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Select item 55287991.

TIPIN depletion leads to apoptosis in breast cancer cells

Céline Baldeyron, Amélie Brisson, Bruno Tesson, Fariba Némati, Stéphane Koundrioukoff, Elie Saliba, Leanne De Koning, Elise Martel, Mengliang Ye, Guillem Rigaill, Didier Meseure, André Nicolas, David Gentien, Didier Decaudin, Michelle Debatisse, Stéphane Depil, Francisco Cruzalegui, Alain Pierré, Sergio Roman-Roman, Gordon C. Tucker, Thierry Dubois

Mol Oncol. 2015 Oct; 9(8): 1580–1598. Published online 2015 May 9. doi: 10.1016/j.molonc.2015.04.010

PMCID:: PMC5528799

Abstract Article PDF–4.2M

Select item 87275862.

Germline polymorphisms in genes maintaining the replication fork predict the efficacy of oxaliplatin and irinotecan in patients with metastatic colorectal cancer

Hiroyuki Arai, Yi Xiao, Joshua Millstein, Jingyuan Wang, Francesca Battaglin, Natsuko Kawanishi, Priya Jayachandran, Shivani Soni, Wu Zhang, Christoph Mancao, Bodour Salhia, Shannon M. Mumenthaler, Aparna R. Parikh, Heinz-Josef Lenz

Br J Cancer. 2022 Jan 1; 126(1): 72–78. Published online 2021 Oct 23. doi: 10.1038/s41416-021-01592-7

PMCID:: PMC8727586

Abstract Article PDF–402K

Select item 56052333.

Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin

Sandro Holzer, Gianluca Degliesposti, Mairi L. Kilkenny, Sarah L. Maslen, Dijana Matak-Vinkovíc, Mark Skehel, Luca Pellegrini

Nucleic Acids Res. 2017 May 19; 45(9): 5555–5563. Published online 2017 Feb 25. doi: 10.1093/nar/gkx139

Correction in:: Nucleic Acids Res. 2020 Jan 10; 48(1): 500.

PMCID:: PMC5605233

Abstract Article PDF–4.4M

Select item 36423204.

The Human Tim-Tipin Complex Interacts Directly with DNA Polymerase ϵ and Stimulates Its Synthetic Activity

Valentina Aria, Mariarita De Felice, Roberta Di Perna, Shuji Uno, Hisao Masai, Juhani E. Syväoja, Barbara van Loon, Ulrich Hübscher, Francesca M. Pisani

J Biol Chem. 2013 May 3; 288(18): 12742–12752. Published online 2013 Mar 19. doi: 10.1074/jbc.M112.398073

PMCID:: PMC3642320

Abstract Article PDF–1.6M

Select item 35749035.

Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases

Won-Ho Cho, Young-Hoon Kang, Yun-Young An, Inger Tappin, Jerard Hurwitz, Joon-Kyu Lee

Proc Natl Acad Sci U S A. 2013 Feb 12; 110(7): 2523–2527. Published online 2013 Jan 28. doi: 10.1073/pnas.1222494110

PMCID:: PMC3574903

Abstract Article PDF–555K

Select item 31262976.

The Replisome Pausing Factor Timeless Is Required for Episomal Maintenance of Latent Epstein-Barr Virus

Jayaraju Dheekollu, Paul M. Lieberman

J Virol. 2011 Jun; 85(12): 5853–5863. doi: 10.1128/JVI.02425-10

PMCID:: PMC3126297

Abstract Article PDF–2.4M

Select item 16541297.

Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function

Danny M. Chou, Stephen J. Elledge

Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48): 18143–18147. Published online 2006 Nov 20. doi: 10.1073/pnas.0609251103

PMCID:: PMC1654129

Abstract Article PDF–882K

Select item 75069918.

Timeless couples G‐quadruplex detection with processing by DDX11 helicase during DNA replication

Leticia K Lerner, Sandro Holzer, Mairi L Kilkenny, Saša Šviković, Pierre Murat, Davide Schiavone, Cara B Eldridge, Alice Bittleston, Joseph D Maman, Dana Branzei, Katherine Stott, Luca Pellegrini, Julian E Sale

EMBO J. 2020 Sep 15; 39(18): e104185. Published online 2020 Jul 23. doi: 10.15252/embj.2019104185

PMCID:: PMC7506991

Abstract Article PDF–1.8M

Select item 18999319.

The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement

Keziban Ünsal-Kaçmaz, Paul D. Chastain, Ping-Ping Qu, Parviz Minoo, Marila Cordeiro-Stone, Aziz Sancar, William K. Kaufmann

Mol Cell Biol. 2007 Apr; 27(8): 3131–3142. Published online 2007 Feb 12. doi: 10.1128/MCB.02190-06

PMCID:: PMC1899931

Abstract Article PDF–610K

Select item 886058510.

TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination

Xuefei Zhu, Jingwei Xue, Xing Jiang, Yamin Gong, Congwen Gao, Ting Cao, Qian Li, Lulu Bai, Yuwei Li, Gaixia Xu, Bin Peng, Xingzhi Xu

Nucleic Acids Res. 2022 Feb 22; 50(3): 1517–1530. Published online 2022 Jan 20. doi: 10.1093/nar/gkac011

PMCID:: PMC8860585

Abstract Article PDF–5.1M

Select item 282357511.

Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion

Adam R. Leman, Chiaki Noguchi, Candice Y. Lee, Eishi Noguchi

J Cell Sci. 2010 Mar 1; 123(5): 660–670. Published online 2010 Feb 2. doi: 10.1242/jcs.057984

PMCID:: PMC2823575

Abstract Article

Select item 287803312.

Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress

Michael G. Kemp, Zafer Akan, Seçil Yilmaz, Mary Grillo, Stephanie L. Smith-Roe, Tae-Hong Kang, Marila Cordeiro-Stone, William K. Kaufmann, Robert T. Abraham, Aziz Sancar, Keziban Ünsal-Kaçmaz

J Biol Chem. 2010 May 28; 285(22): 16562–16571. Published online 2010 Mar 15. doi: 10.1074/jbc.M110.110304

PMCID:: PMC2878033

Abstract Article PDF–1.6M

Select item 455135413.

And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress

Jing Hao, Christelle de Renty, Yongming Li, Haijie Xiao, Michael G Kemp, Zhiyong Han, Melvin L DePamphilis, Wenge Zhu

EMBO J. 2015 Aug 4; 34(15): 2096–2110. Published online 2015 Jun 16. doi: 10.15252/embj.201488016

PMCID:: PMC4551354

Abstract Article PDF–1.6M

Select item 415125014.

Mammalian TIMELESS and Tipin are Evolutionarily Conserved Replication Fork-Associated Factors

Anthony L. Gotter, Christine Suppa, Beverly S. Emanuel

J Mol Biol. Author manuscript; available in PMC 2014 Sep 2.

Published in final edited form as: J Mol Biol. 2007 Feb 9; 366(1): 36–52. Published online 2006 Nov 3. doi: 10.1016/j.jmb.2006.10.097

PMCID:: PMC4151250

Abstract Article PDF–1.7M

Select item 308961815.

Timeless Links Replication Termination to Mitotic Kinase Activation

Jayaraju Dheekollu, Andreas Wiedmer, James Hayden, David Speicher, Anthony L. Gotter, Tim Yen, Paul M. Lieberman

PLoS One. 2011; 6(5): e19596. Published online 2011 May 6. doi: 10.1371/journal.pone.0019596

PMCID:: PMC3089618

Abstract Article PDF–3.0M

Select item 276011216.

MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication

Xiaohua Xu, Patrick J Rochette, Eminet A Feyissa, Tina V Su, Yilun Liu

EMBO J. 2009 Oct 7; 28(19): 3005–3014. Published online 2009 Aug 20. doi: 10.1038/emboj.2009.235

PMCID:: PMC2760112

Abstract Article PDF–1.4M

Select item 398109117.

hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity

Li Wan, Jiangman Lou, Yisui Xia, Bei Su, Ting Liu, Jiamin Cui, Yingying Sun, Huiqiang Lou, Jun Huang

EMBO Rep. 2013 Dec; 14(12): 1104–1112. Published online 2013 Oct 15. doi: 10.1038/embor.2013.159

PMCID:: PMC3981091

Abstract Article PDF–1.4M

Select item 282377018.

Systematic Analysis of Circadian Genes in a Population-Based Sample Reveals Association of TIMELESS with Depression and Sleep Disturbance

Siddheshwar J. Utge, Pia Soronen, Anu Loukola, Erkki Kronholm, Hanna M. Ollila, Sami Pirkola, Tarja Porkka-Heiskanen, Timo Partonen, Tiina Paunio

PLoS One. 2010; 5(2): e9259. Published online 2010 Feb 18. doi: 10.1371/journal.pone.0009259

PMCID:: PMC2823770

Abstract Article PDF–159K

Select item 545090719.

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism

John J Reynolds, Louise S Bicknell, Paula Carroll, Martin R Higgs, Ranad Shaheen, Jennie E Murray, Dimitrios K Papadopoulos, Andrea Leitch, Olga Murina, Žygimantė Tarnauskaitė, Sarah R Wessel, Anastasia Zlatanou, Audrey Vernet, Alex von Kriegsheim, Rachel MA Mottram, Clare V Logan, Hannah Bye, Yun Li, Alexander Brean, Sateesh Maddirevula, Rachel C Challis, Kassiani Skouloudaki, Agaadir Almoisheer, Hessa S Alsaif, Ariella Amar, Natalie J Prescott, Michael B Bober, Angela Duker, Eissa Faqeih, Mohammed Zain Seidahmed, Saeed Al Tala, Abdulrahman Alswaid, Saleem Ahmed, Jumana Yousuf Al-Aama, Janine Altmüller, Mohammed Al Balwi, Angela F Brady, Luciana Chessa, Helen Cox, Rita Fischetto, Raoul Heller, Bertram D Henderson, Emma Hobson, Peter Nürnberg, E Ferda Percin, Angela Peron, Luigina Spaccini, Alan J Quigley, Seema Thakur, Carol A Wise, Grace Yoon, Maha Alnemer, Pavel Tomancak, Gökhan Yigit, A Malcolm R Taylor, Martin AM Reijns, Michael A Simpson, David Cortez, Fowzan S Alkuraya, Christopher G Mathew, Andrew P Jackson, Grant S Stewart

Nat Genet. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Nat Genet. 2017 Apr; 49(4): 537–549. Published online 2017 Feb 13. doi: 10.1038/ng.3790

PMCID:: PMC5450907

Abstract Article PDF–1.5M

Select item 642645520.

Mapping the genetic landscape of human cells

Max A. Horlbeck, Albert Xu, Min Wang, Neal K. Bennett, Chong Y. Park, Derek Bogdanoff, Britt Adamson, Eric D. Chow, Martin Kampmann, Tim R. Peterson, Ken Nakamura, Michael A. Fischbach, Jonathan S. Weissman, Luke A. Gilbert

Cell. Author manuscript; available in PMC 2019 Aug 9.

Published in final edited form as: Cell. 2018 Aug 9; 174(4): 953–967.e22. Published online 2018 Jul 19. doi: 10.1016/j.cell.2018.06.010

PMCID:: PMC6426455

Abstract Article PDF–3.6M

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