury in experimental bacterial pneumonia

Nancy B. Ray, Lakshmi Durairaj, Bill B. Chen, Bryan J. McVerry, Alan J. Ryan, Michael Donahoe, Alisa K. Waltenbaugh, Christopher P. O’Donnell, Florita C. Henderson, Christopher A. Etscheidt, Diann M. McCoy, Marianna Agassandian, Emily C. Hayes-Rowan, Tiffany A. Coon, Phillip L. Butler, Lokesh Gakhar, Satya N. Mathur, Jessica C. Sieren, Yulia Y. Tyurina, Valerian E. Kagan, Geoffrey McLennan, Rama K. Mallampalli

Nat Med. Author manuscript; available in PMC 2015 Jul 13.

Published in final edited form as: Nat Med. 2010 Oct; 16(10): 1120–1127. Published online 2010 Sep 19. doi: 10.1038/nm.2213

PMCID:: PMC4500192

Abstract Article PDF–1.0M

Select item 270099411.

ATP8B1 is essential for maintaining normal hearing

Janneke M. Stapelbroek, Theo A. Peters, Denis H. A. van Beurden, Jo H. A. J. Curfs, Anneke Joosten, Andy J. Beynon, Bibian M. van Leeuwen, Lieke M. van der Velden, Laura Bull, Ronald P. Oude Elferink, Bert A. van Zanten, Leo W. J. Klomp, Roderick H. J. Houwen

Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24): 9709–9714. Published online 2009 May 28. doi: 10.1073/pnas.0807919106

PMCID:: PMC2700994

Abstract Article PDF–1.3M

Select item 349182212.

miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity

Ryan M Allen, Tyler J Marquart, Carolyn J Albert, Frederick J Suchy, David Q-H Wang, Meenakshisundaram Ananthanarayanan, David A Ford, Ángel Baldán

EMBO Mol Med. 2012 Sep; 4(9): 882–895. Published online 2012 Jul 5. doi: 10.1002/emmm.201201228

PMCID:: PMC3491822

Abstract Article PDF–1.3M

Select item 266511813.

Activity of the Bile Salt Export Pump (ABCB11) Is Critically Dependent on Canalicular Membrane Cholesterol Content

Coen C. Paulusma, D. Rudi de Waart, Cindy Kunne, Kam S. Mok, Ronald P. J. Oude Elferink

J Biol Chem. 2009 Apr 10; 284(15): 9947–9954. doi: 10.1074/jbc.M808667200

PMCID:: PMC2665118

Abstract Article PDF–601K

Select item 416469114.

Resistance to Noise-Induced Hearing Loss in 129S6 and MOLF Mice: Identification of Independent, Overlapping, and Interacting Chromosomal Regions

Valerie A. Street, Sharon G. Kujawa, Ani Manichaikul, Karl W. Broman, Jeremy C. Kallman, Dustin J. Shilling, Ayaka J. Iwata, Linda C. Robinson, Carol A. Robbins, Jin Li, M. Charles Liberman, Bruce L Tempel

J Assoc Res Otolaryngol. 2014 Oct; 15(5): 721–738. Published online 2014 Jun 21. doi: 10.1007/s10162-014-0472-x

PMCID:: PMC4164691

Abstract Article PDF–2.8M

Select item 793877015.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 1091766016.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 357241017.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 302253418.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 31099219.

RIKEN Integrated Sequence Analysis (RISA) System—384-Format Sequencing Pipeline with 384 Multicapillary Sequencer

Kazuhiro Shibata, Masayoshi Itoh, Katsunori Aizawa, Sumiharu Nagaoka, Nobuya Sasaki, Piero Carninci, Hideaki Konno, Junichi Akiyama, Katsuo Nishi, Tokuji Kitsunai, Hideo Tashiro, Mari Itoh, Noriko Sumi, Yoshiyuki Ishii, Shin Nakamura, Makoto Hazama, Tsutomu Nishine, Akira Harada, Rintaro Yamamoto, Hiroyuki Matsumoto, Sumito Sakaguchi, Takashi Ikegami, Katsuya Kashiwagi, Syuji Fujiwake, Kouji Inoue, Yoshiyuki Togawa, Masaki Izawa, Eiji Ohara, Masanori Watahiki, Yuko Yoneda, Tomokazu Ishikawa, Kaori Ozawa, Takumi Tanaka, Shuji Matsuura, Jun Kawai, Yasushi Okazaki, Masami Muramatsu, Yorinao Inoue, Akira Kira, Yoshihide Hayashizaki

Genome Res. 2000 Nov; 10(11): 1757–1771. doi: 10.1101/gr.152600

PMCID:: PMC310992

Abstract Article PDF–3.4M

Select item 31098020.

Normalization and Subtraction of Cap-Trapper-Selected cDNAs to Prepare Full-Length cDNA Libraries for Rapid Discovery of New Genes

Piero Carninci, Yuko Shibata, Norihito Hayatsu, Yuichi Sugahara, Kazuhiro Shibata, Masayoshi Itoh, Hideaki Konno, Yasushi Okazaki, Masami Muramatsu, Yoshihide Hayashizaki

Genome Res. 2000 Oct; 10(10): 1617–1630. doi: 10.1101/gr.145100

PMCID:: PMC310980

Abstract Article PDF–1.4M

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