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Select item 97645251.

Ring finger protein 126 promotes breast cancer metastasis and serves as a potential target to improve the therapeutic sensitivity of ATR inhibitors

You Pan, Yuchao Yang, Rong Huang, Huawei Yang, Qinghua Huang, Yinan Ji, Jingxing Dai, Kun Qiao, Wei Tang, Longgui Xie, Ming Yin, Jun Ouyang, Shipeng Ning, Danke Su

Breast Cancer Res. 2022; 24: 92. Published online 2022 Dec 20. doi: 10.1186/s13058-022-01586-0

PMCID:: PMC9764525

Abstract Article PDF–2.5M

Select item 71633352.

High Expression of RING Finger Protein 126 Predicts Unfavorable Prognosis of Epithelial Ovarian Cancer

Chuanjiang Wang, Aiping Wen, Jing Qiao, Yujuan Liu, Yuanyuan Guo, Wenxia Wang

Med Sci Monit. 2020; 26: e921370-1–e921370-9. Prepublished online 2020 Feb 6. Published online 2020 Apr 7. doi: 10.12659/MSM.921370

PMCID:: PMC7163335

Abstract Article PDF–995K

Select item 49719323.

E3 Ubiquitin ligase RNF126 regulates the progression of tongue cancer

Lina Wang, Xin Wang, Yuehan Zhao, Weidong Niu, Guowu Ma, Wei Yin, Chun Shi

Cancer Med. 2016 Aug; 5(8): 2043–2047. Published online 2016 May 26. doi: 10.1002/cam4.771

PMCID:: PMC4971932

Abstract Article PDF–146K

Select item 87484174.

A novel role for RNF126 in the promotion of G2 arrest via interaction with 14–3-3σ

Pengyan Fa, Zhaojun Qiu, Qi-En Wang, Chunhong Yan, Junran Zhang

Int J Radiat Oncol Biol Phys. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2022 Feb 1; 112(2): 542–553. Published online 2021 Sep 24. doi: 10.1016/j.ijrobp.2021.09.025

PMCID:: PMC8748417

Abstract Article PDF–1.5M

Select item 79333515.

E3 ubiquitin ligase RNF126 affects bladder cancer progression through regulation of PTEN stability

Huimin Xu, Lingao Ju, Yaoyi Xiong, Mengxue Yu, Fenfang Zhou, Kaiyu Qian, Gang Wang, Yu Xiao, Xinghuan Wang

Cell Death Dis. 2021 Mar; 12(3): 239. Published online 2021 Mar 4. doi: 10.1038/s41419-021-03521-1

PMCID:: PMC7933351

Abstract Article PDF–7.1M

Select item 58847356.

RNF126 as a biomarker of a poor prognosis in invasive breast cancer and CHK1 inhibitor efficacy in breast cancer cells

Xiaosong Yang, You Pan, Zhaojun Qiu, Zhanwen Du, Yao Zhang, Pengyan Fa, Shashank Gorityala, Shanhuai Ma, Shunqiang Li, Ceshi Chen, Hongbing Wang, Yan Xu, Chunhong Yan, Keri Ruth, Zhefu Ma, Junran Zhang

Clin Cancer Res. Author manuscript; available in PMC 2019 Apr 1.

Published in final edited form as: Clin Cancer Res. 2018 Apr 1; 24(7): 1629–1643. Published online 2018 Jan 11. doi: 10.1158/1078-0432.CCR-17-2242

PMCID:: PMC5884735

Abstract Article PDF–2.6M

Select item 57678647.

Ring finger protein 126 (RNF126) suppresses ionizing radiation–induced p53-binding protein 1 (53BP1) focus formation

Nam Soo Lee, Hae Ryung Chang, Soomi Kim, Jae-Hoon Ji, Joorak Lee, Hyun Ji Lee, Yoojeong Seo, Misun Kang, Joo Seok Han, Kyungjae Myung, Yonghwan Kim, Hongtae Kim

J Biol Chem. 2018 Jan 12; 293(2): 588–598. Published online 2017 Nov 22. doi: 10.1074/jbc.M116.765602

PMCID:: PMC5767864

Abstract Article PDF–3.6M

Select item 53291218.

E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia

Monica Benini, Silvia Fortuni, Ivano Condò, Giulia Alfedi, Florence Malisan, Nicola Toschi, Dario Serio, Damiano Sergio Massaro, Gaetano Arcuri, Roberto Testi, Alessandra Rufini

Cell Rep. 2017 Feb 21; 18(8): 2007–2017. Published online 2017 Feb 21. doi: 10.1016/j.celrep.2017.01.079

PMCID:: PMC5329121

Abstract Article

Select item 76048719.

Overexpression of RNF126 Promotes the Development of Colorectal Cancer via Enhancing p53 Ubiquitination and Degradation

Shiyang Wang, Tianlong Wang, Li Wang, Liansheng Zhong, Kai Li

Onco Targets Ther. 2020; 13: 10917–10929. Published online 2020 Oct 28. doi: 10.2147/OTT.S271855

Correction in:: Onco Targets Ther. 2021; 14: 5293–5294.

PMCID:: PMC7604871

Abstract Article PDF–9.7M

Select item 677944910.

