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Select item 54696021.

Characterization of DNA substrate binding to the phosphatase domain of the DNA repair enzyme, PNKP

Zahra Havali-Shahriari, Michael Weinfeld, J. N. Mark Glover

Biochemistry. Author manuscript; available in PMC 2017 Jun 13.

Published in final edited form as: Biochemistry. 2017 Mar 28; 56(12): 1737–1745. Published online 2017 Mar 15. doi: 10.1021/acs.biochem.6b01236

PMCID:: PMC5469602

Abstract Article PDF–950K

Select item 48200332.

The structural basis for substrate recognition by mammalian polynucleotide kinase 3’ phosphatase

Fernando Garces, Laurence H. Pearl, Antony W. Oliver

Mol Cell. Author manuscript; available in PMC 2016 Apr 4.

Published in final edited form as: Mol Cell. 2011 Nov 4; 44(3): 385–396. doi: 10.1016/j.molcel.2011.08.036

PMCID:: PMC4820033

Abstract Article PDF–2.9M

Select item 27644223.

Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase

N. K. Bernstein, M. Hammel, R. S. Mani, M. Weinfeld, M. Pelikan, J. A. Tainer, J. N. M. Glover

Nucleic Acids Res. 2009 Oct; 37(18): 6161–6173. Published online 2009 Aug 11. doi: 10.1093/nar/gkp597

PMCID:: PMC2764422

Abstract Article PDF–2.4M

Select item 56960154.

XRCC1-mediated repair of strand breaks independent of PNKP binding

Julie K. Horton, Donna F. Stefanick, Ming-Lang Zhao, Agnes K. Janoshazi, Natalie R. Gassman, Hannah J. Seddon, Samuel H. Wilson

DNA Repair (Amst) Author manuscript; available in PMC 2018 Dec 1.

Published in final edited form as: DNA Repair (Amst). 2017 Dec; 60: 52–63. Published online 2017 Oct 19. doi: 10.1016/j.dnarep.2017.10.007

PMCID:: PMC5696015

Abstract Article PDF–1.1M

Select item 35262715.

Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress

Jason L. Parsons, Svetlana V. Khoronenkova, Irina I. Dianova, Nicola Ternette, Benedikt M. Kessler, Pran K. Datta, Grigory L. Dianov

Nucleic Acids Res. 2012 Dec; 40(22): 11404–11415. Published online 2012 Oct 5. doi: 10.1093/nar/gks909

PMCID:: PMC3526271

Abstract Article PDF–2.4M

Select item 32485416.

Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates

Nicolas Coquelle, Zahra Havali-Shahriari, Nina Bernstein, Ruth Green, J. N. Mark Glover

Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52): 21022-21027. Published online 2011 Dec 14. doi: 10.1073/pnas.1112036108

PMCID:: PMC3248541

Abstract Article PDF–1.7M

Select item 83216607.

PNKP is required for maintaining the integrity of progenitor cell populations in adult mice

Wisoo Shin, Whitney Alpaugh, Laura J Hallihan, Sarthak Sinha, Emilie Crowther, Gary R Martin, Teresa Scheidl-Yee, Xiaoyan Yang, Grace Yoon, Taylor Goldsmith, Nelson D Berger, Luiz GN de Almeida, Antoine Dufour, Ina Dobrinski, Michael Weinfeld, Frank R Jirik, Jeff Biernaskie

Life Sci Alliance. 2021 Sep; 4(9): e202000790. Published online 2021 Jul 5. doi: 10.26508/lsa.202000790

PMCID:: PMC8321660

Abstract Article PDF–3.8M

Select item 35262778.

Pol β associated complex and base excision repair factors in mouse fibroblasts

Rajendra Prasad, Jason G. Williams, Esther W. Hou, Samuel H. Wilson

Nucleic Acids Res. 2012 Dec; 40(22): 11571–11582. Published online 2012 Oct 5. doi: 10.1093/nar/gks898

PMCID:: PMC3526277

Abstract Article PDF–2.3M

Select item 47441179.

FBXW7 facilitates non-homologous end-joining via K63-linked polyubiquitylation of XRCC4

Qiang Zhang, David Karnak, Mingjia Tan, Theodore S. Lawrence, Meredith A. Morgan, Yi Sun

Mol Cell. Author manuscript; available in PMC 2017 Feb 4.

Published in final edited form as: Mol Cell. 2016 Feb 4; 61(3): 419–433. Published online 2016 Jan 7. doi: 10.1016/j.molcel.2015.12.010

PMCID:: PMC4744117

Abstract Article PDF–2.6M

Select item 460166510.

