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Select item 103260441.

Clinical profiling of MRD48 and functional characterization of two novel pathogenic RAC1 variants

Manuela Priolo, Erika Zara, Francesca Clementina Radio, Andrea Ciolfi, Francesca Spadaro, Emanuele Bellacchio, Cecilia Mancini, Francesca Pantaleoni, Viviana Cordeddu, Luigi Chiriatti, Marcello Niceta, Emilio Africa, Corrado Mammì, Daniela Melis, Simona Coppola, Marco Tartaglia

Eur J Hum Genet. 2023 Jul; 31(7): 805–814. Published online 2023 Apr 14. doi: 10.1038/s41431-023-01351-7

PMCID:: PMC10326044

Abstract Article PDF–2.4M

Select item 101958342.

Identification of RAC1 in promoting brain metastasis of lung adenocarcinoma using single-cell transcriptome sequencing

Mingyu Chen, Hanyue Li, Xiaolin Xu, Xunxia Bao, Lei Xue, Xinghao Ai, Jian Xu, Ming Xu, Yong Shi, Timing Zhen, Jie Li, Yi Yang, Yang Ji, Zhiliang Fu, Kaichen Xing, Tao Qing, Qiubo Wang, Ping Zhong, Sibo Zhu

Cell Death Dis. 2023 May; 14(5): 330. Published online 2023 May 18. doi: 10.1038/s41419-023-05823-y

PMCID:: PMC10195834

Abstract Article PDF–5.8M

Select item 100769483.

A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells

Ioana Stejerean-Todoran, Phyllis A Gimotty, Andrea Watters, Patricia Brafford, Clemens Krepler, Tetiana Godok, Haiyin Li, Zuriñe Bonilla del Rio, Anke Zieseniss, Dörthe M Katschinski, Sinem M Sertel, Silvio O Rizzoli, Bradley Garman, Katherine L Nathanson, Xiaowei Xu, Qing Chen, Jack H Oswald, Michal Lotem, Gordon B Mills, Michael A Davies, Michael P Schön, Ivan Bogeski, Meenhard Herlyn, Adina Vultur

Neuro Oncol. 2023 Apr; 25(4): 674–686. Published online 2022 Sep 2. doi: 10.1093/neuonc/noac212

PMCID:: PMC10076948

Abstract Article PDF–40M

Select item 98659664.

Clinical Significance of Combined Epithelial–Mesenchymal Transition Markers Expression and Role of Rac1 in Hepatocellular Carcinoma

Seung Kak Shin, Sujin Ryu, Seungyoon Nam, Seung Yeon Ha, Oh Sang Kwon, Yun Soo Kim, Se-Hee Kim, Ju Hyun Kim

Int J Mol Sci. 2023 Jan; 24(2): 1765. Published online 2023 Jan 16. doi: 10.3390/ijms24021765

PMCID:: PMC9865966

Abstract Article PDF–2.6M

Select item 97768105.

RAC1, a Potential Diagnostic and Prognostic Marker for Diffuse Large B Cell Lymphoma

Xue Wu, Yuan Li, Wandong Zhang, Jing Zhang, Baoan Chen, Zheng Ge

Cells. 2022 Dec; 11(24): 4039. Published online 2022 Dec 14. doi: 10.3390/cells11244039

PMCID:: PMC9776810

Abstract Article PDF–2.6M

Select item 97278046.

Agent-based modeling predicts RAC1 is critical for ovarian cancer metastasis

Melanie Rivera, Leslie Toledo-Jacobo, Elsa Romero, Tudor I. Oprea, Melanie E. Moses, Laurie G. Hudson, Angela Wandinger-Ness, Martha M. Grimes

Mol Biol Cell. 2022 Dec 1; 33(14): ar138. Published online 2022 Nov 18. doi: 10.1091/mbc.E21-11-0540

PMCID:: PMC9727804

Abstract Article PDF–5.6M

Select item 97118607.

