PMC Links for Gene (Select 55733) - PMC

Select item 95132561.

Hedgehog acyltransferase catalyzes a random sequential reaction and utilizes multiple fatty acyl-CoA substrates

Adina R. Schonbrun, Marilyn D. Resh

J Biol Chem. 2022 Oct; 298(10): 102422. Published online 2022 Aug 24. doi: 10.1016/j.jbc.2022.102422

PMCID:: PMC9513256

Select item 86938612.

Structure, mechanism, and inhibition of Hedgehog acyltransferase

Claire E. Coupland, Sebastian A. Andrei, T. Bertie Ansell, Loic Carrique, Pramod Kumar, Lea Sefer, Rebekka A. Schwab, Eamon F.X. Byrne, Els Pardon, Jan Steyaert, Anthony I. Magee, Thomas Lanyon-Hogg, Mark S.P. Sansom, Edward W. Tate, Christian Siebold

Mol Cell. 2021 Dec 16; 81(24): 5025–5038.e10. doi: 10.1016/j.molcel.2021.11.018

PMCID:: PMC8693861

Abstract Article PDF–6.2M

Select item 83736483.

Shruti Pande, Periyasamy Radhakrishnan, Naveenchandra M Shetty, Anju Shukla, Katta Mohan Girisha

Am J Med Genet A. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Am J Med Genet A. 2021 Sep; 185(9): 2756–2765. Published online 2021 Mar 22. doi: 10.1002/ajmg.a.62186

PMCID:: PMC8373648

Abstract Article PDF–663K

Select item 47110174.

Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells

Armine Matevossian, Marilyn D Resh

Mol Cancer. 2015; 14: 72. Published online 2015 Apr 1. doi: 10.1186/s12943-015-0345-x

PMCID:: PMC4711017

Abstract Article PDF–1.8M

Select item 43036745.

Membrane Topology of Hedgehog Acyltransferase

Armine Matevossian, Marilyn D. Resh

J Biol Chem. 2015 Jan 23; 290(4): 2235–2243. Published online 2014 Dec 8. doi: 10.1074/jbc.M114.625764

PMCID:: PMC4303674

Abstract Article PDF–2.5M

Select item 87344786.

Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT

Yiyang Jiang, Thomas L. Benz, Stephen B. Long

Science. Author manuscript; available in PMC 2022 Jan 6.

Published in final edited form as: Science. 2021 Jun 11; 372(6547): 1215–1219. doi: 10.1126/science.abg4998

PMCID:: PMC8734478

Abstract Article PDF–1.8M

Select item 46151337.

Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase

Thomas Lanyon-Hogg, Naoko Masumoto, George Bodakh, Antonio D. Konitsiotis, Emmanuelle Thinon, Ursula R. Rodgers, Raymond J. Owens, Anthony I. Magee, Edward W. Tate

Anal Biochem. 2015 Dec 1; 490: 66–72. doi: 10.1016/j.ab.2015.08.025

PMCID:: PMC4615133

Abstract Article PDF–784K

Select item 38219728.

The Hedgehog processing pathway is required for NSCLC growth and survival

Jezabel Rodriguez-Blanco, Neal S. Schilling, Robert Tokhunts, Camilla Giambelli, Jun Long, Dennis Liang Fei, Samer Singh, Kendall E. Black, Zhiqiang Wang, Fabrizio Galimberti, Pablo A. Bejarano, Sharon Elliot, Marilyn K. Glassberg, Dao M. Nguyen, William W. Lockwood, Wan L. Lam, Ethan Dmitrovsky, Anthony J. Capobianco, David J. Robbins

Oncogene. Author manuscript; available in PMC 2014 May 2.

Published in final edited form as: Oncogene. 2013 May 2; 32(18): 10.1038/onc.2012.243. Published online 2012 Jun 25. doi: 10.1038/onc.2012.243

PMCID:: PMC3821972

Abstract Article PDF–3.1M

Select item 24949209.

Hhat Is a Palmitoylacyltransferase with Specificity for N-Palmitoylation of Sonic Hedgehog

John A. Buglino, Marilyn D. Resh

J Biol Chem. 2008 Aug 8; 283(32): 22076–22088. doi: 10.1074/jbc.M803901200

PMCID:: PMC2494920

Abstract Article PDF–702K

Select item 999045110.

