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Select item 109665301.

TRAF4‐Mediated LAMTOR1 Ubiquitination Promotes mTORC1 Activation and Inhibits the Inflammation‐Induced Colorectal Cancer Progression

Linlin Zhao, Ni Gao, Xiaoping Peng, Lei Chen, Tong Meng, Cong Jiang, Jiali Jin, Jiawen Zhang, Qiuhui Duan, Hongling Tian, Linjun Weng, Xinbo Wang, Xiao Tan, Yaxu Li, Huanlong Qin, Jian Yuan, Xin Ge, Lu Deng, Ping Wang

Adv Sci (Weinh) 2024 Mar; 11(12): 2301164. Published online 2024 Jan 16. doi: 10.1002/advs.202301164

PMCID:: PMC10966530

Abstract Article PDF–4.2M

Select item 98909262.

LAMTOR1 degrades MHC-II via the endocytic in hepatocellular carcinoma

Bo Wu, Qian Wang, Bowen Li, Meixi Jiang

Carcinogenesis. 2022 Nov; 43(11): 1059–1070. Published online 2022 Sep 7. doi: 10.1093/carcin/bgac075

PMCID:: PMC9890926

Abstract Article PDF–47M

Select item 64540843.

mTORC1 Signaling Is Palmitoylation-Dependent in Hippocampal Neurons and Non-neuronal Cells and Involves Dynamic Palmitoylation of LAMTOR1 and mTOR

Shaun S. Sanders, Francesca I. De Simone, Gareth M. Thomas

Front Cell Neurosci. 2019; 13: 115. Published online 2019 Apr 2. doi: 10.3389/fncel.2019.00115

PMCID:: PMC6454084

Abstract Article PDF–9.5M

Select item 57428544.

Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane

Zongkai Mu, Lei Wang, Wei Deng, Jiawei Wang, Geng Wu

Cell Discov. 2017; 3: 17049. Published online 2017 Dec 26. doi: 10.1038/celldisc.2017.49

PMCID:: PMC5742854

Abstract Article PDF–2.7M

Select item 33580175.

LAMTOR1 depletion induces p53-dependent apoptosis via aberrant lysosomal activation

M Malek, P Guillaumot, A-L Huber, J Lebeau, V Pétrilli, A Kfoury, I Mikaelian, T Renno, S N Manié

Cell Death Dis. 2012 Apr; 3(4): e300. Published online 2012 Apr 19. doi: 10.1038/cddis.2012.39

PMCID:: PMC3358017

Abstract Article PDF–548K

Select item 73716886.

N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells

Yu-Chuan Chen, Marian S. Navarrete, Ying Wang, Natalie C. McClintock, Reiko Sakurai, Feng Wang, Kathryn T. Chen, Tsui-Fen Chou, Virender K. Rehan, Delphine J. Lee, Begoña Diaz

Sci Rep. 2020; 10: 11952. Published online 2020 Jul 20. doi: 10.1038/s41598-020-68615-w

PMCID:: PMC7371688

Abstract Article PDF–6.2M

Select item 64975607.

Patient-driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion-driven Cancer

Emily K Slotkin, Daniel Diolaiti, Neerav N Shukla, Filemon S Dela Cruz, Jennifer J Clark, Gunes Gundem, Venkata D Yellapantula, Max F Levine, Daoqi You, Peilin Ma, Sagarika Pachhal, Glorymar Ibanez Sanchez, Ryma Benayed, Achim A Jungbluth, Lillian M Smyth, Audrey Mauguen, Irena Gushterova, Hongxu Ding, Lee Spraggon, Robert Darnell, Andrea Califano, Marc Ladanyi, Elli Papaemmanuil, Andrew L Kung, David M Hyman, Stephen S Roberts

Cancer Discov. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: Cancer Discov. 2019 May; 9(5): 605–616. Published online 2019 Mar 15. doi: 10.1158/2159-8290.CD-18-0953

PMCID:: PMC6497560

Abstract Article PDF–1.9M

Select item 59325698.

The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex

Yilun Deng, Yuejuan Qin, Subramanya Srikantan, Anqi Luo, Zi-Ming Cheng, Shahida K Flores, Kris S Vogel, Exing Wang, Patricia L M Dahia

Hum Mol Genet. 2018 May 15; 27(10): 1794–1808. Published online 2018 Mar 14. doi: 10.1093/hmg/ddy095

PMCID:: PMC5932569

Abstract Article PDF–1.1M

Select item 57162769.

LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning

Przemyslaw A. Filipek, Mariana E.G. de Araujo, Georg F. Vogel, Cedric H. De Smet, Daniela Eberharter, Manuele Rebsamen, Elena L. Rudashevskaya, Leopold Kremser, Teodor Yordanov, Philipp Tschaikner, Barbara G. Fürnrohr, Stefan Lechner, Theresia Dunzendorfer-Matt, Klaus Scheffzek, Keiryn L. Bennett, Giulio Superti-Furga, Herbert H. Lindner, Taras Stasyk, Lukas A. Huber

J Cell Biol. 2017 Dec 4; 216(12): 4199–4215. doi: 10.1083/jcb.201703061

PMCID:: PMC5716276

Abstract Article PDF–2.4M

Select item 538378110.

Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling

Xu Li, Min Gao, Jong Min Choi, Beom-Jun Kim, Mao-Tian Zhou, Zhen Chen, Antrix N. Jain, Sung Yun Jung, Jingsong Yuan, Wenqi Wang, Yi Wang, Junjie Chen

Mol Cell Proteomics. 2017 Apr; 16(4): 594–607. Published online 2017 Feb 7. doi: 10.1074/mcp.M116.064543

PMCID:: PMC5383781

Abstract Article PDF–2.6M

Select item 288232411.

