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Select item 103603271.

Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress

Li Li, Shunying Wang, Wenming Wang

BMC Mol Cell Biol. 2023; 24: 22. Published online 2023 Jul 20. doi: 10.1186/s12860-023-00485-2

PMCID:: PMC10360327

Abstract Article PDF–5.5M

Select item 79074802.

Suppression of ELF4 in ulcerative colitis predisposes host to colorectal cancer

Hongqiang Du, Huawei Xia, Tongtong Liu, Yingjie Li, Jilong Liu, Bingteng Xie, Jingxuan Chen, Tong Liu, Lili Cao, Shengde Liu, Siji Li, Peiyan Wang, Dandan Wang, Zeming Zhang, Yunfei Li, Xiaohuan Guo, Aiwen Wu, Mo Li, Fuping You

iScience. 2021 Mar 19; 24(3): 102169. Published online 2021 Feb 9. doi: 10.1016/j.isci.2021.102169

PMCID:: PMC7907480

Abstract Article PDF–7.8M

Select item 30176083.

MEF/ELF4 transactivation by E2F1 is inhibited by p53

Manabu Taura, Mary Ann Suico, Ryosuke Fukuda, Tomoaki Koga, Tsuyoshi Shuto, Takashi Sato, Saori Morino-Koga, Seiji Okada, Hirofumi Kai

Nucleic Acids Res. 2011 Jan; 39(1): 76–88. Published online 2010 Aug 30. doi: 10.1093/nar/gkq762

PMCID:: PMC3017608

Abstract Article PDF–3.1M

Select item 106578224.

The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization

Meiwan Cao, Peiyu Chen, Baoling Peng, Yang Cheng, Jing Xie, Ziang Hou, Huan Chen, Liping Ye, Huiwen Li, Hongli Wang, Lu Ren, Liya Xiong, Lanlan Geng, Sitang Gong

Front Immunol. 2023; 14: 1270411. Published online 2023 Nov 6. doi: 10.3389/fimmu.2023.1270411

PMCID:: PMC10657822

Abstract Article PDF–10M

Select item 97469175.

An ELF4 hypomorphic variant results in NK cell deficiency

Sandra Andrea Salinas, Emily M. Mace, Matilde I. Conte, Chun Shik Park, Yu Li, Joshua I. Rosario-Sepulveda, Sanjana Mahapatra, Emily K. Moore, Evelyn R. Hernandez, Ivan K. Chinn, Abigail E. Reed, Barclay J. Lee, Alexander Frumovitz, Richard A. Gibbs, Jennifer E. Posey, Lisa R. Forbes Satter, Akaluck Thatayatikom, Eric J. Allenspach, Theodore G. Wensel, James R. Lupski, H. Daniel Lacorazza, Jordan S. Orange

JCI Insight. 2022 Dec 8; 7(23): e155481. Published online 2022 Dec 8. doi: 10.1172/jci.insight.155481

PMCID:: PMC9746917

Abstract Article PDF–7.0M

Select item 89858516.

Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation

Paul M. Tyler, Molly L. Bucklin, Mengting Zhao, Timothy J. Maher, Andrew J. Rice, Weizhen Ji, Neil Warner, Jie Pan, Raffaella Morotti, Paul McCarthy, Anne Griffiths, Annemarie M.C. van Rossum, Iris H.I.M. Hollink, Virgil A.S.H. Dalm, Jason Catanzaro, Saquib A. Lakhani, Aleixo M. Muise, Carrie L. Lucas

Nat Immunol. Author manuscript; available in PMC 2022 Apr 6.

Published in final edited form as: Nat Immunol. 2021 Sep; 22(9): 1118–1126. Published online 2021 Jul 29. doi: 10.1038/s41590-021-00984-4

PMCID:: PMC8985851

Abstract Article PDF–3.7M

Select item 60825027.

