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1.
Association between serum anti-ASXL2 antibody levels and acute ischemic stroke, acute myocardial infarction, diabetes mellitus, chronic kidney disease and digestive organ cancer, and their possible association with atherosclerosis and hypertension
Shu-Yang Li, Yoichi Yoshida, Eiichi Kobayashi, Akihiko Adachi, Seiichiro Hirono, Tomoo Matsutani, Seiichiro Mine, Toshio Machida, Mikiko Ohno, Eiichiro Nishi, Yoshiro Maezawa, Minoru Takemoto, Koutaro Yokote, Kenichiro Kitamura, Makoto Sumazaki, Masaaki Ito, Hideaki Shimada, Hirotaka Takizawa, Koichi Kashiwado, Go Tomiyoshi, Natsuko Shinmen, Rika Nakamura, Hideyuki Kuroda, Xiao-Meng Zhang, Hao Wang, Kenichiro Goto, Yasuo Iwadate, Takaki Hiwasa
Int J Mol Med. 2020 Oct; 46(4): 1274–1288. Published online 2020 Jul 29. doi: 10.3892/ijmm.2020.4690
PMCID:
PMC7447314
AbstractArticlePDF–810K
2.
De Novo Truncating Variants in ASXL2 Are Associated with a Unique and Recognizable Clinical Phenotype
Vandana Shashi, Loren D.M. Pena, Katherine Kim, Barbara Burton, Maja Hempel, Kelly Schoch, Magdalena Walkiewicz, Heather M. McLaughlin, Megan Cho, Nicholas Stong, Scott E. Hickey, Christine M. Shuss, Undiagnosed Diseases Network, Michael S. Freemark, Jane S. Bellet, Martha Ann Keels, Melanie J. Bonner, Maysantoine El-Dairi, Megan Butler, Peter G. Kranz, Constance T.R.M. Stumpel, Sylvia Klinkenberg, Karin Oberndorff, Malik Alawi, Rene Santer, Slavé Petrovski, Outi Kuismin, Satu Korpi-Heikkilä, Olli Pietilainen, Palotie Aarno, Mitja I. Kurki, Alexander Hoischen, Anna C. Need, David B. Goldstein, Fanny Kortüm
Am J Hum Genet. 2016 Oct 6; 99(4): 991–999. Published online 2016 Sep 29. doi: 10.1016/j.ajhg.2016.08.017
Correction in:
Am J Hum Genet. 2017 Jan 5; 100(1): 179.
PMCID:
PMC5065681
AbstractArticlePDF–798K
3.
ASXL2 regulates glucose, lipid and skeletal homeostasis
Takashi Izawa, Nidhi Rohatgi, Tomohiro Fukunaga, Qun-Tian Wang, Matthew J. Silva, Michael J. Gardner, Michael L. McDaniel, Nada A. Abumrad, Clay F. Semenkovich, Steven L. Teitelbaum, Wei Zou
Cell Rep. Author manuscript; available in PMC 2016 Jun 16.
Published in final edited form as: Cell Rep. 2015 Jun 16; 11(10): 1625–1637. Published online 2015 Jun 4. doi: 10.1016/j.celrep.2015.05.019
PMCID:
PMC4472564
AbstractArticlePDF–2.0M
4.
Understanding the phenotypic spectrum of ASXL-related disease: 10 cases and a review of the literature
Vishnu Anand Cuddapah, Holly A. Dubbs, Laura Adang, Steven L. Kugler, Elizabeth M. McCormick, Zarazuela Zolkipli-Cunningham, Xilma R. Ortiz-González, Shana McCormack, Elaine Zackai, Daniel J. Licht, Marni J. Falk, Eric D. Marsh
Am J Med Genet A. Author manuscript; available in PMC 2022 Jun 1.
Published in final edited form as: Am J Med Genet A. 2021 Jun; 185(6): 1700–1711. Published online 2021 Mar 10. doi: 10.1002/ajmg.a.62156
PMCID:
PMC8842511
AbstractArticlePDF–442K
5.
Kinetic Characterization of ASXL1/2-Mediated Allosteric Regulation of the BAP1 Deubiquitinase
Hongzhuang Peng, Joel Cassel, Daniel S. McCracken, Jeremy W. Prokop, Eleonora Sementino, Mitchell Cheung, Paul R. Collop, Alexander Polo, Surbhi Joshi, Jacob P. Mandell, Kasirajan Ayyanathan, David Hinds, S. Bruce Malkowicz, J. William Harbour, Anne M. Bowcock, Joseph Salvino, Eileen J. Kennedy, Joseph R. Testa, Frank J. Rauscher, III
Mol Cancer Res. Author manuscript; available in PMC 2022 Jan 1.
