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Select item 89433261.

A comprehensive overview of PPM1A: From structure to disease

Mao Li, Xingfeng Xu, Yan Su, Xiaoyun Shao, Yali Zhou, Jianguo Yan

Exp Biol Med (Maywood) 2022 Mar; 247(6): 453–461. Published online 2021 Dec 3. doi: 10.1177/15353702211061883

PMCID:: PMC8943326

Abstract Article PDF–1.0M

Select item 59714552.

A trapped human PPM1A–phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity

Subrata Debnath, Dalibor Kosek, Harichandra D. Tagad, Stewart R. Durell, Daniel H. Appella, Roderico Acevedo, Alexander Grishaev, Fred Dyda, Ettore Appella, Sharlyn J. Mazur

J Biol Chem. 2018 May 25; 293(21): 7993–8008. Published online 2018 Mar 30. doi: 10.1074/jbc.RA117.001213

PMCID:: PMC5971455

Abstract Article PDF–4.3M

Select item 57725513.

The phosphatase PPM1A controls monocyte-to-macrophage differentiation

Samuel R. Smith, Kaitlyn Schaaf, Nusrah Rajabalee, Frederic Wagner, Alexandra Duverger, Olaf Kutsch, Jim Sun

Sci Rep. 2018; 8: 902. Published online 2018 Jan 17. doi: 10.1038/s41598-017-18832-7

PMCID:: PMC5772551

Abstract Article PDF–4.0M

Select item 55932704.

Conformational Changes in Active and Inactive States of Human PP2Ca Characterized by Hydrogen/Deuterium Exchange–Mass Spectrometry

Sharlyn J. Mazur, Elyssia S. Gallagher, Subrata Debnath, Stewart R. Durell, Kyle W. Anderson, Lisa M. Miller Jenkins, Ettore Appella, Jeffrey W. Hudgens

Biochemistry. Author manuscript; available in PMC 2018 May 30.

Published in final edited form as: Biochemistry. 2017 May 30; 56(21): 2676–2689. Published online 2017 May 12. doi: 10.1021/acs.biochem.6b01220

PMCID:: PMC5593270

Abstract Article PDF–2.8M

Select item 53452365.

Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation

Yali Zhou, Yan Zhao, Yaoying Gao, Wenjun Hu, Yan Qu, Ning Lou, Ying Zhu, Xiaoping Zhang, Hongmei Yang

J Exp Clin Cancer Res. 2017; 36: 42. Published online 2017 Mar 10. doi: 10.1186/s13046-017-0510-8

PMCID:: PMC5345236

Abstract Article PDF–3.6M

Select item 52967586.

Mycobacterium tuberculosis exploits the PPM1A signaling pathway to block host macrophage apoptosis

Kaitlyn Schaaf, Samuel R. Smith, Alexandra Duverger, Frederic Wagner, Frank Wolschendorf, Andrew O. Westfall, Olaf Kutsch, Jim Sun

Sci Rep. 2017; 7: 42101. Published online 2017 Feb 8. doi: 10.1038/srep42101

PMCID:: PMC5296758

Abstract Article PDF–1.8M

Select item 50780807.

Hepatitis B virus X protein amplifies TGF-β promotion on HCC motility through down-regulating PPM1a

Yuan Liu, Yong Xu, Hongxin Ma, Bo Wang, Leiqi Xu, Hualin Zhang, Xiaojia Song, Lifen Gao, Xiaohong Liang, Chunhong Ma

Oncotarget. 2016 May 31; 7(22): 33125–33135. Published online 2016 Apr 21. doi: 10.18632/oncotarget.8884

PMCID:: PMC5078080

Abstract Article PDF–6.4M

Select item 49412498.

Protein Phosphatase, Mg²⁺/Mn²⁺-dependent 1A controls the innate antiviral and antibacterial response of macrophages during HIV-1 and Mycobacterium tuberculosis infection

Jim Sun, Kaitlyn Schaaf, Alexandra Duverger, Frank Wolschendorf, Alexander Speer, Frederic Wagner, Michael Niederweis, Olaf Kutsch

Oncotarget. 2016 Mar 29; 7(13): 15394–15409. Published online 2016 Mar 18. doi: 10.18632/oncotarget.8190

PMCID:: PMC4941249

Abstract Article PDF–7.2M

Select item 41706109.

Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-β/Smad signaling pathway

Jiang Geng, Jie Fan, Qi Ouyang, Xiaopeng Zhang, Xiaolong Zhang, Juan Yu, Zude Xu, Qianyu Li, Xudong Yao, Xiuping Liu, Junhua Zheng

Oncotarget. 2014 Jul; 5(14): 5700–5711. Published online 2014 Jul 1. doi: 10.18632/oncotarget.2144

PMCID:: PMC4170610

Abstract Article PDF–5.4M

Select item 389756910.

PPM1A is a RelA phosphatase with tumor suppressor-like activity

X Lu, H An, R Jin, M Zou, Y Guo, P-F Su, D Liu, Y Shyr, WG Yarbrough

Oncogene. Author manuscript; available in PMC 2014 May 30.

Published in final edited form as: Oncogene. 2014 May 29; 33(22): 2918–2927. Published online 2013 Jul 1. doi: 10.1038/onc.2013.246

PMCID:: PMC3897569

Abstract Article PDF–3.0M

Select item 340698811.

Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4⁺ T cells and inhibits HIV-1 gene expression

Sona Budhiraja, Rajesh Ramakrishnan, Andrew P Rice

Retrovirology. 2012; 9: 52. Published online 2012 Jun 22. doi: 10.1186/1742-4690-9-52

PMCID:: PMC3406988

Abstract Article PDF–763K

Select item 117080312.

Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways.

M Takekawa, T Maeda, H Saito

EMBO J. 1998 Aug 17; 17(16): 4744–4752. doi: 10.1093/emboj/17.16.4744

PMCID:: PMC1170803

Summary PDF–322K

Select item 952482513.

Astrocytic NDRG2-PPM1A interaction exacerbates blood-brain barrier disruption after subarachnoid hemorrhage

Dayun Feng, Jinpeng Zhou, Haixiao Liu, Xun Wu, Fei Li, Junlong Zhao, Yu Zhang, Lei Wang, Min Chao, Qiang Wang, Huaizhou Qin, Shunnan Ge, Qiang Liu, Jian Zhang, Yan Qu

Sci Adv. 2022 Sep; 8(39): eabq2423. Published online 2022 Sep 30. doi: 10.1126/sciadv.abq2423

PMCID:: PMC9524825

Abstract Article PDF–13M

Select item 829185314.

MicroRNA-487a-3p inhibits the growth and invasiveness of oral squamous cell carcinoma by targeting PPM1A

Lishan Wang, Shuqing Ge, Futing Zhou

Bioengineered. 2021; 12(1): 937–947. Published online 2021 Mar 16. doi: 10.1080/21655979.2021.1884396

PMCID:: PMC8291853

Abstract Article PDF–3.1M

Select item 721869115.

Protein phosphatase magnesium-dependent 1A induces inflammation in rheumatoid arthritis

Beomgu Lee, You Seon Song, Christopher Rhodes, Tae Sik Goh, Jong Seong Roh, Hoim Jeong, Jisu Park, Han-Na Lee, Seung-Geun Lee, Soohyun Kim, Mingyo Kim, Sang-Il Lee, Dong Hyun Sohn, William H. Robinson

Biochem Biophys Res Commun. Author manuscript; available in PMC 2021 Feb 12.

Published in final edited form as: Biochem Biophys Res Commun. 2020 Feb 12; 522(3): 731–735. Published online 2019 Nov 30. doi: 10.1016/j.bbrc.2019.11.112

PMCID:: PMC7218691

Abstract Article PDF–1005K

Select item 623429216.

The Cellular Senescence-Inhibited Gene Is Essential for PPM1A Myristoylation To Modulate Transforming Growth Factor β Signaling

Feng Zhu, Nan Xie, Zhe Jiang, Guodong Li, Liwei Ma, Tanjun Tong

Mol Cell Biol. 2018 Dec 1; 38(23): e00414-18. Prepublished online 2018 Sep 10. Published online 2018 Nov 13. doi: 10.1128/MCB.00414-18

PMCID:: PMC6234292

Abstract Article PDF–2.3M

Select item 600117017.

TRIM52 up-regulation in hepatocellular carcinoma cells promotes proliferation, migration and invasion through the ubiquitination of PPM1A

Yi Zhang, Ran Tao, Shan-Shan Wu, Cui-Cui Xu, Jie-Ling Wang, Jie Chen, Yong-Sheng Yu, Zheng-Hao Tang, Xiao-Hua Chen, Guo-Qing Zang

J Exp Clin Cancer Res. 2018; 37: 116. Published online 2018 Jun 13. doi: 10.1186/s13046-018-0780-9

PMCID:: PMC6001170

Abstract Article PDF–7.6M

Select item 502468818.

Loss of expression of protein phosphatase magnesium-dependent 1A during kidney injury promotes fibrotic maladaptive repair

Rohan Samarakoon, Alexandra Rehfuss, Nidah S. Khakoo, Lucas L. Falke, Amy D. Dobberfuhl, Sevann Helo, Jessica M. Overstreet, Roel Goldschmeding, Paul J. Higgins

FASEB J. 2016 Oct; 30(10): 3308–3320. Published online 2016 Jun 21. doi: 10.1096/fj.201500105R

PMCID:: PMC5024688

Abstract Article

Select item 410594119.

The Self-Limiting Dynamics of TGF-β Signaling In Silico and In Vitro, with Negative Feedback through PPM1A Upregulation

Junjie Wang, Lisa Tucker-Kellogg, Inn Chuan Ng, Ruirui Jia, P. S. Thiagarajan, Jacob K. White, Hanry Yu

PLoS Comput Biol. 2014 Jun; 10(6): e1003573. Published online 2014 Jun 5. doi: 10.1371/journal.pcbi.1003573

Correction in:: PLoS Comput Biol. 2014 Aug; 10(8): e1003832.

PMCID:: PMC4105941

Abstract Article PDF–2.2M

Select item 382497120.

Binding of a Third Metal Ion by the Human Phosphatases PP2Cα and Wip1 is Required for Phosphatase Activity

Kan Tanoue, Lisa M. Miller Jenkins, Stewart R. Durell, Subrata Debnath, Hiroyasu Sakai, Harichandra D. Tagad, Kazushige Ishida, Ettore Appella, Sharlyn J. Mazur

Biochemistry. Author manuscript; available in PMC 2014 Aug 27.

Published in final edited form as: Biochemistry. 2013 Aug 27; 52(34): 10.1021/bi4005649. Published online 2013 Aug 16. doi: 10.1021/bi4005649