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Select item 78865141.

I-κB Kinase-ε Deficiency Attenuates the Development of Angiotensin II-Induced Myocardial Hypertrophy in Mice

Yide Cao, Liangpeng Li, Yafeng Liu, Ganyi Chen, Zhonghao Tao, Rui Wang, Wen Chen

Oxid Med Cell Longev. 2021; 2021: 6429197. Published online 2021 Feb 8. doi: 10.1155/2021/6429197

PMCID:: PMC7886514

Abstract Article PDF–2.1M

Select item 75334692.

IKKε deficiency inhibits acute lung injury following renal ischemia reperfusion injury

Chao Meng, Yi Qian, Cui Zhang, Han Liu, Xinwei Mu, Aiping Zhang

Mol Med Rep. 2020 Nov; 22(5): 4213–4220. Published online 2020 Sep 22. doi: 10.3892/mmr.2020.11532

PMCID:: PMC7533469

Abstract Article PDF–770K

Select item 73827483.

A Novel Molecular Mechanism of IKKε-Mediated Akt/mTOR Inhibition in the Cardiomyocyte Autophagy after Myocardial Infarction

Shuai He, Jian Shen, Liangpeng Li, Yueyue Xu, Yide Cao, Li Yin, Zhonghao Tao, Zhibing Qiu, Wen Chen, Xin Chen

Oxid Med Cell Longev. 2020; 2020: 7046923. Published online 2020 Jul 16. doi: 10.1155/2020/7046923

PMCID:: PMC7382748

Abstract Article PDF–3.4M

Select item 69857904.

Hepatic IKKε expression is dispensable for high-fat feeding-induced increases in liver lipid content and alterations in glucose tolerance

J. Jason Collier, Heidi M. Batdorf, Tamra M. Mendoza, David H. Burk, Thomas M. Martin, Jingying Zhang, Randall L. Mynatt, Susan J. Burke

Am J Physiol Endocrinol Metab. 2020 Jan 1; 318(1): E11–E21. Published online 2019 Oct 29. doi: 10.1152/ajpendo.00309.2019

PMCID:: PMC6985790

Abstract Article

Select item 37039665.

IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis

Yi Wang, Xiaolu Lu, Lining Zhu, Yan Shen, Shylet Chengedza, Hao Feng, Laiyee Wang, Jae U. Jung, J. Silvio Gutkind, Pinghui Feng

Proc Natl Acad Sci U S A. 2013 Jul 2; 110(27): 11139–11144. Published online 2013 Jun 14. doi: 10.1073/pnas.1219829110

Correction in:: Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30): 12498.

PMCID:: PMC3703966

Abstract Article PDF–1.1M

Select item 35519226.

IKKi Deficiency Promotes Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis

Jia Dai, Di-Fei Shen, Zhou-Yan Bian, Heng Zhou, Hua-Wen Gan, Jing Zong, Wei Deng, Yuan Yuan, FangFang Li, Qing-Qing Wu, Lu Gao, Rui Zhang, Zhen-Guo Ma, Hong-Liang Li, Qi-Zhu Tang

PLoS One. 2013; 8(1): e53412. Published online 2013 Jan 22. doi: 10.1371/journal.pone.0053412

PMCID:: PMC3551922

Abstract Article PDF–2.0M

Select item 32485347.

IκB kinase ε (IKKε) regulates the balance between type I and type II interferon responses

Sze-Ling Ng, Brad A. Friedman, Sonja Schmid, Jason Gertz, Richard M. Myers, Benjamin R. tenOever, Tom Maniatis

Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52): 21170–21175. Published online 2011 Dec 14. doi: 10.1073/pnas.1119137109

PMCID:: PMC3248534

Abstract Article PDF–629K

Select item 27560608.

The protein kinase IKKe regulates energy expenditure, insulin sensitivity and chronic inflammation in obese mice

Shian-Huey Chiang, Merlijn Bazuine, Carey N. Lumeng, Lynn M. Geletka, Jonathan Mowers, Nicole M. White, Jing-Tyan Ma, Jie Zhou, Nathan Qi, Dan Westcott, Jennifer B. Delproposto, Timothy S. Blackwell, Fiona E. Yull, Alan R. Saltiel

Cell. Author manuscript; available in PMC 2010 Sep 4.

Published in final edited form as: Cell. 2009 Sep 4; 138(5): 961–975. doi: 10.1016/j.cell.2009.06.046

PMCID:: PMC2756060

Abstract Article PDF–4.7M

Select item 108495999.

Atypical inflammatory kinase IKBKE phosphorylates and inactivates FoxA1 to promote liver tumorigenesis

Bing Gao, Xueji Wu, Lang Bu, Qiwei Jiang, Lei Wang, Haining Liu, Xiaomei Zhang, Yuanzhong Wu, Xiaoxing Li, Jingting Li, Ying Liang, Lixia Xu, Wei Xie, Jianping Guo

Sci Adv. 2024 Feb 9; 10(6): eadk2285. Published online 2024 Feb 7. doi: 10.1126/sciadv.adk2285

PMCID:: PMC10849599

Abstract Article PDF–5.3M

Select item 699875110.

IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Inhibiting Inflammation, Oxidative Stress, and Apoptosis

Hao Chai, ZhongHao Tao, YongChao Qi, HaoYu Qi, Wen Chen, YueYue Xu, LeiYang Zhang, HongWei Chen, Xin Chen

Oxid Med Cell Longev. 2020; 2020: 3602824. Published online 2020 Jan 22. doi: 10.1155/2020/3602824

PMCID:: PMC6998751

Abstract Article PDF–2.8M

Select item 529300711.

IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response

Junjie Zhang, Hao Feng, Jun Zhao, Emily R. Feldman, Si-Yi Chen, Weiming Yuan, Canhua Huang, Omid Akbari, Scott A. Tibbetts, Pinghui Feng

Cell Rep. Author manuscript; available in PMC 2017 Feb 6.

Published in final edited form as: Cell Rep. 2016 Jul 12; 16(2): 405–418. Published online 2016 Jun 23. doi: 10.1016/j.celrep.2016.05.083

PMCID:: PMC5293007

Abstract Article PDF–1.1M

Select item 366430612.

MicroRNA-155 controls CD8⁺ T cell responses by regulating interferon signaling

Donald T. Gracias, Erietta Stelekati, Jennifer L. Hope, Alina C. Boesteanu, Travis Doering, Jillian Norton, Yvonne M. Mueller, Joseph A. Fraietta, E. John Wherry, Martin Turner, Peter D. Katsikis

Nat Immunol. Author manuscript; available in PMC 2013 Dec 1.

Published in final edited form as: Nat Immunol. 2013 Jun; 14(6): 593–602. Published online 2013 Apr 21. doi: 10.1038/ni.2576

PMCID:: PMC3664306

Abstract Article PDF–938K

Select item 295286813.

Specification of the NF-κB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKKε

Rita Moreno, Jürgen-Markus Sobotzik, Christian Schultz, M. Lienhard Schmitz

Nucleic Acids Res. 2010 Oct; 38(18): 6029–6044. Published online 2010 May 27. doi: 10.1093/nar/gkq439

PMCID:: PMC2952868

Abstract Article PDF–11M

Select item 221280914.

The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection

Hiroaki Hemmi, Osamu Takeuchi, Shintaro Sato, Masahiro Yamamoto, Tsuneyasu Kaisho, Hideki Sanjo, Taro Kawai, Katsuaki Hoshino, Kiyoshi Takeda, Shizuo Akira

J Exp Med. 2004 Jun 21; 199(12): 1641–1650. doi: 10.1084/jem.20040520

PMCID:: PMC2212809

Abstract Article PDF–391K

Select item 671062915.

Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility

Yunhao Tan, Jonathan C. Kagan

Cell. Author manuscript; available in PMC 2020 Apr 4.

Published in final edited form as: Cell. 2019 Apr 4; 177(2): 384–398.e11. Published online 2019 Mar 7. doi: 10.1016/j.cell.2019.01.039

PMCID:: PMC6710629

Abstract Article PDF–1.2M

Select item 476489916.

The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis

Jinjin Xu, Lei Zhou, Lei Ji, Fengyuan Chen, Karen Fortmann, Kun Zhang, Qingwu Liu, Ke Li, Weicang Wang, Hao Wang, Wei Xie, Qingwei Wang, Jiang Liu, Biao Zheng, Pei Zhang, Shixia Huang, Tieliu Shi, Biaohong Zhang, Yongyan Dang, Jiwu Chen, Bert W. O'Malley, Robb E. Moses, Ping Wang, Lei Li, Jianru Xiao, Alexander Hoffmann, Xiaotao Li

Nat Commun. 2016; 7: 10761. Published online 2016 Feb 22. doi: 10.1038/ncomms10761

PMCID:: PMC4764899

Abstract Article PDF–2.9M

Select item 429925117.

Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation

Meghana N. Patel, William G. Bernard, Nikolay B. Milev, William P. Cawthorn, Nichola Figg, Dan Hart, Xavier Prieur, Sam Virtue, Krisztina Hegyi, Stephanie Bonnafous, Beatrice Bailly-Maitre, Yajing Chu, Julian L. Griffin, Ziad Mallat, Robert V. Considine, Albert Tran, Philippe Gual, Osamu Takeuchi, Shizuo Akira, Antonio Vidal-Puig, Martin R. Bennett, Jaswinder K. Sethi

Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2): 506–511. Published online 2014 Dec 24. doi: 10.1073/pnas.1414536112

PMCID:: PMC4299251

Abstract Article PDF–1.0M

Select item 386937618.

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

Jonathan Mowers, Maeran Uhm, Shannon M Reilly, Joshua Simon, Dara Leto, Shian-Huey Chiang, Louise Chang, Alan R Saltiel

eLife. 2013; 2: e01119. Published online 2013 Dec 24. doi: 10.7554/eLife.01119

PMCID:: PMC3869376

Abstract Article PDF–2.5M

Select item 1076190019.

IKKε and TBK1 prevent RIPK1 dependent and independent inflammation

Remzi Onur Eren, Göksu Gökberk Kaya, Robin Schwarzer, Manolis Pasparakis

Nat Commun. 2024; 15: 130. Published online 2024 Jan 2. doi: 10.1038/s41467-023-44372-y

PMCID:: PMC10761900

Abstract Article PDF–6.9M

Select item 1066603520.

Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS

Seiji Watanabe, Yuri Murata, Yasuyoshi Oka, Kotaro Oiwa, Mai Horiuchi, Yohei Iguchi, Okiru Komine, Akira Sobue, Masahisa Katsuno, Tomoo Ogi, Koji Yamanaka

Proc Natl Acad Sci U S A. 2023 Nov 21; 120(47): e2315347120. Published online 2023 Nov 15. doi: 10.1073/pnas.2315347120

PMCID:: PMC10666035

Abstract Article PDF–8.9M

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