Published in final edited form as: Mol Cancer Res. 2021 Jul; 19(7): 1099–1112. Published online 2021 Mar 17. doi: 10.1158/1541-7786.MCR-20-0080
PMCID:
PMC8254751
AbstractArticlePDF–2.2M
6.
Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains
Hongzhuang Peng, Jeremy Prokop, Jayashree Karar, Kyewon Park, Li Cao, J. William Harbour, Anne M. Bowcock, S. Bruce Malkowicz, Mitchell Cheung, Joseph R. Testa, Frank J. Rauscher, 3rd
Cancer Res. Author manuscript; available in PMC 2019 Mar 1.
Published in final edited form as: Cancer Res. 2018 Mar 1; 78(5): 1200–1213. Published online 2017 Dec 28. doi: 10.1158/0008-5472.CAN-17-2876
PMCID:
PMC6167014
AbstractArticlePDF–1.0M
7.
Infrequent occurrence of TET1, TET3, and ASXL2 mutations in myelodysplastic/myeloproliferative neoplasms
Terra L. Lasho, Rangit Vallapureddy, Christy M. Finke, Abhishek Mangaonkar, Naseema Gangat, Rhett Ketterling, Ayalew Tefferi, Mrinal M. Patnaik
Blood Cancer J. 2018 Mar; 8(3): 32. Published online 2018 Mar 12. doi: 10.1038/s41408-018-0057-8
PMCID:
PMC5849888
ArticlePDF–420K
8.
ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia
Jean-Baptiste Micol, Alessandro Pastore, Daichi Inoue, Nicolas Duployez, Eunhee Kim, Stanley Chun-Wei Lee, Benjamin H. Durham, Young Rock Chung, Hana Cho, Xiao Jing Zhang, Akihide Yoshimi, Andrei Krivtsov, Richard Koche, Eric Solary, Amit Sinha, Claude Preudhomme, Omar Abdel-Wahab
Nat Commun. 2017; 8: 15429. Published online 2017 May 18. doi: 10.1038/ncomms15429
PMCID:
PMC5454368
AbstractArticlePDF–1.9M
9.
Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations
Jean-Baptiste Micol, Nicolas Duployez, Nicolas Boissel, Arnaud Petit, Sandrine Geffroy, Olivier Nibourel, Catherine Lacombe, Helene Lapillonne, Pascaline Etancelin, Martin Figeac, Aline Renneville, Sylvie Castaigne, Guy Leverger, Norbert Ifrah, Hervé Dombret, Claude Preudhomme, Omar Abdel-Wahab, Eric Jourdan
Blood. 2014 Aug 28; 124(9): 1445–1449. Prepublished online 2014 Jun 27. doi: 10.1182/blood-2014-04-571018
PMCID:
PMC4148766
AbstractArticle
10.
The Genomic Landscape of Core-Binding Factor Acute Myeloid Leukemias
Zachary J. Faber, Xiang Chen, Amanda Larson Gedman, Kristy Boggs, Jinjun Cheng, Jing Ma, Ina Radtke, Jyh-Rong Chao, Michael P. Walsh, Guangchun Song, Anna K. Andersson, Jinjun Dang, Li Dong, Yu Liu, Robert Huether, Zhongling Cai, Heather Mulder, Gang Wu, Michael Edmonson, Michael Rusch, Chunxu Qu, Yongjin Li, Bhavin Vadodaria, Jianmin Wang, Erin Hedlund, Xueyuan Cao, Donald Yergeau, Joy Nakitandwe, Stanley B. Pounds, Sheila Shurtleff, Robert S. Fulton, Lucinda L. Fulton, John Easton, Evan Parganas, Ching-Hon Pui, Jeffrey E. Rubnitz, Li Ding, Elaine R. Mardis, Richard K. Wilson, Tanja A. Gruber, Charles G. Mullighan, Richard F. Schlenk, Peter Paschka, Konstanze Döhner, Hartmut Döhner, Lars Bullinger, Jinghui Zhang, Jeffery M. Klco, James R. Downing
Nat Genet. Author manuscript; available in PMC 2017 Jul 13.
Published in final edited form as: Nat Genet. 2016 Dec; 48(12): 1551–1556. Published online 2016 Oct 31. doi: 10.1038/ng.3709
PMCID:
PMC5508996
AbstractArticlePDF–669K
11.
Additional Sex Combs-Like 2 Is Required for Polycomb Repressive Complex 2 Binding at Select Targets
Hsiao-Lei Lai, Q. Tian Wang
PLoS One. 2013; 8(9): e73983. Published online 2013 Sep 9. doi: 10.1371/journal.pone.0073983
PMCID:
PMC3767597
AbstractArticlePDF–1.5M
12.
