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Select item 105250361.

PP2Ac Deficiency Enhances Tumor Immunogenicity by Activating STING-Type I Interferon Signaling in Glioblastoma

Isha Mondal, Oishika Das, Raymond Sun, Jian Gao, Bohyeon Yu, Aaron Diaz, Jinan Behnan, Abhishek Dubey, Zhipeng Meng, Emad Eskandar, Beisi Xu, Rongze Olivia Lu, Winson S. Ho

Cancer Res. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Cancer Res. 2023 Aug 1; 83(15): 2527–2542. doi: 10.1158/0008-5472.CAN-22-3382

PMCID:: PMC10525036

Abstract Article PDF–2.8M

Select item 97796942.

The Pivotal Role of Protein Phosphatase 2A (PP2A) in Brain Tumors

Laura Cucinotta, Alessia Filippone, Giovanna Casili, Marika Lanza, Valentina Bova, Anna Paola Capra, Raffaella Giuffrida, Cristina Colarossi, Dorotea Sciacca, Irene Paterniti, Salvatore Cuzzocrea, Michela Campolo, Emanuela Esposito

Int J Mol Sci. 2022 Dec; 23(24): 15717. Published online 2022 Dec 11. doi: 10.3390/ijms232415717

PMCID:: PMC9779694

Abstract Article PDF–1024K

Select item 68236533.

PP2Ac upregulates PI3K-Akt signaling and induces hepatocyte apoptosis in liver donor after brain death

Yan Xiong, Jianan Lan, Kaixin Huang, Yaruo Zhang, Lewei Zheng, Yanfeng Wang, Qifa Ye

Apoptosis. 2019; 24(11): 921–933. Published online 2019 Oct 11. doi: 10.1007/s10495-019-01570-8

PMCID:: PMC6823653

Abstract Article PDF–2.9M

Select item 65487784.

Inhibition of PP2A activity by H₂O₂ during mitosis disrupts nuclear envelope reassembly and alters nuclear shape

Ju-Hyun Ahn, Min-Guk Cho, Seonghyang Sohn, Jae-Ho Lee

Exp Mol Med. 2019 Jun; 51(6): 64. Published online 2019 Jun 5. doi: 10.1038/s12276-019-0260-0

PMCID:: PMC6548778

Abstract Article PDF–2.0M

Select item 62020345.

Protein Phosphatase 2A Plays a Role in Hydrogen Peroxide-Induced Disruption of Tight Junctions in Caco-2 Cell Monolayers

Parimal Sheth, Geetha Samak, J. Andrew Shull, Ankur Seth, Radhakrishna Rao

Biochem J. Author manuscript; available in PMC 2018 Oct 25.

Published in final edited form as: Biochem J. 2009 Jun 12; 421(1): 59–70. Published online 2009 Jun 12. doi: 10.1042/BJ20081951

PMCID:: PMC6202034

Article PDF–2.3M

Select item 60760516.

Association between PPP2CA polymorphisms and clinical features in southwest Chinese systemic lupus erythematosus patients

Junlong Zhang, Yanming Meng, Hengxu Wu, Yongkang Wu, Bin Yang, Lanlan Wang

Medicine (Baltimore) 2018 Jul; 97(27): e11451. Published online 2018 Jul 6. doi: 10.1097/MD.0000000000011451

PMCID:: PMC6076051

Abstract Article PDF–232K

Select item 55976327.

Genetic variants in PPP2CA are associated with gastric cancer risk in a Chinese population

Tongtong Huang, Kexin He, Yingying Mao, Meng Zhu, Caiwang Yan, Fei Yu, Qi Qi, Tianpei Wang, Yan Wang, Jiangbo Du, Li Liu

Sci Rep. 2017; 7: 11499. Published online 2017 Sep 13. doi: 10.1038/s41598-017-12040-z

PMCID:: PMC5597632

Abstract Article PDF–1.2M

Select item 53900788.

