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Select item 83017761.

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition

Nadezhda S. Dyrkheeva, Aleksandr S. Filimonov, Olga A. Luzina, Alexandra L. Zakharenko, Ekaterina S. Ilina, Anastasia A. Malakhova, Sergey P. Medvedev, Jóhannes Reynisson, Konstantin P. Volcho, Suren M. Zakian, Nariman F. Salakhutdinov, Olga I. Lavrik

Biomolecules. 2021 Jul; 11(7): 973. Published online 2021 Jul 1. doi: 10.3390/biom11070973

PMCID:: PMC8301776

Abstract Article PDF–3.1M

Select item 80571262.

Probing the evolutionary conserved residues Y204, F259, S400 and W590 that shape the catalytic groove of human TDP1 for 3′- and 5′-phosphodiester-DNA bond cleavage

Evgeny Kiselev, Thomas S. Dexheimer, Christophe Marchand, Shar-yin Naomi Huang, Yves Pommier

DNA Repair (Amst) Author manuscript; available in PMC 2021 Apr 20.

Published in final edited form as: DNA Repair (Amst). 2018 Jun-Jul; 66-67: 64–71. Published online 2018 May 2. doi: 10.1016/j.dnarep.2018.05.001

PMCID:: PMC8057126

Abstract Article PDF–1.1M

Select item 68343893.

SCAN1-TDP1 trapping on mitochondrial DNA promotes mitochondrial dysfunction and mitophagy

Arijit Ghosh, Sangheeta Bhattacharjee, Srijita Paul Chowdhuri, Abhik Mallick, Ishita Rehman, Sudipta Basu, Benu Brata Das

Sci Adv. 2019 Nov; 5(11): eaax9778. Published online 2019 Nov 6. doi: 10.1126/sciadv.aax9778

PMCID:: PMC6834389

Abstract Article PDF–5.5M

Select item 68213344.

Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening

George T Lountos, Xue Zhi Zhao, Evgeny Kiselev, Joseph E Tropea, Danielle Needle, Yves Pommier, Terrence R Burke, Jr, David S Waugh

Nucleic Acids Res. 2019 Nov 4; 47(19): 10134–10150. Published online 2019 Jun 14. doi: 10.1093/nar/gkz515

PMCID:: PMC6821334

Abstract Article PDF–10M

Select item 68074185.

Association of Tyrosyl‐DNA Phosphodiesterase 1 Polymorphism With Tourette Syndrome in Taiwanese Patients

Bor‐Tsang Wu, Wei‐Yong Lin, I‐Ching Chou, Hsin‐Ping Liu, Cheng‐Chun Lee, Yuhsin Tsai, Wan‐Chen Wu, Fuu‐Jen Tsai

J Clin Lab Anal. 2013 Jul; 27(4): 323–327. Published online 2013 Jul 12. doi: 10.1002/jcla.21606

PMCID:: PMC6807418

Abstract Article PDF–81K

Select item 57502096.

Structural basis for DNA 3′-end processing by human tyrosyl-DNA phosphodiesterase 1

Fiona J. Flett, Emilija Ruksenaite, Lee A. Armstrong, Shipra Bharati, Roberta Carloni, Elizabeth R. Morris, C. Logan Mackay, Heidrun Interthal, Julia M. Richardson

Nat Commun. 2018; 9: 24. Published online 2018 Jan 2. doi: 10.1038/s41467-017-02530-z

PMCID:: PMC5750209

Abstract Article PDF–2.6M

Select item 57328767.

Common TDP1 polymorphisms in relation to survival among small cell lung cancer patients: a multicenter study from the International Lung Cancer Consortium

Pawadee Lohavanichbutr, Lori C. Sakoda, Christopher I. Amos, Susanne M. Arnold, David C. Christiani, Michael P.A. Davies, John K. Field, Eric B. Haura, Rayjean J. Hung, Takashi Kohno, Maria Teresa Landi, Geoffrey Liu, Yi Liu, Michael W. Marcus, Grainne M. O’Kane, Matthew B. Schabath, Kouya Shiraishi, Stacey A. Slone, Adonina Tardón, Ping Yang, Kazushi Yoshida, Ruyang Zhang, Xuchen Zong, Gary E. Goodman, Noel S. Weiss, Chu Chen

Clin Cancer Res. Author manuscript; available in PMC 2017 Dec 16.

Published in final edited form as: Clin Cancer Res. 2017 Dec 15; 23(24): 7550–7557. Published online 2017 Oct 3. doi: 10.1158/1078-0432.CCR-17-1401

PMCID:: PMC5732876

Abstract Article PDF–496K

Select item 53499438.

Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin

Selma M. Cuya, Evan Q. Comeaux, Keith Wanzeck, Karina J. Yoon, Robert C.A.M. van Waardenburg

Oncotarget. 2016 Dec 27; 7(52): 86660–86674. Published online 2016 Nov 23. doi: 10.18632/oncotarget.13528

PMCID:: PMC5349943

Abstract Article PDF–4.4M

Select item 46738959.

TDP1 promotes assembly of non-homologous end joining protein complexes on DNA

Jinho Heo, Jing Li, Matthew Summerlin, Annette Hays, Sachin Katyal, Peter J. McKinnon, Karin C. Nitiss, John L. Nitiss, Leslyn A. Hanakahi

DNA Repair (Amst) Author manuscript; available in PMC 2016 Jun 1.