Additional evidence for the role of chromosomal imbalances and SOX8, ZNRF3 and HHAT gene variants in early human testis development

Khouloud Rjiba, Soumaya Mougou-Zerelli, Imen hadj Hamida, Ghada Saad, Bochra Khadija, Afef Jelloul, Wafa Slimani, Yosra Hasni, Sarra Dimassi, Hela Ben khelifa, Amira Sallem, Molka Kammoun, Hamza Hadj Abdallah, Moez Gribaa, Joelle Bignon-Topalovic, Sami Chelly, Hédi Khairi, Mohamed Bibi, Maha Kacem, Ali Saad, Anu Bashamboo, Kenneth McElreavey

Reprod Biol Endocrinol. 2023; 21: 2. Published online 2023 Jan 11. doi: 10.1186/s12958-022-01045-7

PMCID:: PMC9990451

Abstract Article PDF–1.2M

Select item 694815411.

Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane

James J. Asciolla, Marilyn D. Resh

Cell Rep. Author manuscript; available in PMC 2020 Jan 8.

Published in final edited form as: Cell Rep. 2019 Dec 24; 29(13): 4608–4619.e4. doi: 10.1016/j.celrep.2019.11.110

PMCID:: PMC6948154

Abstract Article PDF–1.8M

Select item 352228412.

Identification of N-terminal Residues of Sonic Hedgehog Important for Palmitoylation by Hedgehog Acyltransferase

Rayshonda Y. Hardy, Marilyn D. Resh

J Biol Chem. 2012 Dec 14; 287(51): 42881–42889. Published online 2012 Oct 30. doi: 10.1074/jbc.M112.426833

PMCID:: PMC3522284

Abstract Article PDF–1.5M

Select item 400674413.

Loss of Function Mutation in the Palmitoyl-Transferase HHAT Leads to Syndromic 46,XY Disorder of Sex Development by Impeding Hedgehog Protein Palmitoylation and Signaling

Patrick Callier, Pierre Calvel, Armine Matevossian, Periklis Makrythanasis, Pascal Bernard, Hiroshi Kurosaka, Anne Vannier, Christel Thauvin-Robinet, Christelle Borel, Séverine Mazaud-Guittot, Antoine Rolland, Christèle Desdoits-Lethimonier, Michel Guipponi, Céline Zimmermann, Isabelle Stévant, Françoise Kuhne, Béatrice Conne, Federico Santoni, Sandy Lambert, Frederic Huet, Francine Mugneret, Jadwiga Jaruzelska, Laurence Faivre, Dagmar Wilhelm, Bernard Jégou, Paul A. Trainor, Marilyn D. Resh, Stylianos E. Antonarakis, Serge Nef

PLoS Genet. 2014 May; 10(5): e1004340. Published online 2014 May 1. doi: 10.1371/journal.pgen.1004340

PMCID:: PMC4006744

Abstract Article PDF–8.9M

Select item 584108614.

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Samuel A. Hasson, Lesley A. Kane, Koji Yamano, Chiu-Hui Huang, Danielle A. Sliter, Eugen Buehler, Chunxin Wang, Sabrina M. Heman-Ackah, Tara Hessa, Rajarshi Guha, Scott E. Martin, Richard J. Youle

Nature. Author manuscript; available in PMC 2018 Mar 7.

Published in final edited form as: Nature. 2013 Dec 12; 504(7479): 291–295. Published online 2013 Nov 24. doi: 10.1038/nature12748

PMCID:: PMC5841086

Abstract Article PDF–5.3M

Select item 289646415.

Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score

Jed E Rose, Frédérique M Behm, Tomas Drgon, Catherine Johnson, George R Uhl

Mol Med. 2010 Jul-Aug; 16(7-8): 247–253. Published online 2010 Mar 17. doi: 10.2119/molmed.2009.00159

Correction in:: Mol Med. 2012; 18(1): 729.

PMCID:: PMC2896464

Abstract Article PDF–2.4M

Select item 135612916.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

Select item 716998317.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x