MiR-221 negatively regulates innate anti-viral response

Hongqiang Du, Shuang Cui, Yunfei Li, Guang Yang, Peiyan Wang, Erol Fikrig, Fuping You

PLoS One. 2018; 13(8): e0200385. Published online 2018 Aug 8. doi: 10.1371/journal.pone.0200385

PMCID:: PMC6082502

Abstract Article PDF–2.8M

Select item 47853518.

Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms

Takashi Asai, Megan A. Hatlen, Chen Lossos, Delphine Ndiaye-Lobry, Anthony Deblasio, Kazunori Murata, Martin Fleisher, Elena M. Cortizas, Ramiro E. Verdun, John Petrini, Stephen D. Nimer

Sci Rep. 2016; 6: 22760. Published online 2016 Mar 10. doi: 10.1038/srep22760

PMCID:: PMC4785351

Abstract Article PDF–2.3M

Select item 38722509.

The Transcription Factor ELF4 Suppresses Differentiation of Proliferating CD4⁺ T Cells to the Th17 Lineage

Ping-Hsien Lee, Monica Puppi, Kimberly S. Schluns, Li-Yuan Yu-Lee, Chen Dong, H. Daniel Lacorazza

J Immunol. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: J Immunol. 2014 Jan 1; 192(1): 10.4049/jimmunol.1301372. Published online 2013 Nov 20. doi: 10.4049/jimmunol.1301372

PMCID:: PMC3872250

Abstract Article PDF–2.8M

Select item 381292410.

MEF promotes stemness in the pathogenesis of gliomas

Elena Bazzoli, Teodoro Pulvirenti, Moritz C. Oberstadt, Fabiana Perna, Boyoung Wee, Nikolaus Schultz, Jason T. Huse, Elena I. Fomchenko, Francesca Voza, Viviane Tabar, Cameron W. Brennan, Lisa M. DeAngelis, Stephen D. Nimer, Eric C. Holland, Massimo Squatrito

Cell Stem Cell. Author manuscript; available in PMC 2013 Dec 7.

Published in final edited form as: Cell Stem Cell. 2012 Dec 7; 11(6): 10.1016/j.stem.2012.09.012. doi: 10.1016/j.stem.2012.09.012

PMCID:: PMC3812924

Abstract Article PDF–642K

Select item 651461811.

ELF4 facilitates innate host defenses against Plasmodium by activating transcription of Pf4 and Ppbp

Dandan Wang, Zeming Zhang, Shuang Cui, Yingchi Zhao, Samuel Craft, Erol Fikrig, Fuping You

J Biol Chem. 2019 May 10; 294(19): 7787–7796. Published online 2019 Mar 21. doi: 10.1074/jbc.RA118.006321

PMCID:: PMC6514618

Abstract Article PDF–2.1M

Select item 407367712.

The Mef/Elf4 transcription factor fine tunes the DNA damage response

Goro Sashida, Narae Bae, Silvana Di Giandomenico, Takashi Asai, Nadia Gurvich, Elena Bazzoli, Yan Liu, Gang Huang, Xinyang Zhao, Silvia Menendez, Stephen D Nimer

Cancer Res. Author manuscript; available in PMC 2014 Jun 27.

Published in final edited form as: Cancer Res. 2011 Jul 15; 71(14): 4857–4865. Published online 2011 May 26. doi: 10.1158/0008-5472.CAN-11-0455

PMCID:: PMC4073677

Abstract Article PDF–1.9M

Select item 294398313.

Expression of the transcription factor ELF4 is regulated by the mTOR pathway in CD8⁺ T cells

Takeshi Yamada, Kirsten Gierach, Ping-Hsien Lee, Xiaohong Wang, H. Daniel Lacorazza

J Immunol. Author manuscript; available in PMC 2011 Oct 1.

Published in final edited form as: J Immunol. 2010 Oct 1; 185(7): 3824–3828. Published online 2010 Aug 27. doi: 10.4049/jimmunol.1000718

PMCID:: PMC2943983

Abstract Article PDF–342K

Select item 269876914.