The catalytic role of the M2 metal ion in PP2Cα

Chang Pan, Jun-yi Tang, Yun-fei Xu, Peng Xiao, Hong-da Liu, Hao-an Wang, Wen-bo Wang, Fan-guo Meng, Xiao Yu, Jin-peng Sun

Sci Rep. 2015; 5: 8560. Published online 2015 Feb 24. doi: 10.1038/srep08560

PMCID:: PMC5390078

Abstract Article PDF–1.5M

Select item 44978339.

Protein phosphatase 2A inhibition with LB100 enhances radiation-induced mitotic catastrophe and tumor growth delay in glioblastoma

Ira K. Gordon, Jie Lu, Christian A. Graves, Kristin Huntoon, Jason M. Frerich, Ryan H. Hanson, Xiaoping Wang, Christopher S. Hong, Winson Ho, Michael J. Feldman, Barbara Ikejiri, Kheem Bisht, Xiaoyuan S. Chen, Anita Tandle, Chunzhang Yang, W. Tristram Arscott, Donald Ye, John D. Heiss, Russell R. Lonser, Kevin Camphausen, Zhengping Zhuang

Mol Cancer Ther. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Mol Cancer Ther. 2015 Jul; 14(7): 1540–1547. Published online 2015 May 4. doi: 10.1158/1535-7163.MCT-14-0614

PMCID:: PMC4497833

Abstract Article PDF–707K

Select item 413450510.

Phosphorylated protein phosphatase 2A determines poor outcome in patients with metastatic colorectal cancer

I Cristóbal, R Manso, R Rincón, C Caramés, S Zazo, T G del Pulgar, A Cebrián, J Madoz-Gúrpide, F Rojo, J García-Foncillas

Br J Cancer. 2014 Aug 12; 111(4): 756–762. Published online 2014 Jul 8. doi: 10.1038/bjc.2014.376

PMCID:: PMC4134505

Abstract Article PDF–618K

Select item 407398511.

Acetaldehyde disrupts tight junctions in Caco-2 cell monolayers by a protein phosphatase 2A-dependent mechanism

Mitzi Dunagan, Kamaljit Chaudhry, Geetha Samak, R. K. Rao

Am J Physiol Gastrointest Liver Physiol. 2012 Dec 15; 303(12): G1356–G1364. Published online 2012 Oct 11. doi: 10.1152/ajpgi.00526.2011

PMCID:: PMC4073985

Abstract Article

Select item 405916612.

Protein Phosphatase 2A (PP2A) Regulates Low Density Lipoprotein Uptake through Regulating Sterol Response Element-binding Protein-2 (SREBP-2) DNA Binding

Lyndi M. Rice, Melissa Donigan, Muhua Yang, Weidong Liu, Devanshi Pandya, Biny K. Joseph, Valerie Sodi, Tricia L. Gearhart, Jenny Yip, Michael Bouchard, Joseph T. Nickels, Jr.

J Biol Chem. 2014 Jun 13; 289(24): 17268–17279. Published online 2014 Apr 26. doi: 10.1074/jbc.M114.570390

PMCID:: PMC4059166

Abstract Article PDF–3.8M

Select item 399250113.

Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model

A Bhardwaj, S Singh, S K Srivastava, S Arora, S J Hyde, J Andrews, W E Grizzle, A P Singh

Br J Cancer. 2014 Apr 15; 110(8): 2000–2010. Published online 2014 Mar 18. doi: 10.1038/bjc.2014.141

PMCID:: PMC3992501

Abstract Article PDF–2.3M

Select item 397132014.

Protein phosphatase-2A is down-regulated in patients within clear cell renal cell carcinoma

Jun Li, Chang Sheng, Wei Li, Jun-Hua Zheng

Int J Clin Exp Pathol. 2014; 7(3): 1147–1158. Published online 2014 Feb 15.

PMCID:: PMC3971320

Abstract Article PDF–574K

Select item 366939515.

