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Select item 109725991.

PREX1 improves homeostatic proliferation to maintain a naive CD4⁺ T cell compartment in older age

Huimin Zhang, Hirohisa Okuyama, Abhinav Jain, Rohit R. Jadhav, Bowen Wu, Ines Sturmlechner, Jose Morales, Shozo Ohtsuki, Cornelia M. Weyand, Jӧrg J. Goronzy

JCI Insight. 2024 Mar 8; 9(5): e172848. Published online 2024 Feb 8. doi: 10.1172/jci.insight.172848

PMCID:: PMC10972599

Abstract Article PDF–4.9M

Select item 93719732.

Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism

Yong-Gang Chang, Christopher J. Lupton, Charles Bayly-Jones, Alastair C. Keen, Laura D’Andrea, Christina M. Lucato, Joel R. Steele, Hari Venugopal, Ralf B. Schittenhelm, James C. Whisstock, Michelle L. Halls, Andrew M. Ellisdon

Nat Struct Mol Biol. 2022; 29(8): 767–773. Published online 2022 Jul 21. doi: 10.1038/s41594-022-00804-9

PMCID:: PMC9371973

Abstract Article PDF–16M

Select item 74767213.

The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding

Sandeep K. Ravala, Jesse B. Hopkins, Caroline B. Plescia, Samantha R. Allgood, Madison A. Kane, Jennifer N. Cash, Robert V. Stahelin, John J. G. Tesmer

J Biol Chem. 2020 Sep 4; 295(36): 12635–12647. Published online 2020 Jul 13. doi: 10.1074/jbc.RA120.014534

PMCID:: PMC7476721

Abstract Article PDF–2.3M

Select item 70073874.

PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells

Miranda E. Clements, Rachelle W. Johnson

Oncogene. Author manuscript; available in PMC 2020 Apr 21.

Published in final edited form as: Oncogene. 2020 Feb; 39(6): 1318–1334. Published online 2019 Oct 21. doi: 10.1038/s41388-019-1064-3

PMCID:: PMC7007387

Abstract Article PDF–3.2M

Select item 67955195.

Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold

Jennifer N. Cash, Sarah Urata, Sheng Li, Sandeep K. Ravala, Larisa V. Avramova, Michael D. Shost, J. Silvio Gutkind, John J. G. Tesmer, Michael A. Cianfrocco

Sci Adv. 2019 Oct; 5(10): eaax8855. Published online 2019 Oct 16. doi: 10.1126/sciadv.aax8855

PMCID:: PMC6795519

Abstract Article PDF–6.7M

Select item 67380046.

Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 (PREX1) is a Novel Predictor of Prognosis for Breast Cancer Patients: A Retrospective Case Series

Ying Zhong, Jing Zhang, Yidong Zhou, Feng Mao, Yan Lin, Yali Xu, Jinghong Guan, Songjie Shen, Bo Pan, Changjun Wang, Li Peng, Xin Huang, Yan Li, Xi Cao, Qiang Sun

Med Sci Monit. 2019; 25: 6554–6562. Published online 2019 Sep 1. doi: 10.12659/MSM.915845

PMCID:: PMC6738004

Abstract Article PDF–2.1M

Select item 53636337.

Multisite phosphorylation of P-Rex1 by protein kinase C

Juan Carlos Montero, Samuel Seoane, Sara García-Alonso, Atanasio Pandiella

Oncotarget. 2016 Nov 22; 7(47): 77937–77949. Published online 2016 Oct 24. doi: 10.18632/oncotarget.12846

PMCID:: PMC5363633

Abstract Article PDF–4.4M

Select item 53524228.

PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion

Alexander Gont, Manijeh Daneshmand, John Woulfe, Sylvie J. Lavictoire, Ian A.J . Lorimer

Oncotarget. 2017 Jan 31; 8(5): 8559–8573. Published online 2016 Dec 29. doi: 10.18632/oncotarget.14348

PMCID:: PMC5352422

Abstract Article PDF–8.7M

Select item 50256909.

PREX1 Protein Function Is Negatively Regulated Downstream of Receptor Tyrosine Kinase Activation by p21-activated Kinases (PAKs)

Douglas Barrows, John Z. He, Ramon Parsons

J Biol Chem. 2016 Sep 16; 291(38): 20042–20054. Published online 2016 Aug 1. doi: 10.1074/jbc.M116.723882

PMCID:: PMC5025690

Abstract Article PDF–2.3M

Select item 486025210.

Structural and biochemical characterization of the catalytic core of the metastatic factor P-Rex1 and its regulation by PtdIns(3,4,5)P₃

Jennifer N. Cash, Ellen M. Davis, John J. G. Tesmer

Structure. Author manuscript; available in PMC 2017 May 3.

Published in final edited form as: Structure. 2016 May 3; 24(5): 730–740. Published online 2016 Apr 14. doi: 10.1016/j.str.2016.02.022

PMCID:: PMC4860252

Abstract Article PDF–1.8M

Select item 438712411.

