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Select item 112534051.

PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation

Frida Lind-Holm Mogensen, Carole Sousa, Corrado Ameli, Katja Badanjak, Sandro L. Pereira, Arnaud Muller, Tony Kaoma, Djalil Coowar, Andrea Scafidi, Suresh K. Poovathingal, Maria Tziortziou, Paul M. A. Antony, Nathalie Nicot, Aurélien Ginolhac, Daniela M. Vogt Weisenhorn, Wolfgang Wurst, Aurélie Poli, Petr V. Nazarov, Alexander Skupin, Anne Grünewald, Alessandro Michelucci

J Neuroinflammation. 2024; 21: 174. Published online 2024 Jul 16. doi: 10.1186/s12974-024-03164-x

PMCID:: PMC11253405

Abstract Article PDF–6.8M

Select item 106363622.

Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in dendrites in tuberous sclerosis complex and Alzheimer’s disease

Farr Niere, Ayse Uneri, Colin J. McArdle, Zhiyong Deng, Hailey X. Egido-Betancourt, Luisa P. Cacheaux, Sanjeev V. Namjoshi, William C. Taylor, Xin Wang, Samuel H. Barth, Cameron Reynoldson, Juan Penaranda, Michael P. Stierer, Chelcie F. Heaney, Suzanne Craft, C. Dirk Keene, Tao Ma, Kimberly F. Raab-Graham

Proc Natl Acad Sci U S A. 2023 Nov 7; 120(45): e2301534120. Published online 2023 Oct 30. doi: 10.1073/pnas.2301534120

PMCID:: PMC10636362

Abstract Article PDF–7.7M

Select item 95399843.

DJ‐1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons

Melissa Conti Mazza, Sarah C. Shuck, Jiusheng Lin, Michael A. Moxley, John Termini, Mark R. Cookson, Mark A. Wilson

J Neurochem. 2022 Aug; 162(3): 245–261. Published online 2022 Jul 2. doi: 10.1111/jnc.15656

PMCID:: PMC9539984

Abstract Article PDF–6.1M

Select item 81761144.

PARK7 Protects Against Chronic Kidney Injury and Renal Fibrosis by Inducing SOD2 to Reduce Oxidative Stress

Lijun Yin, Honglin Li, Zhiwen Liu, Wenwen Wu, Juan Cai, Chengyuan Tang, Zheng Dong

Front Immunol. 2021; 12: 690697. Published online 2021 May 21. doi: 10.3389/fimmu.2021.690697

PMCID:: PMC8176114

Abstract Article PDF–13M

Select item 77677465.

Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1

Mala Upadhyay, Caroline Milliner, Brent A. Bell, Vera L. Bonilha

Redox Biol. 2020 Oct; 37: 101623. Published online 2020 Jul 17. doi: 10.1016/j.redox.2020.101623

PMCID:: PMC7767746

Abstract Article PDF–13M

Select item 76958766.

Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury

Hajera Amatullah, Tatiana Maron-Gutierrez, Yuexin Shan, Sahil Gupta, James N. Tsoporis, Amir K. Varkouhi, Ana Paula Teixeira Monteiro, Xiaolin He, Jun Yin, John C. Marshall, Patricia R.M. Rocco, Haibo Zhang, Wolfgang M. Kuebler, Claudia C. dos Santos

Redox Biol. 2021 Jan; 38: 101796. Published online 2020 Nov 17. doi: 10.1016/j.redox.2020.101796

PMCID:: PMC7695876

Abstract Article PDF–8.1M

Select item 76428907.

Protective role of DJ-1 in endotoxin-induced acute kidney injury

Joseph Leeds, Yogesh Scindia, Valentina Loi, Ewa Wlazlo, Elizabeth Ghias, Sylvia Cechova, Didier Portilla, Jonathan Ledesma, Sundararaman Swaminathan

Am J Physiol Renal Physiol. 2020 Oct 1; 319(4): F654–F663. Published online 2020 Jul 27. doi: 10.1152/ajprenal.00064.2020

PMCID:: PMC7642890

Abstract Article

Select item 75280918.

DJ-1 (Park7) affects the gut microbiome, metabolites and the development of innate lymphoid cells (ILCs)

Yogesh Singh, Christoph Trautwein, Achal Dhariwal, Madhuri S. Salker, Md Alauddin, Laimdota Zizmare, Lisann Pelzl, Martina Feger, Jakob Admard, Nicolas Casadei, Michael Föller, Vivek Pachauri, David S. Park, Tak W. Mak, Julia-Stefanie Frick, Diethelm Wallwiener, Sara Y. Brucker, Florian Lang, Olaf Riess

Sci Rep. 2020; 10: 16131. Published online 2020 Sep 30. doi: 10.1038/s41598-020-72903-w

PMCID:: PMC7528091

Abstract Article PDF–3.6M

Select item 70628359.

DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondria

Kentaro Ozawa, Hiroki Tsumoto, Yuri Miura, Junji Yamaguchi, Sanae M. M. Iguchi-Ariga, Tetsushi Sakuma, Takashi Yamamoto, Yasuo Uchiyama

Sci Rep. 2020; 10: 4377. Published online 2020 Mar 9. doi: 10.1038/s41598-020-61287-6

PMCID:: PMC7062835

Abstract Article PDF–1.9M

Select item 696259810.

The relationship between DJ-1 and S100A8 in human primary alveolar type II cells in emphysema

Chih-Ru Lin, Karim Bahmed, Dhanendra Tomar, Nathaniel Marchetti, Gerard J. Criner, Sudhir Bolla, Mark A. Wilson, Muniswamy Madesh, Beata Kosmider

Am J Physiol Lung Cell Mol Physiol. 2019 Dec 1; 317(6): L791–L804. Published online 2019 Jul 17. doi: 10.1152/ajplung.00494.2018

PMCID:: PMC6962598

Abstract Article

Select item 635163511.