Modulation of protein phosphatase 2A (PP2A) activity alters androgen-independent growth of prostate cancer cells: therapeutic implications

Arun Bhardwaj, Seema Singh, Sanjeev K. Srivastava, Richard E. Honkanen, Eddie Reed, Ajay P. Singh

Mol Cancer Ther. Author manuscript; available in PMC 2013 May 31.

Published in final edited form as: Mol Cancer Ther. 2011 May; 10(5): 720–731. Published online 2011 Mar 10. doi: 10.1158/1535-7163.MCT-10-1096

PMCID:: PMC3669395

Abstract Article PDF–2.7M

Select item 342195516.

Circumventing Cellular Control of PP2A by Methylation Promotes Transformation in an Akt-Dependent Manner

Jennifer B Jackson, David C Pallas

Neoplasia. 2012 Jul; 14(7): 585–599. doi: 10.1593/neo.12768

PMCID:: PMC3421955

Abstract Article PDF–986K

Select item 323242717.

Effect of microcystin-LR on protein phosphatase 2A and its function in human amniotic epithelial cells

Jing Liang, Tan Li, Ya-li Zhang, Zong-lou Guo, Li-hong Xu

J Zhejiang Univ Sci B. 2011 Dec; 12(12): 951–960. doi: 10.1631/jzus.B1100121

PMCID:: PMC3232427

Abstract Article PDF–899K

Select item 320526918.

Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium

Paul J. M. Wijnker, Peter Boknik, Ulrich Gergs, Frank U. Müller, Joachim Neumann, Cris dos Remedios, Wilhelm Schmitz, Jürgen R. Sindermann, Ger J. M. Stienen, Jolanda van der Velden, Uwe Kirchhefer

J Muscle Res Cell Motil. 2011; 32(3): 221–233. Published online 2011 Sep 30. doi: 10.1007/s10974-011-9261-x

PMCID:: PMC3205269

Abstract Article PDF–557K

Select item 316311019.

Association of PPP2CA polymorphisms with SLE susceptibility in multiple ethnic groups

Wenfeng Tan, Katsue Sunahori, Jian Zhao, Yun Deng, Kenneth M. Kaufman, Jennifer A. Kelly, Carl D. Langefeld, Adrienne H. Williams, Mary E. Comeau, Julie T. Ziegler, Miranda C. Marion, Sang-Cheol Bae, Joo Hyun Lee, Ji-Seon Lee, Deh-Ming Chang, Yeong Wook Song, Chack-Yung Yu, Robert P. Kimberly, Jeffrey C. Edberg, Elizabeth E. Brown, Michelle A. Petri, Rosalind Ramsey-Goldman, Luis M. Vilá, John D. Reveille, Marta E. Alarcón-Riquelme, John B. Harley, Susan A. Boackle, Anne M. Stevens, R. Hal Scofield, Joan T. Merrill, Barry I. Freedman, Juan-Manuel Anaya, Lindsey A. Criswell, Chaim O. Jacob, Timothy J. Vyse, Timothy B. Niewold, Patrick M. Gaffney, Kathy L. Moser, Gary S. Gilkeson, Diane L. Kamen, Judith A. James, Jennifer M. Grossman, Bevra H. Hahn, George C. Tsokos, Betty P. Tsao

Arthritis Rheum. Author manuscript; available in PMC 2012 Sep 1.

Published in final edited form as: Arthritis Rheum. 2011 Sep; 63(9): 2755–2763. doi: 10.1002/art.30452

Correction in:: volume 63 on page 3521

PMCID:: PMC3163110

Abstract Article PDF–810K

Select item 314894120.

Promoter Hypomethylation Results in Increased Expression of Protein Phosphatase 2A in T Cells from Patients with Systemic Lupus Erythematosus

Katsue Sunahori, Yuang-Taung Juang, Vasileios C. Kyttaris, George C. Tsokos

J Immunol. Author manuscript; available in PMC 2012 Apr 1.

Published in final edited form as: J Immunol. 2011 Apr 1; 186(7): 4508–4517. Published online 2011 Feb 23. doi: 10.4049/jimmunol.1000340

PMCID:: PMC3148941

Abstract Article PDF–622K

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