A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G₀/G₁ switch gene 2

Kenta Kamikubo, Hisakazu Kato, Hidetaka Kioka, Satoru Yamazaki, Osamu Tsukamoto, Yuya Nishida, Yoshihiro Asano, Hiromi Imamura, Hiroyuki Kawahara, Yasunori Shintani, Seiji Takashima

J Biol Chem. 2019 Oct 4; 294(40): 14562–14573. Published online 2019 Aug 1. doi: 10.1074/jbc.RA119.008544

PMCID:: PMC6779449

Abstract Article PDF–2.5M

Select item 474028111.

RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression

Ying Wang, Ou Deng, Zhihui Feng, Zhanwen Du, Xiahui Xiong, Jinzhi Lai, Xiaosong Yang, Mengyuan Xu, Hongbing Wang, Derek Taylor, Chunhong Yan, Ceshi Chen, Analisa Difeo, Zhefu Ma, Junran Zhang

Oncogene. Author manuscript; available in PMC 2016 May 18.

Published in final edited form as: Oncogene. 2016 Mar 17; 35(11): 1363–1372. Published online 2015 Aug 3. doi: 10.1038/onc.2015.198

PMCID:: PMC4740281

Abstract Article PDF–1.0M

Select item 714041312.

Non-Thermal Plasma Induces Antileukemic Effect Through mTOR Ubiquitination

Sun-Yong Kim, Hyo Jeong Kim, Haeng Jun Kim, Chul-Ho Kim

Cells. 2020 Mar; 9(3): 595. Published online 2020 Mar 2. doi: 10.3390/cells9030595

PMCID:: PMC7140413

Abstract Article PDF–4.3M

Select item 528858113.

Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair

Noriko Ishida, Tadashi Nakagawa, Shun-Ichiro Iemura, Akira Yasui, Hiroki Shima, Yasutake Katoh, Yuko Nagasawa, Toru Natsume, Kazuhiko Igarashi, Keiko Nakayama

Mol Cell Biol. 2017 Feb 15; 37(4): e00347-16. Prepublished online 2016 Nov 28. Published online 2017 Feb 1. doi: 10.1128/MCB.00347-16

PMCID:: PMC5288581

Abstract Article PDF–3.1M

Select item 487221714.

Structural and functional insights into the E3 ligase, RNF126

Ewelina M. Krysztofinska, Santiago Martínez-Lumbreras, Arjun Thapaliya, Nicola J. Evans, Stephen High, Rivka L. Isaacson

Sci Rep. 2016; 6: 26433. Published online 2016 May 19. doi: 10.1038/srep26433

PMCID:: PMC4872217

Abstract Article PDF–2.2M

Select item 641190215.

RNF126 Quenches RNF168 Function in the DNA Damage Response

Lianzhong Zhang, Zhenzhen Wang, Ruifeng Shi, Xuefei Zhu, Jiahui Zhou, Bin Peng, Xingzhi Xu

Genomics Proteomics Bioinformatics. 2018 Dec; 16(6): 428–438. Published online 2018 Dec 4. doi: 10.1016/j.gpb.2018.07.004

PMCID:: PMC6411902

Abstract Article PDF–2.3M

Select item 907917216.

BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43

Yasar Arfat T. Kasu, Akshaya Arva, Jess Johnson, Christin Sajan, Jasmin Manzano, Andrew Hennes, Jacy Haynes, Christopher S. Brower

iScience. 2022 May 20; 25(5): 104273. Published online 2022 Apr 20. doi: 10.1016/j.isci.2022.104273

PMCID:: PMC9079172

Abstract Article PDF–2.8M

Select item 346078917.

Mining and characterization of ubiquitin E3 ligases expressed in the mouse testis

Xiaojun Hou, Wei Zhang, Zhenyu Xiao, Haiyun Gan, Xiwen Lin, Shangying Liao, Chunsheng Han

BMC Genomics. 2012; 13: 495. Published online 2012 Sep 19. doi: 10.1186/1471-2164-13-495

PMCID:: PMC3460789

Abstract Article PDF–1.7M

Select item 600269718.

The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex

Rakesh Ganji, Sirisha Mukkavalli, Flavio Somanji, Malavika Raman

Mol Cell Biol. 2018 Jul 1; 38(13): e00154-18. Prepublished online 2018 Apr 23. Published online 2018 Jun 14. doi: 10.1128/MCB.00154-18

PMCID:: PMC6002697

Abstract Article PDF–3.8M

Select item 992925719.

RNF126‐Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple‐Negative Breast Cancer to Radiotherapy

Wenjing Liu, Min Zheng, Rou Zhang, Qiuyun Jiang, Guangshi Du, Yingying Wu, Chuanyu Yang, Fubing Li, Wei Li, Luzhen Wang, Jiao Wu, Lei Shi, Wenhui Li, Kai Zhang, Zhongmei Zhou, Rong Liu, Yingzheng Gao, Xinwei Huang, Songqing Fan, Xu Zhi, Dewei Jiang, Ceshi Chen

Adv Sci (Weinh) 2023 Feb; 10(5): 2203884. Published online 2022 Dec 23. doi: 10.1002/advs.202203884