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Select item 75424441.

Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ

Michał S. Barski, Jordan J. Minnell, Zuzana Hodakova, Valerie E. Pye, Andrea Nans, Peter Cherepanov, Goedele N. Maertens

Nat Commun. 2020; 11: 5043. Published online 2020 Oct 7. doi: 10.1038/s41467-020-18874-y

PMCID:: PMC7542444

Abstract Article PDF–2.4M

Select item 73051642.

Structural basis of host protein hijacking in human T-cell leukemia virus integration

Veer Bhatt, Ke Shi, Daniel J. Salamango, Nicholas H. Moeller, Krishan K. Pandey, Sibes Bera, Heather O. Bohl, Fredy Kurniawan, Kayo Orellana, Wei Zhang, Duane P. Grandgenett, Reuben S. Harris, Anna C. Sundborger-Lunna, Hideki Aihara

Nat Commun. 2020; 11: 3121. Published online 2020 Jun 19. doi: 10.1038/s41467-020-16963-6

PMCID:: PMC7305164

Abstract Article PDF–2.2M

Select item 71088653.

A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment

Xinru Wang, Dimitriya H Garvanska, Isha Nasa, Yumi Ueki, Gang Zhang, Arminja N Kettenbach, Wolfgang Peti, Jakob Nilsson, Rebecca Page

eLife. 2020; 9: e55966. Published online 2020 Mar 20. doi: 10.7554/eLife.55966

PMCID:: PMC7108865

Abstract Article PDF–2.6M

Select item 45950734.

PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis

Yong-Sheng Cheng, Oksana Seibert, Nora Klöting, Arne Dietrich, Katrin Straßburger, Sonia Fernández-Veledo, Joan J. Vendrell, Antonio Zorzano, Matthias Blüher, Stephan Herzig, Mauricio Berriel Diaz, Aurelio A. Teleman

PLoS Genet. 2015 Oct; 11(10): e1005561. Published online 2015 Oct 6. doi: 10.1371/journal.pgen.1005561

PMCID:: PMC4595073

Abstract Article PDF–2.3M

Select item 44144345.

Alteration of gene expression profile following PPP2R5C knockdown may be associated with proliferation suppression and increased apoptosis of K562 cells

Sichu Liu, Qi Shen, Yu Chen, Chengwu Zeng, Changshu Cao, Lijian Yang, Shaohua Chen, Xiuli Wu, Bo Li, Yangqiu Li

J Hematol Oncol. 2015; 8: 34. Published online 2015 Apr 12. doi: 10.1186/s13045-015-0125-5

PMCID:: PMC4414434

Abstract Article PDF–707K

Select item 37852126.

Differential Gene Expression Profiles of PPP2R5C-siRNA-Treated Malignant T Cells

Yu Chen, Sichu Liu, Qi Shen, Xianfeng Zha, Haitao Zheng, Lijian Yang, Shaohua Chen, Xiuli Wu, Bo Li, Yangqiu Li

DNA Cell Biol. 2013 Oct; 32(10): 573–581. doi: 10.1089/dna.2013.2138

PMCID:: PMC3785212

Abstract Article PDF–462K

Select item 37781377.

Characterization of B56γ tumor-associated mutations reveals mechanisms for inactivation of B56γ-PP2A

Yumiko Nobumori, Geoffrey P. Shouse, Yong Wu, Kyu Joon Lee, Binghui Shen, Xuan Liu

Mol Cancer Res. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Mol Cancer Res. 2013 Sep; 11(9): 995–1003. Published online 2013 May 30. doi: 10.1158/1541-7786.MCR-12-0633

PMCID:: PMC3778137

Abstract Article PDF–3.0M

Select item 33228848.

HEAT Repeat 1 Motif Is Required for B56γ-containing Protein Phosphatase 2A (B56γ-PP2A) Holoenzyme Assembly and Tumor-suppressive Function

Yumiko Nobumori, Geoffrey P. Shouse, Li Fan, Xuan Liu

J Biol Chem. 2012 Mar 30; 287(14): 11030–11036. Published online 2012 Feb 7. doi: 10.1074/jbc.M111.334094

PMCID:: PMC3322884

Abstract Article PDF–1021K

Select item 31178199.

Expression and distribution of PPP2R5C gene in leukemia

Haitao Zheng, Yu Chen, Shaohua Chen, Yuzhe Niu, Lijian Yang, Bo Li, Yuhong Lu, Suxia Geng, Xin Du, Yangqiu Li

J Hematol Oncol. 2011; 4: 21. Published online 2011 May 6. doi: 10.1186/1756-8722-4-21

PMCID:: PMC3117819

Abstract Article PDF–491K

Select item 951992310.