ELF4/MEF Activates MDM2 Expression and Blocks Oncogene-Induced p16 Activation To Promote Transformation

Goro Sashida, Yan Liu, Shannon Elf, Yasuhiko Miyata, Kazuma Ohyashiki, Miki Izumi, Silvia Menendez, Stephen D. Nimer

Mol Cell Biol. 2009 Jul; 29(13): 3687–3699. Published online 2009 Apr 20. doi: 10.1128/MCB.01551-08

PMCID:: PMC2698769

Abstract Article PDF–1.7M

Select item 327297915.

Integration of Elf-4 into Stem/Progenitor and Erythroid Regulatory Networks through Locus-Wide Chromatin Studies Coupled with InVivo Functional Validation

Aileen M. Smith, Fernando J. Calero-Nieto, Judith Schütte, Sarah Kinston, Richard T. Timms, Nicola K. Wilson, Rebecca L. Hannah, Josette-Renee Landry, Berthold Göttgens

Mol Cell Biol. 2012 Feb; 32(4): 763–773. doi: 10.1128/MCB.05745-11

PMCID:: PMC3272979

Abstract Article PDF–1.7M

Select item 310028916.

The transcription factor ELF4 controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow

Mariela Sivina, Takeshi Yamada, Chun Shik Park, Monica Puppi, Suleyman Coskun, Karen Hirschi, H. Daniel Lacorazza

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2012 May 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 May; 31(5): 1185–1191. Published online 2011 Feb 24. doi: 10.1161/ATVBAHA.111.224436

PMCID:: PMC3100289

Abstract Article PDF–957K

Select item 277479717.

The transcription factor ELF4 controls proliferation and homing of CD8⁺ T cells via the Krüppel-like factors KLF4 and KLF2

Takeshi Yamada, Chun Shik Park, Maksim Mamonkin, Daniel Lacorazza

Nat Immunol. Author manuscript; available in PMC 2009 Dec 1.

Published in final edited form as: Nat Immunol. 2009 Jun; 10(6): 618–626. Published online 2009 May 3. doi: 10.1038/ni.1730

PMCID:: PMC2774797

Abstract Article PDF–4.1M

Select item 393985518.

ELF4 is critical for induction of type I interferon and the host antiviral response

Fuping You, Penghua Wang, Long Yang, Guang Yang, Yang O Zhao, Feng Qian, Wendy Walker, Richard Sutton, Ruth Montgomery, Rongtuan Lin, Akiko Iwasaki, Erol Fikrig

Nat Immunol. Author manuscript; available in PMC 2014 Mar 3.

Published in final edited form as: Nat Immunol. 2013 Dec; 14(12): 1237–1246. Published online 2013 Nov 3. doi: 10.1038/ni.2756

PMCID:: PMC3939855

Abstract Article PDF–3.4M

Select item 299604119.

DNA Damage Signaling in Hematopoietic Cells: A Role for Mre11 Complex Repair of Topoisomerase Lesions

Monica Morales, Yan Liu, Evagelia C. Laiakis, William F. Morgan, Stephen D. Nimer, John H.J. Petrini

Cancer Res. Author manuscript; available in PMC 2010 Dec 2.

Published in final edited form as: Cancer Res. 2008 Apr 1; 68(7): 2186–2193. doi: 10.1158/0008-5472.CAN-07-2355

PMCID:: PMC2996041

Abstract Article PDF–1.0M

Select item 324656520.

ETS-Dependent Regulation of a Distal Gata4 Cardiac Enhancer

William Schachterle, Anabel Rojas, Shan-Mei Xu, Brian L. Black

Dev Biol. Author manuscript; available in PMC 2013 Jan 15.

Published in final edited form as: Dev Biol. 2012 Jan 15; 361(2): 439–449. Published online 2011 Oct 26. doi: 10.1016/j.ydbio.2011.10.023

PMCID:: PMC3246565

Abstract Article PDF–4.4M

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