P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT, and MEK/ERK signaling in breast cancer

Lloye M. Dillon, Jennifer R. Bean, Wei Yang, Kevin Shee, Lynn K. Symonds, Justin M. Balko, W. Hayes McDonald, Shuying Liu, Ana M. Gonzalez-Angulo, Gordon B. Mills, Carlos L. Arteaga, Todd W. Miller

Oncogene. Author manuscript; available in PMC 2016 Jan 23.

Published in final edited form as: Oncogene. 2015 Jul 23; 34(30): 3968–3976. Published online 2014 Oct 6. doi: 10.1038/onc.2014.328

PMCID:: PMC4387124

Abstract Article PDF–2.0M

Select item 430312312.

Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation

Laura Barrio-Real, Lorena G Benedetti, Nora Engel, Yaping Tu, Soonweng Cho, Saraswati Sukumar, Marcelo G Kazanietz

Breast Cancer Res. 2014; 16: 441. Published online 2014 Sep 24. doi: 10.1186/s13058-014-0441-7

PMCID:: PMC4303123

Abstract Article PDF–1.6M

Select item 328216813.

Characterization of P-Rex1 for its role in fMet-Leu-Phe induced superoxide production in reconstituted COS^phox cells

Baoming Nie, Ni Cheng, Mary C. Dinauer, Richard D. Ye

Cell Signal. Author manuscript; available in PMC 2012 Feb 19.

Published in final edited form as: Cell Signal. 2010 May; 22(5): 770–782. Published online 2010 Jan 13. doi: 10.1016/j.cellsig.2010.01.001

PMCID:: PMC3282168

Abstract Article PDF–4.0M

Select item 320248614.

Phosphatidylinositol 3,4,5-Triphosphate-Dependent Rac Exchanger 1 (P-Rex-1), a Guanine Nucleotide Exchange Factor for Rac, Mediates Angiogenic Responses to Stromal Cell-Derived Factor-1/Chemokine Stromal Cell Derived Factor-1 (SDF-1/CXCL-12) Linked to Rac Activation, Endothelial Cell Migration, and in Vitro Angiogenesis

Jorge Carretero-Ortega, Colin T. Walsh, Ricardo Hernández-García, Guadalupe Reyes-Cruz, Joan Heller Brown, José Vázquez-Prado

Mol Pharmacol. 2010 Mar; 77(3): 435–442. doi: 10.1124/mol.109.060400

PMCID:: PMC3202486

Abstract Article PDF–483K

Select item 303834415.

IDENTIFICATION OF THE Rac-GEF P-REX1 AS AN ESSENTIAL MEDIATOR OF ErbB SIGNALING IN BREAST CANCER

Maria Soledad Sosa, Cynthia Lopez-Haber, Chengfeng Yang, Hongbin Wang, Mark A. Lemmon, John M. Busillo, Jiansong Luo, Jeffrey L. Benovic, Andres Klein-Szanto, Hiroshi Yagi, J. Silvio Gutkind, Ramon E. Parsons, Marcelo G. Kazanietz

Mol Cell. Author manuscript; available in PMC 2011 Dec 22.

Published in final edited form as: Mol Cell. 2010 Dec 22; 40(6): 877–892. doi: 10.1016/j.molcel.2010.11.029

PMCID:: PMC3038344

Abstract Article PDF–2.9M

Select item 281910516.

Rac Activation: P-Rex1 — A Convergence Point for PIP₃ and Gβγ?

Orion D. Weiner

Curr Biol. Author manuscript; available in PMC 2010 Feb 10.

Published in final edited form as: Curr Biol. 2002 Jun 25; 12(12): R429. doi: 10.1016/s0960-9822(02)00917-x

PMCID:: PMC2819105

Abstract Article PDF–105K

Select item 1054341917.

Silencing Rac1 and Prex1 Inhibit Epithelial–Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-β1

Xinyan Gao, Xiaoyan Lin, Mengxin Lin, Yanqin Lan, Yao Wang, Riping Wu, Junde Li, Chuanyong Huang, Dongta Zhong

Turk J Gastroenterol. 2023 Sep; 34(9): 975–981. Published online 2023 Sep 1. doi: 10.5152/tjg.2023.23108

PMCID:: PMC10543419

Abstract Article PDF–1.4M

Select item 752241118.

Identification of P-Rex1 in the Regulation of Liver Cancer Cell Proliferation and Migration via HGF/c-Met/Akt Pathway

Wancheng Qiu, Yanhua Chang, Jing Liu, Xu Yang, Yan Yu, Jiajia Li, Qing Liang, Guangchun Sun

Onco Targets Ther. 2020; 13: 9481–9495. Published online 2020 Sep 24. doi: 10.2147/OTT.S265592

PMCID:: PMC7522411

Abstract Article PDF–8.3M

Select item 637897719.

cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits

Sendi Rafael Adame-García, Rodolfo Daniel Cervantes-Villagrana, Lennis Beatriz Orduña-Castillo, Jason C. del Rio, J. Silvio Gutkind, Guadalupe Reyes-Cruz, Susan S. Taylor, José Vázquez-Prado

J Biol Chem. 2019 Feb 15; 294(7): 2232–2246. Published online 2018 Dec 10. doi: 10.1074/jbc.RA118.006691