Impaired non-homologous end joining in human primary alveolar type II cells in emphysema

Beata Kosmider, Chih-Ru Lin, Liudmila Vlasenko, Nathaniel Marchetti, Sudhir Bolla, Gerard J. Criner, Elise Messier, Nichole Reisdorph, Roger L. Powell, Muniswamy Madesh, Steven Kelsen, Nathaniel Xander, Kelly A. Correll, Robert J. Mason, Karim Bahmed

Sci Rep. 2019; 9: 920. Published online 2019 Jan 29. doi: 10.1038/s41598-018-37000-z

PMCID:: PMC6351635

Abstract Article PDF–4.0M

Select item 623122612.

DJ-1 Deficiency Protects Hepatic Steatosis by Enhancing Fatty Acid Oxidation in Mice

Min Xu, Hailong Wu, Meng Li, Yankai Wen, Chang Yu, Lei Xia, Qiang Xia, Xiaoni Kong

Int J Biol Sci. 2018; 14(13): 1892–1900. Published online 2018 Oct 20. doi: 10.7150/ijbs.28620

PMCID:: PMC6231226

Abstract Article PDF–1.4M

Select item 608999113.

Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin

Yuichiro Mita, Yuto Kataoka, Yoshiro Saito, Takuma Kashi, Kojiro Hayashi, Asa Iwasaki, Takanori Imanishi, Tomohiro Miyasaka, Noriko Noguchi

Sci Rep. 2018; 8: 12056. Published online 2018 Aug 13. doi: 10.1038/s41598-018-30561-z

PMCID:: PMC6089991

Abstract Article PDF–4.8M

Select item 602101814.

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

Lena F. Burbulla, Pingping Song, Joseph R. Mazzulli, Enrico Zampese, Yvette C. Wong, Sohee Jeon, David P. Santos, Judith Blanz, Carolin D. Obermaier, Chelsee Strojny, Jeffrey N. Savas, Evangelos Kiskinis, Xiaoxi Zhuang, Rejko Krüger, D. James Surmeier, Dimitri Krainc

Science. Author manuscript; available in PMC 2018 Sep 22.

Published in final edited form as: Science. 2017 Sep 22; 357(6357): 1255–1261. Published online 2017 Sep 7. doi: 10.1126/science.aam9080

PMCID:: PMC6021018

Abstract Article PDF–942K

Select item 581613815.

DJ-1 deficiency impairs synaptic vesicle endocytosis and reavailability at nerve terminals

Jae Won Kyung, Jin-Mo Kim, Wongyoung Lee, Tae-Young Ha, Seon-Heui Cha, Kyung-Hwun Chung, Dong-Joo Choi, Ilo Jou, Woo Keun Song, Eun-Hye Joe, Sung Hyun Kim, Sang Myun Park

Proc Natl Acad Sci U S A. 2018 Feb 13; 115(7): 1629–1634. Published online 2018 Jan 31. doi: 10.1073/pnas.1708754115

PMCID:: PMC5816138

Abstract Article PDF–1.2M

Select item 568808916.

DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation

Hyuk Soon Kim, Seung Taek Nam, Se Hwan Mun, Sun-Kyeong Lee, Hyun Woo Kim, Young Hwan Park, Bokyung Kim, Kyung-Jong Won, Hae-Rim Kim, Yeong-Min Park, Hyung Sik Kim, Michael A. Beaven, Young Mi Kim, Wahn Soo Choi

Nat Commun. 2017; 8: 1519. Published online 2017 Nov 15. doi: 10.1038/s41467-017-01527-y

PMCID:: PMC5688089

Abstract Article PDF–5.1M

Select item 562369017.

DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy

Chuan-Ying Xu, Wen-Yan Kang, Yi-Meng Chen, Tian-Fang Jiang, Jia Zhang, Li-Na Zhang, Jian-Qing Ding, Jun Liu, Sheng-Di Chen

Front Aging Neurosci. 2017; 9: 308. Published online 2017 Sep 27. doi: 10.3389/fnagi.2017.00308

PMCID:: PMC5623690

Abstract Article PDF–3.0M

Select item 535241718.

DJ-1 promotes development of DEN-induced hepatocellular carcinoma and proliferation of liver cancer cells

Bijun Qiu, Junqi Wang, Yingxue Yu, Chao Zhen, Jinyang Gu, Wenjun Liu, Yankai Wen, Lili Chen, Yueqiu Gao, Qiang Xia, Xiaoni Kong

Oncotarget. 2017 Jan 31; 8(5): 8499–8511. Published online 2016 Dec 27. doi: 10.18632/oncotarget.14293

PMCID:: PMC5352417

Abstract Article PDF–8.9M

Select item 532884019.

Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress

Vera L. Bonilha, Brent A. Bell, Mary E. Rayborn, Ivy S. Samuels, Anna King, Joe G. Hollyfield, Chengsong Xie, Huaibin Cai

Free Radic Biol Med. Author manuscript; available in PMC 2018 Mar 1.

Published in final edited form as: Free Radic Biol Med. 2017 Mar; 104: 226–237. Published online 2017 Jan 11. doi: 10.1016/j.freeradbiomed.2017.01.018

PMCID:: PMC5328840

Abstract Article PDF–943K

Select item 506944420.

Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation

Yingxue Yu, Xuehua Sun, Jinyang Gu, Chang Yu, Yankai Wen, Yueqiu Gao, Qiang Xia, Xiaoni Kong

Int J Biol Sci. 2016; 12(10): 1225–1235. Published online 2016 Sep 15. doi: 10.7150/ijbs.15154

PMCID:: PMC5069444

Abstract Article PDF–2.1M

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