Pdro, a Protein Associated with Late Endosomes and Lysosomes and Implicated in Cellular Cholesterol Homeostasis

Patricia Guillaumot, Céline Luquain, Mouhannad Malek, Anne-Laure Huber, Sabine Brugière, Jérome Garin, Didier Grunwald, Daniel Régnier, Virginie Pétrilli, Etienne Lefai, Serge N. Manié

PLoS One. 2010; 5(6): e10977. Published online 2010 Jun 8. doi: 10.1371/journal.pone.0010977

PMCID:: PMC2882324

Abstract Article PDF–1.2M

Select item 278565912.

A Novel Protein Associated with Membrane-type 1 Matrix Metalloproteinase Binds p27^kip1 and Regulates RhoA Activation, Actin Remodeling, and Matrigel Invasion

Daisuke Hoshino, Taizo Tomari, Makoto Nagano, Naohiko Koshikawa, Motoharu Seiki

J Biol Chem. 2009 Oct 2; 284(40): 27315–27326. Published online 2009 Aug 4. doi: 10.1074/jbc.M109.041400

PMCID:: PMC2785659

Abstract Article PDF–3.2M

Select item 981161913.

The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6

Kohei Tsujimoto, Tatsunori Jo, Daiki Nagira, Hachiro Konaka, Jeong Hoon Park, Shin‐ichiro Yoshimura, Akinori Ninomiya, Fuminori Sugihara, Takehiro Hirayama, Eri Itotagawa, Yusei Matsuzaki, Yuki Takaichi, Wataru Aoki, Shotaro Saita, Shuhei Nakamura, Andrea Ballabio, Shigeyuki Nada, Masato Okada, Hyota Takamatsu, Atsushi Kumanogoh

EMBO J. 2023 Jan; 42(1): e111389. Published online 2022 Nov 29. doi: 10.15252/embj.2022111389

PMCID:: PMC9811619

Abstract Article PDF–4.2M

Select item 929844914.

ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation

Dongsheng Bai, Jiaying Du, Xiumin Bu, Wangjia Cao, Tifan Sun, Jiawei Zhao, Yue Zhao, Na Lu

Autophagy. 2022; 18(7): 1673–1693. Published online 2021 Nov 25. doi: 10.1080/15548627.2021.1997051

PMCID:: PMC9298449

Abstract Article PDF–7.7M

Select item 582361115.

Lysosomal Cholesterol Activates mTORC1 via an SLC38A9-Niemann Pick C1 Signaling Complex

Brian M. Castellano, Ashley M. Thelen, Ofer Moldavski, McKenna Feltes, Reini E. N. van der Welle, Laurel Mydock-McGrane, Xuntian Jiang, Robert J van Eijkeren, Oliver B. Davis, Sharon M. Louie, Rushika M. Perera, Douglas Covey, Daniel K. Nomura, Daniel S. Ory, Roberto Zoncu

Science. Author manuscript; available in PMC 2018 Feb 22.

Published in final edited form as: Science. 2017 Mar 24; 355(6331): 1306–1311. doi: 10.1126/science.aag1417

PMCID:: PMC5823611

Abstract Article PDF–698K

Select item 569636016.

Structural basis for the assembly of the Ragulator-Rag GTPase complex

Ryo Yonehara, Shigeyuki Nada, Tomokazu Nakai, Masahiro Nakai, Ayaka Kitamura, Akira Ogawa, Hirokazu Nakatsumi, Keiichi I. Nakayama, Songling Li, Daron M. Standley, Eiki Yamashita, Atsushi Nakagawa, Masato Okada

Nat Commun. 2017; 8: 1625. Published online 2017 Nov 20. doi: 10.1038/s41467-017-01762-3

PMCID:: PMC5696360

Abstract Article PDF–6.3M

Select item 568023317.

Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1

Tianlong Zhang, Rong Wang, Zhijing Wang, Xiangxiang Wang, Fang Wang, Jianping Ding

Nat Commun. 2017; 8: 1394. Published online 2017 Nov 9. doi: 10.1038/s41467-017-01567-4

PMCID:: PMC5680233

Abstract Article PDF–3.1M

Select item 316593118.

Crystal structure of the Gtr1p–Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation

Rui Gong, Li Li, Yi Liu, Ping Wang, Huirong Yang, Ling Wang, Jingdong Cheng, Kun-Liang Guan, Yanhui Xu

Genes Dev. 2011 Aug 15; 25(16): 1668–1673. doi: 10.1101/gad.16968011

PMCID:: PMC3165931

Abstract Article PDF–1.1M

Select item 302480619.

A p27^kip1-binding Protein, p27RF-Rho, Promotes Cancer Metastasis via Activation of RhoA and RhoC

Daisuke Hoshino, Naohiko Koshikawa, Motoharu Seiki

J Biol Chem. 2011 Jan 28; 286(4): 3139–3148. Published online 2010 Nov 17. doi: 10.1074/jbc.M110.159715

PMCID:: PMC3024806

Abstract Article PDF–2.3M

Select item 717640320.

Structural basis for the docking of mTORC1 on the lysosomal surface

Kacper B. Rogala, Xin Gu, Jibril F. Kedir, Monther Abu-Remaileh, Laura F. Bianchi, Alexia M. S. Bottino, Rikke Dueholm, Anna Niehaus, Daan Overwijn, Ange-Célia Priso Fils, Sherry X. Zhou, Daniel Leary, Nouf N. Laqtom, Edward J. Brignole, David M. Sabatini

Science. Author manuscript; available in PMC 2020 Apr 22.

Published in final edited form as: Science. 2019 Oct 25; 366(6464): 468–475. Published online 2019 Oct 10. doi: 10.1126/science.aay0166

PMCID:: PMC7176403

Abstract Article PDF–2.8M

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