Additional Sex Comb-like (ASXL) Proteins 1 and 2 Play Opposite Roles in Adipogenesis via Reciprocal Regulation of Peroxisome Proliferator-activated Receptor γ
Ui-Hyun Park, Seung Kew Yoon, Taesun Park, Eun-Joo Kim, Soo-Jong Um
J Biol Chem. 2011 Jan 14; 286(2): 1354–1363. Published online 2010 Nov 3. doi: 10.1074/jbc.M110.177816
PMCID:
PMC3020743
AbstractArticlePDF–1.5M
13.
The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex
Zongling Ji, Hisham Mohammed, Aaron Webber, Jenna Ridsdale, Namshik Han, Jason S. Carroll, Andrew D. Sharrocks
Nucleic Acids Res. 2014 Jun 1; 42(10): 6232–6242. Published online 2014 Apr 19. doi: 10.1093/nar/gku274
PMCID:
PMC4041447
AbstractArticlePDF–1.0M
14.
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
Salima Daou, Haithem Barbour, Oumaima Ahmed, Louis Masclef, Caroline Baril, Nadine Sen Nkwe, Daméhan Tchelougou, Maxime Uriarte, Eric Bonneil, Derek Ceccarelli, Nazar Mashtalir, Mika Tanji, Jean-Yves Masson, Pierre Thibault, Frank Sicheri, Haining Yang, Michele Carbone, Marc Therrien, El Bachir Affar
Nat Commun. 2018; 9: 4385. Published online 2018 Oct 22. doi: 10.1038/s41467-018-06854-2
PMCID:
PMC6197237
AbstractArticlePDF–5.5M
15.
The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer
Salima Daou, Ian Hammond-Martel, Nazar Mashtalir, Haithem Barbour, Jessica Gagnon, Nicholas V. G. Iannantuono, Nadine Sen Nkwe, Alena Motorina, Helen Pak, Helen Yu, Hugo Wurtele, Eric Milot, Frédérick A. Mallette, Michele Carbone, El Bachir Affar
J Biol Chem. 2015 Nov 27; 290(48): 28643–28663. Published online 2015 Sep 28. doi: 10.1074/jbc.M115.661553
PMCID:
PMC4661380
AbstractArticlePDF–6.7M
16.
ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer
Aileen Patricia Szczepanski, Zibo Zhao, Tori Sosnowski, Young Ah Goo, Elizabeth Thomas Bartom, Lu Wang
Genome Med. 2020; 12: 63. Published online 2020 Jul 15. doi: 10.1186/s13073-020-00760-3
PMCID:
PMC7362484
AbstractArticlePDF–4.2M
17.
The Deubiquitinating Enzyme BAP1 Regulates Cell Growth via Interaction with HCF-1
Yuichi J. Machida, Yuka Machida, Ajay A. Vashisht, James A. Wohlschlegel, Anindya Dutta
J Biol Chem. 2009 Dec 4; 284(49): 34179–34188. Published online 2009 Oct 8. doi: 10.1074/jbc.M109.046755
PMCID:
PMC2797188
AbstractArticlePDF–2.4M
18.
The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and Is a Critical Regulator of Gene Expression
Helen Yu, Nazar Mashtalir, Salima Daou, Ian Hammond-Martel, Julie Ross, Guangchao Sui, Gerald W. Hart, Frank J. Rauscher, III, Elliot Drobetsky, Eric Milot, Yang Shi, El Bachir Affar
Mol Cell Biol. 2010 Nov; 30(21): 5071–5085. Published online 2010 Aug 30. doi: 10.1128/MCB.00396-10
PMCID:
PMC2953049
AbstractArticlePDF–3.3M
19.
Resetting the Epigenetic Balance of Polycomb and COMPASS Function at Enhancers for Cancer Therapy
Lu Wang, Zibo Zhao, Patrick Alexander Ozark, Damiano Fantini, Stacy A. Marshall, Emily J. Rendleman, Kira A. Cozzolino, Nundia Louis, Xingyao He, Marc A. Morgan, Yoh-hei Takahashi, Clayton K. Collings, Edwin R. Smith, Panagiotis Ntziachristos, Jeffrey N. Savas, Lihua Zou, Rintaro Hashizume, Joshua J. Meeks, Ali Shilatifard
Nat Med. Author manuscript; available in PMC 2018 Dec 1.
Published in final edited form as: Nat Med. 2018 Jun; 24(6): 758–769. Published online 2018 May 21. doi: 10.1038/s41591-018-0034-6
PMCID:
PMC6055231
AbstractArticlePDF–1.5M
20.
Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns
Karol Szafranski, Stefanie Schindler, Stefan Taudien, Michael Hiller, Klaus Huse, Niels Jahn, Stefan Schreiber, Rolf Backofen, Matthias Platzer
Genome Biol. 2007; 8(8): R154. Published online 2007 Aug 1. doi: 10.1186/gb-2007-8-8-r154
PMCID:
PMC2374985
AbstractArticlePDF–369K

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