Loss of cell–cell adhesion triggers cell migration through Rac1-dependent ROS generation

Yu-Hsuan Chen, Jinn-Yuan Hsu, Ching-Tung Chu, Yao-Wen Chang, Jia-Rong Fan, Muh-Hwa Yang, Hong-Chen Chen

Life Sci Alliance. 2023 Feb; 6(2): e202201529. Published online 2022 Nov 29. doi: 10.26508/lsa.202201529

PMCID:: PMC9711860

Abstract Article PDF–3.6M

Select item 96731178.

Differential endothelial hydrogen peroxide signaling via Nox isoforms: Critical roles for Rac1 and modulation by statins

Markus Waldeck-Weiermair, Shambhu Yadav, Jonas Kaynert, Venkata Revanth Thulabandu, Arvind K. Pandey, Fotios Spyropoulos, Taylor Covington, Apabrita Ayan Das, Christina Krüger, Thomas Michel

Redox Biol. 2022 Dec; 58: 102539. Published online 2022 Nov 14. doi: 10.1016/j.redox.2022.102539

PMCID:: PMC9673117

Abstract Article PDF–4.8M

Select item 86166009.

Circulating extracellular vesicles of patients with steroid-sensitive nephrotic syndrome have higher RAC1 and induce recapitulation of nephrotic syndrome phenotype in podocytes

Fehime K. Eroglu, Volkan Yazar, Ulku Guler, Muzaffer Yıldırım, Tugce Yildirim, Tulin Gungor, Evra Celikkaya, Deniz Karakaya, Nilsu Turay, Eda Ciftci Dede, Petek Korkusuz, Bekir Salih, Mehmet Bulbul, Ihsan Gursel

Am J Physiol Renal Physiol. 2021 Nov 1; 321(5): F659–F673. Published online 2021 Sep 27. doi: 10.1152/ajprenal.00097.2021

PMCID:: PMC8616600

Abstract Article

Select item 852656810.

Regulation of local GTP availability controls RAC1 activity and cell invasion

Anna Bianchi-Smiraglia, David W. Wolff, Daniel J. Marston, Zhiyong Deng, Zhannan Han, Sudha Moparthy, Rebecca M. Wombacher, Ashley L. Mussell, Shichen Shen, Jialin Chen, Dong-Hyun Yun, Anderson O’Brien Cox, Cristina M. Furdui, Edward Hurley, Maria Laura Feltri, Jun Qu, Thomas Hollis, Jules Berlin Nde Kengne, Bernard Fongang, Rui J. Sousa, Mikhail E. Kandel, Eugene S. Kandel, Klaus M. Hahn, Mikhail A. Nikiforov

Nat Commun. 2021; 12: 6091. Published online 2021 Oct 19. doi: 10.1038/s41467-021-26324-6

Correction in:: Nat Commun. 2021; 12: 6482.

PMCID:: PMC8526568

Abstract Article PDF–2.9M

Select item 791525011.

The Ratio of RAC1B to RAC1 Expression in Breast Cancer Cell Lines as a Determinant of Epithelial/Mesenchymal Differentiation and Migratory Potential

Caroline Eiden, Hendrik Ungefroren

Cells. 2021 Feb; 10(2): 351. Published online 2021 Feb 8. doi: 10.3390/cells10020351

PMCID:: PMC7915250

Abstract Article PDF–1.1M

Select item 785186812.

RAC1 induces nuclear alterations through the LINC complex to enhance melanoma invasiveness

Paula Colón-Bolea, Rocío García-Gómez, Sue Shackleton, Piero Crespo, Xosé R. Bustelo, Berta Casar

Mol Biol Cell. 2020 Dec 1; 31(25): 2768–2778. doi: 10.1091/mbc.E20-02-0127

PMCID:: PMC7851868

Abstract Article PDF–9.3M

Select item 774452213.

Characterization of the erythrocyte GTPase Rac1 in relation to Plasmodium falciparum invasion

Silvio Paone, Sarah D’Alessandro, Silvia Parapini, Francesco Celani, Valentina Tirelli, Manoochehr Pourshaban, Anna Olivieri

Sci Rep. 2020; 10: 22054. Published online 2020 Dec 16. doi: 10.1038/s41598-020-79052-0

PMCID:: PMC7744522

Abstract Article PDF–1.4M

Select item 758347714.