Polynucleotide kinase–phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability

Mikio Shimada, Lavinia C Dumitrache, Helen R Russell, Peter J McKinnon

EMBO J. 2015 Oct 1; 34(19): 2465–2480. Published online 2015 Aug 19. doi: 10.15252/embj.201591363

PMCID:: PMC4601665

Abstract Article PDF–7.3M

Select item 407400911.

Aberrant Topoisomerase-1-DNA Lesions are Pathogenic in Neurodegenerative Genome Instability Syndromes

Sachin Katyal, Youngsoo Lee, Karin C. Nitiss, Susanna M. Downing, Yang Li, Mikio Shimada, Jingfeng Zhao, Helen R. Russell, John H. J. Petrini, John L. Nitiss, Peter J. McKinnon

Nat Neurosci. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Nat Neurosci. 2014 Jun; 17(6): 813–821. Published online 2014 May 4. doi: 10.1038/nn.3715

PMCID:: PMC4074009

Abstract Article PDF–2.2M

Select item 504520012.

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

Yong Wu, Fan-Yan Wei, Layla Kawarada, Takeo Suzuki, Kimi Araki, Yoshihiro Komohara, Atsushi Fujimura, Taku Kaitsuka, Motohiro Takeya, Yuichi Oike, Tsutomu Suzuki, Kazuhito Tomizawa

PLoS Genet. 2016 Sep; 12(9): e1006355. Published online 2016 Sep 30. doi: 10.1371/journal.pgen.1006355

PMCID:: PMC5045200

Abstract Article PDF–2.9M

Select item 286024313.

An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells

Debbie L.C. van den Berg, Tim Snoek, Nick P. Mullin, Adam Yates, Karel Bezstarosti, Jeroen Demmers, Ian Chambers, Raymond A. Poot

Cell Stem Cell. 2010 Apr 2; 6(4): 369–381. doi: 10.1016/j.stem.2010.02.014

PMCID:: PMC2860243

Abstract Article

Select item 452520314.

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells

Paulina A. Latos, Angela Goncalves, David Oxley, Hisham Mohammed, Ernest Turro, Myriam Hemberger

Nat Commun. 2015; 6: 7776. Published online 2015 Jul 24. doi: 10.1038/ncomms8776

PMCID:: PMC4525203

Abstract Article PDF–1.9M

Select item 141356815.

BGEM: An In Situ Hybridization Database of Gene Expression in the Embryonic and Adult Mouse Nervous System

Susan Magdaleno, Patricia Jensen, Craig L Brumwell, Anna Seal, Karen Lehman, Andrew Asbury, Tony Cheung, Tommie Cornelius, Diana M Batten, Christopher Eden, Shannon M Norland, Dennis S Rice, Nilesh Dosooye, Sundeep Shakya, Perdeep Mehta, Tom Curran

PLoS Biol. 2006 Apr; 4(4): e86. Published online 2006 Mar 28. doi: 10.1371/journal.pbio.0040086

PMCID:: PMC1413568

Article PDF–99K

Select item 1683316.

Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray

Tetsuya S. Tanaka, Saied A. Jaradat, Meng K. Lim, George J. Kargul, Xiaohong Wang, Marija J. Grahovac, Serafino Pantano, Yuri Sano, Yulan Piao, Ramaiah Nagaraja, Hirofumi Doi, William H. Wood, III, Kevin G. Becker, Minoru S. H. Ko

Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16): 9127–9132. doi: 10.1073/pnas.97.16.9127

PMCID:: PMC16833

Abstract Article PDF–847K

Select item 255627017.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

Select item 1091766018.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 357241019.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 28355420.

Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

Brian P. Zambrowicz, Alejandro Abuin, Ramiro Ramirez-Solis, Lizabeth J. Richter, James Piggott, Hector BeltrandelRio, Eric C. Buxton, Joel Edwards, Rick A. Finch, Carl J. Friddle, Anupma Gupta, Gwenn Hansen, Yi Hu, Wenhu Huang, Crystal Jaing, Billie Wayne Key, Jr., Peter Kipp, Buckley Kohlhauff, Zhi-Qing Ma, Diane Markesich, Robert Payne, David G. Potter, Ny Qian, Joseph Shaw, Jeff Schrick, Zheng-Zheng Shi, Mary Jean Sparks, Isaac Van Sligtenhorst, Peter Vogel, Wade Walke, Nianhua Xu, Qichao Zhu, Christophe Person, Arthur T. Sands

Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24): 14109–14114. Published online 2003 Nov 10. doi: 10.1073/pnas.2336103100

Correction in:: Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12): 4332.

PMCID:: PMC283554

Abstract Article PDF–481K

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