Published in final edited form as: DNA Repair (Amst). 2015 Jun; 30: 28–37. Published online 2015 Mar 17. doi: 10.1016/j.dnarep.2015.03.003

PMCID:: PMC4673895

Abstract Article PDF–863K

Select item 395067010.

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy

Meryem Alagoz, Owen S. Wells, Sherif F. El-Khamisy

Nucleic Acids Res. 2014 Mar; 42(5): 3089–3103. Published online 2013 Dec 12. doi: 10.1093/nar/gkt1260

PMCID:: PMC3950670

Abstract Article PDF–5.8M

Select item 391914711.

Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel

Rui Gao, Benu Brata Das, Raghunath Chatterjee, Ogan Abaan, Keli Agama, Renata Matuo, Charles Vinson, Paul S. Meltzer, Yves Pommier

DNA Repair (Amst) Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: DNA Repair (Amst). 2014 Jan; 13: 1–9. Published online 2013 Dec 16. doi: 10.1016/j.dnarep.2013.09.001

PMCID:: PMC3919147

Abstract Article PDF–3.4M

Select item 331688212.

SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair

Jessica J.R. Hudson, Shih-Chieh Chiang, Owen S. Wells, Chris Rookyard, Sherif F. El-Khamisy

Nat Commun. 2012 Mar 13; 3: 733. Published online 2012 Mar 13. doi: 10.1038/ncomms1739

PMCID:: PMC3316882

Abstract Article PDF–2.2M

Select item 285312013.

The DNA binding and 3′-end preferential activity of human tyrosyl-DNA phosphodiesterase

Thomas S. Dexheimer, Andrew G. Stephen, Matthew J. Fivash, Robert J. Fisher, Yves Pommier

Nucleic Acids Res. 2010 Apr; 38(7): 2444–2452. Published online 2010 Jan 21. doi: 10.1093/nar/gkp1206

PMCID:: PMC2853120

Abstract Article PDF–441K

Select item 276337014.

Tyrosyl-DNA phosphodiesterase and the repair of 3′-phosphoglycolate-terminated DNA double-strand breaks

Tong Zhou, Konstantin Akopiants, Susovan Mohapatra, Peck-Sun Lin, Kristoffer Valerie, Dale A. Ramsden, Susan P. Lees-Miller, Lawrence F. Povirk

DNA Repair (Amst) Author manuscript; available in PMC 2010 Aug 6.

Published in final edited form as: DNA Repair (Amst). 2009 Aug 6; 8(8): 901–911. Published online 2009 Jun 7. doi: 10.1016/j.dnarep.2009.05.003

PMCID:: PMC2763370

Abstract Article PDF–1.7M

Select item 135100815.

Human Tdp1 Cleaves a Broad Spectrum of Substrates Including Phosphoamide Linkages

Heidrun Interthal, Hong Jing Chen, James J. Champoux

J Biol Chem. Author manuscript; available in PMC 2006 Jan 25.

Published in final edited form as: J Biol Chem. 2005 Oct 28; 280(43): 36518–36528. Published online 2005 Aug 31. doi: 10.1074/jbc.M508898200

PMCID:: PMC1351008

Abstract Article PDF–2.4M

Select item 115088816.

SCAN1 mutant Tdp1 accumulates the enzyme–DNA intermediate and causes camptothecin hypersensitivity

Heidrun Interthal, Hong Jing Chen, Thomas E Kehl-Fie, Jörg Zotzmann, John B Leppard, James J Champoux

EMBO J. 2005 Jun 15; 24(12): 2224–2233. Published online 2005 May 26. doi: 10.1038/sj.emboj.7600694

PMCID:: PMC1150888

Abstract Article PDF–480K

Select item 54615717.

Deficiency in 3′-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

Tong Zhou, Jae Wan Lee, Haritha Tatavarthi, James R. Lupski, Kristoffer Valerie, Lawrence F. Povirk

Nucleic Acids Res. 2005; 33(1): 289–297. Published online 2005 Jan 12. doi: 10.1093/nar/gki170

PMCID:: PMC546157

Abstract Article PDF–1.1M

Select item 5975818.

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

Heidrun Interthal, Jeffrey J. Pouliot, James J. Champoux

Proc Natl Acad Sci U S A. 2001 Oct 9; 98(21): 12009–12014. Published online 2001 Sep 25. doi: 10.1073/pnas.211429198

PMCID:: PMC59758

Abstract Article PDF–648K

Select item 831891819.

Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus

Ishtiaque Rashid, Michal Hammel, Aleksandr Sverzhinsky, Miaw-Sheue Tsai, John M. Pascal, John A. Tainer, Alan E. Tomkinson

J Biol Chem. 2021 Aug; 297(2): 100921. Published online 2021 Jun 25. doi: 10.1016/j.jbc.2021.100921

PMCID:: PMC8318918

Abstract Article PDF–3.5M

Select item 662823620.

Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair

Shar-yin Naomi Huang, Yves Pommier

Int J Mol Sci. 2019 Jun; 20(12): 3015. Published online 2019 Jun 20. doi: 10.3390/ijms20123015

PMCID:: PMC6628236

Abstract Article PDF–1.0M

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