Rac1 repression reverses chemoresistance by targeting tumor metabolism

Shanmugasundaram Ganapathy-Kanniappan

Cancer Biol Ther. 2020; 21(10): 888–890. Published online 2020 Aug 31. doi: 10.1080/15384047.2020.1809923

PMCID:: PMC7583477

Abstract Article PDF–217K

Select item 753591215.

Evaluation of active Rac1 levels in cancer cells: A case of misleading conclusions from immunofluorescence analysis

Martin J. Baker, Mariana Cooke, Gabriel Kreider-Letterman, Rafael Garcia-Mata, Paul A. Janmey, Marcelo G. Kazanietz

J Biol Chem. 2020 Oct 2; 295(40): 13698–13710. Published online 2020 Aug 14. doi: 10.1074/jbc.RA120.013919

PMCID:: PMC7535912

Abstract Article PDF–5.4M

Select item 708120116.

Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer

Qingjian Li, Tao Qin, Zhuofei Bi, Huangming Hong, Lin Ding, Jiewen Chen, Wei Wu, Xiaorong Lin, Wenkui Fu, Fang Zheng, Yandan Yao, Man-Li Luo, Phei Er Saw, Gerburg M. Wulf, Xiaoding Xu, Erwei Song, Herui Yao, Hai Hu

Nat Commun. 2020; 11: 1456. Published online 2020 Mar 19. doi: 10.1038/s41467-020-15308-7

PMCID:: PMC7081201

Abstract Article PDF–4.6M

Select item 699688317.

Identification of a truncated β1-chimaerin variant that inactivates nuclear Rac1

Victoria Casado-Medrano, Laura Barrio-Real, Laura Gutiérrez-Miranda, Rogelio González-Sarmiento, Eladio A. Velasco, Marcelo G. Kazanietz, María J. Caloca

J Biol Chem. 2020 Jan 31; 295(5): 1300–1314. Published online 2019 Dec 22. doi: 10.1074/jbc.RA119.008688

PMCID:: PMC6996883

Abstract Article PDF–3.5M

Select item 695278818.

RAC1B: A Guardian of the Epithelial Phenotype and Protector Against Epithelial-Mesenchymal Transition

Rabea Zinn, Hannah Otterbein, Hendrik Lehnert, Hendrik Ungefroren

Cells. 2019 Dec; 8(12): 1569. Published online 2019 Dec 4. doi: 10.3390/cells8121569

PMCID:: PMC6952788

Abstract Article PDF–2.3M

Select item 687273919.

The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation

Hang Fu, Mohamad Alabdullah, Julia Großmann, Florian Spieler, Reem Abdosh, Veronika Lutz, Katrin Kalies, Kai Knöpp, Max Rieckmann, Susanne Koch, Michel Noutsias, Claudia Pilowski, Jochen Dutzmann, Daniel Sedding, Stefan Hüttelmaier, Kazuo Umezawa, Karl Werdan, Harald Loppnow

Cell Death Dis. 2019 Dec; 10(12): 880. Published online 2019 Nov 21. doi: 10.1038/s41419-019-2109-9

PMCID:: PMC6872739

Abstract Article PDF–2.6M

Select item 676097020.

Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1^P29S Melanoma Cells

Ashwathi S. Mohan, Kevin M. Dean, Tadamoto Isogai, Stacy Y. Kasitinon, Vasanth S. Murali, Philippe Roudot, Alex Groisman, Dana K. Reed, Erik S. Welf, Sangyoon J. Han, Jungsik Noh, Gaudenz Danuser

Dev Cell. Author manuscript; available in PMC 2020 May 6.

Published in final edited form as: Dev Cell. 2019 May 6; 49(3): 444–460.e9. doi: 10.1016/j.devcel.2019.04.007

PMCID:: PMC6760970

Abstract Article PDF–1.8M

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