A functional interaction between liprin-α1 and B56γ regulatory subunit of protein phosphatase 2A supports tumor cell motility

Marta Ripamonti, Andrea Lamarca, Norman E. Davey, Diletta Tonoli, Sara Surini, Ivan de Curtis

Commun Biol. 2022; 5: 1025. Published online 2022 Sep 28. doi: 10.1038/s42003-022-03989-3

PMCID:: PMC9519923

Abstract Article PDF–5.8M

Select item 403155011.

The Protein Phosphatase 2A Regulatory Subunit B56γ Mediates Suppression of T Cell Receptor (TCR)-induced Nuclear Factor-κB (NF-κB) Activity

Rebecca Breuer, Michael S. Becker, Markus Brechmann, Thomas Mock, Rüdiger Arnold, Peter H. Krammer

J Biol Chem. 2014 May 23; 289(21): 14996–15004. Published online 2014 Apr 9. doi: 10.1074/jbc.M113.533547

PMCID:: PMC4031550

Abstract Article PDF–2.2M

Select item 290043712.

A B56? mutation in lung cancer disrupts the p53-dependent tumor suppressor function of protein phosphatase 2A

Geoffrey P. Shouse, Yumiko Nobumori, Xuan Liu

Oncogene. Author manuscript; available in PMC 2011 Jan 1.

Published in final edited form as: Oncogene. 2010 Jul 8; 29(27): 3933–3941. Published online 2010 May 17. doi: 10.1038/onc.2010.161

PMCID:: PMC2900437

Abstract Article PDF–953K

Select item 222329513.

Serine 15 Phosphorylation of p53 Directs Its Interaction with B56γ and the Tumor Suppressor Activity of B56γ-Specific Protein Phosphatase 2A

Geoffrey P. Shouse, Xin Cai, Xuan Liu

Mol Cell Biol. 2008 Jan; 28(1): 448–456. Published online 2007 Oct 29. doi: 10.1128/MCB.00983-07

PMCID:: PMC2223295

Abstract Article PDF–433K

Select item 36042014.

Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus.

R Ruediger, D Roeckel, J Fait, A Bergqvist, G Magnusson, G Walter

Mol Cell Biol. 1992 Nov; 12(11): 4872–4882. doi: 10.1128/mcb.12.11.4872

PMCID:: PMC360420

Summary Page Browse PDF–2.6M

Select item 452748315.

Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth

Chey Loveday, Katrina Tatton-Brown, Matthew Clarke, Isaac Westwood, Anthony Renwick, Emma Ramsay, Andrea Nemeth, Jennifer Campbell, Shelagh Joss, McKinlay Gardner, Anna Zachariou, Anna Elliott, Elise Ruark, Rob van Montfort, The Childhood Overgrowth Collaboration, Nazneen Rahman

Hum Mol Genet. 2015 Sep 1; 24(17): 4775–4779. Published online 2015 May 13. doi: 10.1093/hmg/ddv182

Correction in:: Hum Mol Genet. 2019 May 1; 28(9): 1578.

PMCID:: PMC4527483

Abstract Article PDF–280K

Select item 433536616.

Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes

Xiucui Luo, Jing Pan, Leilei Wang, Peirong Wang, Meijiao Zhang, Meilin Liu, Ziqing Dong, Qian Meng, Xuguang Tao, Xinliang Zhao, Julia Zhong, Weina Ju, Yang Gu, Edmund C Jenkins, W Ted Brown, Qingxi Shi, Nanbert Zhong

BMC Pregnancy Childbirth. 2015; 15: 35. Published online 2015 Feb 15. doi: 10.1186/s12884-015-0460-0

PMCID:: PMC4335366

Abstract Article PDF–3.8M

Select item 54342117.

B56 Regulatory Subunit of Protein Phosphatase 2A Mediates Valproic Acid-Induced p300 Degradation

Jihong Chen, Jonathan R. St-Germain, Qiao Li

Mol Cell Biol. 2005 Jan; 25(2): 525–532. doi: 10.1128/MCB.25.2.525-532.2005

PMCID:: PMC543421

Abstract Article PDF–242K

Select item 30559418.

A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation

Akihiko Ito, Tatsuki R. Kataoka, Masafumi Watanabe, Kazutaka Nishiyama, Yuichi Mazaki, Hisataka Sabe, Yukihiko Kitamura, Hiroshi Nojima

EMBO J. 2000 Feb 15; 19(4): 562–571. doi: 10.1093/emboj/19.4.562

PMCID:: PMC305594

Abstract Article PDF–1.2M

Select item 710530119.

Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis

Travis B. Lear, Karina C. Lockwood, Mads Larsen, Ferhan Tuncer, Jason R. Kennerdell, Christina Morse, Eleanor Valenzi, Tracy Tabib, Michael J. Jurczak, Daniel J. Kass, John W. Evankovich, Toren Finkel, Robert Lafyatis, Yuan Liu, Bill B. Chen

J Biol Chem. 2020 Mar 27; 295(13): 4171–4180. Published online 2020 Feb 17. doi: 10.1074/jbc.AC119.012066