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Select item 111799201.

Identification of Prostaglandin I₂ Synthase Rare Variants in Patients With Williams Syndrome and Severe Peripheral Pulmonary Stenosis

Ayako Chida‐Nagai, Hiroyuki Akagawa, Saori Sawai, Yue‐Jiao Ma, Satoshi Yakuwa, Jun Muneuchi, Kazushi Yasuda, Hirokuni Yamazawa, Toshiyuki Yamamoto, Emi Takakuwa, Utano Tomaru, Yoshiyuki Furutani, Tatsuya Kato, Gen Harada, Kei Inai, Toshio Nakanishi, Atsushi Manabe, Atsuhito Takeda, Zhi‐Cheng Jing

J Am Heart Assoc. 2024 May 7; 13(9): e032872. Published online 2024 Apr 19. doi: 10.1161/JAHA.123.032872

PMCID:: PMC11179920

Abstract Article PDF–2.8M

Select item 105435602.

Validating the role of PTGIS gene in colorectal cancer by bioinformatics analysis and in vitro experiments

Hui Ding, Kai-yun Wang, Si-yang Chen, Kai-Wen Guo, Wen-hong Qiu

Sci Rep. 2023; 13: 16496. Published online 2023 Oct 1. doi: 10.1038/s41598-023-43289-2

PMCID:: PMC10543560

Abstract Article PDF–2.0M

Select item 82559983.

Reduced levels of prostaglandin I₂ synthase: a distinctive feature of the cancer-free trichothiodystrophy

Anita Lombardi, Lavinia Arseni, Roberta Carriero, Emmanuel Compe, Elena Botta, Debora Ferri, Martina Uggè, Giuseppe Biamonti, Fiorenzo A. Peverali, Silvia Bione, Donata Orioli

Proc Natl Acad Sci U S A. 2021 Jun 29; 118(26): e2024502118. Published online 2021 Jun 21. doi: 10.1073/pnas.2024502118

PMCID:: PMC8255998

Abstract Article PDF–1.0M

Select item 55753034.

Nonsteroidal Anti-inflammatory Drug Interaction with Prostacyclin Synthase Protects from Miscarriage

Digna R. Velez Edwards, Todd L. Edwards, Michael J. Bray, Eric Torstenson, Sarah Jones, Martha J. Shrubsole, Harvey J. Muff, Katherine E. Hartmann

Sci Rep. 2017; 7: 9874. Published online 2017 Aug 29. doi: 10.1038/s41598-017-10150-2

PMCID:: PMC5575303

Abstract Article PDF–1.0M

Select item 28611185.

Enhanced Tyrosine Nitration of Prostacyclin Synthase Is Associated with Increased Inflammation in Atherosclerotic Carotid Arteries from Type 2 Diabetic Patients

Chaoyong He, Hyoung Chul Choi, Zhonglin Xie

Am J Pathol. 2010 May; 176(5): 2542–2549. doi: 10.2353/ajpath.2010.090783

PMCID:: PMC2861118

Abstract Article PDF–997K

Select item 28501016.

Characterization of heme environment and mechanism of peroxide bond cleavage in human prostacyclin synthase

Hui-Chun Yeh, Pei-Yung Hsu, Jinn-Shyan Wang, Ah-Lim Tsai, Lee-Ho Wang

Biochim Biophys Acta. Author manuscript; available in PMC 2010 Apr 6.

Published in final edited form as: Biochim Biophys Acta. 2005 Dec 30; 1738(1-3): 121–132. Published online 2005 Dec 20. doi: 10.1016/j.bbalip.2005.11.007

PMCID:: PMC2850101

Abstract Article PDF–1.2M

Select item 28497567.

Characterization of the Peroxidase Mechanism upon Reaction of Prostacyclin Synthase with Peracetic Acid. Identification of a Tyrosyl Radical Intermediate

Hui-Chun Yeh, Gary J. Gerfen, Jinn-Shyan Wang, Ah-Lim Tsai, Lee-Ho Wang

Biochemistry. Author manuscript; available in PMC 2010 Apr 5.

Published in final edited form as: Biochemistry. 2009 Feb 10; 48(5): 917–928. doi: 10.1021/bi801382v

PMCID:: PMC2849756

Abstract Article PDF–1.5M

Select item 12230248.

Solution structure and topology of the N-terminal membrane anchor domain of a microsomal cytochrome P450: prostaglandin I2 synthase.

Ke-He Ruan, Shui-Ping So, Weida Zheng, Jiaxin Wu, Dawei Li, Jennifer Kung

Biochem J. 2002 Dec 15; 368(Pt 3): 721–728. doi: 10.1042/BJ20021001

PMCID:: PMC1223024

Summary PDF–186K

Select item 105997289.

Analysis and experimental validation of fatty acid metabolism-related genes prostacyclin synthase (PTGIS) in endometrial cancer

Bo Wang, Shuwen Ge, Zihao Wang, Wantong Wang, Yuting Wang, Hongrui Leng, Xiaoxin Ma

Aging (Albany NY) 2023 Oct 15; 15(19): 10322–10346. Published online 2023 Oct 4. doi: 10.18632/aging.205080

PMCID:: PMC10599728

Abstract Article PDF–1.9M

Select item 987346710.

Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma

Kai Lei, Ruihao Liang, Binghua Tan, Lin Li, Yingcheng Lyu, Kexi Wang, Wenjian Wang, Kefeng Wang, Xueting Hu, Duoguang Wu, Huayue Lin, Minghui Wang

Oxid Med Cell Longev. 2023; 2023: 6811625. Published online 2023 Jan 17. doi: 10.1155/2023/6811625

PMCID:: PMC9873467

Abstract Article PDF–7.8M

Select item 711383811.

Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension

Xiao-Jian Wang, Xi-Qi Xu, Kai Sun, Ke-Qiang Liu, Su-Qi Li, Xin Jiang, Qin-Hua Zhao, Lan Wang, Fu-Hua Peng, Jue Ye, Yan Wu, Rui Jiang, Jin Zhang, Wei Huang, Wen-Bin Wei, Yi Yan, Jing-Hui Li, Qian-Qian Liu, Sheng Li, Yong Wang, Shu-Yang Zhang, Xue Zhang, Zhi-Cheng Jing

JAMA Cardiol. 2020 Jun; 5(6): 1–8. Published online 2020 Apr 1. doi: 10.1001/jamacardio.2020.0479

PMCID:: PMC7113838

Abstract Article

Select item 285698912.

Protection against Cytokine Toxicity through Endoplasmic Reticulum and Mitochondrial Stress Prevention by Prostacyclin Synthase Overexpression in Insulin-producing Cells

Ewa Gurgul-Convey, Sigurd Lenzen

J Biol Chem. 2010 Apr 9; 285(15): 11121–11128. Published online 2010 Feb 16. doi: 10.1074/jbc.M109.054775

PMCID:: PMC2856989

Abstract Article PDF–767K

Select item 199516313.

Crystal Structure of the Human Prostacyclin Synthase

Chia-Wang Chiang, Hui-Chun Yeh, Lee-Ho Wang, Nei-Li Chan

J Mol Biol. Author manuscript; available in PMC 2007 Sep 28.

Published in final edited form as: J Mol Biol. 2006 Dec 1; 364(3): 266–274. Published online 2006 Sep 20. doi: 10.1016/j.jmb.2006.09.039

PMCID:: PMC1995163

Abstract Article PDF–927K

Select item 409810714.

Functional Prostacyclin Synthase Promoter Polymorphisms. Impact in Pulmonary Arterial Hypertension

Robert S. Stearman, Amber R. Cornelius, Xiao Lu, David S. Conklin, Mark J. Del Rosario, Anita M. Lowe, Mihret T. Elos, Lynsey M. Fettig, Randall E. Wong, Naoko Hara, Joy D. Cogan, John A. Phillips, III, Matthew R. Taylor, Brian B. Graham, Rubin M. Tuder, James E. Loyd, Mark W. Geraci

Am J Respir Crit Care Med. 2014 May 1; 189(9): 1110–1120. Published online 2014 May 1. doi: 10.1164/rccm.201309-1697OC

PMCID:: PMC4098107

Abstract Article PDF–869K

Select item 229329515.

Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change

Yi-Ching Li, Chia-Wang Chiang, Hui-Chun Yeh, Pei-Yung Hsu, Frank G. Whitby, Lee-Ho Wang, Nei-Li Chan

J Biol Chem. Author manuscript; available in PMC 2008 Apr 14.

Published in final edited form as: J Biol Chem. 2008; 283: 2917–2926. doi: 10.1074/jbc.M707470200

PMCID:: PMC2293295

Abstract Article PDF–1.5M

Select item 328416416.

Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli

Mercedes Camacho, Cristina Rodríguez, Anna Guadall, Sonia Alcolea, Mar Orriols, José-Román Escudero, José Martínez-González, Luis Vila

J Lipid Res. 2011 Apr; 52(4): 720–731. doi: 10.1194/jlr.M011007

PMCID:: PMC3284164

Abstract Article PDF–1.4M

Select item 304677317.

Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: Mechanisms of COX-2 inhibitor risk to heart disease

Cheng-Huai Ruan, Shui-Ping So, Ke-He Ruan

Life Sci. Author manuscript; available in PMC 2012 Jan 3.

Published in final edited form as: Life Sci. 2011 Jan 3; 88(1-2): 24–30. Published online 2010 Oct 28. doi: 10.1016/j.lfs.2010.10.017

PMCID:: PMC3046773

Abstract Article PDF–2.2M

Select item 275318318.

Variation in Eicosanoid Genes, Non-fatal Myocardial Infarction and Ischemic Stroke

Rozenn N. Lemaitre, Kenneth Rice, Kristin Marciante, Joshua C. Bis, Thomas S. Lumley, Kerri L. Wiggins, Nicholas L. Smith, Susan R. Heckbert, Bruce M. Psaty

Atherosclerosis. Author manuscript; available in PMC 2010 Jun 1.

Published in final edited form as: Atherosclerosis. 2009 Jun; 204(2): e58–e63. Published online 2008 Nov 1. doi: 10.1016/j.atherosclerosis.2008.10.011

PMCID:: PMC2753183

Abstract Article PDF–67K

Select item 290826119.

Genetic Risk Factors for Hepatopulmonary Syndrome in Patients With Advanced Liver Disease

Kari E. Roberts, Steven M. Kawut, Michael J. Krowka, Robert S. Brown, Jr, James F. Trotter, Vijay Shah, Inga Peter, Hocine Tighiouart, Nandita Mitra, Elizabeth Handorf, James A. Knowles, Steven Zacks, Michael B. Fallon

Gastroenterology. Author manuscript; available in PMC 2010 Aug 1.

Published in final edited form as: Gastroenterology. 2010 Jul; 139(1): 130–9.e24. Published online 2010 Mar 24. doi: 10.1053/j.gastro.2010.03.044